-
1
-
-
0142259345
-
New tools for functional mammalian cancer genetics
-
Brummelkamp, T. R. & Bernards, R. New tools for functional mammalian cancer genetics. Nature Rev. Cancer 3, 781-789 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 781-789
-
-
Brummelkamp, T.R.1
Bernards, R.2
-
2
-
-
4644350944
-
Unlocking the potential of the human genome with RNA interference
-
Hannon, C. J. & Rossi, J. J. Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378 (2004).
-
(2004)
Nature
, vol.431
, pp. 371-378
-
-
Hannon, C.J.1
Rossi, J.J.2
-
3
-
-
0033555703
-
RNAi and double-strand RNA
-
Sharp, P. A. RNAi and double-strand RNA. Genes Dev. 13, 139-141 (1999).
-
(1999)
Genes Dev.
, vol.13
, pp. 139-141
-
-
Sharp, P.A.1
-
4
-
-
3142615372
-
The RNAi revolution
-
Novina, C. D. & Sharp, P. A. The RNAi revolution. Nature 430, 161-164 (2004).
-
(2004)
Nature
, vol.430
, pp. 161-164
-
-
Novina, C.D.1
Sharp, P.A.2
-
5
-
-
4644223259
-
Mechanisms of gene silencing by double-stranded RNA
-
Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343-349 (2004).
-
(2004)
Nature
, vol.431
, pp. 343-349
-
-
Meister, G.1
Tuschl, T.2
-
6
-
-
24644446398
-
Ribo-gnome: The big world of small RNAs
-
Zamore, P. D. & Haley, B. Ribo-gnome: the big world of small RNAs. Science 309, 1519-1524 (2005).
-
(2005)
Science
, vol.309
, pp. 1519-1524
-
-
Zamore, P.D.1
Haley, B.2
-
7
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998). First demonstration in animals that dsRNA can target gene-specific knockdown.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
8
-
-
0034676457
-
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
-
Fraser, A. G. et al. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330 (2000).
-
(2000)
Nature
, vol.408
, pp. 325-330
-
-
Fraser, A.G.1
-
9
-
-
0037448540
-
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
-
Kamath, R. S. et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231-237 (2003).
-
(2003)
Nature
, vol.421
, pp. 231-237
-
-
Kamath, R.S.1
-
10
-
-
0037448528
-
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
-
Ashrafi, K. et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268-272 (2003).
-
(2003)
Nature
, vol.421
, pp. 268-272
-
-
Ashrafi, K.1
-
11
-
-
0037470952
-
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
-
Lum, L. et al. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299, 2039-2045 (2003).
-
(2003)
Science
, vol.299
, pp. 2039-2045
-
-
Lum, L.1
-
12
-
-
0842309871
-
Genome-wide RNAi analysis of growth and viability in Drosophila cells
-
Boutros, M. et al. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303, 832-835 (2004).
-
(2004)
Science
, vol.303
, pp. 832-835
-
-
Boutros, M.1
-
13
-
-
0031657551
-
How cells respond to interferons
-
Stark, G. R., Kerr, I. M., Williams, B. R., Silverman, R. H. & Schreiber, R. D. How cells respond to interferons. Annu. Rev. Biochem. 67, 227-264 (1998).
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 227-264
-
-
Stark, G.R.1
Kerr, I.M.2
Williams, B.R.3
Silverman, R.H.4
Schreiber, R.D.5
-
14
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001). Seminal discovery that short dsRNAs trigger gene silencing in mammalian cells in the absence of nonspecific responses.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
15
-
-
0036273940
-
Gene silencing using micro-RNA designed hairpins
-
McManus, M. T., Petersen, C. P., Haines, B. B., Chen, J. & Sharp, P. A. Gene silencing using micro-RNA designed hairpins. RNA 8, 842-850 (2002).
-
(2002)
RNA
, vol.8
, pp. 842-850
-
-
McManus, M.T.1
Petersen, C.P.2
Haines, B.B.3
Chen, J.4
Sharp, P.A.5
-
16
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002). One of the first demonstrations that plasmid-based shRNAs can target gene-specific knockdown.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
17
-
-
0036976008
-
Lentiviral-mediated RNA interference
-
Abbas-Terki, T., Blanco-Bose, W., Deglon, N., Pralong, W. & Aebischer, P. Lentiviral-mediated RNA interference. Hum. Gene Ther. 13, 2197-2201 (2002).
-
(2002)
Hum. Gene Ther.
, vol.13
, pp. 2197-2201
-
-
Abbas-Terki, T.1
Blanco-Bose, W.2
Deglon, N.3
Pralong, W.4
Aebischer, P.5
-
18
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J. & Conklin, D. S. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16, 948-958 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Caudy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
19
-
-
0344375083
-
Lentivirus-delivered stable gene silencing by RNAi in primary cells
-
Stewart, S. A. et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493-501 (2003).
-
(2003)
RNA
, vol.9
, pp. 493-501
-
-
Stewart, S.A.1
-
20
-
-
10944254152
-
Transcription and processing of human microRNA precursors
-
Cullen, B. R. Transcription and processing of human microRNA precursors. Mol. Cell 16, 861-865 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 861-865
-
-
Cullen, B.R.1
-
21
-
-
0036294527
-
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
-
Zeng, Y., Wagner, E. J. & Cullen, B. R. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9, 1327-1333 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 1327-1333
-
-
Zeng, Y.1
Wagner, E.J.2
Cullen, B.R.3
-
22
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genomes
-
Silva, J. M. et al. Second-generation shRNA libraries covering the mouse and human genomes. Nature Genet. 37, 1281-1288 (2005). Describes the first shRNA-mir library that targets all human and mouse genes with 2-3 constructs per gene.
-
(2005)
Nature Genet.
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
-
23
-
-
0026713151
-
Interactions between double-stranded RNA regulators and the protein kinase DAI
-
Manche, L., Green, S. R., Schmedt, C. & Mathews, M. B. Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol. Cell. Biol. 12, 5238-5248 (1992).
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 5238-5248
-
-
Manche, L.1
Green, S.R.2
Schmedt, C.3
Mathews, M.B.4
-
24
-
-
0018801485
-
Structural requirements of double-stranded RNA for the activation of 2′,5′-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells
-
Minks, M. A., West, D. K., Benvin, S. & Baglioni, C. Structural requirements of double-stranded RNA for the activation of 2′,5′- oligo(A) polymerase and protein kinase of interferon-treated HeLa cells. J. Biol. Chem. 254, 10180-10183 (1979).
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 10180-10183
-
-
Minks, M.A.1
West, D.K.2
Benvin, S.3
Baglioni, C.4
-
25
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-437 (2004). The first large-scale retroviral library that was used in a pooled infection screen.
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
-
26
-
-
12144288006
-
A resource for large-scale RNA-interference-based screens in mammals
-
Paddison, P. J. et al. A resource for large-scale RNA-interference-based screens in mammals. Nature 428, 427-431 (2004).
-
(2004)
Nature
, vol.428
, pp. 427-431
-
-
Paddison, P.J.1
-
27
-
-
10744221455
-
Adenoviral vectors expressing siRNAs for discovery and validation of gene function
-
Arts, G. J. et al. Adenoviral vectors expressing siRNAs for discovery and validation of gene function. Genome Res. 13, 2325-2332 (2003).
-
(2003)
Genome Res.
, vol.13
, pp. 2325-2332
-
-
Arts, G.J.1
-
28
-
-
33644543320
-
A lentiviral RNAi library targeting human and mouse genes: Construction, characterization and application to an arrayed high-content screen
-
in the press
-
Moffat, J. et al. A lentiviral RNAi library targeting human and mouse genes: construction, characterization and application to an arrayed high-content screen. Cell (in the press). Describes the first large-scale lentiviral shRNA library and arrayed viral infection screen.
-
Cell
-
-
Moffat, J.1
-
29
-
-
0141750434
-
Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening
-
Aza-Blanc, P. et al. Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol. Cell 12, 627-637 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 627-637
-
-
Aza-Blanc, P.1
-
30
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
-
Mackeigan, J. P., Murphy, L. O. & Blenis, J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature Cell Biol. 7, 591-600 (2005).
-
(2005)
Nature Cell Biol.
, vol.7
, pp. 591-600
-
-
Mackeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
31
-
-
21844440569
-
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
-
Pelkmans, L. et al. Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature 436, 78-86 (2005). Describes the first genome-wide siRNA transfection screen of human kinases that are required for endocytosis and a systems-level analysis of the screening results.
-
(2005)
Nature
, vol.436
, pp. 78-86
-
-
Pelkmans, L.1
-
32
-
-
21844473275
-
High-throughput RNAi screening in vitro: From cell lines to primary cells
-
Ovcharenko, D., Jarvis, R., Hunicke-Smith, S., Kelnar, K. & Brown, D. High-throughput RNAi screening in vitro: from cell lines to primary cells. RNA 11, 985-993 (2005).
-
(2005)
RNA
, vol.11
, pp. 985-993
-
-
Ovcharenko, D.1
Jarvis, R.2
Hunicke-Smith, S.3
Kelnar, K.4
Brown, D.5
-
33
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
-
Brummelkamp, T. R., Nijman, S. M., Dirac, A. M. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797-801 (2003).
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
34
-
-
9344235449
-
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
-
Cai, X., Hagedorn, C. H. & Cullen, B. R. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10, 1957-1966 (2004).
-
(2004)
RNA
, vol.10
, pp. 1957-1966
-
-
Cai, X.1
Hagedorn, C.H.2
Cullen, B.R.3
-
35
-
-
8144225486
-
MicroRNA genes are transcribed by RNA polymerase II
-
Lee, Y. et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23, 4051-4060 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 4051-4060
-
-
Lee, Y.1
-
36
-
-
0141843656
-
The nuclear RNase III Drosha initiates microRNA processing
-
Lee, Y. et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415-419 (2003).
-
(2003)
Nature
, vol.425
, pp. 415-419
-
-
Lee, Y.1
-
37
-
-
9144224451
-
Processing of primary microRNAs by the Microprocessor complex
-
Denli, A. M., Tops, B. B., Plasterk, R. H., Ketting, R. F. & Hannon, G. J. Processing of primary microRNAs by the Microprocessor complex. Nature 432, 231-235 (2004).
-
(2004)
Nature
, vol.432
, pp. 231-235
-
-
Denli, A.M.1
Tops, B.B.2
Plasterk, R.H.3
Ketting, R.F.4
Hannon, G.J.5
-
38
-
-
10344248903
-
The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis
-
Landthaler, M., Yalcin, A. & Tuschl, T. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. Curr. Biol. 14, 2162-2167 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 2162-2167
-
-
Landthaler, M.1
Yalcin, A.2
Tuschl, T.3
-
39
-
-
10644234841
-
The Drosha-DGCR8 complex in primary microRNA processing
-
Han, J. et al. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18, 3016-3027 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 3016-3027
-
-
Han, J.1
-
40
-
-
9144225636
-
The Microprocessor complex mediates the genesis of microRNAs
-
Gregory, R. I. et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235-240 (2004).
-
(2004)
Nature
, vol.432
, pp. 235-240
-
-
Gregory, R.I.1
-
41
-
-
0347361541
-
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
-
Yi, R., Qin, Y., Macara, I. G. & Cullen, B. R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 3011-3016
-
-
Yi, R.1
Qin, Y.2
Macara, I.G.3
Cullen, B.R.4
-
42
-
-
0347988235
-
Nuclear export of microRNA precursors
-
Lund, E., Guttinger, S., Calado, A., Dahlberg, J. E. & Kutay, U. Nuclear export of microRNA precursors. Science 303, 95-98 (2004).
-
(2004)
Science
, vol.303
, pp. 95-98
-
-
Lund, E.1
Guttinger, S.2
Calado, A.3
Dahlberg, J.E.4
Kutay, U.5
-
43
-
-
27644582893
-
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
-
Dickins, R. A. et al. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nature Genet. 37, 1289-1295 (2005). Elegant study that demonstrates the potential of shRNA-mirs in vitro and in vivo.
-
(2005)
Nature Genet.
, vol.37
, pp. 1289-1295
-
-
Dickins, R.A.1
-
44
-
-
24944560377
-
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
-
Stegmeier, F., Hu, G., Rickles, R. J., Hannon, G. J. & Elledge, S. J. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl Acad. Sci. USA 102, 13212-13217 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13212-13217
-
-
Stegmeier, F.1
Hu, G.2
Rickles, R.J.3
Hannon, G.J.4
Elledge, S.J.5
-
45
-
-
0037022382
-
Stable suppression of gene expression by RNAi in mammalian cells
-
Paddison, P. J., Caudy, A. A. & Hannon, G. J. Stable suppression of gene expression by RNAi in mammalian cells. Proc. Natl Acad. Sci. USA 99, 1443-1448 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 1443-1448
-
-
Paddison, P.J.1
Caudy, A.A.2
Hannon, G.J.3
-
46
-
-
0842310832
-
Restriction enzyme-generated siRNA (REGS) vectors and libraries
-
Sen, G., Wehrman, T. S., Myers, J. W. & Blau, H. M. Restriction enzyme-generated siRNA (REGS) vectors and libraries. Nature Genet. 36, 183-189 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 183-189
-
-
Sen, G.1
Wehrman, T.S.2
Myers, J.W.3
Blau, H.M.4
-
47
-
-
0842332405
-
Enzymatic production of RNAi libraries from cDNAs
-
Shirane, D. et al. Enzymatic production of RNAi libraries from cDNAs. Nature Genet. 36, 190-196 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 190-196
-
-
Shirane, D.1
-
48
-
-
1842631431
-
Small interfering RNA production by enzymatic engineering of DNA (SPEED)
-
Luo, B., Heard, A. D. & Lodish, H. F. Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc. Natl Acad. Sci. USA 101, 5494-5499 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 5494-5499
-
-
Luo, B.1
Heard, A.D.2
Lodish, H.F.3
-
49
-
-
19944367565
-
An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division
-
Kittler, R. et al. An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature 432, 1036-1040 (2004).
-
(2004)
Nature
, vol.432
, pp. 1036-1040
-
-
Kittler, R.1
-
50
-
-
0347089019
-
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells
-
Zheng, L. et al. An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc. Natl Acad. Sci. USA 101, 135-140 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 135-140
-
-
Zheng, L.1
-
51
-
-
25644448153
-
Mammalian RNAi: A practical guide
-
Sandy, P., Ventura, A. & Jacks, T. Mammalian RNAi: a practical guide. Biotechniques 39, 215-224 (2005).
-
(2005)
Biotechniques
, vol.39
, pp. 215-224
-
-
Sandy, P.1
Ventura, A.2
Jacks, T.3
-
52
-
-
9144260199
-
Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells
-
Downward, J. Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells. Oncogene 23, 8376-8383 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 8376-8383
-
-
Downward, J.1
-
53
-
-
0033529707
-
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
-
Winzeler, E. A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901-906 (1999).
-
(1999)
Science
, vol.285
, pp. 901-906
-
-
Winzeler, E.A.1
-
54
-
-
20444376939
-
A genetic screen for candidate tumor suppressors identifies REST
-
Westbrook, T. F. et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 121, 837-848 (2005).
-
(2005)
Cell
, vol.121
, pp. 837-848
-
-
Westbrook, T.F.1
-
55
-
-
20444426889
-
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity
-
Kolfschoten, I. G. et al. A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell 121, 849-858 (2005).
-
(2005)
Cell
, vol.121
, pp. 849-858
-
-
Kolfschoten, I.G.1
-
56
-
-
20044366920
-
Cell microarrays and RNA interference chip away at gene function
-
Wheeler, D. B., Carpenter, A. E. & Sabatini, D. M. Cell microarrays and RNA interference chip away at gene function. Nature Genet. 37, S25-S30 (2005).
-
(2005)
Nature Genet.
, vol.37
-
-
Wheeler, D.B.1
Carpenter, A.E.2
Sabatini, D.M.3
-
57
-
-
31744445957
-
Microarrays of lentiviruses for gene function screens in immortalized and primary cells
-
Bailey, S. N., Ali, S. M., Carpenter, A. E., Higgins, C. O. & Sabatini, D. M. Microarrays of lentiviruses for gene function screens in immortalized and primary cells. Nature Meth. 3, 117-122 (2006).
-
(2006)
Nature Meth.
, vol.3
, pp. 117-122
-
-
Bailey, S.N.1
Ali, S.M.2
Carpenter, A.E.3
Higgins, C.O.4
Sabatini, D.M.5
-
58
-
-
19944413010
-
Genome-wide survey of protein kinases required for cell cycle progression
-
Bettencourt-Dias, M. et al. Genome-wide survey of protein kinases required for cell cycle progression. Nature 432, 980-987 (2004).
-
(2004)
Nature
, vol.432
, pp. 980-987
-
-
Bettencourt-Dias, M.1
-
59
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang, J. H., Chung, T. D. & Oldenburg, K. R. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4, 67-73 (1999).
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.2
Oldenburg, K.R.3
-
60
-
-
0038419800
-
Induction of an interferon response by RNAi vectors in mammalian cells
-
Bridge, A. J., Pebernard, S., Ducraux, A., Nicoulaz, A. L. & Iggo, R. Induction of an interferon response by RNAi vectors in mammalian cells. Nature Genet. 34, 263-264 (2003).
-
(2003)
Nature Genet.
, vol.34
, pp. 263-264
-
-
Bridge, A.J.1
Pebernard, S.2
Ducraux, A.3
Nicoulaz, A.L.4
Iggo, R.5
-
61
-
-
4744373229
-
Noise amidst the silence: Off-target effects of siRNAs?
-
Jackson, A. L. & Linsley, P. S. Noise amidst the silence: off-target effects of siRNAs? Trends Genet. 20, 521-524 (2004).
-
(2004)
Trends Genet.
, vol.20
, pp. 521-524
-
-
Jackson, A.L.1
Linsley, P.S.2
-
62
-
-
3042786293
-
A gene network for navigating the literature
-
Hoffmann, R. & Valencia, A. A gene network for navigating the literature. Nature Genet. 36, 664 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 664
-
-
Hoffmann, R.1
Valencia, A.2
-
63
-
-
27744543196
-
Text mining for metabolic pathways, signaling cascades, and protein networks
-
Hoffmann, R. et al. Text mining for metabolic pathways, signaling cascades, and protein networks. Sci. STKE 283, pe21 (2005).
-
(2005)
Sci. STKE
, vol.283
-
-
Hoffmann, R.1
-
64
-
-
27544448536
-
Implementing the iHOP concept for navigation of biomedical literature
-
Hoffmann, R. & Valencia, A. Implementing the iHOP concept for navigation of biomedical literature. Bioinformatics 21 (Suppl. 2), ii252-ii258 (2005).
-
(2005)
Bioinformatics
, vol.21
, Issue.2 SUPPL.
-
-
Hoffmann, R.1
Valencia, A.2
-
65
-
-
4444231522
-
'Harvester': A fast meta search engine of human protein resources
-
Liebel, U., Kindler, B. & Pepperkok, R. 'Harvester': a fast meta search engine of human protein resources. Bioinformatics 20, 1962-1963 (2004).
-
(2004)
Bioinformatics
, vol.20
, pp. 1962-1963
-
-
Liebel, U.1
Kindler, B.2
Pepperkok, R.3
-
66
-
-
10744230485
-
Global mapping of the yeast genetic interaction network
-
Tong, A. H. et al. Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004).
-
(2004)
Science
, vol.303
, pp. 808-813
-
-
Tong, A.H.1
-
67
-
-
18244400410
-
Functional genomic analysis of the Wnt-Wingless signaling pathway
-
DasGupta, R., Kaykas, A., Moon, R. T. & Perrimon, N. Functional genomic analysis of the Wnt-Wingless signaling pathway. Science 308, 826-833 (2005).
-
(2005)
Science
, vol.308
, pp. 826-833
-
-
DasGupta, R.1
Kaykas, A.2
Moon, R.T.3
Perrimon, N.4
-
68
-
-
0036295684
-
Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity
-
Huang, D., Moffat, J. & Andrews, B. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Mol. Cell. Biol. 22, 5076-5088 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5076-5088
-
-
Huang, D.1
Moffat, J.2
Andrews, B.3
-
69
-
-
27544500981
-
Growing roles for the mTOR pathway
-
Sarbassov, D. D., Ali, S. M. & Sabatini, D. M. Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17, 596-603 (2005).
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 596-603
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sabatini, D.M.3
-
70
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M. & Sabatini, D. M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
71
-
-
0347089037
-
Electroporation and RNA interference in the rodent retina in vivo and in vitro
-
Matsuda, T. & Cepko, C. L. Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc. Natl Acad. Sci. USA 101, 16-22 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 16-22
-
-
Matsuda, T.1
Cepko, C.L.2
-
72
-
-
0346216853
-
Local gene knockdown in the brain using viral-mediated RNA interference
-
Hommel, J. D., Sears, R. M., Georgescu, D., Simmons, D. L. & DiLeone, R. J. Local gene knockdown in the brain using viral-mediated RNA interference. Nature Med. 9, 1539-1544 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 1539-1544
-
-
Hommel, J.D.1
Sears, R.M.2
Georgescu, D.3
Simmons, D.L.4
DiLeone, R.J.5
-
73
-
-
0036787671
-
siRNA-mediated gene silencing in vitro and in vivo
-
Xia, H., Mao, Q., Paulson, H. L. & Davidson, B. L. siRNA-mediated gene silencing in vitro and in vivo. Nature Biotechnol. 20, 1006-1010 (2002).
-
(2002)
Nature Biotechnol.
, vol.20
, pp. 1006-1010
-
-
Xia, H.1
Mao, Q.2
Paulson, H.L.3
Davidson, B.L.4
-
74
-
-
1942494048
-
Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA
-
Kishida, T. et al. Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA. J. Gene Med. 6, 105-110 (2004).
-
(2004)
J. Gene Med.
, vol.6
, pp. 105-110
-
-
Kishida, T.1
-
75
-
-
0038708339
-
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype
-
Kunath, T. et al. Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nature Biotechnol. 21, 559-561 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 559-561
-
-
Kunath, T.1
-
76
-
-
3142708570
-
Cre-lox-regulated conditional RNA interference from transgenes
-
Ventura, A. et al. Cre-lox-regulated conditional RNA interference from transgenes. Proc. Natl Acad. Sci. USA 101, 10380-10385 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10380-10385
-
-
Ventura, A.1
-
77
-
-
0037452812
-
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
-
Tiscornia, G., Singer, O., Ikawa, M. & Verma, I. M. A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc. Natl Acad. Sci. USA 100, 1844-1848 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1844-1848
-
-
Tiscornia, G.1
Singer, O.2
Ikawa, M.3
Verma, I.M.4
-
78
-
-
0037370498
-
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
-
Rubinson, D. A. et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nature Genet. 33, 401-406 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 401-406
-
-
Rubinson, D.A.1
-
79
-
-
13844280638
-
Synthetic shRNAs as potent RNAi triggers
-
Siolas, D. et al. Synthetic shRNAs as potent RNAi triggers. Nature Biotechnol. 23, 227-231 (2005).
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 227-231
-
-
Siolas, D.1
-
80
-
-
0346728473
-
Systematic genome-wide screens of gene function
-
Carpenter, A. E. & Sabatini, D. M. Systematic genome-wide screens of gene function. Nature Rev. Genet. 5, 11-22 (2004).
-
(2004)
Nature Rev. Genet.
, vol.5
, pp. 11-22
-
-
Carpenter, A.E.1
Sabatini, D.M.2
|