Kaposi Sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: A potential positive feedback loop for sustained ORF50 gene expression

Virology

Volumn 392, Issue 1, 2009, Pages 34-51

  Bottero, Virginie ^a   Sharma Walia, Neelam ^a   Kerur, Nagaraj ^a   Paul, Arun George ^a   Sadagopan, Sathish ^a   Cannon, Mark ^b   Chandran, Bala ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

KSHV; ORF50; Promoter; Signaling; vGPCR

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN SUBUNIT G ALPHA 12; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN SUBUNIT G ALPHA Q; HISTONE DEACETYLASE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASE D; RAC GUANOSINE TRIPHOSPHATASE; RAC PROTEIN; RHO FACTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP1; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; LYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

BASE SEQUENCE; BINDING SITES; CELL LINE; DOXYCYCLINE; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION; GENES, VIRAL; HERPESVIRUS 8, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; MODELS, BIOLOGICAL; MUTATION; PROMOTER REGIONS, GENETIC; RECEPTORS, CHEMOKINE; RHO GTP-BINDING PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA, VIRAL; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EID: 69249210886     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.07.002     Document Type: Article

References (101)

1. Aktories K. Bacterial toxins that target Rho proteins. J. Clin. Invest. 99 5 (1997) 827-829
2. Alberts B., Johnson A., Raff M., Roberts K., and Walter P. Molecular biology of the cell (2002) Fifth edition. Chapter 15, pages 879-964
3. Bais C., Van Geelen A., Eroles P., Mutlu A., Chiozzini C., Dias S., Silverstein R.L., Rafii S., and Mesri E.A. Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/KDR. Cancer Cell 3 2 (2003) 131-143
4. Bhende P.M., Dickerson S.J., Sun X., Feng W.H., and Kenney S.C. X-box-binding protein 1 activates lytic Epstein-Barr virus gene expression in combination with protein kinase D. J. Virol. 81 14 (2007) 7363-7370
5. Borras A.M., Strominger J.L., and Speck S.H. Characterization of the ZI domains in the Epstein-Barr virus BZLF1 gene promoter: role in phorbol ester induction. J. Virol. 70 6 (1996) 3894-3901
6. Brummelkamp T.R., Bernards R., and Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2 3 (2002) 243-247
7. Bu W., Palmeri D., Krishnan R., Marin R., Aris V.M., Soteropoulos P., and Lukac D.M. Identification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localization. J. Virol. 82 21 (2008) 10709-10723
8. Burns D.L. Subunit structure and enzymic activity of pertussis toxin. Microbiol. Sci. 5 9 (1988) 285-287
9. Byun H., Gwack Y., Hwang S., and Choe J. Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Mol. Cell 14 2 (2002) 185-191
10. Cai X., Lu S., Zhang Z., Gonzalez C.M., Damania B., and Cullen B.R. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc. Natl. Acad. Sci. U.S.A. 102 15 (2005) 5570-5575
11. Cai Q., Lan K., Verma S.C., Si H., Lin D., and Robertson E.S. Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: latency control under low oxygen conditions. J. Virol. 80 16 (2006) 7965-7975
12. Cannon M. The KSHV and other human herpesviral G protein-coupled receptors. Curr. Top Microbiol. Immunol. 312 (2007) 137-156
13. Cannon M.L., and Cesarman E. The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells. Oncogene 23 2 (2004) 514-523
14. Cannon J.S., Ciufo D., Hawkins A.L., Griffin C.A., Borowitz M.J., Hayward G.S., and Ambinder R.F. A new primary effusion lymphoma-derived cell line yields a highly infectious Kaposi's sarcoma herpesvirus-containing supernatant. J. Virol. 74 21 (2000) 10187-10193
15. Cannon M., Philpott N.J., and Cesarman E. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells. J. Virol. 77 1 (2003) 57-67
16. Cannon M., Cesarman E., and Boshoff C. KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2. Blood 107 1 (2006) 277-284
17. Casarosa P., Bakker R.A., Verzijl D., Navis M., Timmerman H., Leurs R., and Smit M.J. Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28. J. Biol. Chem. 276 2 (2001) 1133-1137
18. Cesarman E., Chang Y., Moore P.S., Said J.W., and Knowles D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332 18 (1995) 1186-1191
19. Chang M., Brown H.J., Collado-Hidalgo A., Arevalo J.M., Galic Z., Symensma T.L., Tanaka L., Deng H., Zack J.A., Sun R., and Cole S.W. beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. J. Virol. 79 21 (2005) 13538-13547
20. Chang S., Bezprozvannaya S., Li S., and Olson E.N. An expression screen reveals modulators of class II histone deacetylase phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 102 23 (2005) 8120-8125
21. Chiou C.J., Poole L.J., Kim P.S., Ciufo D.M., Cannon J.S., ap Rhys C.M., Alcendor D.J., Zong J.C., Ambinder R.F., and Hayward G.S. Patterns of gene expression and a transactivation function exhibited by the vGCR (ORF74) chemokine receptor protein of Kaposi's sarcoma-associated herpesvirus. J. Virol. 76 7 (2002) 3421-3439
22. Countryman J., and Miller G. Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA. Proc. Natl. Acad. Sci. U.S.A. 82 12 (1985) 4085-4089
23. Dadke D., Fryer B.H., Golemis E.A., and Field J. Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation. Cancer Res. 63 24 (2003) 8837-8847
24. Davis D.A., Rinderknecht A.S., Zoeteweij J.P., Aoki Y., Read-Connole E.L., Tosato G., Blauvelt A., and Yarchoan R. Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Blood 97 10 (2001) 3244-3250
25. Deng H., Young A., and Sun R. Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. J. Gen. Virol. 81 Pt. 12 (2000) 3043-3048
26. Deutsch E., Cohen A., Kazimirsky G., Dovrat S., Rubinfeld H., Brodie C., and Sarid R. Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. J. Virol. 78 18 (2004) 10187-10192
27. Dourmishev L.A., Dourmishev A.L., Palmeri D., Schwartz R.A., and Lukac D.M. Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol. Mol. Biol. Rev. 67 2 (2003) 175-212 table of contents
28. Follenzi A., Ailles L.E., Bakovic S., Geuna M., and Naldini L. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat. Genet. 25 2 (2000) 217-222
29. Ford P.W., Bryan B.A., Dyson O.F., Weidner D.A., Chintalgattu V., and Akula S.M. Raf/MEK/ERK signalling triggers reactivation of Kaposi's sarcoma-associated herpesvirus latency. J. Gen. Virol. 87 Pt. 5 (2006) 1139-1144
30. Ganem, D. Kaposi's sarcoma-associated herpesvirus. Fields of Virology Fifth edition, Volume 2, Chapter 72, 2847-2888.
31. Graham F.L., and van der Eb A.J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52 2 (1973) 456-467
32. Grozinger C.M., and Schreiber S.L. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl. Acad. Sci. U.S.A. 97 14 (2000) 7835-7840
33. Gruffat H., Manet E., and Sergeant A. MEF2-mediated recruitment of class II HDAC at the EBV immediate early gene BZLF1 links latency and chromatin remodeling. EMBO Rep. 3 2 (2002) 141-146
34. Gschwendt M., Muller H.J., Kielbassa K., Zang R., Kittstein W., Rincke G., and Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 199 1 (1994) 93-98
35. Gschwendt M., Dieterich S., Rennecke J., Kittstein W., Mueller H.J., and Johannes F.J. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 392 2 (1996) 77-80
36. Gwack Y., Byun H., Hwang S., Lim C., and Choe J. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J. Virol. 75 4 (2001) 1909-1917
37. Haque M., Davis D.A., Wang V., Widmer I., and Yarchoan R. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia. J. Virol. 77 12 (2003) 6761-6768
38. Harrison B.C., Kim M.S., van Rooij E., Plato C.F., Papst P.J., Vega R.B., McAnally J.A., Richardson J.A., Bassel-Duby R., Olson E.N., and McKinsey T.A. Regulation of cardiac stress signaling by protein kinase d1. Mol. Cell Biol. 26 10 (2006) 3875-3888
39. Isomura H., Tsurumi T., and Stinski M.F. Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replication. J. Virol. 78 23 (2004) 12788-12799
40. Isomura H., Stinski M.F., Kudoh A., Daikoku T., Shirata N., and Tsurumi T. Two Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication. J. Virol. 79 15 (2005) 9597-9607
41. Jenner R.G., Alba M.M., Boshoff C., and Kellam P. Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays. J. Virol. 75 2 (2001) 891-902
42. Jeong J., Papin J., and Dittmer D. Differential regulation of the overlapping Kaposi's sarcoma-associated herpesvirus vGCR (orf74) and LANA (orf73) promoters. J. Virol. 75 4 (2001) 1798-1807
43. Jones K.A., and Tjian R. Sp1 binds to promoter sequences and activates herpes simplex virus 'immediate-early' gene transcription in vitro. Nature 317 6033 (1985) 179-182
44. Kim D.B., and DeLuca N.A. Phosphorylation of transcription factor Sp1 during herpes simplex virus type 1 infection. J. Virol. 76 13 (2002) 6473-6479
45. Krishnan H.H., Naranatt P.P., Smith M.S., Zeng L., Bloomer C., and Chandran B. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J. Virol. 78 7 (2004) 3601-3620
46. Lan K., Kuppers D.A., Verma S.C., and Robertson E.S. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency. J. Virol. 78 12 (2004) 6585-6594
47. Lan K., Kuppers D.A., and Robertson E.S. Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathway. J. Virol. 79 6 (2005) 3468-3478
48. Lee B.J., Koszinowski U.H., Sarawar S.R., and Adler H. A gammaherpesvirus G protein-coupled receptor homologue is required for increased viral replication in response to chemokines and efficient reactivation from latency. J. Immunol. 170 1 (2003) 243-251
49. Lee S., Deng H., Yu F., Melega W.P., Damoiseaux R., Bradley K.A., and Sun R. Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways. J. Acquir. Immune Defic. Syndr. 48 5 (2008) 531-540
50. Li X., Song S., Liu Y., Ko S.H., and Kao H.Y. Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins. J. Biol. Chem. 279 33 (2004) 34201-34208
51. Li Q., Zhou F., Ye F., and Gao S.J. Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology (2008) 379(2):234-244
52. Liang Y., and Ganem D. Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc. Natl. Acad. Sci. U.S.A. 100 14 (2003) 8490-8495
53. Liu S., Borras A.M., Liu P., Suske G., and Speck S.H. Binding of the ubiquitous cellular transcription factors Sp1 and Sp3 to the ZI domains in the Epstein-Barr virus lytic switch BZLF1 gene promoter. Virology 228 1 (1997) 11-18
54. Liu C., Sandford G., Fei G., and Nicholas J. Galpha protein selectivity determinant specified by a viral chemokine receptor-conserved region in the C tail of the human herpesvirus 8 g protein-coupled receptor. J. Virol. 78 5 (2004) 2460-2471
55. Lu F., Zhou J., Wiedmer A., Madden K., Yuan Y., and Lieberman P.M. Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency. J. Virol. 77 21 (2003) 11425-11435
56. Lu M., Suen J., Frias C., Pfeiffer R., Tsai M.H., Chuang E., and Zeichner S.L. Dissection of the Kaposi's sarcoma-associated herpesvirus gene expression program by using the viral DNA replication inhibitor cidofovir. J. Virol. 78 24 (2004) 13637-13652
57. Lu F., Day L., Gao S.J., and Lieberman P.M. Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription. J. Virol. 80 11 (2006) 5273-5282
58. Lukac D.M., Renne R., Kirshner J.R., and Ganem D. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252 2 (1998) 304-312
59. Mackay H.J., and Twelves C.J. Targeting the protein kinase C family: are we there yet?. Nat. Rev. Cancer 7 7 (2007) 554-562
60. Martin M.J., Tanos T., Garcia A.B., Martin D., Gutkind J.S., Coso O.A., and Marinissen M.J. The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis. J. Biol. Chem. 282 47 (2007) 34510-34524
61. Martin D., Galisteo R., Ji Y., Montaner S., and Gutkind J.S. An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia. Oncogene 27 13 (2008) 1844-1852
62. Meier J.L., Keller M.J., and McCoy J.J. Requirement of multiple cis-acting elements in the human cytomegalovirus major immediate-early distal enhancer for viral gene expression and replication. J. Virol. 76 1 (2002) 313-326
63. Milanini-Mongiat J., Pouyssegur J., and Pages G. Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J. Biol. Chem. 277 23 (2002) 20631-20639
64. Miyoshi H., Blomer U., Takahashi M., Gage F.H., and Verma I.M. Development of a self-inactivating lentivirus vector. J. Virol. 72 10 (1998) 8150-8157
65. Montaner S., Sodhi A., Molinolo A., Bugge T.H., Sawai E.T., He Y., Li Y., Ray P.E., and Gutkind J.S. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 3 1 (2003) 23-36
66. Montaner S., Sodhi A., Servitja J.M., Ramsdell A.K., Barac A., Sawai E.T., and Gutkind J.S. The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. Blood 104 9 (2004) 2903-2911
67. Moorman N.J., Virgin H.W.t., and Speck S.H. Disruption of the gene encoding the gammaHV68 v-GPCR leads to decreased efficiency of reactivation from latency. Virology 307 2 (2003) 179-190
68. Oliveira S.A., and Shenk T.E. Murine cytomegalovirus M78 protein, a G protein-coupled receptor homologue, is a constituent of the virion and facilitates accumulation of immediate-early viral mRNA. Proc. Natl. Acad. Sci. U.S.A. 98 6 (2001) 3237-3242
69. Polson A.G., Wang D., DeRisi J., and Ganem D. Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus. Cancer Res. 62 15 (2002) 4525-4530
70. Ragoczy T., and Miller G. Autostimulation of the Epstein-Barr virus BRLF1 promoter is mediated through consensus Sp1 and Sp3 binding sites. J. Virol. 75 11 (2001) 5240-5251
71. Ragoczy T., Heston L., and Miller G. The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytes. J. Virol. 72 10 (1998) 7978-7984
72. Rosenkilde M.M., Kledal T.N., Brauner-Osborne H., and Schwartz T.W. Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. J. Biol. Chem. 274 2 (1999) 956-961
73. Sakakibara S., Ueda K., Chen J., Okuno T., and Yamanishi K. Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expression. J. Virol. 75 15 (2001) 6894-6900
74. Samols M.A., Hu J., Skalsky R.L., and Renne R. Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. J. Virol. 79 14 (2005) 9301-9305
75. Sarid R., Wiezorek J.S., Moore P.S., and Chang Y. Characterization and cell cycle regulation of the major Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter. J. Virol. 73 2 (1999) 1438-1446
76. Shepard L.W., Yang M., Xie P., Browning D.D., Voyno-Yasenetskaya T., Kozasa T., and Ye R.D. Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA. J. Biol. Chem. 276 49 (2001) 45979-45987
77. Sodhi A., Montaner S., Patel V., Zohar M., Bais C., Mesri E.A., and Gutkind J.S. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res. 60 17 (2000) 4873-4880
78. Sodhi A., Montaner S., and Gutkind J.S. Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?. Faseb J. 18 3 (2004) 422-427
79. Song M.J., Brown H.J., Wu T.T., and Sun R. Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus. J. Virol. 75 7 (2001) 3129-3140
80. Song M.J., Li X., Brown H.J., and Sun R. Characterization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J. Virol. 76 10 (2002) 5000-5013
81. Song M.J., Deng H., and Sun R. Comparative study of regulation of RTA-responsive genes in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J. Virol. 77 17 (2003) 9451-9462
82. Staskus K.A., Zhong W., Gebhard K., Herndier B., Wang H., Renne R., Beneke J., Pudney J., Anderson D.J., Ganem D., and Haase A.T. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J. Virol. 71 1 (1997) 715-719
83. Staudt M.R., and Dittmer D.P. Promoter switching allows simultaneous transcription of LANA and K14/vGPCR of Kaposi's sarcoma-associated herpesvirus. Virology 350 1 (2006) 192-205
84. Staudt M.R., and Dittmer D.P. The Rta/Orf50 transactivator proteins of the gamma-herpesviridae. Curr. Top Microbiol. Immunol. 312 (2007) 71-100
85. Sun R., Lin S.F., Staskus K., Gradoville L., Grogan E., Haase A., and Miller G. Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. J. Virol. 73 3 (1999) 2232-2242
86. Tiscornia G., Singer O., and Verma I.M. Design and cloning of lentiviral vectors expressing small interfering RNAs. Nat. Protoc. 1 1 (2006) 234-240
87. Tiscornia G., Singer O., and Verma I.M. Production and purification of lentiviral vectors. Nat. Protoc. 1 1 (2006) 241-245
88. Vega R.B., Harrison B.C., Meadows E., Roberts C.R., Papst P.J., Olson E.N., and McKinsey T.A. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol. Cell Biol. 24 19 (2004) 8374-8385
89. Wang Y., and Yuan Y. Essential role of RBP-Jkappa in activation of the K8 delayed-early promoter of Kaposi's sarcoma-associated herpesvirus by ORF50/RTA. Virology 359 1 (2007) 19-27
90. Wang S.E., Wu F.Y., Yu Y., and Hayward G.S. CCAAT/enhancer-binding protein-alpha is induced during the early stages of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic cycle reactivation and together with the KSHV replication and transcription activator (RTA) cooperatively stimulates the viral RTA, MTA, and PAN promoters. J. Virol. 77 17 (2003) 9590-9612
91. Wang S.E., Wu F.Y., Chen H., Shamay M., Zheng Q., and Hayward G.S. Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway. J. Virol. 78 8 (2004) 4248-4267
92. Won J., Yim J., and Kim T.K. Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells. J. Biol. Chem. 277 41 (2002) 38230-38238
93. Xu Y., AuCoin D.P., Huete A.R., Cei S.A., Hanson L.J., and Pari G.S. A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replication. J. Virol. 79 6 (2005) 3479-3487
94. Yada K., Do E., Sakakibara S., Ohsaki E., Ito E., Watanabe S., and Ueda K. KSHV RTA induces a transcriptional repressor, HEY1 that represses rta promoter. Biochem. Biophys. Res. Commun. 345 1 (2006) 410-418
95. Yang T.Y., Chen S.C., Leach M.W., Manfra D., Homey B., Wiekowski M., Sullivan L., Jenh C.H., Narula S.K., Chensue S.W., and Lira S.A. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma. J. Exp. Med. 191 3 (2000) 445-454
96. Ye J., Shedd D., and Miller G. An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate. J. Virol. 79 3 (2005) 1397-1408
97. Ye J., Gradoville L., Daigle D., and Miller G. De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists. J. Virol. 81 17 (2007) 9279-9291
98. Yu Y., Black J.B., Goldsmith C.S., Browning P.J., Bhalla K., and Offermann M.K. Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells. J. Gen. Virol. 80 Pt. 1 (1999) 83-90
99. Yu F., Harada J.N., Brown H.J., Deng H., Song M.J., Wu T.T., Kato-Stankiewicz J., Nelson C.G., Vieira J., Tamanoi F., Chanda S.K., and Sun R. Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. PLoS Pathog. 3 3 (2007) e44
100. Zhong W., Wang H., Herndier B., and Ganem D. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc. Natl. Acad. Sci. U.S.A. 93 13 (1996) 6641-6646
101. Zufferey R., Donello J.E., Trono D., and Hope T.J. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73 4 (1999) 2886-2892