Deregulation of cell growth by the K1 gene of Kaposi's sarcoma- associated herpesvirus

Nature Medicine

Volumn 4, Issue 4, 1998, Pages 435-440

  Lee, Heuiran ^a   Veazey, Ronald ^a   Williams, Kenneth ^a   Li, Mengtao ^a   Guo, Jie ^a   Neipel, Frank ^b   Fleckenstein, Bernhard ^b   Lackner, Andrew ^a   Desrosiers, Ronald C ^a   Jung, Jae U ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SAIMIRI TRANSFORMING PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN HERPESVIRUS 8; LYMPHOMA; MARMOSET; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; RODENT; T LYMPHOCYTE; VIRUS GENE; VIRUS RECOMBINANT;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; COS CELLS; DNA PRIMERS; DNA, VIRAL; GENES, VIRAL; HERPESVIRUS 2, SAIMIRIINE; HERPESVIRUS 8, HUMAN; HUMANS; MALE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS, VIRAL; OPEN READING FRAMES; POLYMERASE CHAIN REACTION; RATS; RECOMBINANT FUSION PROTEINS; SARCOMA, KAPOSI; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION; VIRAL PROTEINS;

ANIMALIA; CALLITHRIX JACCHUS; HERPESVIRIDAE; HERPESVIRUS 8; HUMAN HERPESVIRUS 8; MARMOSETS; RODENTIA; SAIMIRI; SAIMIRIINE HERPESVIRUS 2;

EID: 17344385795     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0498-435     Document Type: Article

References (39)

1. Chang, Y. et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869 (1994).
2. Huang, Y.Q. et al. Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma. Lancet 345, 759-761 (1995).
3. Albini, A. et al. Oncogenesis in HIV-infection: KSHV and Kaposi's sarcoma. Int. J. Oncol. 9, 5-8 (1996).
4. Marchioli, C.C. et al. Prevalence of human herpesvirus 8 DNA sequences in several patient populations. J. Clin. Microbiol. 34, 2635-2638 (1996).
5. Dupin, N. et al. Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma. Lancet 345, 761-762 (1995).
6. Soulier, J. et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86, 1276-1280 (1997).
7. Rettig, M.B. et al. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 276, 1851-1854 (1997).
8. Cesarman E., Chang, Y., Moore, P.S., Said, J.W. & Knowles, D.M. Kaposi's sarcoma-associated Herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332, 1186-1191 (1995).
9. Renne, R. et al. Lytic growth of Kaposi's sarcoma-associate herpesvirus (human herpesvirus 8) in culture. Nature Med. 2, 342-346 (1996).
10. Russo, J.J. et al. Nucleotide sequence of the Kaposi's sarcoma-associated herpesvirus (HHV8). Proc. Natl. Acad. Sci. USA 93, 14862-14867 (1996).
11. Desrosiers, R.C. et al. A herpesvirus of rhesus monkeys related to the human kaposi's sarcoma-associated herpesvirus. J. Virol. 71, 9764-9769 (1997).
12. Desrosiers, R.C. et al. A region of the Herpesvirus saimiri genome required for oncogenicity. Science 228, 184-187 (1985).
13. Medveczky, M.M. et al. IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus. Virology 196, 402-412 (1993).
14. Koomey, J.M., Mulder, C., Burghoff, R.L., Fleckenstein, B. & Desrosiers, R.C. Deletion of DNA sequences in a nononcogenic variant of Herpesvirus saimiri. J. Virol. 50, 662-665 (1984).
15. Murthy, S.C.S., Trimble, J.J. & Desrosiers, R.C. Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation. J. Virol. 63, 3307-3314 (1989).
16. Duboise, S.M., Guo, J., Czajak, S., Desrosiers, R.C. & Jung, J.U. STP and tip are essential for Herpesvirus saimiri oncogenicity. J. Virol. 72, 1308-1313 (1998).
17. Lee, H. et al. Genetic variation of herpesvirus saimiri subgroup A transforming protein and its association with cellular src. J. Virol. 71, 3817-3825 (1997).
18. Mäkelä, T.P. et al. A cyclin associated with the CDK-activating kinase M015. Nature 371, 254-257 (1994).
19. Jung, J.U. et al. Identification of transforming genes of subgroup A and C strains of herpesvirus saimiri. Proc. Natl. Acad. Sci. U.S.A. 88, 7051-7055 (1991).
20. Duboise, S.M., Guo, J., Desrosiers, R.C. & Jung, J.U. Use of virion DNA as a cloning vector for the construction of mutant and recombinant herpesviruses. Proc. Natl. Acad. Sci. U.S.A. 93, 11389-11394 (1996).
21. Desrosiers, R.C., Silva, D., Waldron, L.M. & Letvin, N.L. Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization. J. Virol. 57, 701-705 (1986).
22. Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M.C. & Cesarman, E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 385, 347-350 (1997).
23. Thome, M. et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386, 517-521 (1997).
24. Gao, S.-J. et al. KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway. Oncogene 15, 1979-1985 (1997).
25. Li, M. et al. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J. Virol. 71, 1984-1991 (1997).
26. Godden-Kent, D. et al. The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1. J. Virol. 71, 4193-4198 (1997).
27. Ganem, D. Viruses, cytokines and Kaposi's sarcoma. Curr. Biol. 5, 469-471 (1995).
28. Ganem, D. KSHV and Kaposi's sarcoma: The end of the beginning. Cell 91, 157-160 (1997).
29. Ensoli, B. et al. Synergy between basic fibroblast growth factor and HIV-1 tat protein in induction of Kaposi's sarcoma. Nature 371, 674-680 (1994).
30. Moore, P.S., Boshoff, C., Weiss, R.A. & Chang, Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274, 1739-1744 (1996).
31. Nicholas, J. et al. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nature Med. 3, 287-292 (1997).
32. Rickinson, A.B. & Kieff, E. Epstein-Barr Virus, in Fields Virology. Third edn. (eds. Fields, B.N., et al,) 2397-2446 (Lippincott-Raven, Philadelphia, (1996).
33. Wang, D., Liebowitz, D. & Kieff, E. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 831-840 (1987).
34. Langunoff, M. & Ganem, D. The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated Herpesvirus (human Herpesvirus 8). Virology 236, 147-154 (1997).
35. Jung, J.U. & Desrosiers, R.C. Association of the viral oncoprotein STP-C488 with cellular ras. Mol. Cell. Biol. 15, 6506-6512 (1995).
36. Mosialos, G. et al. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80, 389-399 (1995).
37. Izumi, K.M., Kaye, K.M. & Kieff, E.D. The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc. Natl. Acad. Sci. U.S.A. 94, 1447-1452 (1997).
38. Neipel, F. et al. Human herpesvirus 8 encodes a homolog of interleukin-6. J. Virol. 71, 839-842 (1997).
39. Guo, J. et al. Substitution of ras for the herpesvirus saimiri STP oncogene in lymphocyte transformation. J. Virol. In the press.