Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma

AIDS

Volumn 23, Issue 14, 2009, Pages 1918-1922

  Bihl, Florian ^a   Berger, Christoph ^b   Chisholm, John V ^c   Henry, Leah M ^c   Bertisch, Barbara ^d   Trojan, Andreas ^e   Nadal, David ^b   Speck, Roberto F ^d   Flepp, Markus ^f   Brander, Christian ^c,g   Mueller, Nicolas J ^d  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Division of Infectious Diseases and Hospital Epidemiology   (Switzerland)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f KLINIK IM PARK   (Switzerland)

^g HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DOXORUBICIN; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA; VINCRISTINE SULFATE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CANCER CHEMOTHERAPY; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE COURSE; HERPES VIRUS INFECTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; KAPOSI SARCOMA; PRIORITY JOURNAL; T LYMPHOCYTE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ACUTE DISEASE; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; HUMANS; IMMUNITY, CELLULAR; SARCOMA, KAPOSI; TREATMENT OUTCOME; VIRAL LOAD;

EID: 70249097745     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3283300a91     Document Type: Article

References (13)

1. Antman K, Chang Y. Kaposi's sarcoma. N Engl J Med 2000; 342:1027-1038
2. Ledergerber B, Telenti A, Egger M. Risk of HIV related Kaposi's sarcoma and non-Hodgkin's lymphoma with potent antiretro-viral therapy: prospective cohort study. Swiss HIV Cohort Study. BMJ 1999; 319:23-24.
3. Pellet C, Chevret S, Blum L, Gauvillé C, Hurault M, Blanchard G, et al. Virologic and immunologic parameters that predict clinical response of AIDS-associated Kaposi's sarcoma to highly active antiretroviral therapy. J Invest Dermatol 2001; 117:858-863.
4. Bihl F, Mosam A, Henry LN, Chisholm JV III, Dollard S, Gumbi P, et al. Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma. AIDS 2007; 21:1245-1252.
5. Bourboulia D, Aldam D, Lagos D, Allen E, Williams I, Cornforth D, et al. Short-and long-term effects of highly active anti-retroviral therapy on Kaposi's sarcoma-associated herpesvirus immune responses and viraemia. AIDS 2004; 18:485-493.
6. Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8R T cells. Blood 2006; 107:4781-4789.
7. Bihl F, Narayan M, Chisholm JV III, Henry LM, Suscovich TJ, Brown EE, et al. Lytic and latent antigens of the human gam-maherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J Virol 2007; 81: 4904-4908.
8. Woodberry T, Suscovich TJ, Henry LM, Martin JN, Dollard S, O'Connor PG, et al. Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. J Infect Dis 2005; 192:622-629.
9. Russo JJ, Bohenzky RA, Chien MC, Chen J, Yan M, Maddalena D, et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA 1996; 93:14862-14867.
10. Berger C, Hug M, Gysin C, Molinari L, Frei M, Bossart W, Nadal D. Distribution patterns of beta-and gamma-herpesviruses within Waldeyer's ring organs. J Med Virol 2007; 79:1147-1152.
11. Guihot A, Dupin N, Marcelin AG, Gorin I, Bedin AS, Bossi P, et al. Low T cell responses to human herpesvirus 8 in patients with AIDS-related and classic Kaposi sarcoma. J Infect Dis 2006; 194:1078-1088.
12. Lambert M, Gannage M, Karras A, Abel M, Legendre C, Kerob D, et al. Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma. Blood 2006; 108:3871-3880.
13. Guihot A, Oksenhendler E, Galicier L, Marcelin AG, Papagno L, Bedin AS, et al. Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8R T cells. Blood 2008; 111:1387-1395.