Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

Genes and Development

Volumn 15, Issue 20, 2001, Pages 2654-2659

  Ketting, R F ^a   Fischer, S E J ^a   Bernstein, E ^a   Sijen, T ^a   Hannon, G J ^a   Plasterk, R H A ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Development; Dicer; PTGS; RNAi; siRNA

Indexed keywords

DOUBLE STRANDED RNA;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL FREE SYSTEM; COMPLEX FORMATION; DELETION MUTANT; EMBRYO DEVELOPMENT; GENE SILENCING; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; RNA DEGRADATION; RNA SYNTHESIS; TRANSCRIPTION REGULATION; TRANSPOSON;

ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; DNA PRIMERS; DROSOPHILA; EMBRYO, NONMAMMALIAN; ENDORIBONUCLEASES; FEMALE; GENE DELETION; GENES, REPORTER; GERM CELLS; POLYMERASE CHAIN REACTION; RABBITS; RECEPTORS, TUMOR NECROSIS FACTOR; RIBONUCLEASE III; RNA, ANTISENSE; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR DECOY RECEPTORS;

ANIMALIA; CAENORHABDITIS ELEGANS; INVERTEBRATA;

EID: 0035887005     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.927801     Document Type: Article

References (40)

1. A viral suppressor of gene silencing in plants
2. Double-stranded RNA as a template for gene silencing
3. Gene silencing: RNA makes RNA makes no protein
4. Role for a bidentate ribonuclease in the initiation step of RNA interference
5. AGO1 defines a novel locus of Arabidopsis controlling leaf development
6. Domains in gene silencing and cell differentiation proteins: The novel PAZ domain and redefinition of the Piwi domain
7. Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana
8. SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis
9. RNA interference is mediated by 21- and 22-nucleotide RNAs
10. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
11. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
12. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
13. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation
14. A species of small antisense RNA in posttranscriptional gene silencing in plants
15. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
16. Post-transcriptional gene silencing by double-stranded RNA
17. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
18. Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems
19. Reverse genetics by chemical mutagenesis in Caenorhabditis elegan
20. A counterdefensive strategy of plant viruses: Suppression of posttranscriptional gene silencing
21. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
22. Listening to the silent genes: Transgene silencing, gene regulation and pathogen control
23. Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus
24. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
25. Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co-suppression of homologous genes in trans
26. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
27. Functional anatomy of a dsRNA trigger. Differential requirement for the two trigger strands in RNA interference
28. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
29. The silence of the genes
30. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
31. RNA interference 2001
32. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
33. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
34. The rde-1 gene, RNA interference, and transposon silencing in C. elegans
35. Flavonoid genes in Petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
36. Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants
37. Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-box RNA helicase
38. Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos
39. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals