Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 2, 2012, Pages 304-316

  Borghese, Cecilia M ^a   Blednov, Yuri A ^a   Quan, Yu ^a   Iyer, Sangeetha V ^a,b   Xiong, Wei ^d   John Mihic, S ^a   Zhang, Li ^d   Lovinger, David M ^d   Trudell, James R ^e   Homanics, Gregg E ^c   Adron Harris, R ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^e STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; FLUNITRAZEPAM; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1 SUBUNIT; MUTANT PROTEIN; STRYCHNINE; UNCLASSIFIED DRUG; ZINC;

ALPHA HELIX; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN NERVE CELL; BRAIN STEM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; GENE TARGETING; GLYCINERGIC TRANSMISSION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; LIGAND BINDING; MEMBRANE CURRENT; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; MUTATIONAL ANALYSIS; NEUROTRANSMISSION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SURVIVAL; TREMOR; WEIGHT REDUCTION;

ALCOHOLS; AMINO ACID SUBSTITUTION; ANIMALS; BINDING, COMPETITIVE; BRAIN STEM; CELLS, CULTURED; DRUG SYNERGISM; ELECTROPHYSIOLOGICAL PHENOMENA; ETHANOL; FEMALE; FLUNITRAZEPAM; GENE EXPRESSION; GENE KNOCK-IN TECHNIQUES; GENOTYPE; GLYCINE; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, MOLECULAR; MOTOR NEURON DISEASE; MUTATION; NEURONS; OOCYTES; PHENOTYPE; RECEPTORS, GLYCINE; SPINAL CORD; STRYCHNINE; TAURINE; TRANSFECTION; XENOPUS LAEVIS; ZINC;

EID: 84862907619     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.185116     Document Type: Article

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