Targets for ethanol action and antagonism in Loop 2 of the extracellular domain of glycine receptors

Journal of Neurochemistry

Volumn 106, Issue 3, 2008, Pages 1337-1349

  Perkins, Daya I ^a   Trudell, James R ^b   Crawford, Daniel K ^a,c   Alkana, Ronald L ^a   Davies, Daryl L ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ethanol sites of action; Glycine receptor; Increased atmospheric pressure; Ion channels; Two electrode voltage clamp; Xenopus oocytes

Indexed keywords

ALCOHOL; GLYCINE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ANIMALS; DRUG DELIVERY SYSTEMS; ETHANOL; EXTRACELLULAR FLUID; FEMALE; HUMANS; OOCYTES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; XENOPUS LAEVIS;

EID: 48249132803     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05476.x     Document Type: Article

References (73)

1. - current in cultured mouse neurons. J. Pharmacol. Exp. Ther. 270, 61 69.
2. Alkana R. L. Malcolm R. D. (1980) The effects of low level hyperbaric treatment on acute ethanol intoxication. Adv. Exp. Med. Biol. 126, 499 507.
3. Alkana R. L. Malcolm R. D. (1981) Low-level hyperbaric ethanol antagonism in mice. Dose and pressure response. Pharmacology 22, 199 208.
4. Alkana R. L. Malcolm R. D. (1982) Hyperbaric ethanol antagonism in mice: studies on oxygen, nitrogen, strain and sex. Psychopharmacology 77, 11 16.
5. Alkana R. L., Jones B. L., Palomares M. L., Crabbe J. C. Bejanian M. (1992) Mechanism of low level hyperbaric ethanol antagonism: specificity versus other drugs. Alcohol Alcohol. Suppl. 1, 63.
6. Alkana R. L., Davies D. L., Morland J., Parker E. S. Bejanian M. (1995) Low level hyperbaric exposure antagonizes locomotor effects of ethanol and n-propanol but not morphine in C57BL mice. Alcohol. Clin. Exp. Res. 19, 693 700.
7. Bejanian M., Jones B. L. Alkana R. L. (1993) Low-level hyperbaric antagonism of ethanol-induced locomotor depression in C57BL/6J mice: dose response. Alcohol. Clin. Exp. Res. 17, 935 939.
8. Betz H. (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. TINS 14, 458 461.
9. Bowser-Riley F., Daniels S. Smith E. B. (1988) Investigations into the origin of the high pressure neurological syndrome: the interaction between pressure, strychnine and 1,2-propandiols in the mouse. Br. J. Pharmacol. 94, 1069 1076.
10. Cardoso R. A., Brozowski S. J., Chavez-Noriega L. E., Harpold M., Valenzuela C. F. Harris R. A. (1999) Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 289, 774 780.
11. Colombo G., Orrù A., Lai P., Cabras C., Maccioni P., Rubio M., Gessa G. L. Carai M. A. (2007) The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence. Mol. Neurobiol. 36, 102 112.
12. Crawford D. K., Trudell J. R., Bertaccini E., Li K. X., Davies D. L. Alkana R. L. (2007) Evidence that ethanol acts on a target in loop 2 of the extracellular domain of alpha1 glycine receptors. J. Neurochem. 102, 2097 2109.
13. A receptors by increased atmospheric pressure. Alcohol. Clin. Exp. Res. 22, 1689 1697.
14. A receptor function in short sleep and long sleep mouse brain membranes. Alcohol. Clin. Exp. Res. 25, 478 483.
15. Davies D. L., Morland J., Jones B. L. Alkana R. L. (1994) Low-level hyperbaric antagonism of ethanol's anticonvulsant property in C57BL/6J mice. Alcohol. Clin. Exp. Res. 18, 1190 1195.
16. Davies D. L., Bejanian M., Parker E. S., Morland J., Bolger M. B., Brinton R. D. Alkana R. L. (1996) Low-level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice. J. Pharmacol. Exp. Ther. 276, 667 675.
17. Davies D. L., Bolger M. B., Brinton R. D., Finn D. A. Alkana R. L. (1999) In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol. Psychopharmacology 141, 339 350.
18. Davies D. L., Trudell J. R., Mihic S. J., Crawford D. K. Alkana R. L. (2003) Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcohol. Clin. Exp. Res. 27, 1 13.
19. Davies D. L., Crawford D. K., Trudell J. R., Mihic S. J. Alkana R. L. (2004) Multiple sites of ethanol action in α1 and α2 glycine receptors suggested by sensitivity to pressure antagonism. J. Neurochem. 89, 1175 1185.
20. Deitrich R., Dunwiddie T., Harris R. A. Erwin V. G. (1989) Mechanism of action of ethanol: initial central nervous system actions. Pharmacol. Rev. 41, 489 537.
21. Dougherty D. A. (1996) Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. Science 271, 163 168.
22. A receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine site ligands. Mol. Pharmacol. 56, 768 774.
23. Eckenhoff R. G. Johansson J. S. (1997) Molecular interactions between inhaled anesthetics and proteins. Pharmacol. Rev. 49, 343 367.
24. Eggers E. D., O'Brien J. A. Berger A. J. (2000) Developmental changes in the modulation of synaptic glycine receptors by ethanol. J. Neurophysiol. 84, 2409 2416.
25. Eisenberg D., Weiss R. M. Terwilliger T. C. (1984) The hydrophobic moment detects periodicity in protein hydrophobicity. Proc. Natl Acad. Sci. USA 81, 140 144.
26. - fluxes in rat brain synaptoneurosomes. J. Neurochem. 57, 384 390.
27. Franks N. P. Lieb W. R. (1994) Molecular and cellular mechanisms of general anaesthesia. Nature 367, 607 614.
28. Franks N. P. Lieb W. R. (1997) Inhibitory synapses: anaesthetics set their sites on ion channels. Nature 389, 334 335.
29. Grant B. F., Dawson D. A., Stinson F. S., Chou P., Dufour M. C. Pickering R. P. (2004) The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002. Drug Alcohol Depend. 74, 223 234.
30. Harris R. A. (1999) Ethanol actions on multiple ion channels: which are important? Alcohol. Clin. Exp. Res. 23, 1563 1570.
31. Heilig M. Egli M. (2006) Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol. Ther. 111, 855 876.
32. Imai T., Isogai H., Seto T., Kovalenko A. Hirata F. (2006) Theoretical study of volume changes accompanying xenon-lysozyme binding: implications for the molecular mechanism of pressure reversal of anesthesia. J. Phys. Chem. 110, 12149 12154.
33. Johnson B. A., Rosenthal N., Capece J. A. et al. (2007) Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA 298, 1641 1651.
34. Karlin A. (2002) Emerging structure of the nicotinic acetylcholine receptors. Nat. Rev. Neurosci. 3, 102 114.
35. Karlin A. Akabas M. H. (1998) Substituted-cysteine accessibility method. Methods Enzymol. 293, 123 145.
36. Kendig J. J. (1984) Pressure dependence of excitable cell function. TINS 7, 483 486.
37. Little H. J. (1996) How has molecular pharmacology contributed to our understanding of the mechanism(s) of general anesthesia? Pharmacol. Ther. 69, 37 58.
38. Lobo I. A., Harris R. A. Trudell J. R. (2007) Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J. Neurochem. 104, 1649 1662.
39. Malashkevich V. N., Kammerer R. A., Efimov V. P., Schulthess T. Engel J. (1996) The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel? Science 274, 761 765.
40. Malosio M. L., Marquèze-Pouey B., Kuhse J. Betz H. (1991) Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J. 10, 2401 2409.
41. Mascia M. P., Machu T. L. Harris R. A. (1996a) Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br. J. Pharmacol. 119, 1331 1336.
42. Mascia M. P., Mihic S. J., Valenzuela C. F., Schofield P. R. Harris R. A. (1996b) A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors. Mol. Pharmacol. 50, 402 406.
43. Mascia M. P., Trudell J. R. Harris R. A. (2000) Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc. Natl Acad. Sci. USA 97, 9305 9310.
44. Mastrangelo C. J., Kendig J. J., Trudell J. R. Cohen E. N. (1979) Nerve membrane lipid fluidity: opposing effects of high pressure and ethanol. Undersea Biomed. Res, 6, 47 53.
45. A and strychnine-sensitive glycine receptors expressed by lateral/basolateral amygdala neurons. Brain Res. 963, 165 177.
46. A and glycine receptors. Nature 389, 385 389.
47. Miller K. W., Paton W. D. M., Smith R. A. Smith E. B. (1973) The pressure reversal of anaesthesia and the critical volume hypothesis. Mol. Pharmacol. 9, 131 143.
48. Molander A. Söderpalm B. (2005) Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system. Alcohol. Clin. Exp. Res. 29, 27 37.
49. Molander A., Lidö H. H., Löf E., Ericson M. Söderpalm B. (2007) The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats. Alcohol Alcohol. 42, 11 18.
50. Mori T., Matubayasi N. Ueda I. (1984) Membrane expansion and inhalation anesthetics. Mean excess volume hypothesis. Mol. Pharmacol. 25, 123 130.
51. Ortells M. O. Lunt G. G. (1995) Evolutionary history of the ligand-gated ion-channel superfamily of receptors. TINS 18, 121 127.
52. Quillin M. L., Breyer W. A., Griswold I. J. Matthews B. W. (2000) Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme. J. Mol. Biol. 302, 955 977.
53. Rajendra S., Lynch J. W. Schofield P. R. (1997) The glycine receptor. Pharmacol. Ther. 73, 121 146.
54. Ryan S. G., Buckwalter M. S., Lynch J. W., Handford C. A., Segura L., Shiang R., Wasmuth J. J., Camper S. A., Schofield P. R. O'Connel P. (1994) A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse. Nat. Genet. 7, 131 135.
55. Saul B., Schmieden V., Kling C., Mülgardt C., Gass P., Kuhse J. Becker C.-M. (1994) Point mutation of glycine receptor α1 subunit in the spasmodic mouse affects agoinst responses. FEBS Lett. 350, 71 76.
56. A receptor shows a ligand-gated receptor super-family. Nature 328, 221 227.
57. Steensland P., Simms J. A., Holgate J., Richards J. K. Bartlett S. E. (2007) Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proc. Natl Acad. Sci. USA 104, 12518 12523.
58. Syapin P. J., Chen J., Finn D. A. Alkana R. L. (1988) Antagonism of ethanol-induced depression of mouse locomotor activity by hyperbaric exposure. Life Sci. 43, 2221 2229.
59. Tao L. Ye J. H. (2002) Protein kinase C modulation of ethanol inhibition of glycine-activated current in dissociated neurons of rat ventral tegmental area. J. Pharmacol. Exp. Ther. 300, 967 975.
60. Tapia J. C., Aguilar L. F., Sotomayor C. P. Aguayo L. G. (1998) Ethanol affects the function of a neurotransmitter receptor protein without altering the membrane lipid phase. Eur. J. Pharmacol. 354, 239 244.
61. Trudell J. R., Hubbell W. L. Cohen E. N. (1973) Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles. Biochim. Biophys. Acta 291, 328 334.
62. Trudell J. R., Payan D. G., Chin J. H. Cohen E. N. (1974) Pressure-induced elevation of phase transition temperature in dipalmitoylphosphatidylcholine bilayers: an electron spin resonance measurement of the enthalpy of phase transition. Biochim. Biophys. Acta 373, 436 443.
63. Valenzuela C. F., Cardoso R. A., Wick M. J., Weiner J. L., Dunwiddie T. V. Harris R. A. (1998) Effects of ethanol on recombinant glycine receptors expressed in mammalian cell lines. Alcohol. Clin. Exp. Res. 22, 1132 1136.
64. Wallner M., Hanchar H. J. Olsen R. W. (2006) Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513. Proc. Natl Acad. Sci. USA 103, 8540 8545.
65. Wann K. T. MacDonald A. G. (1988) Actions and interactions of high pressure and general anesthetics. Prog. Neurobiol. 30, 271 307.
66. Weber G. Drickamer H. G. (1983) The effect of high pressure upon proteins and other biomolecules. Q. Rev. Biophys. 16, 89 112.
67. Wick M. J., Mihic S. J., Ueno S., Mascia M. P., Trudell J. R., Brozowski S. J., Ye Q., Harrison N. L. Harris R. A. (1998) Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc. Natl Acad. Sci. USA 95, 6504 6509.
68. Ye Q., Koltchine V. V., Mihic S. J., Mascia M. P., Wick M. J., Finn S. E., Harrison N. L. Harris R. A. (1998) Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position α267. J. Biol. Chem. 273, 3314 3319.
69. Ye J. H., Tao L., Krnjevic K. McArdle J. J. (2002) Decay of ethanol-induced suppression of glycine-activated current of ventral tegmental area neurons. Neuropharmacology 43, 788 798.
70. Yevenes G. E., Moraga-Cid G., Guzmán L., Haeger S., Oliveira L., Olate J., Schmalzing G. Aguayo L. G. (2006) Molecular determinants for G protein betagamma modulation of ionotropic glycine receptors. J. Biol. Chem. 281, 39300 39307.
71. 3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells. J. Pharmacol. Exp. Ther. 278, 732 740.
72. Zimmerman J. M., Eliezer N. Simha R. (1968) The characterization of amino acid sequences in proteins by statistical methods. J. Theor. Biol. 21, 170 201.
73. Ziskind-Conhaim L., Gao B. X. Hinckley C. (2003) Ethanol dual modulatory actions on spontaneous postsynaptic currents in spinal motoneurons. J. Neurophysiol. 89, 806 813.