A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 21, 2012, Pages 8212-8217

  Xue, Wen ^a,d   Kitzing, Thomas ^a,c   Roessler, Stephanie ^b   Zuber, Johannes ^a   Krasnitz, Alexander ^a   Schultz, Nikolaus ^c   Revill, Kate ^a   Weissmueller, Susann ^a,c   Rappaport, Amy R ^a   Simon, Janelle ^a,c   Zhang, Jack ^a   Luo, Weijun ^a   Hicks, James ^a   Zender, Lars ^a,e,f   Wang, Xin Wei ^b   Powers, Scott ^a   Wigler, Michael ^a   Lowe, Scott W ^a,c  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^f HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cancer genomics; Chromosome 8p deletion; RNAi screen

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CHROMOSOME 17P; CHROMOSOME 8P; CHROMOSOME DELETION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE CLUSTER; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 8; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GENOMICS; HAPLOINSUFFICIENCY; HUMANS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, NUDE; MONOSOMY; RNA INTERFERENCE; STEM CELLS;

MURINAE; MUS;

EID: 84861428789     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1206062109     Document Type: Article

References (40)

1. Baker SJ, et al. (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244:217-221. (Pubitemid 19110302)
2. Birnbaum D, et al. (2003) Chromosome arm 8p and cancer: A fragile hypothesis. Lancet Oncol 4:639-642. (Pubitemid 37258407)
3. Xue W, et al. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev 22:1439-1444. (Pubitemid 351793078)
4. El Gammal AT, et al. (2010) Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer. Clin Cancer Res 16:56-64.
5. Cooke SL, et al. (2008) High-resolution array CGH clarifies events occurring on 8p in carcinogenesis. BMC Cancer 8:288.
6. Williams SV, et al. (2010) High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma. Genes Chromosomes Cancer 49:642-659.
7. Berger AH, et al. (2010) Identification of DOK genes as lung tumor suppressors. Nat Genet 42:216-223.
8. Gorringe KL, et al. (2009) Are there any more ovarian tumor suppressor genes? A new perspective using ultra high-resolution copy number and loss of heterozygosity analysis. Genes Chromosomes Cancer 48:931-942.
9. Beroukhim R, et al. (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463:899-905.
10. Chiang DY, et al. (2008) Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 68:6779-6788.
11. Zender L, et al. (2008) An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135:852-864.
12. Yu HT, et al. (2009) Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1α with decreased levels of hepassocin in human hepatocellular carcinoma. J Biol Chem 284:13335-13347.
13. Lai MW, et al. (2009) Expression of the HCRP1 mRNA in HCC as an independent predictor of disease-free survival after surgical resection. Hepatol Res 39:164-176.
14. Bric A, et al. (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell 16:324-335.
15. Zhang J, Ney PA (2009) Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ 16:939-946.
16. Hagens O, Minina E, Schweiger S, Ropers HH, Kalscheuer V (2006) Characterization of FBX25, encoding a novel brain-expressed F-box protein. Biochim Biophys Acta 1760:110-118. (Pubitemid 41790638)
17. Kimura F, et al. (2003) Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function. J Biol Chem 278:25046-25054. (Pubitemid 37548668)
18. Jia D, et al. (2011) Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma. Hepatology 54:1227-1236.
19. Huang J, et al. (2010) Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest 120:223-241.
20. Scuoppo C, et al. (2012) A tumor suppressor network relying on the polyamine-hypusine axis. Nature, in press.
21. Ramalingam A, et al. (2008) Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging. Cancer Res 68:1683-1690. (Pubitemid 351416552)
22. Mourra N, et al. (2008) High-resolution genotyping of chromosome 8 in colon adenocarcinomas reveals recurrent break point but no gene mutation in the 8p21 region. Diagn Mol Pathol 17:90-93.
23. Jia HL, et al. (2007) Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. Clin Cancer Res 13:1133-1139.
24. Roessler S, et al. (2010) A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res 70:10202-10212.
25. Ren N, et al. (2006) The prognostic value of circulating plasma DNA level and its allelic imbalance on chromosome 8p in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol 132:399-407.
26. Ink4a. Nature 448:943-946.
27. Pole JC, et al. (2006) High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation. Oncogene 25:5693-5706. (Pubitemid 44387624)
28. Roessler S, et al. (2011) Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology 142:957-966.
29. Guan Y, et al. (2007) Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res 13:5745-5755. (Pubitemid 47583899)
30. Kendall J, et al. (2007) Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer. Proc Natl Acad Sci USA 104:16663-16668. (Pubitemid 350211073)
31. Sawey ET, et al. (2011) Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening. Cancer Cell 19:347-358.
32. Zender L, et al. (2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125:1253-1267. (Pubitemid 43929093)
33. Hicks J, et al. (2006) Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Res 16:1465-1479. (Pubitemid 44878486)
34. Taylor BS, et al. (2010) Integrative genomic profiling of human prostate cancer. Cancer Cell 18:11-22.
35. Zuber J, et al. (2011) Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol 29:79-83.
36. Dickins RA, et al. (2005) Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet 37:1289-1295. (Pubitemid 41568715)
37. Zender L, et al. (2005) Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors. Cold Spring Harb Symp Quant Biol 70:251-261. (Pubitemid 44124879)
38. Xue W, et al. (2007) Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445:656-660. (Pubitemid 46232886)
39. Zuber J, et al. (2009) Mouse models of human AML accurately predict chemotherapy response. Genes Dev 23:877-889.
40. Schmitt CA, et al. (2002) Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1:289-298. (Pubitemid 41039153)