-
2
-
-
0347444723
-
MicroRNAs: Genomics, biogenesis, mechanism, and function
-
Bartel, D. P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
3
-
-
0037062951
-
RNA interference
-
Hannon, G. J. RNA interference. Nature 418, 244-251 (2002).
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
4
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel, D. P. MicroRNAs: Target recognition and regulatory functions. Cell 136, 215-233 (2009).
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
5
-
-
38349169664
-
Mechanisms of posttranscriptional regulation by microRNAs: Are the answers in sight?
-
Filipowicz, W., Bhattacharyya, S. N. Sonenberg, N. Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9, 102-114 (2008).
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
6
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
7
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, T. R., Bernards, R., Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
8
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J. Conklin, D. S. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16, 948-958 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Caudy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
9
-
-
0036273940
-
Gene silencing using micro-RNA designed hairpins
-
McManus, M. T., Petersen, C. P., Haines, B. B., Chen, J., Sharp, P. A. Gene silencing using micro-RNA designed hairpins. RNA 8, 842-850 (2002).
-
(2002)
RNA
, vol.8
, pp. 842-850
-
-
McManus, M.T.1
Petersen, C.P.2
Haines, B.B.3
Chen, J.4
Sharp, P.A.5
-
10
-
-
0036294527
-
Both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells
-
Zeng, Y., Wagner, E. J. Cullen, B. R. Both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9, 1327-1333 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 1327-1333
-
-
Zeng, Y.1
Wagner, E.J.2
Cullen, B.R.3
-
11
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genome
-
Silva, J. M. et al. Second-generation shRNA libraries covering the mouse and human genome. Nat. Genet. 37, 1281-1288 (2005).
-
(2005)
Nat. Genet.
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
-
12
-
-
33645804365
-
Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155
-
Chung, K. H. et al. Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155. Nucleic Acids Res. 34, e53 (2006).
-
(2006)
Nucleic Acids Res.
, vol.34
-
-
Chung, K.H.1
-
13
-
-
44349178186
-
Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo
-
Ely, A., Naidoo, T., Mufamadi, S., Crowther, C., Arbuthnot, P. Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo. Mol. Ther. 16, 1105-1112 (2008).
-
(2008)
Mol. Ther.
, vol.16
, pp. 1105-1112
-
-
Ely, A.1
Naidoo, T.2
Mufamadi, S.3
Crowther, C.4
Arbuthnot, P.5
-
14
-
-
56349155978
-
Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs
-
Aagaard, L. A. et al. Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. Gene Ther. 15, 1536-1549 (2008).
-
(2008)
Gene Ther.
, vol.15
, pp. 1536-1549
-
-
Aagaard, L.A.1
-
15
-
-
44349164025
-
Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron
-
Liu, Y. P., Haasnoot, J., ter Brake, O., Berkhout, B., Konstantinova, P. Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron. Nucleic Acids Res. 36, 2811-2824 (2008).
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 2811-2824
-
-
Liu, Y.P.1
Haasnoot, J.2
Ter Brake, O.3
Berkhout, B.4
Konstantinova, P.5
-
16
-
-
44449121785
-
Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi
-
McBride, J. L. et al. Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. Proc. Natl Acad. Sci. USA 105, 5868-5873 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 5868-5873
-
-
McBride, J.L.1
-
17
-
-
58149232358
-
Artificial microRNAs as siRNA shuttles: Improved safety as compared to shRNAs in vitro and in vivo
-
Boudreau, R. L., Martins, I., Davidson, B. L. Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol. Ther. 17, 169-175 (2008).
-
(2008)
Mol. Ther.
, vol.17
, pp. 169-175
-
-
Boudreau, R.L.1
Martins, I.2
Davidson, B.L.3
-
18
-
-
34548548614
-
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC
-
Castanotto, D. et al. Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res. 35, 5154-5164, (2007).
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 5154-5164
-
-
Castanotto, D.1
-
19
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm, D. et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441, 537-541 (2006).
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
-
20
-
-
27644582893
-
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
-
Dickins, R. A. et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat. Genet. 37, 1289-1295 (2005).
-
(2005)
Nat. Genet.
, vol.37
, pp. 1289-1295
-
-
Dickins, R.A.1
-
21
-
-
24944560377
-
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
-
Stegmeier, F., Hu, G., Rickles, R. J., Hannon, G. J. Elledge, S. J. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl Acad. Sci. USA 102, 13212-13217 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 13212-13217
-
-
Stegmeier, F.1
Hu, G.2
Rickles, R.J.3
Hannon, G.J.4
Elledge, S.J.5
-
22
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson, A. L. et al. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21, 635-637 (2003).
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
-
23
-
-
33646188259
-
3' UTR seed matches, but not overall identity, are associated with RNAi off-targets
-
Birmingham, A. et al. 3' UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat. Methods 3, 199-204 (2006).
-
(2006)
Nat. Methods
, vol.3
, pp. 199-204
-
-
Birmingham, A.1
-
24
-
-
79952697845
-
Functional identification of optimized RNAi triggers using a massively parallel sensor assay
-
Fellmann, C. et al. Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol. Cell 41, 733-746 (2011).
-
(2011)
Mol. Cell
, vol.41
, pp. 733-746
-
-
Fellmann, C.1
-
25
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds, A. et al. Rational siRNA design for RNA interference. Nat. Biotechnol. 22, 326-330 (2004).
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
-
26
-
-
10744225153
-
Asymmetry in the assembly of the RNAi enzyme complex
-
Schwarz, D. S. et al. Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208 (2003).
-
(2003)
Cell
, vol.115
, pp. 199-208
-
-
Schwarz, D.S.1
-
27
-
-
0142165224
-
Functional siRNAs and miRNAs exhibit strand bias
-
Khvorova, A., Reynolds, A., Jayasena, S. D. Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209-216 (2003).
-
(2003)
Cell
, vol.115
, pp. 209-216
-
-
Khvorova, A.1
Reynolds, A.2
Jayasena, S.D.3
-
28
-
-
23444437819
-
Design of a genome-wide siRNA library using an artificial neural network
-
Huesken, D. et al. Design of a genome-wide siRNA library using an artificial neural network. Nat. Biotechnol. 23, 995-1001 (2005).
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 995-1001
-
-
Huesken, D.1
-
29
-
-
33845663097
-
An accurate and interpretable model for siRNA efficacy prediction
-
Vert, J. P., Foveau, N., Lajaunie, C., Vandenbrouck, Y. An accurate and interpretable model for siRNA efficacy prediction. BMC Bioinformatics 7, 520 (2006).
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 520
-
-
Vert, J.P.1
Foveau, N.2
Lajaunie, C.3
Vandenbrouck, Y.4
-
30
-
-
38449100230
-
A protocol for designing siRNAs with high functionality and specificity
-
Birmingham, A. et al. A protocol for designing siRNAs with high functionality and specificity. Nat. Protoc. 2, 2068-2078 (2007).
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2068-2078
-
-
Birmingham, A.1
-
31
-
-
33747761923
-
On the art of identifying effective and specific siRNAs
-
Pei, Y., Tuschl, T. On the art of identifying effective and specific siRNAs. Nat. Methods 3, 670-676 (2006).
-
(2006)
Nat. Methods
, vol.3
, pp. 670-676
-
-
Pei, Y.1
Tuschl, T.2
-
32
-
-
33645151304
-
Criteria for effective design, construction, and gene knockdown by shRNA vectors
-
Taxman, D. J. et al. Criteria for effective design, construction, and gene knockdown by shRNA vectors. BMC Biotechnol. 6, 7 (2006).
-
(2006)
BMC Biotechnol.
, vol.6
, pp. 7
-
-
Taxman, D.J.1
-
33
-
-
67349251607
-
Rapid creation and quantitative monitoring of high coverage shRNA libraries
-
Bassik, M. C. et al. Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat. Methods 6, 443-445 (2009).
-
(2009)
Nat. Methods
, vol.6
, pp. 443-445
-
-
Bassik, M.C.1
-
34
-
-
7444260786
-
Validating siRNA using a reporter made from synthetic DNA oligonucleotides
-
Du, Q., Thonberg, H., Zhang, H. Y., Wahlestedt, C., Liang, Z. Validating siRNA using a reporter made from synthetic DNA oligonucleotides. Biochem. Biophys. Res. Commun. 325, 243-249 (2004).
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.325
, pp. 243-249
-
-
Du, Q.1
Thonberg, H.2
Zhang, H.Y.3
Wahlestedt, C.4
Liang, Z.5
-
35
-
-
0142092529
-
High-throughput selection of effective RNAi probes for gene silencing
-
Kumar, R., Conklin, D. S. Mittal, V. High-throughput selection of effective RNAi probes for gene silencing. Genome Res. 13, 2333-2340 (2003).
-
(2003)
Genome Res.
, vol.13
, pp. 2333-2340
-
-
Kumar, R.1
Conklin, D.S.2
Mittal, V.3
-
36
-
-
68749113985
-
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
-
Mayr, C., Bartel, D. P. Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 138, 673-684 (2009).
-
(2009)
Cell
, vol.138
, pp. 673-684
-
-
Mayr, C.1
Bartel, D.P.2
-
37
-
-
46249092601
-
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites
-
Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A. Burge, C. B. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science 320, 1643-1647 (2008).
-
(2008)
Science
, vol.320
, pp. 1643-1647
-
-
Sandberg, R.1
Neilson, J.R.2
Sarma, A.3
Sharp, P.A.4
Burge, C.B.5
-
38
-
-
84863012654
-
Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy
-
Tan, X. et al. Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proc. Natl Acad. Sci. USA 109, 869-874 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 869-874
-
-
Tan, X.1
-
39
-
-
84875890034
-
SiRNA design software for a target gene-specific RNA interference
-
Naito, Y., Ui-Tei, K. siRNA design software for a target gene-specific RNA interference. Front. Genet. 3, 102 (2012).
-
(2012)
Front. Genet.
, vol.3
, pp. 102
-
-
Naito, Y.1
Ui-Tei, K.2
-
40
-
-
84876041468
-
Optimized models for design of efficient miR30-based shRNAs
-
Matveeva, O. V., Nazipova, N. N., Ogurtsov, A. Y. Shabalina, S. A. Optimized models for design of efficient miR30-based shRNAs. Front. Genet. 3, 163 (2012).
-
(2012)
Front. Genet.
, vol.3
, pp. 163
-
-
Matveeva, O.V.1
Nazipova, N.N.2
Ogurtsov, A.Y.3
Shabalina, S.A.4
-
41
-
-
84864326893
-
Use and abuse of RNAi to study mammalian gene function
-
Kaelin, W. G. Jr. Use and abuse of RNAi to study mammalian gene function. Science 337, 421-422 (2012).
-
(2012)
Science
, vol.337
, pp. 421-422
-
-
Kaelin Jr., W.G.1
-
42
-
-
74049124186
-
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
-
Jackson, A. L. Linsley, P. S. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat. Rev. Drug Discov. 9, 57-67 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 57-67
-
-
Jackson, A.L.1
Linsley, P.S.2
-
43
-
-
34250805982
-
MicroRNA targeting specificity in mammals: Determinants beyond seed pairing
-
Grimson, A. et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27, 91-105 (2007).
-
(2007)
Mol. Cell
, vol.27
, pp. 91-105
-
-
Grimson, A.1
-
44
-
-
0038121109
-
Specificity of short interfering RNA determined through gene expression signatures
-
Semizarov, D. et al. Specificity of short interfering RNA determined through gene expression signatures. Proc. Natl Acad. Sci. USA 100, 6347-6352 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
-
45
-
-
12844285548
-
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs
-
Yi, R., Doehle, B. P., Qin, Y., Macara, I. G. Cullen, B. R. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA 11, 220-226 (2005).
-
(2005)
RNA
, vol.11
, pp. 220-226
-
-
Yi, R.1
Doehle, B.P.2
Qin, Y.3
MacAra, I.G.4
Cullen, B.R.5
-
46
-
-
67149115119
-
Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
-
Khan, A. A. et al. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat. Biotechnol. 27, 549-555 (2009).
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 549-555
-
-
Khan, A.A.1
-
47
-
-
79952696452
-
A rapid and scalable system for studying gene function in mice using conditional RNA interference
-
Premsrirut, P. K. et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145, 145-158 (2011).
-
(2011)
Cell
, vol.145
, pp. 145-158
-
-
Premsrirut, P.K.1
-
48
-
-
84869037267
-
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of Dicer processing in vivo
-
Gu, S. et al. The loop position of shRNAs and pre-miRNAs is critical for the accuracy of Dicer processing in vivo. Cell 151, 900-911 (2012).
-
(2012)
Cell
, vol.151
, pp. 900-911
-
-
Gu, S.1
-
49
-
-
33847317017
-
Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
-
Kawahara, Y. et al. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315, 1137-1140 (2007).
-
(2007)
Science
, vol.315
, pp. 1137-1140
-
-
Kawahara, Y.1
-
50
-
-
33644519040
-
Building mammalian signalling pathways with RNAi screens
-
Moffat, J., Sabatini, D. M. Building mammalian signalling pathways with RNAi screens. Nat. Rev. Mol. Cell Biol. 7, 177-187 (2006).
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 177-187
-
-
Moffat, J.1
Sabatini, D.M.2
-
51
-
-
33645306041
-
A loss-of-function RNA interference screen for molecular targets in cancer
-
Ngo, V. N. et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 441, 106-110 (2006).
-
(2006)
Nature
, vol.441
, pp. 106-110
-
-
Ngo, V.N.1
-
52
-
-
20444376939
-
A genetic screen for candidate tumor suppressors identifies REST
-
Westbrook, T. F. et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 121, 837-848 (2005).
-
(2005)
Cell
, vol.121
, pp. 837-848
-
-
Westbrook, T.F.1
-
53
-
-
84863541457
-
Recurrent hemizygous deletions in cancers may optimize proliferative potential
-
Solimini, N. L. et al. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science 337, 104-109 (2012).
-
(2012)
Science
, vol.337
, pp. 104-109
-
-
Solimini, N.L.1
-
54
-
-
70349536006
-
In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression
-
Meacham, C. E., Ho, E. E., Dubrovsky, E., Gertler, F. B. Hemann, M. T. In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nat. Genet. 41, 1133-1137 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1133-1137
-
-
Meacham, C.E.1
Ho, E.E.2
Dubrovsky, E.3
Gertler, F.B.4
Hemann, M.T.5
-
55
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad, A. et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483, 100-103 (2012).
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
-
56
-
-
79961062492
-
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
-
Cheung, H. W. et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc. Natl Acad. Sci. USA 108, 12372-12377 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 12372-12377
-
-
Cheung, H.W.1
-
57
-
-
77149130553
-
Automated microscopy for high-content RNAi screening
-
Conrad, C., Gerlich, D. W. Automated microscopy for high-content RNAi screening. J. Cell Biol. 188, 453-461 (2010).
-
(2010)
J. Cell Biol.
, vol.188
, pp. 453-461
-
-
Conrad, C.1
Gerlich, D.W.2
-
58
-
-
77950387346
-
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
-
Neumann, B. et al. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464, 721-727 (2010).
-
(2010)
Nature
, vol.464
, pp. 721-727
-
-
Neumann, B.1
-
59
-
-
84859218649
-
A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens
-
Sigoillot, F. D. et al. A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. Nat. Methods 9, 363-366 (2012).
-
(2012)
Nat. Methods
, vol.9
, pp. 363-366
-
-
Sigoillot, F.D.1
-
60
-
-
84875978905
-
ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens
-
Shao, D. D. et al. ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens. Genome Res. 23, 665-678 (2013).
-
(2013)
Genome Res.
, vol.23
, pp. 665-678
-
-
Shao, D.D.1
-
61
-
-
84876573362
-
GenomeRNAi: A database for cell-based and in vivo RNAi phenotypes, 2013 update
-
Schmidt, E. E. et al. GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update. Nucleic Acids Res. 41, D1021-D1026 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
-
-
Schmidt, E.E.1
-
62
-
-
84874113985
-
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility
-
Bassik, M. C. et al. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell 152, 909-922 (2013).
-
(2013)
Cell
, vol.152
, pp. 909-922
-
-
Bassik, M.C.1
-
63
-
-
34548217651
-
Maximizing mouse cancer models
-
Frese, K. K. Tuveson, D. A. Maximizing mouse cancer models. Nat. Rev. Cancer 7, 645-658 (2007).
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 645-658
-
-
Frese, K.K.1
Tuveson, D.A.2
-
64
-
-
0033826530
-
Genetic analysis of chemoresistance in primary murine lymphomas
-
Schmitt, C. A., Rosenthal, C. T. Lowe, S. W. Genetic analysis of chemoresistance in primary murine lymphomas. Nat. Med. 6, 1029-1035 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 1029-1035
-
-
Schmitt, C.A.1
Rosenthal, C.T.2
Lowe, S.W.3
-
65
-
-
64349109459
-
Mouse models of human AML accurately predict chemotherapy response
-
Zuber, J. et al. Mouse models of human AML accurately predict chemotherapy response. Genes Dev. 23, 877-889 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 877-889
-
-
Zuber, J.1
-
66
-
-
80051513341
-
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
-
Zuber, J. et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 25, 1628-1640 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 1628-1640
-
-
Zuber, J.1
-
67
-
-
32344453096
-
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells
-
Beard, C., Hochedlinger, K., Plath, K., Wutz, A., Jaenisch, R. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis 44, 23-28 (2006).
-
(2006)
Genesis
, vol.44
, pp. 23-28
-
-
Beard, C.1
Hochedlinger, K.2
Plath, K.3
Wutz, A.4
Jaenisch, R.5
-
68
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen, M., Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA 89, 5547-5551 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
69
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen, M. et al. Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-1769 (1995).
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
-
70
-
-
34347344980
-
Tissue-specific and reversible RNA interference in transgenic mice
-
Dickins, R. A. et al. Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet 39, 914-921 (2007).
-
(2007)
Nat Genet
, vol.39
, pp. 914-921
-
-
Dickins, R.A.1
-
71
-
-
65549123686
-
Generation of shRNA transgenic mice
-
Hitz, C., Steuber-Buchberger, P., Delic, S., Wurst, W., Kuhn, R. Generation of shRNA transgenic mice. Methods Mol. Biol. 530, 101-129 (2009).
-
(2009)
Methods Mol. Biol.
, vol.530
, pp. 101-129
-
-
Hitz, C.1
Steuber-Buchberger, P.2
Delic, S.3
Wurst, W.4
Kuhn, R.5
-
72
-
-
33144460778
-
A transgenic approach for RNA interference-based genetic screening in mice
-
Peng, S., York, J. P. Zhang, P. A transgenic approach for RNA interference-based genetic screening in mice. Proc. Natl Acad. Sci. USA 103, 2252-2256 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 2252-2256
-
-
Peng, S.1
York, J.P.2
Zhang, P.3
-
73
-
-
79955561070
-
Reversible suppression of an essential gene in adult mice using transgenic RNA interference
-
McJunkin, K. et al. Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proc. Natl Acad. Sci. USA 108, 7113-7118 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 7113-7118
-
-
McJunkin, K.1
-
74
-
-
84858397489
-
Life in the fast lane: Mammalian disease models in the genomics era
-
Dow, L. E. Lowe, S. W. Life in the fast lane: mammalian disease models in the genomics era. Cell 148, 1099-1109 (2012).
-
(2012)
Cell
, vol.148
, pp. 1099-1109
-
-
Dow, L.E.1
Lowe, S.W.2
-
75
-
-
84861171712
-
Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis
-
Lin, C. J. et al. Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep. 1, 325-333 (2012).
-
(2012)
Cell Rep.
, vol.1
, pp. 325-333
-
-
Lin, C.J.1
-
76
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber, J. et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478, 524-528 (2011).
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
-
77
-
-
0037370309
-
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo
-
Hemann, M. T. et al. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat. Genet. 33, 396-400 (2003).
-
(2003)
Nat. Genet.
, vol.33
, pp. 396-400
-
-
Hemann, M.T.1
-
78
-
-
56349121125
-
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
-
Zender, L. et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135, 852-864 (2008).
-
(2008)
Cell
, vol.135
, pp. 852-864
-
-
Zender, L.1
-
79
-
-
70349454058
-
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
-
Bric, A. et al. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell 16, 324-335 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 324-335
-
-
Bric, A.1
-
80
-
-
84863720872
-
A tumour suppressor network relying on the polyamine-hypusine axis
-
Scuoppo, C. et al. A tumour suppressor network relying on the polyamine-hypusine axis. Nature 487, 244-248 (2012).
-
(2012)
Nature
, vol.487
, pp. 244-248
-
-
Scuoppo, C.1
-
81
-
-
84861428789
-
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
-
Xue, W. et al. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc. Natl Acad. Sci. USA 109, 8212-8217 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 8212-8217
-
-
Xue, W.1
-
82
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato, R. et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476, 346-350 (2011).
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
-
83
-
-
84880011146
-
In vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling
-
Miller, P. G. et al. In vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell 24, 45-58 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 45-58
-
-
Miller, P.G.1
-
84
-
-
84876206165
-
A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration
-
Wuestefeld, T. et al. A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell 153, 389-401 (2013).
-
(2013)
Cell
, vol.153
, pp. 389-401
-
-
Wuestefeld, T.1
-
85
-
-
78651312134
-
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
-
Zuber, J. et al. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat. Biotechnol. 29, 79-83 (2011).
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 79-83
-
-
Zuber, J.1
-
86
-
-
3142729150
-
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
-
Okamura, K., Ishizuka, A., Siomi, H., Siomi, M. C. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18, 1655-1666 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 1655-1666
-
-
Okamura, K.1
Ishizuka, A.2
Siomi, H.3
Siomi, M.C.4
-
87
-
-
34447291764
-
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1
-
Forstemann, K., Horwich, M. D., Wee, L., Tomari, Y., Zamore, P. D. Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell 130, 287-297 (2007).
-
(2007)
Cell
, vol.130
, pp. 287-297
-
-
Forstemann, K.1
Horwich, M.D.2
Wee, L.3
Tomari, Y.4
Zamore, P.D.5
-
88
-
-
84876059864
-
MiRNA-like duplexes as RNAi triggers with improved specificity
-
Betancur, J. G., Yoda, M., Tomari, Y. miRNA-like duplexes as RNAi triggers with improved specificity. Front. Genet. 3, 127 (2012).
-
(2012)
Front. Genet.
, vol.3
, pp. 127
-
-
Betancur, J.G.1
Yoda, M.2
Tomari, Y.3
-
89
-
-
20844438492
-
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis
-
Cleary, M. A. et al. Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat. Methods 1, 241-248 (2004).
-
(2004)
Nat. Methods
, vol.1
, pp. 241-248
-
-
Cleary, M.A.1
-
90
-
-
78649467088
-
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
-
Loewer, S. et al. Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat. Genet. 42, 1113-1117 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 1113-1117
-
-
Loewer, S.1
-
91
-
-
84876367541
-
Endogenous miRNA sponge lincRNA-RoR regulates Oct4 Nanog and Sox2 in human embryonic stem cell self-renewal
-
Wang, Y. et al. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev. Cell 25, 69-80 (2013).
-
(2013)
Dev. Cell
, vol.25
, pp. 69-80
-
-
Wang, Y.1
-
92
-
-
84872533627
-
RNA interference in the nucleus: Roles for small RNAs in transcription, epigenetics and beyond
-
Castel, S. E. Martienssen, R. A. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nat. Rev. Genet. 14, 100-112 (2013).
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 100-112
-
-
Castel, S.E.1
Martienssen, R.A.2
-
93
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31, 822-826 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 822-826
-
-
Fu, Y.1
-
94
-
-
0001359591
-
Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
-
Napoli, C., Lemieux, C., Jorgensen, R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2, 279-289 (1990).
-
(1990)
Plant Cell
, vol.2
, pp. 279-289
-
-
Napoli, C.1
Lemieux, C.2
Jorgensen, R.3
-
95
-
-
0025405838
-
Flavonoid genes in petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
-
van der Krol, A. R., Mur, L. A., Beld, M., Mol, J. N. Stuitje, A. R. Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell 2, 291-299 (1990).
-
(1990)
Plant Cell
, vol.2
, pp. 291-299
-
-
Van Der Krol, A.R.1
Mur, L.A.2
Beld, M.3
Mol, J.N.4
Stuitje, A.R.5
-
96
-
-
0027751663
-
The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
-
Lee, R. C., Feinbaum, R. L. Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854 (1993).
-
(1993)
Cell
, vol.75
, pp. 843-854
-
-
Lee, R.C.1
Feinbaum, R.L.2
Ambros, V.3
-
97
-
-
0027730383
-
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. Elegans
-
Wightman, B., Ha, I., Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855-862 (1993).
-
(1993)
Cell
, vol.75
, pp. 855-862
-
-
Wightman, B.1
Ha, I.2
Ruvkun, G.3
-
98
-
-
0014690698
-
Gene regulation for higher cells: A theory
-
Britten, R. J. Davidson, E. H. Gene regulation for higher cells: a theory. Science 165, 349-357 (1969).
-
(1969)
Science
, vol.165
, pp. 349-357
-
-
Britten, R.J.1
Davidson, E.H.2
-
99
-
-
54249116230
-
Genetic regulatory mechanisms in the synthesis of proteins
-
Jacob F. Monod J. Genetic regulatory mechanisms in the synthesis of proteins.J. Mol. Biol.3.318-356.1961.
-
(1961)
J. Mol. Biol.
, vol.3
, pp. 318-356
-
-
Jacob, F.1
Monod, J.2
-
100
-
-
0035955374
-
Identification of novel genes coding for small expressed RNAs
-
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853-858 (2001).
-
(2001)
Science
, vol.294
, pp. 853-858
-
-
Lagos-Quintana, M.1
Rauhut, R.2
Lendeckel, W.3
Tuschl, T.4
-
101
-
-
0035955361
-
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
-
Lau, N. C., Lim, L. P., Weinstein, E. G. Bartel, D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862 (2001).
-
(2001)
Science
, vol.294
, pp. 858-862
-
-
Lau, N.C.1
Lim, L.P.2
Weinstein, E.G.3
Bartel, D.P.4
-
102
-
-
0035955366
-
An extensive class of small RNAs in Caenorhabditis elegans
-
Lee, R. C. Ambros, V. An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864 (2001).
-
(2001)
Science
, vol.294
, pp. 862-864
-
-
Lee, R.C.1
Ambros, V.2
-
103
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
104
-
-
8144225486
-
MicroRNA genes are transcribed by RNA polymerase II
-
Lee, Y. et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23, 4051-4060 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 4051-4060
-
-
Lee, Y.1
-
105
-
-
36749037521
-
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race
-
Aravin, A. A., Hannon, G. J. Brennecke, J. The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science 318, 761-764 (2007).
-
(2007)
Science
, vol.318
, pp. 761-764
-
-
Aravin, A.A.1
Hannon, G.J.2
Brennecke, J.3
-
106
-
-
0037009364
-
MicroRNA maturation: Stepwise processing and subcellular localization
-
Lee, Y., Jeon, K., Lee, J. T., Kim, S., Kim, V. N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21, 4663-4670 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 4663-4670
-
-
Lee, Y.1
Jeon, K.2
Lee, J.T.3
Kim, S.4
Kim, V.N.5
-
107
-
-
0141843656
-
The nuclear RNase III Drosha initiates microRNA processing
-
Lee, Y. et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415-419 (2003).
-
(2003)
Nature
, vol.425
, pp. 415-419
-
-
Lee, Y.1
-
108
-
-
0344668836
-
Human let-7 stemloop precursors harbor features of RNase III cleavage products
-
Basyuk, E., Suavet, F., Doglio, A., Bordonne, R., Bertrand, E. Human let-7 stemloop precursors harbor features of RNase III cleavage products. Nucleic Acids Res. 31, 6593-6597 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 6593-6597
-
-
Basyuk, E.1
Suavet, F.2
Doglio, A.3
Bordonne, R.4
Bertrand, E.5
-
109
-
-
0347361541
-
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
-
Yi, R., Qin, Y., Macara, I. G. Cullen, B. R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 3011-3016
-
-
Yi, R.1
Qin, Y.2
MacAra, I.G.3
Cullen, B.R.4
-
110
-
-
0347988235
-
Nuclear export of microRNA precursors
-
Lund, E., Guttinger, S., Calado, A., Dahlberg, J. E. Kutay, U. Nuclear export of microRNA precursors. Science 303, 95-98 (2004).
-
(2004)
Science
, vol.303
, pp. 95-98
-
-
Lund, E.1
Guttinger, S.2
Calado, A.3
Dahlberg, J.E.4
Kutay, U.5
-
111
-
-
1642499415
-
Exportin 5 is a RanGTP-dependent dsRNAbinding protein that mediates nuclear export of pre-miRNAs
-
Bohnsack, M. T., Czaplinski, K., Gorlich, D. Exportin 5 is a RanGTP-dependent dsRNAbinding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185-191 (2004).
-
(2004)
RNA
, vol.10
, pp. 185-191
-
-
Bohnsack, M.T.1
Czaplinski, K.2
Gorlich, D.3
-
112
-
-
0035887005
-
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. Elegans
-
Ketting, R. F. et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15, 2654-2659 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2654-2659
-
-
Ketting, R.F.1
-
113
-
-
17844364875
-
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. Elegans developmental timing
-
Grishok, A., et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23-34 (2001).
-
(2001)
Cell
, vol.106
, pp. 23-34
-
-
Grishok, A.1
-
114
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
Bernstein, E., Caudy, A. A., Hammond, S. M. Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
-
(2001)
Nature
, vol.409
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
115
-
-
0035800521
-
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
-
Hutvagner, G., et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834-838 (2001).
-
(2001)
Science
, vol.293
, pp. 834-838
-
-
Hutvagner, G.1
-
116
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
-
Hammond, S. M., Bernstein, E., Beach, D., Hannon, G. J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-296 (2000).
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
117
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore, P. D. Tuschl, T., Sharp, P. A. Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000).
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
118
-
-
0033615491
-
A species of small antisense RNA in posttranscriptional gene silencing in plants
-
Hamilton, A. J. Baulcombe, D. C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286, 950-952 (1999).
-
(1999)
Science
, vol.286
, pp. 950-952
-
-
Hamilton, A.J.1
Baulcombe, D.C.2
-
119
-
-
0035863097
-
RNA interference is mediated by 21-and 22-nucleotide RNAs
-
Elbashir, S. M. Lendeckel, W., Tuschl, T. RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev. 15, 188-200 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
120
-
-
33645763485
-
Cleavage of the siRNA passenger strand during RISC assembly in human cells
-
Leuschner, P. J. Ameres, S. L. Kueng, S., Martinez, J. Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep. 7, 314-320 (2006).
-
(2006)
EMBO Rep.
, vol.7
, pp. 314-320
-
-
Leuschner, P.J.1
Ameres, S.L.2
Kueng, S.3
Martinez, J.4
-
121
-
-
27744590896
-
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
-
Matranga, C., Tomari, Y., Shin, C., Bartel, D. P. Zamore, P. D. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607-620 (2005).
-
(2005)
Cell
, vol.123
, pp. 607-620
-
-
Matranga, C.1
Tomari, Y.2
Shin, C.3
Bartel, D.P.4
Zamore, P.D.5
-
122
-
-
27744506761
-
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
-
Rand, T. A. Petersen, S., Du, F., Wang, X. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 123, 621-629 (2005).
-
(2005)
Cell
, vol.123
, pp. 621-629
-
-
Rand, T.A.1
Petersen, S.2
Du, F.3
Wang, X.4
-
123
-
-
0035839109
-
Argonaute2, a link between genetic and biochemical analyses of RNAi
-
Hammond, S. M. Boettcher, S., Caudy, A. A. Kobayashi, R., Hannon, G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146-1150 (2001).
-
(2001)
Science
, vol.293
, pp. 1146-1150
-
-
Hammond, S.M.1
Boettcher, S.2
Caudy, A.A.3
Kobayashi, R.4
Hannon, G.J.5
-
124
-
-
0041691111
-
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
-
Zeng, Y., Yi, R., Cullen, B. R. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100, 9779-9784 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 9779-9784
-
-
Zeng, Y.1
Yi, R.2
Cullen, B.R.3
-
125
-
-
0037144546
-
A microRNA in a multiple-turnover RNAi enzyme complex
-
Hutvagner, G., Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
-
(2002)
Science
, vol.297
, pp. 2056-2060
-
-
Hutvagner, G.1
Zamore, P.D.2
-
127
-
-
4444302947
-
Crystal structure of Argonaute and its implications for RISC slicer activity
-
Song, J. J. Smith, S. K. Hannon, G. J. Joshua-Tor L.Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305, 1434-1437 (2004).
-
(2004)
Science
, vol.305
, pp. 1434-1437
-
-
Song, J.J.1
Smith, S.K.2
Hannon, G.J.3
Joshua-Tor, L.4
-
128
-
-
4444368187
-
Argonaute2 is the catalytic engine of mammalian RNA
-
Liu, J., et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437-1441 (2004).
-
(2004)
Science
, vol.305
, pp. 1437-1441
-
-
Liu, J.1
-
129
-
-
3042602447
-
Kinetic analysis of the RNAi enzyme complex
-
Haley, B., Zamore, P. D. Kinetic analysis of the RNAi enzyme complex. Nat. Struct. Mol. Biol. 11, 599-606 (2004).
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 599-606
-
-
Haley, B.1
Zamore, P.D.2
-
130
-
-
84874086395
-
Beyond secondary structure: Primary-sequence determinants license pri-miRNA hairpins for processing
-
Auyeung V. C. Ulitsky, I., McGeary, S. E. Bartel, D. P. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell 152 844-858 (2013).
-
(2013)
Cell
, vol.152
, pp. 844-858
-
-
Auyeung, V.C.1
Ulitsky, I.2
McGeary, S.E.3
Bartel, D.P.4
-
131
-
-
84890985901
-
An optimized microRNA backbone for effective single-copy RNAi
-
http://dx.doi.org/10.1016/j.celrep.2013.11.020 (2013)
-
Fellmann, C., et al. An optimized microRNA backbone for effective single-copy RNAi. Cell Rep.
-
Cell Rep.
-
-
Fellmann, C.1
-
132
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat J. et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298 (2006).
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
-
133
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns, K., et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-437 (2004).
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
-
134
-
-
77953183812
-
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
-
Cheloufi, S., Dos Santos, C. O. Chong, M. M. Hannon, G. J. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465, 584-589 (2010).
-
(2010)
Nature
, vol.465
, pp. 584-589
-
-
Cheloufi, S.1
Dos Santos, C.O.2
Chong, M.M.3
Hannon, G.J.4
-
135
-
-
77953897182
-
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity
-
Cifuentes, D., et al. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science 328, 1694-1698 (2010).
-
(2010)
Science
, vol.328
, pp. 1694-1698
-
-
Cifuentes, D.1
-
136
-
-
77956995245
-
Conserved vertebrate miR-451 provides a platform for Dicerindependent, Ago2-mediated microRNA biogenesis
-
Yang, J. S. et al. Conserved vertebrate miR-451 provides a platform for Dicerindependent, Ago2-mediated microRNA biogenesis. Proc. Natl Acad. Sci. USA 107, 15163-15168 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 15163-15168
-
-
Yang, J.S.1
-
137
-
-
72549115018
-
Dicer1 functions as a haploinsufficient tumor suppressor
-
Kumar, M. S. et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 23. 2700-2704.2009.
-
(2009)
Genes Dev.
, vol.23
, pp. 2700-2704
-
-
Kumar, M.S.1
-
138
-
-
54249116230
-
Genetic regulatory mechanisms in the synthesis of proteins
-
Jacob, F., Monod, J. Genetic regulatory mechanisms in the synthesis of proteins. J. Mol. Biol. 3, 318-356 (1961).
-
(1961)
J. Mol. Biol.
, vol.3
, pp. 318-356
-
-
Jacob, F.1
Monod, J.2
-
139
-
-
0035955374
-
Identification of novel genes coding for small expressed RNAs
-
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853-858 (2001).
-
(2001)
Science
, vol.294
, pp. 853-858
-
-
Lagos-Quintana, M.1
Rauhut, R.2
Lendeckel, W.3
Tuschl, T.4
-
140
-
-
0035955361
-
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
-
Lau, N. C. Lim, L. P. Weinstein, E. G. Bartel, D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862 (2001).
-
(2001)
Science
, vol.294
, pp. 858-862
-
-
Lau, N.C.1
Lim, L.P.2
Weinstein, E.G.3
Bartel, D.P.4
-
141
-
-
0035955366
-
An extensive class of small RNAs in Caenorhabditis elegans
-
Lee, R. C. Ambros, V. An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864 (2001).
-
(2001)
Science
, vol.294
, pp. 862-864
-
-
Lee, R.C.1
Ambros, V.2
-
142
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A., et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
143
-
-
8144225486
-
MicroRNA genes are transcribed by RNA polymerase II
-
Lee, Y., et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23, 4051-4060 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 4051-4060
-
-
Lee, Y.1
-
144
-
-
36749037521
-
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race
-
Aravin, A. A. Hannon, G. J. Brennecke, J. The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science 318, 761-764 (2007).
-
(2007)
Science
, vol.318
, pp. 761-764
-
-
Aravin, A.A.1
Hannon, G.J.2
Brennecke, J.3
-
145
-
-
0037009364
-
MicroRNA maturation: Stepwise processing and subcellular localization
-
Lee, Y., Jeon, K., Lee, J. T. Kim, S., Kim, V. N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21, 4663-4670 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 4663-4670
-
-
Lee, Y.1
Jeon, K.2
Lee, J.T.3
Kim, S.4
Kim, V.N.5
-
146
-
-
0141843656
-
The nuclear RNase III Drosha initiates microRNA processing
-
Lee, Y., et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415-419 (2003).
-
(2003)
Nature
, vol.425
, pp. 415-419
-
-
Lee, Y.1
-
147
-
-
0344668836
-
Human let-7 stemloop precursors harbor features of RNase III cleavage products
-
Basyuk, E., Suavet, F., Doglio, A., Bordonne, R., Bertrand, E. Human let-7 stemloop precursors harbor features of RNase III cleavage products. Nucleic Acids Res. 31, 6593-6597 (2003).
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 6593-6597
-
-
Basyuk, E.1
Suavet, F.2
Doglio, A.3
Bordonne, R.4
Bertrand, E.5
-
148
-
-
0347361541
-
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
-
Yi, R., Qin, Y., Macara, I. G. Cullen, B. R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 3011-3016
-
-
Yi, R.1
Qin, Y.2
MacAra, I.G.3
Cullen, B.R.4
-
149
-
-
0347988235
-
Nuclear export of microRNA precursors
-
Lund, E., Guttinger, S., Calado, A., Dahlberg, J. E. Kutay, U. Nuclear export of microRNA precursors. Science 303, 95-98 (2004).
-
(2004)
Science
, vol.303
, pp. 95-98
-
-
Lund, E.1
Guttinger, S.2
Calado, A.3
Dahlberg, J.E.4
Kutay, U.5
-
150
-
-
1642499415
-
Exportin 5 is a RanGTP-dependent dsRNAbinding protein that mediates nuclear export of pre-miRNAs
-
Bohnsack, M. T. Czaplinski, K., Gorlich, D. Exportin 5 is a RanGTP-dependent dsRNAbinding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185-191 (2004).
-
(2004)
RNA
, vol.10
, pp. 185-191
-
-
Bohnsack, M.T.1
Czaplinski, K.2
Gorlich, D.3
-
151
-
-
0035887005
-
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. Elegans
-
Ketting, R. F. et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15, 2654-2659 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2654-2659
-
-
Ketting, R.F.1
-
152
-
-
17844364875
-
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. Elegans developmental timing
-
Grishok, A., et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23-34 (2001).
-
(2001)
Cell
, vol.106
, pp. 23-34
-
-
Grishok, A.1
-
153
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
Bernstein, E., Caudy, A. A. Hammond, S. M. Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
-
(2001)
Nature
, vol.409
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
154
-
-
0035800521
-
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
-
Hutvagner, G., et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834-838 (2001).
-
(2001)
Science
, vol.293
, pp. 834-838
-
-
Hutvagner, G.1
-
155
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
-
Hammond, S. M. Bernstein, E., Beach, D., Hannon, G. J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-296 (2000).
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
156
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore, P. D. Tuschl, T., Sharp, P. A. Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000).
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
157
-
-
0033615491
-
A species of small antisense RNA in posttranscriptional gene silencing in plants
-
Hamilton, A. J. Baulcombe, D. C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286, 950-952 (1999).
-
(1999)
Science
, vol.286
, pp. 950-952
-
-
Hamilton, A.J.1
Baulcombe, D.C.2
-
158
-
-
0035863097
-
RNA interference is mediated by 21-and 22-nucleotide RNAs
-
Elbashir, S. M. Lendeckel, W., Tuschl, T. RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev. 15, 188-200 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
159
-
-
33645763485
-
Cleavage of the siRNA passenger strand during RISC assembly in human cells
-
Leuschner, P. J. Ameres, S. L. Kueng, S., Martinez, J. Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep. 7, 314-320 (2006).
-
(2006)
EMBO Rep.
, vol.7
, pp. 314-320
-
-
Leuschner, P.J.1
Ameres, S.L.2
Kueng, S.3
Martinez, J.4
-
160
-
-
27744590896
-
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
-
Matranga, C., Tomari, Y., Shin, C., Bartel, D. P. Zamore, P. D. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607-620 (2005).
-
(2005)
Cell
, vol.123
, pp. 607-620
-
-
Matranga, C.1
Tomari, Y.2
Shin, C.3
Bartel, D.P.4
Zamore, P.D.5
-
161
-
-
27744506761
-
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
-
Rand, T. A. Petersen, S., Du, F., Wang, X. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 123, 621-629 (2005).
-
(2005)
Cell
, vol.123
, pp. 621-629
-
-
Rand, T.A.1
Petersen, S.2
Du, F.3
Wang, X.4
-
162
-
-
0035839109
-
Argonaute2, a link between genetic and biochemical analyses of RNAi
-
Hammond, S. M. Boettcher, S., Caudy, A. A. Kobayashi, R., Hannon, G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146-1150 (2001).
-
(2001)
Science
, vol.293
, pp. 1146-1150
-
-
Hammond, S.M.1
Boettcher, S.2
Caudy, A.A.3
Kobayashi, R.4
Hannon, G.J.5
-
163
-
-
0041691111
-
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
-
Zeng, Y., Yi, R., Cullen, B. R. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100, 9779-9784 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 9779-9784
-
-
Zeng, Y.1
Yi, R.2
Cullen, B.R.3
-
164
-
-
0037144546
-
A microRNA in a multiple-turnover RNAi enzyme complex
-
Hutvagner, G., Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
-
(2002)
Science
, vol.297
, pp. 2056-2060
-
-
Hutvagner, G.1
Zamore, P.D.2
-
166
-
-
4444302947
-
Crystal structure of Argonaute and its implications for RISC slicer activity
-
Song, J. J. Smith, S. K. Hannon, G. J. Joshua-Tor, L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305, 1434-1437 (2004).
-
(2004)
Science
, vol.305
, pp. 1434-1437
-
-
Song, J.J.1
Smith, S.K.2
Hannon, G.J.3
Joshua-Tor, L.4
-
167
-
-
4444368187
-
Argonaute2 is the catalytic engine of mammalian RNAi
-
Liu, J., et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437-1441 (2004).
-
(2004)
Science
, vol.305
, pp. 1437-1441
-
-
Liu, J.1
-
168
-
-
3042602447
-
Kinetic analysis of the RNAi enzyme complex
-
Haley, B., Zamore, P. D. Kinetic analysis of the RNAi enzyme complex. Nat. Struct. Mol. Biol. 11, 599-606 (2004).
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 599-606
-
-
Haley, B.1
Zamore, P.D.2
-
169
-
-
84874086395
-
Beyond secondary structure: Primary-sequence determinants license pri-miRNA hairpins for processing
-
Auyeung, V. C. Ulitsky, I., McGeary, S. E. Bartel, D. P. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell 152, 844-858 (2013).
-
(2013)
Cell
, vol.152
, pp. 844-858
-
-
Auyeung, V.C.1
Ulitsky, I.2
McGeary, S.E.3
Bartel, D.P.4
-
170
-
-
84890985901
-
An optimized microRNA backbone for effective single-copy RNAi
-
http://dx.doi.org/10.1016/j.celrep.2013.11.020
-
Fellmann, C., et al. An optimized microRNA backbone for effective single-copy RNAi. Cell Rep. http://dx.doi.org/10.1016/j.celrep.2013.11.020 (2013).
-
(2013)
Cell Rep.
-
-
Fellmann, C.1
-
171
-
-
33646033137
-
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
-
Moffat, J., et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298 (2006).
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
-
172
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns, K., et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-437 (2004).
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
-
173
-
-
77953183812
-
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
-
Cheloufi, S., Dos Santos, C. O. Chong, M. M. Hannon, G. J. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465, 584-589 (2010).
-
(2010)
Nature
, vol.465
, pp. 584-589
-
-
Cheloufi, S.1
Dos Santos, C.O.2
Chong, M.M.3
Hannon, G.J.4
-
174
-
-
77953897182
-
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity
-
Cifuentes, D., et al. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science 328, 1694-1698 (2010).
-
(2010)
Science
, vol.328
, pp. 1694-1698
-
-
Cifuentes, D.1
-
175
-
-
77956995245
-
Conserved vertebrate miR-451 provides a platform for Dicerindependent, Ago2-mediated microRNA biogenesis
-
Yang, J. S. et al. Conserved vertebrate miR-451 provides a platform for Dicerindependent, Ago2-mediated microRNA biogenesis. Proc. Natl Acad. Sci. USA 107, 15163-15168 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 15163-15168
-
-
Yang, J.S.1
-
176
-
-
72549115018
-
Dicer1 functions as a haploinsufficient tumor suppressor
-
Kumar, M. S. et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 23, 2700-2704 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 2700-2704
-
-
Kumar, M.S.1
|