Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein- coupled receptor in mammalian cells in culture

Journal of Clinical Investigation

Volumn 102, Issue 8, 1998, Pages 1469-1472

  Gershengorn, Marvin C ^a   Geras Raaka, Elizabeth ^a   Varma, Anjali ^a   Clark Lewis, Ian ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Constitutive signaling; Growth related protein ; Human herpesvirus 8; Interleukin 8; Platelet factor 4

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8; THROMBOCYTE FACTOR 4;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS CELL TRANSFORMATION;

EID: 0032532063     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI4461     Document Type: Article

References (27)

1. Rangan, S.R., L.N. Martin, F.M. Enright, and C.R. Abee. 1977. Herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys. J. Nutl. Cancer Inst. 59:165-171.
2. Miller, G. 1974. The oncogenicity of Epstein-Barr virus. J. Infect. Dis. 130:187-205.
3. Nador, R.G., E. Cesarman, A. Chadburn, D.B. Dawson, M.Q. Ansari, J. Said, and D.M. Knowles. 1996. Primary effusion lymphoma: a distinct clinico-pathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood. 88:645-656.
4. Offermann, M.K. 1996. Kaposi's sarcoma and HHV-8. Trends Microbiol. 4:419.
5. Cesarman, E., R.G. Nador, F. Bai, R.A. Bohenzky, J.J. Russo, P.S. Moore, Y. Chang, and D.M. Knowles. 1996. Kaposi's sarcoma associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J. Virol. 70:8218-8223.
6. Russo, J.J., R.A. Bohenzky, M.C. Chien, J. Chen, M. Yan, D. Maddalena, J.P. Parry, D. Peruzzi, I.S. Edelman, Y.A. Chang, and P.S. Moore. 1996. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. USA. 93:14862-14867.
7. Arvanitakis, L., E. Geras-Raaka, A. Varma, M.C. Gershengorn, and E. Cesarman. 1997. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature. 385:347-350.
8. Bais, C., B. Santomasso, O. Coso, L. Arvanitakis, E. Geras-Raaka, J.S. Gutkind, A.S. Asch, E. Cesarman, M.C. Gershengorn, and E.A. Mesri. 1998. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 391:86-89.
9. Nakamura, S., K. Murakami-Mori, N. Rao, H.A. Weich, and B. Rajeev. 1997. Vascular endothelial growth factor is a potent angiogenic factor in AIDS-associated Kaposi's sarcoma-derived spindle cells. J. Immunol. 158:4992-5001.
10. Masood, R., J. Cai, T. Zheng, D.L. Smith, Y. Naidu, and P.S. Gill. 1997. Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma. Proc. Natl. Acad. Sci. USA. 94:979-984.
11. Baggiolini, M., B. Dewald, and B. Moser. 1997. Human chemokines: an update. Annu. Rev. Immunol. 15:675-705.
12. Loetscher, M., B. Gerber, P. Loetscher, S.A. Jones, L. Piali, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1996. Chemokine receptor specific for IP10 and Mig: structure, function, and expression in activated T-lymphocytes. J. Exp. Med. 184:963-969.
13. Farber, J.M. 1997. Mig and IP-10: CXC chemokines that target lymphocytes. J. Leukocyte Biol. 61:246-257.
14. Geras-Raaka. E., A. Varma, H. Ho, I. Clark-Lewis, and M.C. Gershengorn. 1998. Human interferon-γ-inducible protein (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. J. Exp. Med. 188:405-408.
15. Clark-Lewis, I., B. Moser, A. Walz, M. Baggiolini, G.J. Scott, and R. Aebersold. 1991. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2. Biochemistry. 30:3128-3135.
16. Moser, B., B. Dewald, L. Barella, C. Schumacher, M. Baggiolini, and I. Clark-Lewis. 1993. Interleukin-8 antagonists generated by N-terminal modification. J. Biol. Chem. 268:7125-7128.
17. Jones, S.A., B. Dewald, I. Clark-Lewis, and M. Baggiolini. 1997. Chemokine antagonists that discriminate between interleukin-8 receptors: selective blockers of CXCR2. J. Biol. Chem. 272:16166-16169.
18. Clark-Lewis, I., B. Dewald, T. Geiser, B. Moser, and M. Baggiolini. 1993. Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg. Proc. Natl. Acad. Sci. USA. 90:3574-3577.
19. Baggiolini, M., B. Dewald, and B. Moser. 1994. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55:97-179.
20. Clore, G.M., E. Appella, M. Yamada, K. Matsushima, and A.M. Gronenborn. 1990. Three-dimensional structure of interleukin-8 in solution. Biochemistry. 29:1689-1696.
21. Baldwin, E.T., I.T. Weber, R. St. Charles, J.-C. Xuan, E. Appella, M. Yamada, K. Matsushima, B.F.P. Edwards, G.M. Clore, A.M. Gronenborn, and A. Wlodawer. 1991. Crystal structure of interleukin-8: symbiosis of NMR and crystallography. Proc. Natl. Acad. Sci. USA. 88:502-506.
22. Clark-Lewis, I., B. Dewald, M. Loetscher, B. Moser, and M. Baggiolini. 1994. Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids. J. Biol. Chem. 269:16075-16081.
23. Schutz, W., and M. Freissmuth. 1992. Reverse intrinsic activity of antagonists on G protein-coupled receptors. Trends Pharmacol. Sci. 13:376-380.
24. Luster, A.D. 1998. Chemokines: chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338:436-445.
25. Hadley, T.J., and S.C. Peiper. 1997. From malaria to chemokine receptor: the emerging physiologic role of the duffy blood group antigen. Blood. 89: 3077-3091.
26. Luster, A.D., S.M. Greenberg, and P. Leder. 1995. The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J. Exp. Med. 182:219-231.
27. Moore, B.B., M.P. Keane, C.L. Addison, D.A. Arenberg, and R.M. Strieter. 1998. CXC chemokine modulation of angiogenesis: the importance of balance between angiogenic and angiostatic members of the family. J. Invest. Med. 46:113-120.