Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus

Trends in Microbiology

Volumn 17, Issue 3, 2009, Pages 119-129

  Aresté, Cristina ^a   Blackbourn, David J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHEMOKINE; CYTOKINE; INTERFERON; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADAPTIVE IMMUNITY; AFRICA; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; B LYMPHOCYTE; CELL FUNCTION; COMPLEMENT ACTIVATION; HUMAN; HUMAN HERPESVIRUS 8; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; INNATE IMMUNITY; KAPOSI SARCOMA; MOLECULAR RECOGNITION; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PRIMARY EFFUSION LYMPHOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; T LYMPHOCYTE; VIRUS GENE; VIRUS GENOME;

ANIMALS; ANTIBODY FORMATION; GENOME, VIRAL; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNE SYSTEM; IMMUNITY, ACTIVE; IMMUNITY, INNATE;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EID: 61449100471     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tim.2008.12.001     Document Type: Review

References (80)

1. Colman R., and Blackbourn D.J. Risk factors in the development of Kaposi's sarcoma. AIDS 22 (2008) 1629-1632
2. Parkin D.M. The global health burden of infection-associated cancers in the year 2002. Int. J. Cancer 118 (2006) 3030-3044
3. Chang Y., et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266 (1994) 1865-1869
4. Ganem D. Kaposi's sarcoma-associated herpesvirus. In: Knipe D.M., and Howley P.M. (Eds). Field's Virology (2007), Lippincott Williams & Wilkins 2847-2888
5. Rezaee S.A.R., et al. KSHV immune modulation: an overview. J. Gen. Virol. 87 (2006) 1781-1804
6. Qian S.B., et al. Tight linkage between translation and MHC class I peptide ligand generation implies specialized antigen processing for defective ribosomal products. J. Immunol. 177 (2006) 227-233
7. Guihot A., et al. Low T cell responses to human herpesvirus 8 in patients with AIDS-related and classic Kaposi sarcoma. J. Infect. Dis. 194 (2006) 1078-1088
8. Osman M., et al. Identification of human herpesvirus 8-specific cytotoxic T-cell responses. J. Virol. 73 (1999) 6136-6140
9. Brander C., et al. Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. J. Infect. Dis. 184 (2001) 119-126
10. Stebbing J., et al. Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes. J. Virol. 77 (2003) 4306-4314
11. Milligan S., et al. Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells. J. Virol. 78 (2004) 2591-2596
12. Blackbourn D.J., et al. Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 13125-13130
13. Rappocciolo G., et al. Human Herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN. J. Virol. 82 (2008) 4793-4806
14. Coscoy L., et al. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J. Cell Biol. 155 (2001) 1265-1273
15. Duncan L.M., et al. Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules. EMBO J. 25 (2006) 1635-1645
16. Cadwell K., and Coscoy L. Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Science 309 (2005) 127-130
17. Cadwell K., and Coscoy L. The specificities of Kaposi's sarcoma-associated herpesvirus-encoded E3 ubiquitin ligases are determined by the positions of lysine or cysteine residues within the intracytoplasmic domains of their targets. J. Virol. 82 (2008) 4184-4189
18. Adang L.A., et al. Intracellular Kaposi's sarcoma-associated herpesvirus load determines early loss of immune synapse components. J. Virol. 81 (2007) 5079-5090
19. Mansouri M., et al. Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells. Blood 108 (2006) 1932-1940
20. Krishnan H.H., et al. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J. Virol. 78 (2004) 3601-3620
21. Lagos D., et al. Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells. Blood 109 (2007) 1550-1558
22. Li Q., et al. Downregulation of Gamma Interferon Receptor 1 by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5. J. Virol. 81 (2007) 2117-2127
23. Goodbourn S., et al. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J. Gen. Virol. 81 (2000) 2341-2364
24. Glaunsinger B., and Ganem D. Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover. Mol. Cell 13 (2004) 713-723
25. Zuo J., et al. The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function. J. Virol. 82 (2008) 2385-2393
26. Barbera A.J., et al. The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science 311 (2006) 856-861
27. Zaldumbide A., et al. In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus. Mol. Immunol. 44 (2007) 1352-1360
28. Kwun H.J., et al. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing. J. Virol. 81 (2007) 8225-8235
29. Ambroziak J.A., et al. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268 (1995) 582-583
30. Wilson S.J., et al. X Box Binding Protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. J. Virol. 81 (2007) 13578-13586
31. Yu F., et al. B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus. FEBS Lett. 581 (2007) 3485-3488
32. Blackbourn D.J., et al. Human herpesvirus 8 detection in nasal secretions and saliva. J. Infect. Dis. 177 (1998) 213-216
33. Bartee E., et al. Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog. 2 (2006) e107
34. Jouvenet N., et al. Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J. Virol. 83 (2009) 1837-1844
35. Baltimore D., et al. MicroRNAs: new regulators of immune cell development and function. Nat. Immunol. 9 (2008) 839-845
36. Cai X., et al. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5570-5575
37. Pfeffer S., et al. Identification of microRNAs of the herpesvirus family. Nat. Methods 2 (2005) 269-276
38. Gottwein E., and Cullen B.R. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 3 (2008) 375-387
39. Samols M.A., et al. Identification of cellular genes targeted by KSHV-encoded microRNAs. PLoS Pathog. 3 (2007) e65
40. Gottwein E., et al. A viral microRNA functions as an orthologue of cellular miR-155. Nature 450 (2007) 1096-1099
41. Skalsky R.L., et al. Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. J. Virol. 81 (2007) 12836-12845
42. Stern-Ginossar N., et al. Host immune system gene targeting by a viral miRNA. Science 317 (2007) 376-381
43. Lee B.S., et al. Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1. J. Exp. Med. 192 (2000) 11-21
44. Tomlinson C.C., and Damania B. critical role for endocytosis in the regulation of signaling by the Kaposi's sarcoma-associated herpesvirus K1 protein. J. Virol. 82 (2008) 6514-6523
45. Brinkmann M.M., and Schulz T.F. Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae. J. Gen. Virol. 87 (2006) 1047-1074
46. Brinkmann M.M., et al. Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus. J. Virol. 81 (2007) 42-58
47. Wang L., et al. Functional characterization of the M-type K15-encoded membrane protein of Kaposi's sarcoma-associated herpesvirus. J. Gen. Virol. 88 (2007) 1698-1707
48. Lim C.S., et al. The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction. Biochemistry 46 (2007) 9874-9885
49. Choi J.K., et al. Identification of the novel K15 gene at the rightmost end of the Kaposi's sarcoma-associated herpesvirus genome. J. Virol. 74 (2000) 436-446
50. Kimball L.E., et al. Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcoma. J. Infect. Dis. 189 (2004) 2016-2022
51. Rosa G.T., et al. IgG fc receptors provide an alternative infection route for murine gamma-herpesvirus-68. PLoS One 2 (2007) e560
52. Rezaee S.A., et al. Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein. AIDS 19 (2005) 1907-1910
53. Foster-Cuevas M., et al. Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor. J. Virol. 78 (2004) 7667-7676
54. Chung Y.H., et al. Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein activates myeloid-lineage cells to induce inflammatory cytokine production. J. Virol. 76 (2002) 4688-4698
55. Blue C.E., et al. The relevance of complement to virus biology. Virology 319 (2004) 176-184
56. Spiller O.B., et al. Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. J. Virol. 77 (2003) 592-599
57. Spiller O.B., et al. Dissecting the regions of virion-associated Kaposi's Sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding. J. Virol. 80 (2006) 4068-4078
58. Mark L., et al. Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies. Immunology 123 (2008) 228-238
59. Hiscott J. Triggering the innate antiviral response through IRF-3 activation. J. Biol. Chem. 282 (2007) 15325-15329
60. Paun A., and Pitha P.M. The IRF family, revisited. Biochimie 89 (2007) 744-753
61. Offermann M.K. Kaposi sarcoma herpesvirus-encoded interferon regulator factors. Curr. Top. Microbiol. Immunol. 312 (2007) 185-209
62. Gao S.J., et al. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene 15 (1997) 1979-1985
63. Park J., et al. Identification of the DNA sequence interacting with Kaposi's Sarcoma-associated herpesvirus viral interferon regulatory factor 1. J. Virol. 81 (2007) 12680-12684
64. Fuld S., et al. Inhibition of interferon signalling by the Kaposi's sarcoma-associated herpesvirus (KSHV) full-length vIRF-2 protein. J. Virol. 80 (2006) 3092-3097
65. Joo C.H., et al. Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3. J. Virol. 81 (2007) 8282-8292
66. Kanno T., et al. Expression of Kaposi's sarcoma-associated herpesvirus-encoded K10/10.1 protein in tissues and its interaction with poly(A)-binding protein. Virology 352 (2006) 100-109
67. Lefort S., et al. Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression. J. Virol. 81 (2007) 10950-10960
68. Randall R.E., and Goodbourn S. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89 (2008) 1-47
69. Perry S.T., and Compton T. Kaposi's sarcoma-associated herpesvirus virions inhibit interferon responses induced by envelope glycoprotein gpK8. 1. J. Virol. 80 (2006) 11105-11114
70. Akira S., et al. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
71. Ishikawa H., and Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455 (2008) 674-678
72. West J., and Damania B. Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection. J. Virol. 82 (2008) 5440-5449
73. Lagos D., et al. Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus. Cell Host Microbe 4 (2008) 470-483
74. Sanchez D.J., et al. A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. J. Virol. 82 (2008) 2208-2217
75. Guggemoos S., et al. TLR9 contributes to antiviral immunity during gammaherpesvirus infection. J. Immunol. 180 (2008) 438-443
76. Choi Y.B., and Nicholas J. Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines. J. Virol. 82 (2008) 6501-6513
77. Hu F., and Nicholas J. Signal transduction by human herpesvirus 8 viral interleukin-6 (vIL-6) is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6. J. Virol. 80 (2006) 10874-10878
78. Chatterjee M., et al. Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science 298 (2002) 1432-1435
79. Ishido S., et al. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity 13 (2000) 365-374
80. Thomas M., et al. Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 1656-1661