Dihydromyricetin as a novel anti-alcohol intoxication medication

Journal of Neuroscience

Volumn 32, Issue 1, 2012, Pages 390-401

  Shen, Yi ^a   Lindemeyer, Kerstin ^a   Gonzalez, Claudia ^b   Shao, Xuesi M ^b   Spigelman, Igor ^a   Olsen, Richard W ^a   Liang, Jing ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPELOPSIN; FLAVONOL DERIVATIVE; HERBACEOUS AGENT;

ALCOHOL INTOXICATION; ALCOHOLISM; ANIMAL; ARTICLE; DISEASE MODEL; FEMALE; MALE; METABOLISM; METHODOLOGY; PREGNANCY; PRIMARY CELL CULTURE; RAT; SPRAGUE DAWLEY RAT;

ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; ALCOHOLIC INTOXICATION; ANIMALS; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FEMALE; FLAVONOLS; MALE; PREGNANCY; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84855965122     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4639-11.2012     Document Type: Article

References (50)

1. Aguayo LG, Peoples RW, Yeh HH, Yevenes GE (2002) GABAA receptors as molecular sites of ethanol action. Direct or indirect actions? Curr Top Med Chem 2:869-885.
2. Arolfo MP, Overstreet DH, Yao L, Fan P, Lawrence AJ, Tao G, Keung WM, Vallee BL, Olive MF, Gass JT, Rubin E, Anni H, Hodge CW, Besheer J, Zablocki J, Leung K, Blackburn BK, Lange LG, Diamond I (2009) Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res 33:1935-1944.
3. Boehm SL, 2nd, Ponomarev I, Jennings AW, Whiting PJ, Rosahl TW, Garrett EM, Blednov YA, Harris RA (2004) γ-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. Biochem Pharmacol 68:1581-1602.
4. Cagetti E, Liang J, Spigelman I, Olsen RW (2003) Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Mol Pharmacol 63:53-64.
5. Chen SH, Zhong GS, Li AL, Li SH, Wu LK (2006) Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking. Zhongguo Zhong Yao Za Zhi 31:1094-1096.
6. Devaud LL, Purdy RH, Finn DA, Morrow AL (1996) Sensitization of gamma-aminobutyric acid A receptors to neuroactive steroids in rats during ethanol withdrawal. J Pharmacol Exp Ther 278:510-517.
7. Devaud LL, Fritschy JM, Sieghart W, Morrow AL (1997) Bidirectional alterations of GABAA receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. J Neurochem 69:126-130.
8. Du J, He D, Sun LN, Han T, Zhang H, Qin LP, Rahman K (2010) Semen Hoveniae extract protects against acute alcohol-induced liver injury in mice. Pharm Biol 48:953-958.
9. Hanchar HJ, Dodson PD, Olsen RW, Otis TS, Wallner M (2005) Alcoholinduced motor impairment caused by increased extrasynaptic GABAA receptor activity. Nat Neurosci 8:339-345.
10. Heilig M, Egli M (2006) Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther 111:855-876.
11. Heilig M, Egli M, Crabbe JC, Becker HC (2010) Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addict Biol 15:169-184.
12. Hester R, Miller W (2003) Treatment approaches: effective alternatives. Needham Heights, MA: Allyn and Bacon.
13. Hobbs WR, Rall TW, Verdoorn TA (1996) Hypnotics and sedatives; ethanol. In: The pharmacological basis of therapeutics, 9th ed (Hardman JG, Limbird LE, Molinoff PB, et al., eds.), pp 361-396. New York: McGraw-Hill.
14. Hunkeler W, Mohler H, Pieri L, Polc P, Bonetti EP, Cumin R, Schaffner R, Haefely W (1981) Selective antagonists of benzodiazepines. Nature 290:514-516.
15. Johnson BA (2010) Medication treatment of different types of alcoholism. Am J Psychiatry 167:630-639.
16. Keung WM, Vallee BL (1993) Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc Natl Acad Sci U S A 90:1247-1251.
17. Kim KH, Chung YT, Lee JH, Park YS, Shin MK, Kim HS, Kim DH, Lee HY (2000) Hepatic detoxification activity and reduction of serum alcohol concentration of Hovenia dulcis Thunb from Korea and China. Korean J Med Crop Sci 8:225-233.
18. Koob GF (2004) A role for GABA mechanisms in the motivational effects of alcohol. Biochem Pharmacol 68:1515-1525.
19. A receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 205:529-564.
20. A) receptors. J Biol Chem 285:8615-8620.
21. Li J, Cheng Y, Bian W, Liu X, Zhang C, Ye JH (2010) Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone. Alcohol Clin Exp Res 34:1742-1750.
22. Li S (1590) Compendium of Materia Medica.
23. Li YQ, Yu ZG, Lu WC (2003) Dihydromyricetin and myricetin content in Ampelopsis grossedentata measured with HPLC technique. Chin. Tradit Herb Drugs 34:1098.
24. A receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence. J Pharmacol Exp Ther 310:1234-1245.
25. Liang J, Zhang N, Cagetti E, Houser CR, Olsen RW, Spigelman I (2006) Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. J Neurosci 26:1749-1758.
26. Liang J, Suryanarayanan A, Abriam A, Snyder B, Olsen RW, Spigelman I (2007) Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication. J Neurosci 27:12367-12377.
27. Liang J, Spigelman I, Olsen RW (2009) Tolerance to sedative/hypnotic actions of GABAergic drugs correlates with tolerance to potentiation of extrasynaptic tonic currents of alcohol-dependent rats. J Neurophysiol 102:224-233.
28. Lin RC, Li TK (1998) Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. Am J Clin Nutr 68:1512S-1515S.
29. Lovinger DM, Homanics GE (2007) Tonic for what ails us? High-affinity GABAA receptors and alcohol. Alcohol 41:139-143.
30. Lukas SE, Penetar D, Berko J, Vicens L, Palmer C, Mallya G, Macklin EA, Lee DY (2005) An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting. Alcohol Clin Exp Res 29:756-762.
31. A receptors. Mol Pharmacol 67:775-788.
32. Morrow AL, Montpied P, Lingford-Hughes A, Paul SM (1990) Chronic ethanol and pentobarbital administration in the rat: effects on GABAA receptor function and expression in brain. Alcohol 7:237-244.
33. Morrow AL, Biggio G, Serra M, Becker HC, Lopez MF, Porcu P, Alward SE, O'Buckley TK (2008) The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress. Alcohol 43:521-530.
34. Mukherjee S, Das SK, Vaidyanathan K, Vasudevan DM (2008) Consequences of alcohol consumption on neurotransmitters-an overview. Curr Neurovasc Res 5:266-272.
35. Olsen RW, Homanics GE (2000) Function of GABAA receptors: insights from mutant and knockout mice, in GABA in the nervous system: the view at fifty years (Martin DL, Olsen RW. eds), pp 81-96. Philadelphia: Lippincott Williams and Wilkins.
36. A receptor plasticity in alcohol withdrawal. In: Jasper's basic mechanisms of the epilepsies, Ed 4, Ch. 43 (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds). New York: Oxford UP, pp 562-573.
37. O'Malley SS, Rounsaville BJ, Farren C, Namkoong K, Wu R, Robinson J, O'Connor PG (2003) Initial and maintenance naltrexone treatment for alcohol dependence using primary care vs specialty care: a nested sequence of 3 randomized trials. Arch Intern Med 163:1695-1704.
38. Paul SM (2006) Alcohol-sensitive GABA receptors and alcohol antagonists. Proc Natl Acad Sci U S A 103:8307-8308.
39. Shen Y, Lindemeyer AK, Spigelman I, Sieghart W, Olsen RW, Liang J (2011) Plasticity of GABAA receptors following ethanol pre-exposure in cultured hippocampal neurons. Mol Pharmacol 79:432-442.
40. Siggins GR, Roberto M, Nie Z (2005) The tipsy terminal: presynaptic effects of ethanol. Pharmacol Ther 107:80-98.
41. Su J (659) The Tang Materia Medica.
42. Suzdak PD, Glowa JR, Crawley JN, Schwartz RD, Skolnick P, Paul SM (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234:1243-1247.
43. Trevisan LA, Boutros N, Petrakis IL, Krystal JH (1998) Complications of alcohol withdrawal: pathophysiological insights. Alcohol Health Res World 22:61-66.
44. Valenzuela CF (1997) Alcohol and neurotransmitter interactions. Alcohol Health Res World 21:144-148.
45. Wallner M, Olsen RW (2008) Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAARs as an opportunity for drug 2012 development? Br J Pharmacol 154:288-298.
46. Wallner M, Hanchar HJ, Olsen RW (2003) Ethanol enhances α4β3δ and α 6 β 3 δ gamma-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc Natl Acad Sci U S A 100:15218-15223.
47. Wallner M, Hanchar HJ, Olsen RW (2006) Low-dose alcohol actions on α 4 β 3 δ GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513. Proc Natl Acad Sci U S A 103:8540-8545.
48. A receptors in hippocampal neurons. J Neurosci 24:8379-8382.
49. Weiner JL, Valenzuela CF (2006) Ethanol modulation of GABAergic transmission: the view from the slice. Pharmacol Ther 111:533-554.
50. Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C (2003) Interaction between flavonoids and the blood-brain barrier: in vitro studies. J Neurochem 85:180-192.