-
1
-
-
34447102459
-
Molecular basis for target RNA recognition and cleavage by human RISC
-
Ameres S.L., Martinez J., Schroeder R. Molecular basis for target RNA recognition and cleavage by human RISC. Cell 2007, 130:101-112.
-
(2007)
Cell
, vol.130
, pp. 101-112
-
-
Ameres, S.L.1
Martinez, J.2
Schroeder, R.3
-
2
-
-
84874086395
-
Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing
-
Auyeung V.C., Ulitsky I., McGeary S.E., Bartel D.P. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell 2013, 152:844-858.
-
(2013)
Cell
, vol.152
, pp. 844-858
-
-
Auyeung, V.C.1
Ulitsky, I.2
McGeary, S.E.3
Bartel, D.P.4
-
3
-
-
0347444723
-
MicroRNAs: genomics, biogenesis, mechanism, and function
-
Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
4
-
-
2342471249
-
Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins
-
Boden D., Pusch O., Silbermann R., Lee F., Tucker L., Ramratnam B. Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins. Nucleic Acids Res. 2004, 32:1154-1158.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 1154-1158
-
-
Boden, D.1
Pusch, O.2
Silbermann, R.3
Lee, F.4
Tucker, L.5
Ramratnam, B.6
-
5
-
-
50649121877
-
Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs
-
Boudreau R.L., Monteys A.M.A.S., Davidson B.L. Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs. RNA 2008, 14:1834-1844.
-
(2008)
RNA
, vol.14
, pp. 1834-1844
-
-
Boudreau, R.L.1
Monteys, A.M.A.S.2
Davidson, B.L.3
-
6
-
-
58149232358
-
Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs invitro and invivo
-
Boudreau R.L., Martins I., Davidson B.L. Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs invitro and invivo. Mol. Ther. 2009, 17:169-175.
-
(2009)
Mol. Ther.
, vol.17
, pp. 169-175
-
-
Boudreau, R.L.1
Martins, I.2
Davidson, B.L.3
-
7
-
-
60149088848
-
Origins and Mechanisms of miRNAs and siRNAs
-
Carthew R.W., Sontheimer E.J. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009, 136:642-655.
-
(2009)
Cell
, vol.136
, pp. 642-655
-
-
Carthew, R.W.1
Sontheimer, E.J.2
-
8
-
-
34548548614
-
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC
-
Castanotto D., Sakurai K., Lingeman R., Li H., Shively L., Aagaard L., Soifer H., Gatignol A., Riggs A., Rossi J.J. Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res. 2007, 35:5154-5164.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 5154-5164
-
-
Castanotto, D.1
Sakurai, K.2
Lingeman, R.3
Li, H.4
Shively, L.5
Aagaard, L.6
Soifer, H.7
Gatignol, A.8
Riggs, A.9
Rossi, J.J.10
-
9
-
-
77952368550
-
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
-
Chiang H.R., Schoenfeld L.W., Ruby J.G., Auyeung V.C., Spies N., Baek D., Johnston W.K., Russ C., Luo S., Babiarz J.E., et al. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 2010, 24:992-1009.
-
(2010)
Genes Dev.
, vol.24
, pp. 992-1009
-
-
Chiang, H.R.1
Schoenfeld, L.W.2
Ruby, J.G.3
Auyeung, V.C.4
Spies, N.5
Baek, D.6
Johnston, W.K.7
Russ, C.8
Luo, S.9
Babiarz, J.E.10
-
10
-
-
33645804365
-
Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155
-
Chung K.-H., Hart C.C., Al-Bassam S., Avery A., Taylor J., Patel P.D., Vojtek A.B., Turner D.L. Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155. Nucleic Acids Res. 2006, 34:e53.
-
(2006)
Nucleic Acids Res.
, vol.34
-
-
Chung, K.-H.1
Hart, C.C.2
Al-Bassam, S.3
Avery, A.4
Taylor, J.5
Patel, P.D.6
Vojtek, A.B.7
Turner, D.L.8
-
11
-
-
27644582893
-
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
-
Dickins R.A., Hemann M.T., Zilfou J.T., Simpson D.R., Ibarra I., Hannon G.J., Lowe S.W. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat. Genet. 2005, 37:1289-1295.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1289-1295
-
-
Dickins, R.A.1
Hemann, M.T.2
Zilfou, J.T.3
Simpson, D.R.4
Ibarra, I.5
Hannon, G.J.6
Lowe, S.W.7
-
12
-
-
84858382422
-
A pipeline for the generation of shRNA transgenic mice
-
Dow L.E., Premsrirut P.K., Zuber J., Fellmann C., McJunkin K., Miething C., Park Y., Dickins R.A., Hannon G.J., Lowe S.W. A pipeline for the generation of shRNA transgenic mice. Nat. Protoc. 2012, 7:374-393.
-
(2012)
Nat. Protoc.
, vol.7
, pp. 374-393
-
-
Dow, L.E.1
Premsrirut, P.K.2
Zuber, J.3
Fellmann, C.4
McJunkin, K.5
Miething, C.6
Park, Y.7
Dickins, R.A.8
Hannon, G.J.9
Lowe, S.W.10
-
13
-
-
0031710033
-
A third-generation lentivirus vector with a conditional packaging system
-
Dull T., Zufferey R., Kelly M., Mandel R.J., Nguyen M., Trono D., Naldini L. A third-generation lentivirus vector with a conditional packaging system. J.Virol. 1998, 72:8463-8471.
-
(1998)
J.Virol.
, vol.72
, pp. 8463-8471
-
-
Dull, T.1
Zufferey, R.2
Kelly, M.3
Mandel, R.J.4
Nguyen, M.5
Trono, D.6
Naldini, L.7
-
14
-
-
79952697845
-
Functional identification of optimized RNAi triggers using a massively parallel sensor assay
-
Fellmann C., Zuber J., McJunkin K., Chang K., Malone C.D., Dickins R.A., Xu Q., Hengartner M.O., Elledge S.J., Hannon G.J., Lowe S.W. Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol. Cell 2011, 41:733-746.
-
(2011)
Mol. Cell
, vol.41
, pp. 733-746
-
-
Fellmann, C.1
Zuber, J.2
McJunkin, K.3
Chang, K.4
Malone, C.D.5
Dickins, R.A.6
Xu, Q.7
Hengartner, M.O.8
Elledge, S.J.9
Hannon, G.J.10
Lowe, S.W.11
-
15
-
-
80655149142
-
Drosha processing controls the specificity and efficiency of global microRNA expression
-
Feng Y., Zhang X., Song Q., Li T., Zeng Y. Drosha processing controls the specificity and efficiency of global microRNA expression. Biochim. Biophys. Acta 2011, 1809:700-707.
-
(2011)
Biochim. Biophys. Acta
, vol.1809
, pp. 700-707
-
-
Feng, Y.1
Zhang, X.2
Song, Q.3
Li, T.4
Zeng, Y.5
-
16
-
-
38349169664
-
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
-
Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat. Rev. Genet. 2008, 9:102-114.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 102-114
-
-
Filipowicz, W.1
Bhattacharyya, S.N.2
Sonenberg, N.3
-
17
-
-
77953479619
-
Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2
-
Frank F., Sonenberg N., Nagar B. Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature 2010, 465:818-822.
-
(2010)
Nature
, vol.465
, pp. 818-822
-
-
Frank, F.1
Sonenberg, N.2
Nagar, B.3
-
18
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D., Streetz K.L., Jopling C.L., Storm T.A., Pandey K., Davis C.R., Marion P., Salazar F., Kay M.A. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006, 441:537-541.
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
Streetz, K.L.2
Jopling, C.L.3
Storm, T.A.4
Pandey, K.5
Davis, C.R.6
Marion, P.7
Salazar, F.8
Kay, M.A.9
-
19
-
-
84869037267
-
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing invivo
-
Gu S., Jin L., Zhang Y., Huang Y., Zhang F., Valdmanis P.N., Kay M.A. The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing invivo. Cell 2012, 151:900-911.
-
(2012)
Cell
, vol.151
, pp. 900-911
-
-
Gu, S.1
Jin, L.2
Zhang, Y.3
Huang, Y.4
Zhang, F.5
Valdmanis, P.N.6
Kay, M.A.7
-
20
-
-
33744520104
-
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
-
Han J., Lee Y., Yeom K.-H., Nam J.-W., Heo I., Rhee J.-K., Sohn S.Y., Cho Y., Zhang B.-T., Kim V.N. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006, 125:887-901.
-
(2006)
Cell
, vol.125
, pp. 887-901
-
-
Han, J.1
Lee, Y.2
Yeom, K.-H.3
Nam, J.-W.4
Heo, I.5
Rhee, J.-K.6
Sohn, S.Y.7
Cho, Y.8
Zhang, B.-T.9
Kim, V.N.10
-
21
-
-
4644350944
-
Unlocking the potential of the human genome with RNA interference
-
Hannon G.J., Rossi J.J. Unlocking the potential of the human genome with RNA interference. Nature 2004, 431:371-378.
-
(2004)
Nature
, vol.431
, pp. 371-378
-
-
Hannon, G.J.1
Rossi, J.J.2
-
22
-
-
77952568022
-
Autonomous role of medullary thymic epithelial cells in central CD4(+) Tcell tolerance
-
Hinterberger M., Aichinger M., Prazeres da Costa O., Voehringer D., Hoffmann R., Klein L. Autonomous role of medullary thymic epithelial cells in central CD4(+) Tcell tolerance. Nat. Immunol. 2010, 11:512-519.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 512-519
-
-
Hinterberger, M.1
Aichinger, M.2
Prazeres da Costa, O.3
Voehringer, D.4
Hoffmann, R.5
Klein, L.6
-
23
-
-
84856481543
-
A primer on using pooled shRNA libraries for functional genomic screens
-
Hu G., Luo J. A primer on using pooled shRNA libraries for functional genomic screens. Acta Biochim. Biophys. Sin. (Shanghai) 2012, 44:103-112.
-
(2012)
Acta Biochim. Biophys. Sin. (Shanghai)
, vol.44
, pp. 103-112
-
-
Hu, G.1
Luo, J.2
-
24
-
-
78651293534
-
MiRBase: integrating microRNA annotation and deep-sequencing data
-
Kozomara A., Griffiths-Jones S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 2011, 39(Database issue):D152-D157.
-
(2011)
Nucleic Acids Res.
, vol.39
, Issue.DATABASE ISSUE
-
-
Kozomara, A.1
Griffiths-Jones, S.2
-
25
-
-
44349164025
-
Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron
-
Liu Y.P., Haasnoot J., ter Brake O., Berkhout B., Konstantinova P. Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron. Nucleic Acids Res. 2008, 36:2811-2824.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 2811-2824
-
-
Liu, Y.P.1
Haasnoot, J.2
ter Brake, O.3
Berkhout, B.4
Konstantinova, P.5
-
26
-
-
44449121785
-
Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi
-
McBride J.L., Boudreau R.L., Harper S.Q., Staber P.D., Monteys A.M., Martins I., Gilmore B.L., Burstein H., Peluso R.W., Polisky B., et al. Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. Proc. Natl. Acad. Sci. USA 2008, 105:5868-5873.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 5868-5873
-
-
McBride, J.L.1
Boudreau, R.L.2
Harper, S.Q.3
Staber, P.D.4
Monteys, A.M.5
Martins, I.6
Gilmore, B.L.7
Burstein, H.8
Peluso, R.W.9
Polisky, B.10
-
27
-
-
84867594876
-
RNAi screening: new approaches, understandings, and organisms
-
Mohr S.E., Perrimon N. RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip. Rev. RNA 2012, 3:145-158.
-
(2012)
Wiley Interdiscip. Rev. RNA
, vol.3
, pp. 145-158
-
-
Mohr, S.E.1
Perrimon, N.2
-
28
-
-
84858702140
-
A dynamic perspective of RNAi library development
-
Pan Q., van der Laan L.J.W., Janssen H.L., Peppelenbosch M.P. A dynamic perspective of RNAi library development. Trends Biotechnol. 2012, 30:206-215.
-
(2012)
Trends Biotechnol.
, vol.30
, pp. 206-215
-
-
Pan, Q.1
van der Laan, L.J.W.2
Janssen, H.L.3
Peppelenbosch, M.P.4
-
29
-
-
79952696452
-
A rapid and scalable system for studying gene function in mice using conditional RNA interference
-
Premsrirut P.K., Dow L.E., Kim S.Y., Camiolo M., Malone C.D., Miething C., Scuoppo C., Zuber J., Dickins R.A., Kogan S.C., et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 2011, 145:145-158.
-
(2011)
Cell
, vol.145
, pp. 145-158
-
-
Premsrirut, P.K.1
Dow, L.E.2
Kim, S.Y.3
Camiolo, M.4
Malone, C.D.5
Miething, C.6
Scuoppo, C.7
Zuber, J.8
Dickins, R.A.9
Kogan, S.C.10
-
30
-
-
33646479480
-
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research
-
Schambach A., Galla M., Modlich U., Will E., Chandra S., Reeves L., Colbert M., Williams D.A., von Kalle C., Baum C. Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp. Hematol. 2006, 34:588-592.
-
(2006)
Exp. Hematol.
, vol.34
, pp. 588-592
-
-
Schambach, A.1
Galla, M.2
Modlich, U.3
Will, E.4
Chandra, S.5
Reeves, L.6
Colbert, M.7
Williams, D.A.8
von Kalle, C.9
Baum, C.10
-
31
-
-
27644436787
-
Second-generation shRNA libraries covering the mouse and human genomes
-
Silva J.M., Li M.Z., Chang K., Ge W., Golding M.C., Rickles R.J., Siolas D., Hu G., Paddison P.J., Schlabach M.R., et al. Second-generation shRNA libraries covering the mouse and human genomes. Nat. Genet. 2005, 37:1281-1288.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1281-1288
-
-
Silva, J.M.1
Li, M.Z.2
Chang, K.3
Ge, W.4
Golding, M.C.5
Rickles, R.J.6
Siolas, D.7
Hu, G.8
Paddison, P.J.9
Schlabach, M.R.10
-
32
-
-
24944560377
-
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
-
Stegmeier F., Hu G., Rickles R.J., Hannon G.J., Elledge S.J. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA 2005, 102:13212-13217.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13212-13217
-
-
Stegmeier, F.1
Hu, G.2
Rickles, R.J.3
Hannon, G.J.4
Elledge, S.J.5
-
33
-
-
33845663097
-
An accurateand interpretable model for siRNA efficacy prediction
-
Vert J.P., Foveau N., Lajaunie C., Vandenbrouck Y. An accurateand interpretable model for siRNA efficacy prediction. BMC Bioinformatics 2006, 7:520.
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 520
-
-
Vert, J.P.1
Foveau, N.2
Lajaunie, C.3
Vandenbrouck, Y.4
-
34
-
-
0036294527
-
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
-
Zeng Y., Wagner E.J., Cullen B.R. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 2002, 9:1327-1333.
-
(2002)
Mol. Cell
, vol.9
, pp. 1327-1333
-
-
Zeng, Y.1
Wagner, E.J.2
Cullen, B.R.3
-
35
-
-
38049107787
-
A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs
-
Zhu X., Santat L.A., Chang M.S., Liu J., Zavzavadjian J.R., Wall E.A., Kivork C., Simon M.I., Fraser I.D. A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs. BMC Mol. Biol. 2007, 8:98.
-
(2007)
BMC Mol. Biol.
, vol.8
, pp. 98
-
-
Zhu, X.1
Santat, L.A.2
Chang, M.S.3
Liu, J.4
Zavzavadjian, J.R.5
Wall, E.A.6
Kivork, C.7
Simon, M.I.8
Fraser, I.D.9
-
36
-
-
78651312134
-
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
-
Zuber J., McJunkin K., Fellmann C., Dow L.E., Taylor M.J., Hannon G.J., Lowe S.W. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat. Biotechnol. 2011, 29:79-83.
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 79-83
-
-
Zuber, J.1
McJunkin, K.2
Fellmann, C.3
Dow, L.E.4
Taylor, M.J.5
Hannon, G.J.6
Lowe, S.W.7
-
37
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber J., Shi J., Wang E., Rappaport A.R., Herrmann H., Sison E.A., Magoon D., Qi J., Blatt K., Wunderlich M., et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011, 478:524-528.
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
-
38
-
-
80051513341
-
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
-
Zuber J., Rappaport A.R., Luo W., Wang E., Chen C., Vaseva A.V., Shi J., Weissmueller S., Fellmann C., Taylor M.J., et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 2011, 25:1628-1640.
-
(2011)
Genes Dev.
, vol.25
, pp. 1628-1640
-
-
Zuber, J.1
Rappaport, A.R.2
Luo, W.3
Wang, E.4
Chen, C.5
Vaseva, A.V.6
Shi, J.7
Weissmueller, S.8
Fellmann, C.9
Taylor, M.J.10
|