The TM2 6′ position of GABA A receptors mediates alcohol inhibition

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 2, 2012, Pages 445-456

  Johnson II, W David ^a   Howard, Rebecca J ^a   Trudell, James R ^b   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; ALCOHOL; AMINO ACID; CYSTEINE; ETOMIDATE; GLUTAMIC ACID; LIGAND GATED ION CHANNEL; MEMBRANE RECEPTOR; METHANOL; METHIONINE; THIOMESYLIC ACID METHYL ESTER; TRYPTOPHAN; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; ALCOHOL DERIVATIVE; COMPLEMENTARY DNA; CYSTINE; DRUG DERIVATIVE; GABRA2 PROTEIN, HUMAN; GABRB2 PROTEIN, HUMAN; GABRG2 PROTEIN, HUMAN; MESYLIC ACID METHYL ESTER;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; INHIBITION KINETICS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN MODIFICATION; RECEPTOR BINDING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS; ANIMAL; BINDING COMPETITION; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; GENETICS; HUMAN; METABOLISM; MOLECULAR DYNAMICS; PATCH CLAMP; PHYSIOLOGY;

ALCOHOLS; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CYSTEINE; CYSTINE; DNA, COMPLEMENTARY; DRUG SYNERGISM; ELECTROPHYSIOLOGICAL PHENOMENA; ETHANOL; ETOMIDATE; GABA-A RECEPTOR ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; METHIONINE; METHYL METHANESULFONATE; MOLECULAR DYNAMICS SIMULATION; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, GABA-A; TRYPTOPHAN; XENOPUS LAEVIS;

EID: 84855987146     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.188037     Document Type: Article

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