The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2641-2648

  Montaner, Silvia ^a   Sodhi, Akrit ^a,b   Pece, Salvatore ^a   Mesri, Enrique A ^c   Gutkind, J Silvio ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN; VIRUS PROTEIN; WORTMANNIN;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPINDLE CELL; UMBILICAL VEIN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; COS CELLS; CRICETINAE; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; LYMPHOKINES; NF-KAPPA B; PERTUSSIS TOXIN; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VIRAL PROTEINS; VIRULENCE FACTORS, BORDETELLA;

EID: 0035866812     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Kaposi's sarcoma-associated herpesvirus
2. Kaposi's sarcoma-associated herpesvirus-encoded oncogenes and oncogenesis
3. Antiviral activity of tumor-suppressor pathways: Clues from molecular piracy by KSHV
4. Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8)
5. KSHV and Kaposi's sarcoma: The end of the beginning?
6. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)
7. Human herpesvirus 8 and its role in the genesis of Kaposi's sarcoma
8. The role of HHV-8 in Kaposi's sarcoma
9. The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases
10. Kaposi's sarcoma-associated herpesvirus: Epidemiology, virology, and molecular biology
11. G-Protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a virai oncogene and angiogenesis
12. Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6
13. AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6
14. Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma
15. Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma
16. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation
17. Characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in Kaposi's sarcoma
18. Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi's sarcoma herpesvirus-G protein-coupled receptor
19. The Kaposi's sarcoma associated herpesvirus G protein-coupled receptor upregulates VEGF expression and secretion through MAPK and p38 pathways acting on H1F-1α
20. Viral G protein-coupled receptor and Kaposi's sarcoma. A model of paracrine neoplasia?
21. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma
22. Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor activation of c-jun amino-terminal kinase/stress-activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2
23. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
24. Cellular survival: A play in three Akts
25. Mechanisms and consequences of activation of protein kinase B/Akt
26. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
27. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for F1k-1/KDR activation
28. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for α and β gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinase γ
29. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
30. A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: A role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5
31. Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms
32. G-Protein-coupled receptors and Fcγ-receptors mediate activation of Akt/protein kinase B in human phagocytes
33. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes
34. Akt/PKB localization and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
35. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase
36. cAMP stimulates protein kinase B in a Wortmannin-insensitive manner
37. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27
38. Phosphoinositide kinases
39. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
40. The molecular and cellular biology of the chemokines
41. Dual effect of β-adrenergic receptors on mitogen-activated protein kinase. Evidence for a β γ-dependent activation and a G α s-cAMP-mediated inhibition
42. Agonist-independent regulation of constitutively active G-protein-coupled receptors
43. The N terminus of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor is necessary for high affinity chemokine binding but not for constitutive activity
44. Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74
45. Kaposi's sarcoma-associated herpesvirus (KSHV)chemokine vMIP-II and human SDF-1α inhibit signaling by KSHV G protein-coupled receptor
46. Human interferon-γ-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
47. NF-κB activation by tumor necrosis factor requires the Akt serine-threonine kinase
48. NF-κB is a target of AKT in anti-apoptotic PDGF signaling
49. Activation of the nuclear factor-κB by Rho, CDC42, and Rac-1 proteins
50. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
51. Apoptosis in viral infections
52. Viruses and apoptosis
53. p53 inhibition by the LANA protein of KSHV protects against cell death
54. The inhibitor of death receptor signaling. FLICE-inhibitory protein defines a new class of tumor progression factors
55. A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
56. Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells
57. Transformation of chicken cells by the gene encoding the catalytic subunit of P13-kinase
58. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
59. Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells
60. Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism
61. Polyoma middle T antigen activates the Ser/Thr kinase Akt in a P13-kinase-dependent manner
62. Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen
63. Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells