Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's Sarcoma-associated herpesvirus protein ORF45

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 746-756

  Sathish, Narayanan ^a   Zhu, Fan Xiu ^b   Golub, Ellis E ^a   Liang, Qiming ^b   Yuan, Yan ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; ANTIVIRAL RESPONSE; AUTOINHIBITION; CLOSED FORM; CRITICAL DOMAIN; HYDROPHOBIC RESIDUES; IMMUNE RESPONSE; INHIBITORY DOMAINS; INTRAMOLECULAR INTERACTIONS; KAPOSI'S SARCOMA; MASTER REGULATORS; NUCLEAR TRANSLOCATIONS; SUB-DOMAINS; TYPE I INTERFERONS; VIRAL INFECTIONS;

ANTIBIOTICS; GLYCOPROTEINS; IMMUNOLOGY; PHOSPHORYLATION; PROTEINS; VIRUSES;

HYDROPHOBICITY;

INTERFERON REGULATORY FACTOR 7; PROTEIN ORF45; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ALPHA HELIX; ARTICLE; BETA SHEET; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; HYDROPHOBICITY; IMMUNE RESPONSE; INHIBITION KINETICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM; VIRUS INFECTION; YEAST;

AMINO ACID SEQUENCE; HEK293 CELLS; HERPESVIRUS 8, HUMAN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMEDIATE-EARLY PROTEINS; INTERFERON REGULATORY FACTOR-7; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; SUBSTRATE SPECIFICITY; TRANSCRIPTIONAL ACTIVATION;

HUMAN HERPESVIRUS 8;

EID: 78650935780     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.150920     Document Type: Article

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