KSHV: Pathways to tumorigenesis and persistent infection

Advances in Virus Research

Volumn 88, Issue , 2014, Pages 111-159

  Giffin, Louise ^a,b   Damania, Blossom ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

HHV8; Kaposi's sarcoma; KSHV; Latency locus; Lytic replication; Multicentric Castleman's disease; Primary effusion lymphoma; Viral immune evasion; Viral oncogenes

Indexed keywords

ARTICLE; CARCINOGENESIS; HHV8; HOST PATHOGEN INTERACTION; HUMAN; HUMAN HERPESVIRUS 8; IMMUNE EVASION; KAPOSI'S SARCOMA; KSHV; LATENCY LOCUS; LYTIC REPLICATION; MULTICENTRIC CASTLEMAN'S DISEASE; PHYSIOLOGY; PRIMARY EFFUSION LYMPHOMA; VIRAL IMMUNE EVASION; VIRAL ONCOGENES; VIRUS LATENCY;

HHV8; KAPOSI'S SARCOMA; KSHV; LATENCY LOCUS; LYTIC REPLICATION; MULTICENTRIC CASTLEMAN'S DISEASE; PRIMARY EFFUSION LYMPHOMA; VIRAL IMMUNE EVASION; VIRAL ONCOGENES;

CARCINOGENESIS; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; VIRUS LATENCY;

EID: 84891053990     PISSN: 00653527     EISSN: 15578399     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800098-4.00002-7     Document Type: Chapter

References (320)

1. Abend J.R., Ramalingam D., Kieffer-Kwon P., Uldrick T.S., Yarchoan R., Ziegelbauer J.M. Kaposi's sarcoma-associated herpesvirus micrornas target IRAK1 and MYD88, two components of the toll-like receptor/interleukin-1R signaling cascade, to reduce inflammatory-cytokine expression. Journal of Virology 2012, 86(21):11663-11674.
2. Abend J.R., Uldrick T., Ziegelbauer J.M. Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by Kaposi's sarcoma-associated herpesvirus microRNA prevents TWEAK-induced apoptosis and inflammatory cytokine expression. Journal of Virology 2010, 84(23):12139-12151.
3. Ahmad A., Groshong J.S., Matta H., Schamus S., Punj V., Robinson L.J., et al. Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Cancer Biology and Therapy 2010, 10(10):1033-1040.
4. Ahmad H., Gubbels R., Ehlers E., Meyer F., Waterbury T., Lin R., et al. Kaposi sarcoma-associated herpesvirus degrades cellular toll-interleukin-1 receptor domain-containing adaptor-inducing β-interferon (TRIF). Journal of Biological Chemistry 2011, 286(10):7865-7872.
5. Akula S.M., Naranatt P.P., Walia N.-S., Wang F.-Z., Fegley B., Chandran B. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) infection of human fibroblast cells occurs through endocytosis. Journal of Virology 2003, 77(14):7978-7990.
6. Akula S.M., Pramod N.P., Wang F.-Z., Chandran B. Integrin α3β1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 2002, 108(3):407-419.
7. Akula S.M., Wang F.-Z., Vieira J., Chandran B. Human herpesvirus 8 interaction with target cells involves heparan sulfate. Virology 2001, 282(2):245-255.
8. Ambroziak J.A., Blackbourn D.J., Herndier B.G., Glogau R.G., Gullett J.H., McDonald A.R., et al. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 1995, 268(5210):582-583.
9. An F.-Q., Compitello N., Horwitz E., Sramkoski M., Knudsen E.S., Renne R. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest. Journal of Biological Chemistry 2005, 280(5):3862-3874.
10. Andreoni M., Goletti D., Pezzotti P., Pozzetto A., Monini P., Sarmati L., et al. Prevalence, incidence and correlates of HHV-8/KSHV infection and Kaposi's sarcoma in renal and liver transplant recipients. Journal of Infection 2001, 43(3):195-199.
11. Antman K., Chang Y. Kaposi's sarcoma. New England Journal of Medicine 2000, 342(14):1027-1038.
12. Aoki Y., Jaffe E., Chang Y., Jones K., Teruya-Feldstein J., Moore P., et al. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood 1999, 93(12):4034-4043.
13. Aoki Y., Narazaki M., Kishimoto T., Tosato G. Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus: Presented in part at the 42nd annual meeting of the American Society of Hematology, December 4, 2000, in San Francisco, CA. Blood 2001, 98(10):3042-3049.
14. Aoki Y., Tosato G., Fonville T.W., Pittaluga S. Serum viral interleukin-6 in AIDS-related multicentric Castleman disease. Blood 2001, 97(8):2526-2527.
15. Aoki Y., Yarchoan R., Wyvill K., Okamoto S., Little R.F., Tosato G. Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. Blood 2001, 97(7):2173-2176.
16. Aresté C., Blackbourn D.J. Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus. Trends in Microbiology 2009, 17(3):119-129.
17. Aresté C., Mutocheluh M., Blackbourn D.J. Identification of caspase-mediated decay of interferon regulatory factor-3, exploited by a Kaposi sarcoma-associated herpesvirus immunoregulatory protein. Journal of Biological Chemistry 2009, 284(35):23272-23285.
18. Arvanitakis L., Geras-Raaka E., Varma A., Gershengorn M.C., Cesarman E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 1997, 385(6614):347-350.
19. AuCoin D.P., Colletti K.S., Cei S.A., Papousková I., Tarrant M., Pari G.S. Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP). Virology 2004, 318(2):542-555.
20. Bais C., Santomasso B., Coso O., Arvanitakis L., Raaka E.G., Gutkind J.S., et al. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998, 391(6662):86-89.
21. Bais C., Van Geelen A., Eroles P., Mutlu A., Chiozzini C., Dias S., et al. Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/KDR. Cancer Cell 2003, 3(2):131-143.
22. Ballestas M.E., Kaye K.M. The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency. Future Microbiology 2011, 6(12):1399-1413.
23. Ballon G., Chen K., Perez R., Tam W., Cesarman E. Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. The Journal of Clinical Investigation 2011, 121(3):1141-1153.
24. Barbera A.J., Ballestas M.E., Kaye K.M. The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1N terminus is essential for chromosome association, DNA replication, and episome persistence. Journal of Virology 2004, 78(1):294-301.
25. Barbera A.J., Chodaparambil J.V., Kelley-Clarke B., Joukov V., Walter J.C., Luger K., et al. The nucleosomal surface as a docking station for Kaposi's sarcoma Herpesvirus LANA. Science 2006, 311(5762):856-861.
26. Barnes B.J., Bi X., Mancl M.E., Yang L. Modulation of interferon regulatory factor 5 activities by the Kaposi sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3 contributes to immune evasion and lytic induction. Journal of Interferon and Cytokine Research 2011, 31(4):373-382.
27. Barozzi P., Luppi M., Facchetti F., Mecucci C., Alu M., Sarid R., et al. Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. Nature Medicine 2003, 9(5):554-561.
28. Bartee E., McCormack A., Früh K. Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathogens 2006, 2(10):e107.
29. Bechtel J., Grundhoff A., Ganem D. RNAs in the virion of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2005, 79(16):10138-10146.
30. Bechtel J.T., Winant R.C., Ganem D. Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2005, 79(8):4952-4964.
31. Bélanger C., Gravel A., Tomoiu A., Janelle M.E., Gosselin J., Tremblay M.J., et al. Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation. Journal of Human Virology 2001, 4(2):62-73.
32. Bellare P., Ganem D. Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: An evolutionary adaptation that fine-tunes lytic reactivation. Cell Host and Microbe 2009, 6(6):570-575.
33. Beral V., Newton R. Overview of the epidemiology of immunodeficiency-associated cancers. JNCI Monographs 1998, 1998(23):1-6.
34. Beral V., Peterman T.A., Berkelman R.L., Jaffe H.W. Kaposi's sarcoma among persons with AIDS: A sexually transmitted infectionα. The Lancet 1990, 335(8682):123-128.
35. Biggar R., Rabkin C. The epidemiology of AIDS-related neoplasms. Hematology/Oncology Clinics of North America 1996, 10(5):997-1010.
36. Bihl F., Berger C., Chisholm J., Henry L., Bertisch B., Trojan A., et al. Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma. AIDS (London) 2009, 23(14):1918-1922.
37. Bihl F., Mosam A., Henry L., Chisholm J., Dollard S., Gumbi P., et al. Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma. AIDS (London) 2007, 21(10):1245-1252.
38. Birkmann A., Mahr K., Ensser A., Yaǧuboǧlu S., Titgemeyer F., Fleckenstein B., et al. Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1. Journal of Virology 2001, 75(23):11583-11593.
39. Blasig C., Zietz C., Haar B., Neipel F., Esser S., Brockmeyer N.H., et al. Monocytes in Kaposi's sarcoma lesions are productively infected by human herpesvirus 8. Journal of Virology 1997, 71(10):7963-7968.
40. Boshoff C., Schulz T.F., Kennedy M.M., Graham A.K., Fisher C., Thomas A., et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nature Medicine 1995, 1(12):1274-1278.
41. Boss I.W., Nadeau P.E., Abbott J.R., Yang Y., Mergia A., Renne R. A Kaposi's sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rγnull mice. Journal of Virology 2011, 85(19):9877-9886.
42. Bottero V., Sharma-Walia N., Kerur N., Paul A.G., Sadagopan S., Cannon M., et al. Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: A potential positive feedback loop for sustained ORF50 gene expression. Virology 2009, 392(1):34-51.
43. Boulanger M.J., Chow D.-C., Brevnova E., Martick M., Sandford G., Nicholas J., et al. Molecular mechanisms for viral mimicry of a human cytokine: Activation of gp130 by HHV-8 Interleukin-6. Journal of Molecular Biology 2004, 335(2):641-654.
44. Boulanger E., Gérard L., Gabarre J., Molina J.-M., Rapp C., Abino J.-F., et al. Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS. Journal of Clinical Oncology 2005, 23(19):4372-4380.
45. Bower M., Nelson M., Young A.M., Thirlwell C., Newsom-Davis T., Mandalia S., et al. Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma. Journal of Clinical Oncology 2005, 23(22):5224-5228.
46. Brinkmann M.M., Glenn M., Rainbow L., Kieser A., Henke-Gendo C., Schulz T.F. Activation of mitogen-activated protein kinase and NF-κB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein. Journal of Virology 2003, 77(17):9346-9358.
47. Brinkmann M.M., Pietrek M., Dittrich-Breiholz O., Kracht M., Schulz T.F. Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2007, 81(1):42-58.
48. Brinkmann M.M., Schulz T.F. Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae. Journal of General Virology 2006, 87(5):1047-1074.
49. Bubman D., Guasparri I., Cesarman E. Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigen. Oncogene 2007, 26(34):4979-4986.
50. Burysek L., Yeow W.-S., Lubyova B., Kellum M., Schafer S.L., Huang Y.Q., et al. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. Journal of Virology 1999, 73(9):7334-7342.
51. Burysek L., Yeow W., Pitha P. Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2). Journal of Human Virology 1999, 2(1):19-32.
52. Butler L.M., Jeffery H.C., Wheat R.L., Long H.M., Rae P.C., Nash G.B., et al. Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3. Journal of Virology 2012, 86(13):7158-7166.
53. Cai X., Lu S., Zhang Z., Gonzalez C.M., Damania B., Cullen B.R. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(15):5570-5575.
54. Cannon M., Cesarman E., Boshoff C. KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2. Blood 2006, 107(1):277-284.
55. Carbone A., Gloghini A. KSHV/HHV8-associated lymphomas. British Journal of Haematology 2008, 140(1):13-24.
56. Carbone A., Gloghini A., Larocca L.M., Capello D., Pierconti F., Canzonieri V., et al. Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas. Blood 2001, 97(3):744-751.
57. Carbone A., Gloghini A., Vaccher E., Cerri M., Gaidano G., Dalla-Favera R., et al. Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8-positive solid lymphomas: A tissue-based variant of primary effusion lymphoma. The Journal of Molecular Diagnostics 2005, 7(1):17-27.
58. Casper C., Wald A. The use of antiviral drugs in the prevention and treatment of Kaposi sarcoma, multicentric Castleman disease and primary effusion lymphoma. Current Topics in Microbiology and Immunology 2007, 312:289-307.
59. Cattani P., Capuano M., Cerimele F., La Parola I.L., Santangelo R., Masini C., et al. Human herpesvirus 8 seroprevalence and evaluation of nonsexual transmission routes by detection of DNA in clinical specimens from human immunodeficiency virus-seronegative patients from Central and Southern Italy, with and without Kaposi's sarcoma. Journal of Clinical Microbiology 1999, 37(4):1150-1153.
60. Cesarman E. Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients. Cancer Letters 2011, 305(2):163-174.
61. Cesarman E., Chang Y., Moore P.S., Said J.W., Knowles D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. New England Journal of Medicine 1995, 332(18):1186-1191.
62. Cesarman E., Knowles D.M. The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases. Seminars in Cancer Biology 1999, 9(3):165-174.
63. Cesarman E., Nador R.G., Bai F., Bohenzky R.A., Russo J.J., Moore P.S., et al. Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. Journal of Virology 1996, 70(11):8218-8223.
64. Chadburn A., Hyjek E.M., Tam W., Liu Y., Rengifo T., Cesarman E., et al. Immunophenotypic analysis of the Kaposi sarcoma herpesvirus (KSHV; HHV-8)-infected B cells in HIV+ multicentric Castleman disease (MCD). Histopathology 2008, 53(5):513-524.
65. Chandriani S., Ganem D. Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2010, 84(11):5565-5573.
66. Chang Y., Cesarman E., Pessin M.S., Lee F., Culpepper J., Knowles D.M., et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994, 266(5192):1865-1869.
67. Chang P.-C., Li M. Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. Journal of Virology 2008, 82(1):278-290.
68. Chang Y., Moore P.S., Talbot S.J., Boshoff C.H., Zarkowska T., Godden-Kent D., et al. Cyclin encoded by KS herpesvirus. Nature 1996, 382(6590):410.
69. Chang J., Renne R., Dittmer D., Ganem D. Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology 2000, 266(1):17-25.
70. Chatterjee M., Osborne J., Bestetti G., Chang Y., Moore P.S. Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science 2002, 298(5597):1432-1435.
71. Chen D., Choi Y.B., Sandford G., Nicholas J. Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6. Journal of Virology 2009, 83(13):6874-6882.
72. Chen D., Sandford G., Nicholas J. Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6. Journal of Virology 2009, 83(2):722-733.
73. Chen J., Ye F., Xie J., Kuhne K., Gao S.-J. Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. Virology 2009, 386(2):290-302.
74. Chiou C.-J., Poole L.J., Kim P.S., Ciufo D.M., Cannon J.S., ap Rhys C.M., et al. Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2002, 76(7):3421-3439.
75. Cho N.-H., Choi Y.-K., Choi J.-K. Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities. Experimental and Molecular Medicine 2008, 40:565-573.
76. Choi J.-K., Lee B.-S., Shim S.N., Li M., Jung J.U. Identification of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome. Journal of Virology 2000, 74(1):436-446.
77. Chow D., He X., Snow A.L., Rose-John S., Garcia K.C. Structure of an extracellular gp130 cytokine receptor signaling complex. Science 2001, 291(5511):2150-2155.
78. Chugh P., Matta H., Schamus S., Zachariah S., Kumar A., Richardson J.A., et al. Constitutive NF-κB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(36):12885-12890.
79. Coscoy L., Ganem D. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. The Journal of Clinical Investigation 2001, 107(12):1599-1606.
80. Coscoy L., Sanchez D.J., Ganem D. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. The Journal of Cell Biology 2001, 155(7):1265-1274.
81. Cotter M.A., Robertson E.S. The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology 1999, 264(2):254-264.
82. Dahlke C., Maul K., Christalla T., Walz N., Schult P., Stocking C., et al. A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo. PLoS One 2012, 7(11):e49435.
83. Dairaghi D.J., Fan R.A., McMaster B.E., Hanley M.R., Schall T.J. HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8: Agonist and antagonist profiles of viral chemokines. Journal of Biological Chemistry 1999, 274(31):21569-21574.
84. de França T.R.T., de Araújo R.A., Ribeiro C.M.B., Leao J.C. Salivary shedding of HHV-8 in people infected or not by human immunodeficiency virus 1. Journal of Oral Pathology and Medicine 2011, 40(1):97-102.
85. de Sanjose S., Mbisa G., Perez-Alvarez S., Benavente Y., Sukvirach S., Hieu N.T., et al. Geographic variation in the prevalence of Kaposi sarcoma-associated herpesvirus and risk factors for transmission. Journal of Infectious Diseases 2009, 199(10):1449-1456.
86. Dela Cruz C.S., Lee Y., Viswanathan S.R., El-Guindy A.S., Gerlach J., Nikiforow S., et al. N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6. The Journal of Experimental Medicine 2004, 199(4):503-514.
87. Desai P.J., Pryce E.N., Henson B.W., Luitweiler E.M., Cothran J. Reconstitution of the Kaposi's sarcoma-associated herpesvirus nuclear egress complex and formation of nuclear membrane vesicles by coexpression of ORF67 and ORF69 gene products. Journal of Virology 2012, 86(1):594-598.
88. DeWire S.M., Damania B. The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation. Journal of Virology 2005, 79(5):3127-3138.
89. Dheekollu J., Chen H.-S., Kaye K.M., Lieberman P.M. Timeless-dependent DNA replication-coupled recombination promote KSHV episome maintenance and terminal repeat stability. Journal of Virology 2013, 87(7):3699-3709.
90. DiGiovanna J., Safai B. Kaposi's sarcoma. Retrospective study of 90 cases with particular emphasis on the familial occurrence, ethnic background and prevalence of other diseases. American Journal of Medicine 1981, 71(5):779-783.
91. Dillon P.J., Gregory S.M., Tamburro K., Sanders M.K., Johnson G.L., Raab-Traub N., et al. Tousled-like kinases modulate reactivation of gammaherpesviruses from latency. Cell Host and Microbe 2013, 13(2):204-214.
92. Dittmer D., Lagunoff M., Renne R., Staskus K., Haase A., Ganem D. A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. Journal of Virology 1998, 72(10):8309-8315.
93. Du M.-Q., Liu H., Diss T.C., Ye H., Hamoudi R.A., Dupin N., et al. Kaposi sarcoma-associated herpesvirus infects monotypic (IgMλ) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood 2001, 97(7):2130-2136.
94. Dupin N., Diss T.L., Kellam P., Tulliez M., Du M.-Q., Sicard D., et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood 2000, 95(4):1406-1412.
95. Dupin N., Fisher C., Kellam P., Ariad S., Tulliez M., Franck N., et al. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proceedings of the National Academy of Sciences of the United States of America 1999, 96(8):4546-4551.
96. Duprez R., Lacoste V., Brière J., Couppié P., Frances C., Sainte-Marie D., et al. Evidence for a multiclonal origin of multicentric advanced lesions of Kaposi sarcoma. Journal of the National Cancer Institute 2007, 99(14):1086-1094.
97. Dutz W., Stout A. Kaposi's sarcoma in infants and children. Cancer 1960, 13:684-694.
98. Ellis M., Peng Chew Y., Fallis L., Freddersdorf S., Boshoff C., Weiss R.A., et al. Degradation of p27Kip cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex. The EMBO Journal 1999, 18(3):644-653.
99. Endres M.J., Garlisi C.G., Xiao H., Shan L., Hedrick J.A. The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8. The Journal of Experimental Medicine 1999, 189(12):1993-1998.
100. Engels E., Pfeiffer R., Goedert J., Virgo P., McNeel T., Scoppa S., et al. Trends in cancer risk among people with AIDS in the United States. AIDS 2006, 20(12):1645-1654.
101. Fakhari F.D., Jeong J.H., Kanan Y., Dittmer D.P. The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphoma. The Journal of Clinical Investigation 2006, 116(3):735-742.
102. Francès C., Marcelin A.G., Legendre C., Chevret S., Dussaix E., Lejeune J., et al. The impact of preexisting or acquired Kaposi sarcoma herpesvirus infection in kidney transplant recipients on morbidity and survival. American Journal of Transplantation 2009, 9(11):2580-2586.
103. Friborg J., Kong W., Hottiger M.O., Nabel G.J. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 1999, 402(6764):889-894.
104. Friedman-Kien A.E., Saltzman B.R. Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi's sarcoma. Journal of the American Academy of Dermatology 1990, 22(6, Part 2):1237-1250.
105. Fujimuro M., Wu F.Y., ApRhys C., Kajumbula H., Young D.B., Hayward G.S., et al. A novel viral mechanism for dysregulation of [beta]-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nature Medicine 2003, 9(3):300-306.
106. Fuld S., Cunningham C., Klucher K., Davison A.J., Blackbourn D.J. Inhibition of interferon signaling by the Kaposi's sarcoma-associated herpesvirus full-length viral interferon regulatory factor 2 protein. Journal of Virology 2006, 80(6):3092-3097.
107. Gack M.U., Shin Y.C., Joo C.-H., Urano T., Liang C., Sun L., et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 2007, 446(7138):916-920.
108. Garrigues H.J., Rubinchikova Y.E., DiPersio C.M., Rose T.M. Integrin αVβ3 binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor. Journal of Virology 2008, 82(3):1570-1580.
109. Gershengorn M.C., Geras-Raaka E., Varma A., Clark-Lewis I. Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. The Journal of Clinical Investigation 1998, 102(8):1469-1472.
110. Gessain A., Sudaka A., Briere J., Fouchard N., Nicola M., Rio B., et al. Kaposi sarcoma-associated herpes-like virus (human herpesvirus type 8) DNA sequences in multicentric Castleman's disease: Is there any relevant association in non-human immunodeficiency virus-infected patientsα [letter; comment]. Blood 1996, 87(1):414-416.
111. Glenn M., Rainbow L., Auradé F., Davison A., Schulz T.F. Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus. Journal of Virology 1999, 73(8):6953-6963.
112. Godden-Kent D., Talbot S.J., Boshoff C., Chang Y., Moore P., Weiss R.A., et al. The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1. Journal of Virology 1997, 71(6):4193-4198.
113. Gottwein E., Cullen B.R. A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest. Journal of Virology 2010, 84(10):5229-5237.
114. Gottwein E., Mukherjee N., Sachse C., Frenzel C., Majoros W.H., Chi J.-T.A., et al. A viral microRNA functions as an orthologue of cellular miR-155. Nature 2007, 450(7172):1096-1099.
115. Gregory S.M., Damania B. KSHV and the toll of innate immune activation. Cell Cycle 2009, 8(20):3246-3247.
116. Gregory S.M., Davis B.K., West J.A., Taxman D.J., Matsuzawa S., Reed J.C., et al. Discovery of a viral NLR homolog that inhibits the inflammasome. Science 2011, 331(6015):330-334.
117. Gregory S.M., Wang L., West J.A., Dittmer D.P., Damania B. Latent Kaposi's sarcoma-associated herpesvirus infection of monocytes downregulates expression of adaptive immune response costimulatory receptors and proinflammatory cytokines. Journal of Virology 2012, 86(7):3916-3923.
118. Gregory S.M., West J.A., Dillon P.J., Hilscher C., Dittmer D.P., Damania B. Toll-like receptor signaling controls reactivation of KSHV from latency. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(28):11725-11730.
119. Guito J., Lukac D.M. KSHV Rta promoter specification and viral reactivation. Frontiers in Microbiology 2012, 3(30):1-21.
120. Guo H.-G., Sadowska M., Reid W., Tschachler E., Hayward G., Reitz M. Kaposi's sarcoma-like tumors in a human herpesvirus 8 ORF74 transgenic mouse. Journal of Virology 2003, 77(4):2631-2639.
121. Hansen A., Henderson S., Lagos D., Nikitenko L., Coulter E., Roberts S., et al. KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. Genes and Development 2010, 24(2):195-205.
122. Hideshima T., Chauhan D., Teoh G., Raje N., Treon S.P., Tai Y.-T., et al. Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6. Clinical Cancer Research 2000, 6(3):1180-1189.
123. Hislop A.D., Sabbah S. CD8+ T cell immunity to Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus. Seminars in Cancer Biology 2008, 18(6):416-422.
124. Hladik W., Dollard S.C., Mermin J., Fowlkes A.L., Downing R., Amin M.M., et al. Transmission of human herpesvirus 8 by blood transfusion. New England Journal of Medicine 2006, 355(13):1331-1338.
125. Hong Y.-K., Foreman K., Shin J.W., Hirakawa S., Curry C.L., Sage D.R., et al. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nature Genetics 2004, 36(7):683-685.
126. Hu J., Garber A.C., Renne R. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells. Journal of Virology 2002, 76(22):11677-11687.
127. Hu F., Nicholas J. Signal transduction by human herpesvirus 8 viral interleukin-6 (vIL-6) is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6. Journal of Virology 2006, 80(21):10874-10878.
128. Hussein M. Immunohistological evaluation of immune cell infiltrate in cutaneous Kaposi's sarcoma. Cell Biology International 2008, 32:157-162.
129. Inn K.-S., Lee S.-H., Rathbun J.Y., Wong L.-Y., Toth Z., Machida K., et al. Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64. Journal of Virology 2011, 85(20):10899-10904.
130. Ishido S., Wang C., Lee B.-S., Cohen G.B., Jung J.U. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. Journal of Virology 2000, 74(11):5300-5309.
131. Jacobs S.R., Damania B. The viral interferon regulatory factors of KSHV: Immunosuppressors or oncogenesα. Frontiers in Immunology 2011, 2:19.
132. Jacobs S.R., Gregory S.M., West J.A., Wollish A.C., Bennett C.L., Blackbourn D.J., et al. The viral interferon regulatory factors of Kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. Journal of Virology 2013, 87(2):798-806.
133. Jenner R.G., Maillard K., Cattini N., Weiss R.A., Boshoff C., Wooster R., et al. Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile. Proceedings of the National Academy of Sciences of the United States of America 2003, 100(18):10399-10404.
134. Jeong J.H., Orvis J., Kim J.W., McMurtrey C.P., Renne R., Dittmer D.P. Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. Journal of Biological Chemistry 2004, 279(16):16822-16831.
135. Jha H.C., Upadhyay S.K., Aj M.P., Lu J., Cai Q., Saha A., et al. H2AX phosphorylation is important for LANA mediated KSHV episome persistence. Journal of Virology 2013, 87(9):5255-5269.
136. Jones K.D., Aoki Y., Chang Y., Moore P.S., Yarchoan R., Tosato G. Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. Blood 1999, 94(8):2871-2879.
137. Joo C.H., Shin Y.C., Gack M., Wu L., Levy D., Jung J.U. Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3. Journal of Virology 2007, 81(15):8282-8292.
138. Judde J.-G., Lacoste V., Brière J., Kassa-Kelembho E., Clyti E., Couppié P., et al. Monoclonality or oligoclonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases. Journal of the National Cancer Institute 2000, 92(9):729-736.
139. Kaleeba J.A.R., Berger E.A. Broad target cell selectivity of Kaposi's sarcoma-associated herpesvirus glycoprotein-mediated cell fusion and virion entry. Virology 2006, 354(1):7-14.
140. Kaleeba J.A.R., Berger E.A. Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: Cystine transporter xCT. Science 2006, 311(5769):1921-1924.
141. Kaposi M. Idiopathisches multiples Pigmentsarkom der Haut. Archiv für Dermatologie und Syphilis 1872, 4:265-273.
142. Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: Update on toll-like receptors. Nature Immunology 2010, 11(5):373-384.
143. Kawai T., Takahashi K., Sato S., Coban C., Kumar H., Kato H., et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nature Immunology 2005, 6(10):981-988.
144. Kerur N., Veettil M.V., Sharma-Walia N., Bottero V., Sadagopan S., Otageri P., et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpesvirus infection. Cell Host and Microbe 2011, 9(5):363-375.
145. Kliche S., Nagel W., Kremmer E., Atzler C., Ege A., Knorr T., et al. Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Molecular Cell 2001, 7(4):833-843.
146. Krishnan H.H., Sharma-Walia N., Zeng L., Gao S.-J., Chandran B. Envelope glycoprotein gB of Kaposi's sarcoma-associated herpesvirus is essential for egress from infected cells. Journal of Virology 2005, 79(17):10952-10967.
147. Kwun H.J., da Silva S.R., Shah I.M., Blake N., Moore P.S., Chang Y. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing. Journal of Virology 2007, 81(15):8225-8235.
148. Kyalwazi S.K. Kaposi's sarcoma: Clinical features, experience in Uganda. Antibiotics and Chemotherapy 1981, 29:59-69.
149. Lagos D., Trotter M.W.B., Vart R.J., Wang H.-W., Matthews N.C., Hansen A., et al. Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells. Blood 2007, 109(4):1550-1558.
150. Lagos D., Vart R.J., Gratrix F., Westrop S.J., Emuss V., Wong P.-P., et al. Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus. Cell Host and Microbe 2008, 4(5):470-483.
151. Lagunoff M., Bechtel J., Venetsanakos E., Roy A.-M., Abbey N., Herndier B., et al. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. Journal of Virology 2002, 76(5):2440-2448.
152. Lagunoff M., Majeti R., Weiss A., Ganem D. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proceedings of the National Academy of Sciences of the United States of America 1999, 96(10):5704-5709.
153. Lambert M., Gannagé M., Karras A., Abel M., Legendre C., Kerob D., et al. Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma. Blood 2006, 108(12):3871-3880.
154. Lan K., Kuppers D.A., Robertson E.S. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jκ, the major downstream effector of the notch signaling pathway. Journal of Virology 2005, 79(6):3468-3478.
155. Lan K., Kuppers D.A., Verma S.C., Robertson E.S. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: A potential mechanism for virus-mediated control of latency. Journal of Virology 2004, 78(12):6585-6594.
156. Lee B.-S., Alvarez X., Ishido S., Lackner A.A., Jung J.U. Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1. The Journal of Experimental Medicine 2000, 192(1):11-22.
157. Lee B.-S., Connole M., Tang Z., Harris N.L., Jung J.U. Structural analysis of the Kaposi's sarcoma-associated herpesvirus K1 protein. Journal of Virology 2003, 77(14):8072-8086.
158. Lee H., Guo J., Li M., Choi J.-K., DeMaria M., Rosenzweig M., et al. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. Molecular and Cellular Biology 1998, 18(9):5219-5228.
159. Lee B.-S., Lee S.-H., Feng P., Chang H., Cho N.-H., Jung J.U. Characterization of the Kaposi's sarcoma-associated herpesvirus K1 signalosome. Journal of Virology 2005, 79(19):12173-12184.
160. Lee H., Veazey R., Williams K., Li M., Guo J., Neipel F., et al. Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Nature Medicine 1998, 4(4):435-440.
161. Lefort S., Soucy-Faulkner A., Grandvaux N., Flamand L. Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. Journal of Virology 2007, 81(20):10950-10960.
162. Lei X., Bai Z., Ye F., Xie J., Kim C.-G., Huang Y., et al. Regulation of NF-[kappa]B inhibitor I[kappa]B[alpha] and viral replication by a KSHV microRNA. Nature Cell Biology 2010, 12(2):193-199.
163. Lei X., Zhu Y., Jones T., Bai Z., Huang Y., Gao S.-J. A Kaposi's sarcoma-associated herpesvirus microRNA and its variants target the transforming growth factor β pathway to promote cell survival. Journal of Virology 2012, 86(21):11698-11711.
164. Leidner R.S., Aboulafia D. Recrudescent Kaposi's sarcoma after initiation of HAART: A manifestation of immune reconstitution syndrome. AIDS Patient Care and STDs 2005, 19(10):635-644.
165. Letang E., Lewis J., Bower M., Mosam A., Borok M., Campbell T., et al. Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: Higher incidence and mortality in Africa than in the UK. AIDS (London) 2013, 27(10):1603-1613.
166. Li M., Lee H., Yoon D.W., Albrecht J.C., Fleckenstein B., Neipel F., et al. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. Journal of Virology 1997, 71(3):1984-1991.
167. Li Q., Means R., Lang S., Jung J.U. Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5. Journal of Virology 2007, 81(5):2117-2127.
168. Li H., Wang H., Nicholas J. Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling. Journal of Virology 2001, 75(7):3325-3334.
169. Liang Q., Fu B., Wu F., Li X., Yuan Y., Zhu F. ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKe and TBK1 as an alternative substrate. Journal of Virology 2012, 86(18):10162-10172.
170. Lim C.S., Seet B.T., Ingham R.J., Gish G., Matskova L., Winberg G., et al. The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction. Biochemistry 2007, 46(35):9874-9885.
171. Lin R., Genin P., Mamane Y., Sgarbanti M., Battistini A., Harrington W., et al. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene 2001, 20(7):800-811.
172. Lin Y.-T., Kincaid R.P., Arasappan D., Dowd S.E., Hunicke-Smith S.P., Sullivan C.S. Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs. RNA 2010, 16(8):1540-1558.
173. Lin X., Li X., Liang D., Lan K. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirus virions. Journal of Virology 2012, 86(23):12717-12730.
174. Lin C.L., Li H., Wang Y., Zhu F.X., Kudchodkar S., Yuan Y. Kaposi's sarcoma-associated herpesvirus lytic origin (ori-Lyt)-dependent DNA replication: Identification of the ori-Lyt and association of K8 bZip protein with the origin. Journal of Virology 2003, 77(10):5578-5588.
175. Liu L., Eby M.T., Rathore N., Sinha S.K., Kumar A., Chaudhary P.M. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the IκB kinase complex. Journal of Biological Chemistry 2002, 277(16):13745-13751.
176. Liu J., Martin H.J., Liao G., Hayward S.D. The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc. Journal of Virology 2007, 81(19):10451-10459.
177. Lu F., Stedman W., Yousef M., Renne R., Lieberman P.M. Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway. Journal of Virology 2010, 84(6):2697-2706.
178. Lu M., Suen J., Frias C., Pfeiffer R., Tsai M.-H., Chuang E., et al. Dissection of the Kaposi's sarcoma-associated herpesvirus gene expression program by using the viral DNA replication inhibitor cidofovir. Journal of Virology 2004, 78(24):13637-13652.
179. Luitweiler E.M., Henson B.W., Pryce E.N., Patel V., Coombs G., McCaffery J.M., et al. Interactions of the Kaposi's sarcoma-associated herpesvirus nuclear egress complex: ORF69 is a potent factor for remodeling cellular membranes. Journal of Virology 2013, 87(7):3915-3929.
180. Lukac D.M., Kirshner J.R., Ganem D. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. Journal of Virology 1999, 73(11):9348-9361.
181. Lukac D.M., Renne R., Kirshner J.R., Ganem D. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 1998, 252(2):304-312.
182. Marcelin A., Calvez V., Dussaix E. KSHV after an organ transplant: Should we screenα. Current Topics in Microbiology and Immunology 2007, 312:245-262.
183. Mark L., Lee W.H., Spiller O.B., Proctor D., Blackbourn D.J., Villoutreix B.O., et al. The Kaposi's sarcoma-associated herpesvirus complement control protein mimics human molecular mechanisms for inhibition of the complement system. Journal of Biological Chemistry 2004, 279(43):45093-45101.
184. Mark L., Proctor D.G., Blackbourn D.J., Blom A.M., Spiller O.B. Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies. Immunology 2008, 123(2):228-238.
185. Marshall V., Parks T., Bagni R., Wang C.D., Samols M.A., Hu J., et al. Conservation of virally encoded microRNAs in Kaposi sarcoma-associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease. Journal of Infectious Diseases 2007, 195(5):645-659.
186. Martinon F., Burns K., Tschopp J. The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Molecular Cell 2002, 10(2):417-426.
187. Matta H., Sun Q., Moses G., Chaudhary P.M. Molecular genetic analysis of human herpes virus 8-encoded viral flice inhibitory protein-induced NF-κB activation. Journal of Biological Chemistry 2003, 278(52):52406-52411.
188. Mbulaiteye S.M., Biggar R.J., Goedert J.J., Engels E.A. Immune deficiency and risk for malignancy among persons with AIDS. Journal of Acquired Immune Deficiency Syndromes 2003, 32(5):527-533.
189. McCormick C., Ganem D. The Kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science 2005, 307(5710):739-741.
190. McCormick C., Ganem D. Phosphorylation and function of the kaposin B direct repeats of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2006, 80(12):6165-6170.
191. Meads M.B., Medveczky P.G. Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: Evidence for a unique autocrine signaling mechanism. Journal of Biological Chemistry 2004, 279(50):51793-51803.
192. Molden J., Chang Y., You Y., Moore P.S., Goldsmith M.A. A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. Journal of Biological Chemistry 1997, 272(31):19625-19631.
193. Monini P., Carlini F., Stürzl M., Rimessi P., Superti F., Franco M., et al. Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells. Journal of Virology 1999, 73(5):4029-4041.
194. Montaner S. Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma. Cell Cycle 2007, 6(4):438-443.
195. Montaner S., Sodhi A., Molinolo A., Bugge T.H., Sawai E.T., He Y., et al. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 2003, 3(1):23-36.
196. Montaner S., Sodhi A., Pece S., Mesri E.A., Gutkind J.S. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Research 2001, 61(6):2641-2648.
197. Moore P.S., Boshoff C., Weiss R.A., Chang Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 1996, 274(5293):1739-1744.
198. Mori Y., Nishimoto N., Ohno M., Inagi R., Dhepakson P., Amou K., et al. Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion. Journal of Medical Virology 2000, 61(3):332-335.
199. Morris V.A., Punjabi A.S., Lagunoff M. Activation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cells. Journal of Virology 2008, 82(17):8771-8779.
200. Mullick J., Bernet J., Singh A.K., Lambris J.D., Sahu A. Kaposi's sarcoma-associated herpesvirus (Human Herpesvirus 8) open reading frame 4 protein (Kaposica) is a functional homolog of complement control proteins. Journal of Virology 2003, 77(6):3878-3881.
201. Muralidhar S., Pumfery A.M., Hassani M., Sadaie M.R., Azumi N., Kishishita M., et al. Identification of kaposin (Open Reading Frame K12) as a human herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus) transforming gene. Journal of Virology 1998, 72(6):4980-4988.
202. Nachmani D., Stern-Ginossar N., Sarid R., Mandelboim O. Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host and Microbe 2009, 5(4):376-385.
203. Nador R., Cesarman E., Chadburn A., Dawson D., Ansari M., Sald J., et al. Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 1996, 88(2):645-656.
204. Naranatt P.P., Akula S.M., Zien C.A., Krishnan H.H., Chandran B. Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-ζ-MEK-ERK signaling pathway in target cells early during infection: Implications for infectivity. Journal of Virology 2003, 77(2):1524-1539.
205. Naranatt P.P., Krishnan H.H., Smith M.S., Chandran B. Kaposi's sarcoma-associated herpesvirus modulates microtubule dynamics via RhoA-GTP-Diaphanous 2 signaling and utilizes the dynein motors to deliver its DNA to the nucleus. Journal of Virology 2005, 79(2):1191-1206.
206. Nealon K., Newcomb W.W., Pray T.R., Craik C.S., Brown J.C., Kedes D.H. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: Isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. Journal of Virology 2001, 75(6):2866-2878.
207. Neipel F., Albrecht J.C., Ensser A., Huang Y.Q., Li J.J., Friedman-Kien A.E., et al. Human herpesvirus 8 encodes a homolog of interleukin-6. Journal of Virology 1997, 71(1):839-842.
208. Nicholas J., Ruvolo V.R., Burns W.H., Sandford G., Wan X., Ciufo D., et al. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nature Medicine 1997, 3(3):287-292.
209. Nishi J.-I., Arimura K., Utsunomiya A., Yonezawa S., Kawakami K., Maeno N., et al. Expression of vascular endothelial growth factor in sera and lymph nodes of the plasma cell type of Castleman's disease. British Journal of Haematology 1999, 104(3):482-485.
210. Nishimoto N., Kanakura Y., Aozasa K., Johkoh T., Nakamura M., Nakano S., et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 2005, 106(8):2627-2632.
211. O'Hara A.J., Chugh P., Wang L., Netto E.M., Luz E., Harrington W.J., et al. Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma. PLoS Pathogens 2009, 5(4):e1000389.
212. Ojala P.M., Yamamoto K., Castanos-Velez E., Biberfeld P., Korsmeyer S.J., Makela T.P. The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Nature Cell Biology 2000, 2(11):819-825.
213. Oksenhendler E., Boulanger E., Galicier L., Du M., Dupin N., Diss T., et al. High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease. Blood 2002, 99(7):2331-2336.
214. Oksenhendler E., Carcelain G., Aoki Y., Boulanger E., Maillard A., Clauvel J., et al. High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients. Blood 2000, 96(6):2069-2073.
215. Oksenhendler E., Duarte M., Soulier J., Cacoub P., Welker Y., Cadranel J., et al. Multicentric Castleman's disease in HIV infection: A clinical and pathological study of 20 patients. AIDS (London) 1996, 10(1):61-67.
216. Osborne J., Moore P.S., Chang Y. KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways. Human Immunology 1999, 60(10):921-927.
217. Parkin D.M. The global health burden of infection-associated cancers in the year 2002. International Journal of Cancer 2006, 118(12):3030-3044.
218. Parkin D., Wabinga H., Nambooze S., Wabwire-Mangen F. AIDS-related cancers in Africa: Maturation of the epidemic in Uganda. AIDS 1999, 13(18):2563-2570.
219. Parravicini C., Corbellino M., Paulli M., Magrini U., Lazzarino M., Moore P., et al. Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease. The American Journal of Pathology 1997, 151(6):1517-1522.
220. Pauk J., Huang M.-L., Brodie S.J., Wald A., Koelle D.M., Schacker T., et al. Mucosal shedding of human herpesvirus 8 in men. New England Journal of Medicine 2000, 343(19):1369-1377.
221. Pearce M., Matsumura S., Wilson A.C. Transcripts encoding K12, v-FLIP, v-Cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter. Journal of Virology 2005, 79(22):14457-14464.
222. Pertel P.E. Human herpesvirus 8 glycoprotein B (gB), gH, and gL can mediate cell fusion. Journal of Virology 2002, 76(9):4390-4400.
223. Pfeffer S., Sewer A., Lagos-Quintana M., Sheridan R., Sander C., Grasser F.A., et al. Identification of microRNAs of the herpesvirus family. Nature Methods 2005, 2(4):269-276.
224. Polizzotto M.N., Uldrick T.S., Hu D., Yarchoan R. Clinical manifestations of Kaposi sarcoma herpesvirus (KSHV) lytic activation: Multicentric castleman disease (KSHV-MCD) and the KSHV inflammatory cytokine syndrome (KICS). Frontiers in Microbiology 2012, 3(73):1-9.
225. Poole L.J., Zong J.-C., Ciufo D.M., Alcendor D.J., Cannon J.S., Ambinder R., et al. Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. Journal of Virology 1999, 73(8):6646-6660.
226. Prakash O., Swamy O.R., Peng X., Tang Z.-Y., Li L., Larson J.E., et al. Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: Implications for lymphomagenesis. Blood 2005, 105(10):3987-3994.
227. Prakash O., Tang Z.-Y., Peng X., Coleman R., Gill J., Farr G., et al. Tumorigenesis and aberrant signaling in transgenic mice expressing the human herpesvirus-8 K1 gene. Journal of the National Cancer Institute 2002, 94(12):926-935.
228. Qin Z., Dai L., Defee M., Findlay V.J., Watson D.K., Toole B.P., et al. Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection. Journal of Virology 2013, 87(1):621-635.
229. Radaszkiewicz T., Hansmann M., Lennert K. Monoclonality and polyclonality of plasma cells in Castleman's disease of the plasma cell variant. Histopathology 1989, 14(1):11-24.
230. Radkov S.A., Kellam P., Boshoff C. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nature Medicine 2000, 6(10):1121-1127.
231. Raghu H., Sharma-Walia N., Veettil M.V., Sadagopan S., Caballero A., Sivakumar R., et al. Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but dispensable for binding and entry. Journal of Virology 2007, 81(15):7941-7959.
232. Raghu H., Sharma-Walia N., Veettil M.V., Sadagopan S., Chandran B. Kaposi's sarcoma-associated herpesvirus utilizes an actin polymerization-dependent macropinocytic pathway to enter human dermal microvascular endothelial and human umbilical vein endothelial cells. Journal of Virology 2009, 83(10):4895-4911.
233. Rappocciolo G., Hensler H.R., Jais M., Reinhart T.A., Pegu A., Jenkins F.J., et al. Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN. Journal of Virology 2008, 82(10):4793-4806.
234. Rappocciolo G., Jenkins F.J., Hensler H.R., Piazza P., Jais M., Borowski L., et al. DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages. The Journal of Immunology 2006, 176(3):1741-1749.
235. Ray A., Marshall V., Uldrick T., Leighty R., Labo N., Wyvill K., et al. Sequence analysis of Kaposi sarcoma-associated herpesvirus (KSHV) microRNAs in patients with multicentric Castleman disease and KSHV-associated inflammatory cytokine syndrome. Journal of Infectious Diseases 2012, 205(11):1665-1676.
236. Renne R., Blackbourn D., Whitby D., Levy J., Ganem D. Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. Journal of Virology 1998, 72(6):5182-5188.
237. Renne R., Lagunoff M., Zhong W., Ganem D. The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. Journal of Virology 1996, 70(11):8151-8154.
238. Rivas C., Thlick A.-E., Parravicini C., Moore P.S., Chang Y. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. Journal of Virology 2001, 75(1):429-438.
239. Robey R.C., Lagos D., Gratrix F., Henderson S., Matthews N.C., Vart R.J., et al. The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens. PLoS One 2009, 4(6):e5890.
240. Sabbah S., Jagne Y.J., Zuo J., de Silva T., Ahasan M.M., Brander C., et al. T-cell immunity to Kaposi sarcoma-associated herpesvirus: Recognition of primary effusion lymphoma by LANA-specific CD4+ T cells. Blood 2012, 119(9):2083-2092.
241. Sadler R., Wu L., Forghani B., Renne R., Zhong W., Herndier B., et al. A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 1999, 73(7):5722-5730.
242. Samols M.A., Hu J., Skalsky R., Renne R. Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2005, 79(14):9301-9305.
243. Sathish N., Zhu F.X., Golub E.E., Liang Q., Yuan Y. Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's sarcoma-associated herpesvirus protein ORF45. Journal of Biological Chemistry 2011, 286(1):746-756.
244. Schwam D.R., Luciano R.L., Mahajan S.S., Wong L., Wilson A.C. Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies. Journal of Virology 2000, 74(18):8532-8540.
245. Shapiro-Shelef M., Calame K. Regulation of plasma-cell development. Nature Reviews Immunology 2005, 5(3):230-242.
246. Sharma-Walia N., Krishnan H.H., Naranatt P.P., Zeng L., Smith M.S., Chandran B. ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (Human Herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection. Journal of Virology 2005, 79(16):10308-10329.
247. Sharp T.V., Wang H.-W., Koumi A., Hollyman D., Endo Y., Ye H., et al. K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. Journal of Virology 2002, 76(2):802-816.
248. Shelburne S.A., Hamill R., Rodriguez-Barradas M., Greenberg S., Atmar R., Musher D., et al. Immune reconstitution inflammatory syndrome: Emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore) 2002, 81(3):213-227.
249. Si H., Robertson E.S. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function. Journal of Virology 2006, 80(2):697-709.
250. Siegel J., Alper J., Schutte J., Robbins H., Blaufox L. Disseminated visceral Kaposi's sarcoma: Appearance after human renal homograft operation. JAMA 1969, 207(8):1493-1496.
251. Simonelli C., Tedeschi R., Gloghini A., Spina M., Talamini R., De Paoli P., et al. Prognostic factors in human herpesvirus 8-related lymphoproliferative disorders associated with HIV infection. Journal of Clinical Oncology 2006, 24(1):209.
252. Sin S.-H., Dittmer D.P. Viral latency locus augments B cell response in vivo to induce chronic marginal zone enlargement, plasma cell hyperplasia and lymphoma. Blood 2013, 121(15):2952-2963.
253. Singh V.V., Kerur N., Bottero V., Dutta S., Chakraborty S., Ansari M.A., et al. Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes. Journal of Virology 2013, 87(8):4417-4431.
254. Skalsky R.L., Samols M.A., Plaisance K.B., Boss I.W., Riva A., Lopez M.C., et al. Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. Journal of Virology 2007, 81(23):12836-12845.
255. Sodhi A., Chaisuparat R., Hu J., Ramsdell A.K., Manning B.D., Sausville E.A., et al. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell 2006, 10(2):133-143.
256. Soulier J., Grollet L., Oksenhendler E., Cacoub P., Cazals-Hatem D., Babinet P., et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995, 86(4):1276-1280.
257. Spiller O.B., Blackbourn D.J., Mark L., Proctor D.G., Blom A.M. Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus. Journal of Biological Chemistry 2003, 278(11):9283-9289.
258. Staskus K.A., Sun R., Miller G., Racz P., Jaslowski A., Metroka C., et al. Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Journal of Virology 1999, 73(5):4181-4187.
259. Staskus K.A., Zhong W., Gebhard K., Herndier B., Wang H., Renne R., et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. Journal of Virology 1997, 71(1):715-719.
260. Stein M., Spencer D., Ruff P., Lakier R., MacPhail P., Bezwoda W. Endemic African Kaposi's sarcoma: Clinical and therapeutic implications. 10-year experience in the Johannesburg Hospital (1980-1990). Oncology 1994, 51(1):63-69.
261. Stine J.T., Wood C., Hill M., Epp A., Raport C.J., Schweickart V.L., et al. KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells. Blood 2000, 95(4):1151-1157.
262. Subramanian R., Sehgal I., D'Auvergne O., Kousoulas K.G. Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells. Journal of Virology 2010, 84(4):1704-1714.
263. Suffert G., Malterer G., Hausser J., Viiliäinen J., Fender A., Contrant M., et al. Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis. PLoS Pathogens 2011, 7(12):e1002405.
264. Sun R., Lin S.F., Gradoville L., Miller G. Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirus. Proceedings of the National Academy of Sciences of the United States of America 1996, 93(21):11883-11888.
265. Sun R., Lin S.-F., Gradoville L., Yuan Y., Zhu F., Miller G. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proceedings of the National Academy of Sciences of the United States of America 1998, 95(18):10866-10871.
266. Sun R., Lin S.-F., Staskus K., Gradoville L., Grogan E., Haase A., et al. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. Journal of Virology 1999, 73(3):2232-2242.
267. Sun Q., Zachariah S., Chaudhary P.M. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-κB activation. Journal of Biological Chemistry 2003, 278(52):52437-52445.
268. Suthaus J., Stuhlmann-Laeisz C., Tompkins V.S., Rosean T.R., Klapper W., Tosato G., et al. HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood 2012, 119(22):5173-5181.
269. Talbot S.J., Weiss R.A., Kellam P., Boshoff C. Transcriptional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, and 74 in a primary effusion lymphoma cell line. Virology 1999, 257(1):84-94.
270. Tamburro K.M., Yang D., Poisson J., Fedoriw Y., Roy D., Lucas A., et al. Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A. Virology 2012, 433(1):220-225.
271. Taylor J., Templeton A., Vogel C., Ziegler J., Kyalwazi S. Kaposi's sarcoma in Uganda: A clinico-pathological study. International Journal of Cancer 1971, 15(8):122-135.
272. Thomas J.O. Acquired immunodeficiency syndrome-associated cancers in Sub-Saharan Africa. Seminars in Oncology 2001, 28(2):198-206.
273. Thomas M., Boname J.M., Field S., Nejentsev S., Salio M., Cerundolo V., et al. Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America 2008, 105(5):1656-1661.
274. Thome M., Schneider P., Hofmann K., Fickenscher H., Meinl E., Neipel F., et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 1997, 386(6624):517-521.
275. Tomescu C., Law W.K., Kedes D.H. Surface downregulation of major histocompatibility complex class I, PE-CAM, and ICAM-1 following de novo infection of endothelial cells with Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2003, 77(17):9669-9684.
276. Tomlinson C.C., Damania B. The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. Journal of Virology 2004, 78(4):1918-1927.
277. Tomlinson C.C., Damania B. Critical role for endocytosis in the regulation of signaling by the Kaposi's sarcoma-associated herpesvirus K1 protein. Journal of Virology 2008, 82(13):6514-6523.
278. Tsai Y.-H., Wu M.-F., Wu Y.-H., Chang S.-J., Lin S.-F., Sharp T.V., et al. The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion. Journal of Virology 2009, 83(2):622-632.
279. Uldrick T.S., Wang V., O'Mahony D., Aleman K., Wyvill K.M., Marshall V., et al. An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without multicentric Castleman disease. Clinical Infectious Diseases 2010, 51(3):350-358.
280. Uldrick T.S., Whitby D. Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma. Cancer Letters 2011, 305(2):150-162.
281. Umbach J.L., Cullen B.R. In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machinery. Journal of Virology 2010, 84(2):695-703.
282. Verma S.C., Borah S., Robertson E.S. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. Journal of Virology 2004, 78(19):10348-10359.
283. Verma S.C., Choudhuri T., Kaul R., Robertson E.S. Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeats. Journal of Virology 2006, 80(5):2243-2256.
284. Verschuren E.W., Hodgson J.G., Gray J.W., Kogan S., Jones N., Evan G.I. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Research 2004, 64(2):581-589.
285. Wahman A., Melnick S.L., Rhame F.S., Potter J.D. The epidemiology of Classic, African, and immunosuppressed Kaposi's sarcoma. Epidemiologic Reviews 1991, 13(1):178-199.
286. Wan X., Wang H., Nicholas J. Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6. Journal of Virology 1999, 73(10):8268-8278.
287. Wang F.-Z., Akula S.M., Sharma-Walia N., Zeng L., Chandran B. Human herpesvirus 8 envelope glycoprotein B mediates cell adhesion via its RGD sequence. Journal of Virology 2003, 77(5):3131-3147.
288. Wang L., Brinkmann M.M., Pietrek M., Ottinger M., Dittrich-Breiholz O., Kracht M., et al. Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. Journal of General Virology 2007, 88(6):1698-1707.
289. Wang L., Dittmer D.P., Tomlinson C.C., Fakhari F.D., Damania B. Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. Cancer Research 2006, 66(7):3658-3666.
290. Wang Q.J., Jenkins F.J., Jacobson L.P., Kingsley L.A., Day R.D., Zhang Z.-W., et al. Primary human herpesvirus 8 infection generates a broadly specific CD8+ T-cell response to viral lytic cycle proteins. Blood 2001, 97(8):2366-2373.
291. Wang L., Wakisaka N., Tomlinson C.C., DeWire S.M., Krall S., Pagano J.S., et al. The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors. Cancer Research 2004, 64(8):2774-2781.
292. Waterston A., Bower M. Fifty years of multicentric Castleman's disease. Acta Oncologica 2004, 43(8):698-704.
293. Weber K.S.C., Gröne H.-J., Röcken M., Klier C., Gu S., Wank R., et al. Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II. European Journal of Immunology 2001, 31(8):2458-2466.
294. Wen K.W., Damania B. Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1. Oncogene 2010, 29(24):3532-3544.
295. West J., Damania B. Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection. Journal of Virology 2008, 82(11):5440-5449.
296. West J.A., Gregory S.M., Sivaraman V., Su L., Damania B. Activation of plasmacytoid dendritic cells by Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2011, 85(2):895-904.
297. Wies E., Hahn A.S., Schmidt K., Viebahn C., Rohland N., Lux A., et al. The Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 inhibits cellular IRF-5. Journal of Biological Chemistry 2009, 284(13):8525-8538.
298. Wu F.Y., Ahn J.-H., Alcendor D.J., Jang W.-J., Xiao J., Hayward S.D., et al. Origin-independent assembly of Kaposi's sarcoma-associated herpesvirus DNA replication compartments in transient cotransfection assays and association with the ORF-K8 protein and cellular PML. Journal of Virology 2001, 75(3):1487-1506.
299. Wu L., Lo P., Yu X., Stoops J., Forghani B., Zhou Z. Three-dimensional structure of the human herpesvirus 8 capsid. Journal of Virology 2000, 74(20):9646-9654.
300. Xu Y., AuCoin D.P., Huete A.R., Cei S.A., Hanson L.J., Pari G.S. A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. Journal of Virology 2005, 79(6):3479-3487.
301. Yang T.-Y., Chen S.-C., Leach M.W., Manfra D., Homey B., Wiekowski M., et al. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma. The Journal of Experimental Medicine 2000, 191(3):445-454.
302. Ye F., Zhou F., Bedolla R.G., Jones T., Lei X., Kang T., et al. Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathogens 2011, 7(5):e1002054.
303. Yoo J., Kang J., Lee H.N., Aguilar B., Kafka D., Lee S., et al. Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. PLoS Pathogens 2010, 6(8):e1001046.
304. Yoshizaki K., Matsuda T., Nishimoto N., Kuritani T., Taeho L., Aozasa K., et al. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 1989, 74(4):1360-1367.
305. Yu Y., Black J.B., Goldsmith C.S., Browning P.J., Bhalla K., Offermann M.K. Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells. Journal of General Virology 1999, 80(1):83-90.
306. Yu F., Feng J., Harada J.N., Chanda S.K., Kenney S.C., Sun R. B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus. FEBS Letters 2007, 581(18):3485-3488.
307. Yu Y., Wang S.E., Hayward G.S. The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity 2005, 22(1):59-70.
308. Zaldumbide A., Ossevoort M., Wiertz E.J.H.J., Hoeben R.C. In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma Herpes virus. Molecular Immunology 2007, 44(6):1352-1360.
309. Zheng D., Wan J., Cho Y.G., Wang L., Chiou C.-J., Pai S., et al. Comparison of humoral immune responses to Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus using a viral proteome microarray. Journal of Infectious Diseases 2011, 204(11):1683-1691.
310. Zhou F., Xue M., Qin D., Zhu X., Wang C., Zhu J., et al. HIV-1 tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway. PLoS One 2013, 8(1):e53145.
311. Zhu F.X., Chong J.M., Wu L., Yuan Y. Virion proteins of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 2005, 79(2):800-811.
312. Zhu F.X., Cusano T., Yuan Y. Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus. Journal of Virology 1999, 73(7):5556-5567.
313. Zhu X., Guo Y., Yao S., Yan Q., Xue M., Hao T., et al. Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: Role of the AKT signaling pathway. Oncogene 2013.
314. Zhu F.X., King S.M., Smith E.J., Levy D.E., Yuan Y. A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation. Proceedings of the National Academy of Sciences of the United States of America 2002, 99(8):5573-5578.
315. Zhu F.X., Sathish N., Yuan Y. Antagonism of host antiviral responses by Kaposi's sarcoma-associated herpesvirus tegument protein ORF45. PLoS One 2010, 5(5):e10573.
316. Zhu F.X., Yuan Y. The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions. Journal of Virology 2003, 77(7):4221-4230.
317. Ziegelbauer J., Grundhoff A., Ganem D. Exploring the DNA binding interactions of the Kaposi's sarcoma-associated herpesvirus lytic switch protein by selective amplification of bound sequences in vitro. Journal of Virology 2006, 80(6):2958-2967.
318. Zipfel P.F., Skerka C. Complement regulators and inhibitory proteins. Nature Reviews Immunology 2009, 9(10):729-740.
319. Zuo J., Hislop A.D., Leung C., Sabbah S., Rowe M. KSHV encoded vIRF3 modulates MHC-II antigen presentation through CIITA dependent and independent mechanisms: Implications for oncogenesis. Journal of Virology 2013, 87:5340-5350.
320. Zuo J., Thomas W., van Leeuwen D., Middeldorp J.M., Wiertz E.J.H.J., Ressing M.E., et al. The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function. Journal of Virology 2008, 82(5):2385-2393.