Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 44, 2012, Pages

  Spurny, Radovan ^a   Ramerstorfer, Joachim ^b   Price, Kerry ^c   Brams, Marijke ^a   Ernst, Margot ^b   Nury, Hugues ^d   Verheij, Mark ^e   Legrand, Pierre ^f   Bertrand, Daniel ^g   Bertrand, Sonia ^g   Dougherty, Dennis A ^h   De Esch, Iwan J P ^e   Corringer, Pierre Jean ^d   Sieghart, Werner ^b   Lummis, Sarah C R ^c   Ulens, Chris ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d CNRS   (France)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

^f SYNCHROTRON SOLEIL   (France)

^g HiQScreen   (Switzerland)

^h CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; FLUNITRAZEPAM; FLURAZEPAM; LIGAND GATED ION CHANNEL; PROTEIN ELIC; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING; MOLECULAR RECOGNITION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS LAEVIS;

ANIMALS; BENZODIAZEPINES; BINDING SITES; BIOPOLYMERS; CRYSTALLOGRAPHY, X-RAY; GAMMA-AMINOBUTYRIC ACID; ION CHANNEL GATING; ION CHANNELS; LIGANDS; MODELS, MOLECULAR; RECEPTORS, GABA-A; XENOPUS;

PROKARYOTA;

EID: 84868116573     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208208109     Document Type: Article

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