Redirection of silencing targets by adenosine-to-inosine editing of miRNAs

Science

Volumn 315, Issue 5815, 2007, Pages 1137-1140

  Kawahara, Yukio ^a   Zinshteyn, Boris ^a   Sethupathy, Praveen ^b   Iizasa, Hisashi ^a   Hatzigeorgiou, Artemis G ^b,c   Nishikura, Kazuko ^a  

^a WISTAR INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; COMPLEMENTARY DNA; INOSINE; MESSENGER RNA; MICRORNA; RIBOSEPHOSPHATE PYROPHOSPHOKINASE; URIC ACID;

GENE EXPRESSION; HYBRIDIZATION; NUCLEIC ACID; RNA;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHROMOSOME 12; CHROMOSOME 14; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; HEART; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; LIVER; MEDULLA OBLONGATA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EDITING; RNA PROCESSING; RNA TRANSCRIPTION; TISSUE SPECIFICITY;

3' UNTRANSLATED REGIONS; ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; BASE SEQUENCE; BRAIN; HELA CELLS; HUMANS; INOSINE; LIVER; MICE; MICRORNAS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; ORGAN SPECIFICITY; PROTEIN-SERINE-THREONINE KINASES; RIBOSE-PHOSPHATE PYROPHOSPHOKINASE; RNA EDITING; RNA INTERFERENCE; URIC ACID;

EID: 33847317017     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1138050     Document Type: Article

References (21)

1. D. P. Sartel, Cell 116, 281 (2004).
2. T. Du, P. D. Zamore, Development 132, 4645 (2005).
3. S. M. Hammond, Curr. Opin. Genet. Dev. 16, 4 (2006).
4. L. He, G. J. Hannon, Nat. Rev. Genet. 5, 522 (2004).
5. V. N. Kim, Nat. Rev. Mol. Cell Biol. 6, 376 (2005).
6. M. J. Blow et al. Genome Biol. 7, R27 (2006).
7. D. J. Luciano, H. Mirsky, N. J. Vendetti, S. Maas, RNA 10, 1174 (2004).
8. W. Yang et al., Nat. Struct. Mol. Biol. 13, 13 (2006).
9. H. Seitz et al., Genome Res. 14, 1741 (2004).
10. M. N. Poy et al., Nature 432, 226 (2004).
11. Materials and methods are available as supporting material on Science Online.
12. B. L. Bass, Annu. Rev. Biochem. 71, 817 (2002).
13. K. Nishikura, Nat. Rev. Mol. Cell Biol. 7, 919 (2006).
14. R. A. Reenan, Trends Genet. 17, 53 (2001).
15. P. H. Seeburg, Neuron 35, 17 (2002).
16. M. Higuchi et al., Nature 406, 78 (2000).
17. J. C. Hartner et al., J. Biol. Chem. 279, 4894 (2004).
18. Q. Wang et al., J. Biol. Chem. 279, 4952 (2004).
19. M. Ahmed, W. Taylor, P. R. Smith, M. A. Becker, J. Biol. Chem. 274, 7482 (1999).
20. S. Pfeffer et al., Nat. Methods 2, 269 (2005).
21. -/- mice, Q. Wang for mouse embryo RNAs, Z. Mourelatos and J. M. Murray for reading and comments, and S. Lui and U. Samala for technical assistance.