Modulation of interferon regulatory factor 5 activities by the Kaposi sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3 contributes to immune evasion and lytic induction

Journal of Interferon and Cytokine Research

Volumn 31, Issue 4, 2011, Pages 373-382

  Bi, Xiaohui ^a   Yang, Lisong ^a   Mancl, Margo E ^b   Barnes, Betsy J ^a,b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; DNA BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 5; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; UNCLASSIFIED DRUG; VIRAL INTERFERON REGULATORY FACTOR 3;

AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; DISEASE ASSOCIATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNE EVASION; PRIMARY EFFUSION LYMPHOMA; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HERPESVIRUS 8, HUMAN; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTORS; INTERFERON TYPE I; LYMPHOMA, PRIMARY EFFUSION; SARCOMA, KAPOSI;

HUMAN HERPESVIRUS 8;

EID: 79953248552     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2010.0084     Document Type: Article

References (52)

1. Barnes BJ, Field AE, Pitha PM. 2003a. Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes. J Biol Chem 278:16630-16641. (Pubitemid 36799526)
2. Barnes BJ, Kellum MJ, Field AE, Pitha PM. 2002. Multiple regulatory domains of IRF-5 control activation, cellular localization and induction of chemokines that mediate T-lymphocyte recruitment. Mol Cell Biol 22:5721-5740. (Pubitemid 34815822)
3. Barnes BJ, Kellum MJ, Pinder KE, Frisancho JA, Pitha PM. 2003b. IRF-5, a novel mediator of cell-cycle arrest and cell death. Cancer Res 63:6424-6431. (Pubitemid 37255192)
4. Barnes BJ, Moore PA, Pitha PM. 2001. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. J Biol Chem 276:23382-23390.
5. Barnes BJ, Richards J, Mancl M, Hanash S, Beretta L, Pitha PM. 2004. Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection. J Biol Chem 279:45194-45207. (Pubitemid 39430935)
6. Bechet JM, Guetard D. 2006. Differential cytotoxicity of tumour promoter TPA for EBV-negative human lymphoma cell lines and their EBV-converted sublines. Internat J Canc 32:61-65.
7. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PM. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
8. Cheung SC, Chattopadhyay SK, Hartley JW, Morse HC 3rd, Pitha PM. 1991. Aberrant expression of cytokine genes in peritoneal macrophages from mice infected with LP-BM5 MuLV, a murine model of AIDS. J Immunol 146:121-127.
9. Cohen A, Brodie C, Sarid R. 2006. An essential role of ERK signaling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus. J Gen Virol 87:795-802.
10. Cohen A, Wolf DG, Guttman-Yassky E, Sarid R. 2005. Kaposi's sarcoma-associated herpesvirus: Clinical, diagnostic, and epidemiological aspects. Crit Rev Clin Lab Sci 42:101-153. (Pubitemid 41647726)
11. Couzinet A, Tamura K, Chen HM, Nishimura K, Wang Z, Morishita Y, Takeda K, Yagita H, Yanai H, Taniguchi T, Tamura T. 2008. A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis. Proc Natl Acad Sci USA 105:2556-2561. (Pubitemid 351520552)
12. Cunningham C, Barnard S, Blackbourn DJ, Davison AJ. 2003. Transcription mapping of human herpesvirus 8 genes encoding viral interferon regulatory factors. J Gen Virol 84:1471-1483. (Pubitemid 36675517)
13. Davis DA, Rinderknecht AS, Zoeteweij JP, Aoki Y, Read-Connole EL, Tosato G, Blauvelt A, Yarchoan R. 2001. Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Blood 97:3244-3250.
14. Dourmishev LA, Dourmishev AL, Palmeri D, Schwartz RA, Lukac DM. 2003. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol Mol Biol Rev 67:175-212. (Pubitemid 36693471)
15. Esteban M, Garcia MA, Domingo-Gil E, Arroyo J, Nombela C, Rivas C. 2003. The latency protein LANA2 from Kaposi's sarcoma-associated herpesvirus inhibits apoptosis induced by dsRNA-activated protein kinase but not RNase L activation. J Gen Virol 84:1463-1470. (Pubitemid 36675516)
16. Friborg J Jr., Kong W, Hottinger MO, Nabel GJ. 1999. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402:889-894.
17. Gradoville L, Gerlach J, Grogan E, Shedd D, Nikiforow S, Metroka C, Miller G. 2000. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J Virol 74:6207-6212. (Pubitemid 30412996)
18. Grundhoff A, Ganem D. 2004. Inefficient establishment of KSHV latency suggests an additional role for contrinued lytic replication in Kaposi sarcoma pathogenesis. J Clin Invest 113: 124-136. (Pubitemid 38541639)
19. Guasparri I, Keller SA, Cesarman E. 2004. KSHV vFLIP is essential for the survival of infected lymphoma cells. J Exp Med 199:993-1003. (Pubitemid 38481090)
20. Harrington W Jr., Sieczkowski S, Sosa C, Chan-a-Sue S, Cai JP, Cabral L, Wood C. 1997. Activation of HHV-8 by HIV-1 tat. Lancet 349:774-775. (Pubitemid 27122465)
21. Hu G, Barnes BJ. 2009. IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway. J Biol Chem 284:2767-2777.
22. Hu G, Mancl ME, Barnes BJ. 2005. Signaling through interferon regulatory factor-5 sensitizes p53-deficient tumor to DNA damage-induced apoptosis and cell death. Cancer Res 65: 7403-7412. (Pubitemid 41161274)
23. Kliche S, Nagel W, Kremmer E, Atzier C, Ege A, Knorr T, Koszinowski U, Kolanus W, Haas J. 2001. Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Mol Cell 7:833-843. (Pubitemid 32436443)
24. Kovaleva M, Bussmeyer I, Rabe B, Grotzinger J, Sudarman E, Eichler J, Conrad U, Rose-John S, Scheller J. 2006. Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display. J Virol 80:8510-8520. (Pubitemid 44384863)
25. Krishnan HH, Naranatt PP, Smith MS, Zeng L, Bloomer C, Chandran B. 2004. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78:3601-3620. (Pubitemid 38568301)
26. Lee H, Veazey R, Williams K, Li M, Guo J, Neipel F, Fleckenstein B, Lackner A, Desrosiers RC, Jung JU. 1998. Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Nat Med 4:435-440. (Pubitemid 28212759)
27. Lubyova B, Kellum MJ, Frisancho AJ, Pitha PM. 2004. Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 stimulates the transcriptional activity of cellular IRF-3 and IRF-7. J Biol Chem 279:7643-7654. (Pubitemid 38294645)
28. Lubyova B, Kellum MJ, Frisancho JA, Pitha PM. 2007. Stimulation of c-myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus. J Biol Chem 282:31944-31953. (Pubitemid 350106417)
29. Lubyova B, Pitha PM. 2000. Characterization of a novel human herpesvirus 8-encoded protein, vIRF3, that shows homology to viral and cellular interferon regulatory factors. J Virol 74: 8194-8201. (Pubitemid 30641667)
30. Mancl ME, Hu G, Sangster-Guity N, Olshalsky SL, Hoops K, Fitzgerald-Bocarsly P, Pitha PM, Barnes BJ. 2005. Two distinct promoters regulate the alternative-spliced human Interferon regulatory factor-5 variants: Multiple variants with distinct cell-type specific expression, localization, regulation and function. J Biol Chem 280:21078-21090. (Pubitemid 40805667)
31. Moore PS, Boshoff C, Weiss RA, Chang Y. 1996. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274:1739-1744. (Pubitemid 26414912)
32. Mori T, Anazawa Y, Liizumi M, Fukuda S, Nakamura Y, Arakawa H. 2002. Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53. Oncogene 21:2914-2918. (Pubitemid 34499391)
33. Naranatt PP, Krishnan HH, Svojanovsky SR, Bloomer C, Mathur S, Chandran B. 2004. Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infection. Cancer Res 64:72-84. (Pubitemid 38114084)
34. Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 2: 342-346. (Pubitemid 26080656)
35. Rivas C, Thlick AE, Parravicini C, Moore PS, Chang Y. 2001. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell specific latent viral protein that inhibits p53. J Virol 75:429-438.
36. Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Pitha PM, Fitzgerald KA, Golenbock DT. 2005. The interferon regulatory factor, IRF5, is a central mediator of TLR7 signaling. J Biol Chem 280:17005-17012. (Pubitemid 41389162)
37. Schulz TF. 2006. The pleiotropic effects of Kaposi's sarcoma herpesvirus. J Pathol 208:187-198. (Pubitemid 43126112)
38. Shin YC, Nahamura H, Liang X, Feng P, Chang H, Kowalik TF, Jung JU. 2006. Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. J Virol 80:2257-2266. (Pubitemid 43271532)
39. Staskus KA, Zhong W, Gebhard K, Herndier B, Wang H, Renne R, Beneke J, Pudney J, Anderson DJ, Ganem D, Haase AT. 1997. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 71:715-719.
40. Swanton C, Mann, DJ, Fleckenstein B, Neipel F, Peters G, Jones N. 1997. Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature 390:184-187. (Pubitemid 27507989)
41. Takaoka A, Tamura T, Taniguchi T. 2008. Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci 99:467-478. (Pubitemid 351228562)
42. Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TW, Taniguchi T. 2005. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434:243-249. (Pubitemid 40388058)
43. Vieira J, O'Hearn P, Kimball L, Chandran B, Corey L. 2001. Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. J Virol 75:1378-1386. (Pubitemid 32094696)
44. Vieira J, O'Hearn PM. 2004. Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology 325:225-240. (Pubitemid 38902789)
45. West JT, Wood C. 2003. The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression. Oncogene 22:5150-5163. (Pubitemid 37059596)
46. Wies E, Hahn AS, Schmidt K, Viebahn C, Rohland N, Lux A, Schellhorn T, Holzer A, Jung JU, Neipel F. 2009. The Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 inhibits cellular IRF-5. J Biol Chem 284:8525-8538.
47. Wies E, Mori Y, Hahn A, Kremmer E, Sturzl M, Fleckenstein B, Neipel F. 2008. The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells. Blood 111:320-327.
48. CIP1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-α. Proc Natl Acad Sci USA 99:10683-10688.
49. Wu FY, Wang SE, Tang QQ, Fujimoro M, Chiou CJ, Zheng Q, Chen H, Hayward SD, Lane MD, Hayward GS. 2003. Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication- associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/ Enhancer-binding protein a and p21Cip1. J Virol 77:8893-8914. (Pubitemid 36936100)
50. Yanai H, Chen HM, Inuzuka T, Kondo S, Mak TW, Takaoka A, Honda K, Taniguchi T. 2007. Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci USA 104:3402-3407. (Pubitemid 46364171)
51. Yeow WS, Au WC, Juang YT, Fields CD, Dent CL, Gewert DR, Pitha PM. 2000. Reconstitution of virus-mediated expression of interferon alpha genes in human fibroblast cells by ectopic interferon regulatory factor-7. J Biol Chem 275:6313-6320. (Pubitemid 30129924)
52. Zhong W, Wang H, Herndier B, Ganem D. 1996. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci USA 93:6641-6646. (Pubitemid 26230362)