K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function

Journal of Virology

Volumn 76, Issue 2, 2002, Pages 802-816

  Sharp, T V ^a   Wang, H W ^a   Koumi, A ^a   Hollyman, D ^a   Endo, Y ^a   Ye, H ^a   Du, M Q ^a   Boshoff, C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; GUANINE; PROTEIN HAX 1; PROTEIN K15; REGULATOR PROTEIN; UNCLASSIFIED DRUG; URACIL; VIRUS PROTEIN;

ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EFFUSION; ENDOPLASMIC RETICULUM; EPSTEIN BARR VIRUS; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; LYMPHOMA CELL LINE; MITOCHONDRION; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSLATION INITIATION; TWO HYBRID SYSTEM;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BINDING SITES; CELL LINE; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES; VIRAL PROTEINS; VIRUS LATENCY;

EID: 0036140439     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.2.802-816.2002     Document Type: Article

References (49)

1. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
2. Kaposi's sarcoma-associated herpesvirus: A new DNA tumor virus
3. NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells
4. Molecular piracy of Kaposi's sarcoma associated herpesvirus
5. Identification of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome
6. Signal peptidases in prokaryotes and eukaryotes - A new protease family
7. Signaling activities of gammaherpesvirus membrane proteins
8. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma
9. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma
10. A novel genetic system to detect protein-protein interactions
11. The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton
12. Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus
13. KSHV strains: The origins and global spread of the virus
14. The biology of Kaposi's sarcoma
15. The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells
16. The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain
17. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
18. Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays
19. Interaction of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) with HS1-associated protein X-1: Implication of cytoplasmic function of EBNA-LP
20. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation
21. The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues
22. Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells
23. Epstein-Barr virus and its replication
24. Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons
25. Quantitative analysis of human herpesvirus 8 viral load using a real-time PCR assay
26. Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein
27. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases
28. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
29. Processing of the Epstein-Barr virus-encoded latent membrane protein p63/LMP
30. Biochemical, genetic, and functional analyses of the phosphorylation sites on the Epstein-Barr virus-encoded oncogenic latent membrane protein LMP-1
31. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
32. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
33. A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
34. Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
35. Risk of Kaposi's sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi's sarcoma patients
36. Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro
37. Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)
38. Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines
39. Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end
40. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53
41. SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases
42. DiOC6(3): A useful dye for staining the endoplasmic reticulum
43. Kaposi's sarcoma-associated herpesvirus: Epidemiology, virology, and molecular biology
44. HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases
45. Activation of Arp2/3 complex-mediated actin polymerization by cortactin
46. The signal peptide
47. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation
48. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis
49. Evidence that hax-1 is an interleukin-1alpha n-terminal binding protein