G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

Nature

Volumn 391, Issue 6662, 1998, Pages 86-89

  Bais, Carlos ^a   Santomasso, Bianca ^a   Coso, Omar ^b,d   Arvanitakis, Leandros ^a,c   Raaka, Elizabeth Geras ^a   Gutkind, J Silvio ^b   Asch, Adam S ^a   Cesarman, Ethel ^a   Gerhengorn, Marvin C ^a   Mesri, Enrique A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c HELLENIC PASTEUR INSTITUTE   (Greece)

^d INSTITUTO DE FISIOLOGÍA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE; VASCULOTROPIN; VIRUS RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL TRANSFORMATION; ENZYME ACTIVATION; HUMAN HERPESVIRUS 8; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL;

3T3 CELLS; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL TRANSFORMATION, NEOPLASTIC; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL GROWTH FACTORS; FEMALE; GTP-BINDING PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOKINES; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; ONCOGENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, CHEMOKINE; SARCOMA, KAPOSI; SIGNAL TRANSDUCTION; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VIRAL PROTEINS;

ANIMALIA; HERPESVIRIDAE; HERPESVIRUS 8; HUMAN HERPESVIRUS 8;

EID: 0031937076     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/34193     Document Type: Article

References (30)

1. Chang, Y. et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposis's sarcoma. Science 266, 1865-1869 (1994).
2. Mesri, E. A. et al. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B-cells. J. Exp. Med. 183, 2385-2390 (1996).
3. Renne, R. et al. Lytic growth of Kaposi's sarcoma associated herpesvirus (HHV-8) in culture. Nature Med. 2, 342-346 (1996).
4. Russo, J. L. et al. Nucelotide sequence of the Kaposi's sarcoma associated herpesvirus (HHV8). Proc. Natl Acad. Sci. USA 93, 14862-14867 (1997).
5. Boshoff, C. & Weiss, R. A. Kaposis sarcoma-associated herpesvirus. Curr. Opin. Inject. Dis. 10, 26-31 (1997).
6. Cesarman, E., Chang, Y., Moore, P. S., Said, J. W. & Knowles, D. M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences are present in AIDS-related body cavity B-cell lymphomas. N. Engl. J. Med. 332, 1186-1191 (1995).
7. Boshoff, C. et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nature Med. 1, 1274-1278 (1995).
8. Arvanitakis, L. et al. Establishment and characterization of a body cavity-based lymphoma cell line (BC-3) harboring Kapos's Sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of EBV. Blood 86, 2708-2714 (1996).
9. Cesarman, E. et al. Kaposis sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposis sarcoma and malignant lymphoma. J. Virol. 70, 8218-8223 (1996).
10. Ensoli, B., Barillari, G. & Gallo, R. C. Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's Sarcoma. Immunol. Rev. 127, 147-155 (1992).
11. Guo, H. G. et al. Characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in Kaposi's sarcoma. Virology 228, 371-378 (1997).
12. Arvanitakis, L., Geras Raaka, E., Varma, A., Gershengorn, M. & Cesarman, E. Human herpesvirus KSHV encodes a constitutively active G-protein coupled receptor linked to cell proliferation. Nature 385, 347-350 (1997).
13. Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 356-364 (1996).
14. Ferrara, N. Vascular endothelial growth factor. Eur. J. Cancer 14, 2413-2422 (1996).
15. Masood, R. et al. Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor in AIDS-Kaposi's sarcoma. Proc. Natl Acad. Sci. USA 94, 979-984 (1997).
16. Nakamura, S., Murakamimori, K., Rao, N., Weich, H. A. & Rajeev, B. Vascular endothehal growth factor is a potent angiogenic factor in aids-associated kaposis-sarcoma-derived spindle cells. J. Immunol. 158, 4992-5001 (1997).
17. Cornali, E. et al. Vascular endothelial growth factor regulates angiogenesis and vascular permeability in kaposis sarcoma. Am. J. Pathol. 149, 1851-1869 (1996).
18. Kyriakis, J. M. & Avruch, J. Sounding the alarm - Protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271, 24313-24316 (1996).
19. Samaniego, F., Markham, P. D., Gallo, R. C. & Ensoli, B. Inflammatory cytokines induce AIDS-Kaposi's sarcoma-derived spindle cells to produce and release basic fibroblast growth factor and enhance Kaposi's sarcoma-like lesion formation in nude mice. J. Immunol. 154, 3582-3592 (1994).
20. Gutkind, S., Novotny, E. A., Brann, M. R. & Robbins, K. C. Muscarinic acetylcholine receptors as agonist dependent oncogenes. Proc. Natl Acad. Sci. USA 88, 4703-4707 (1991).
21. Van Sande, J. et al. Genetic basis of endocrine disease: Somatic and germline mutations of the TSH receptor gene in thyroid diseases. J. Clin. Endocr. Metab. 80, 2577-2585 (1995).
22. Premont, R. T., Inglese, J. & Lefkowitz, R. J. Protein kinases that phosphorylate activated G-protein coupled receptors. FASEB J. 9, 175-182 (1995).
23. Geras Raaka, E. et al. Inhibitionof constitutive signalling of Kaposi's sarcoma associated herpesvirus G protein coupled receptor by protein kinases in mammalian cells in culture. J. Exp. Med. (submitted).
24. Koch, A. E. et al. Interleukin-8 as a macrophage mediator of angiogenesis. Science 258, 1798-1801 (1992).
25. Kolch, W., Martiny-Baron, G., Kieser, A. & Marme, D. Regulation of the expression of the VEGF/VPS and its receptors: role in rumor angiogenesis. Breast Cancer Res. Treat. 36, 139-155 (1995).
26. Goto, F., Goto, K., Weindel, K. & Folkman, J. Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab. Invest. 69, 508-517 (1993).
27. Montesano, R., Pepper, M. S. & Orci, L. Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. J. Cell Sci. 105, 1013-1024 (1993).
28. Rickinson, A. B. & Kieff, E. in Fields Virology 3rd edn (eds Fields, B. N., Knipe, D. M. & Howley, P. M.) 2397-2446 (Lippincott-Raven, Philadelphia, 1996).
29. Mesri, E. A., Federoff, H. J. & Brownlee, M. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circ. Res. 76, 161-167 (1995).
30. Coso, O. A. et al. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/ SAPK signaling pathway. Cell 81, 1137-1146 (1995).