A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

Journal of Cell Biology

Volumn 155, Issue 7, 2001, Pages 1265-1273

  Coscoy, Laurent ^a   Sanchez, David Jesse ^a   Ganem, Don ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Endocytosis; Herpesvirus; Immunity; KSHV; Ubiquitin

Indexed keywords

ADENOSINE TRIPHOSPHATE; CD86 ANTIGEN; CELL PROTEIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIGASE; LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MEMBRANE PROTEIN; MODULATOR OF IMMUNE RECOGNITION 1; MODULATOR OF IMMUNE RECOGNITION 2; UBIQUITIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; HELA CELL; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IN VITRO STUDY; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; ZINC FINGER MOTIF;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CHIMERA; ENDOCYTOSIS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; HELA CELLS; HERPESVIRIDAE; HLA-B7 ANTIGEN; HUMANS; INTRACELLULAR MEMBRANES; ISOENZYMES; LIGASES; MAJOR HISTOCOMPATIBILITY COMPLEX; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHATE TRANSPORT PROTEINS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

DNA VIRUSES; HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EID: 0035945349     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200111010     Document Type: Article

References (32)

1. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process
2. Mhc class I ubiquitination by a viral phd/lap finger protein
3. Solution structure of the PHD domain from the KAP-1 corepressor: Structural determinants for PHD, RING and LIM zinc-binding domains
4. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis
5. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation
6. c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route
7. A viral inhibitor of peptide transporters for antigen presentation
8. Immune evasion by cyromegalovirus - Survival strategies of a highly adapted opportunist
9. Cytomegaloviral control of MHC class I function in the mouse
10. A new ticket for entry into budding vesicles-ubiquitin
11. Protein regulation by monoubiquirin
12. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein
13. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins
14. The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
15. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
16. Human cytomegalovitus US3 impairs transport and maturation of major hisrocompatibility complex class I heavy chains
17. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation
18. Biochemical analyses of the AF10 protein: The extended LAP/PHD-finger mediates oligomerisation
19. SUMO - Nonclassical ubiquitin
20. A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins
21. Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor
22. Mechanisms underlying ubiquitination
23. Vital strategies of immune evasion
24. A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation
25. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
26. Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses
27. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
28. Kaposi's sarcoma herpesvirus as a new paradigm for virus-induced oncogenesis
29. The human cytomegalovitus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
30. Cytomegaloviruses use multiple mechanisms to elude the host immune response
31. Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex
32. A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes