Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties

Food and Chemical Toxicology

Volumn 61, Issue , 2013, Pages 112-120

  Kasiotis, Konstantinos M ^a   Pratsinis, Harris ^b   Kletsas, Dimitris ^b   Haroutounian, Serkos A ^c  

^a BENAKI PHYTOPATHOLOGICAL INSTITUTE   (Greece)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c AGRICULTURAL UNIVERSITY OF ATHENS   (Greece)

Author keywords

Aging; Angiogenesis; Lifespan; Polyphenol; Resveratrol; Stilbenes

Indexed keywords

2 (2 CHLOROSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; 3,4,4' TRIHYDROXY TRANS STILBENE; 3,4,4',5 THRIHYDROXY TRANS AZA STILBENE; 4,4 DIHYDROXY TRANS STILBENE; AMURENSIN G; BENZAMIDINE DERIVATIVE; BENZOFURAN DERIVATIVE; CYCLOOXYGENASE 1 INHIBITOR; DIHYDRORESVERATROL; HEXAHYDROXYSTILBENE; HYDROXYL GROUP; ISORHAPONTIGENIN; PICEATANNOL; PTEROSTILBENE; RESVERATROL; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIAGING ACTIVITY; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG CANCER; NONHUMAN; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUPERCRITICAL FLUID EXTRACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AGING; ANGIOGENESIS; LIFESPAN; POLYPHENOL; RESVERATROL; STILBENES;

AGING; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOFURANS; DIBENZOCYCLOHEPTENES; DIETARY SUPPLEMENTS; HUMANS; PLANTS; RESORCINOLS; RODENTIA; STILBENES;

EID: 84888836884     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.03.038     Document Type: Article

References (137)

1. Alex D., Leong E.C., Zhang Z.J., Yan G.T.H., Cheng S.H., Leong C.W., Li Z.H., Lam K.H., Chan S.W., Lee S.M.Y. Resveratrol derivative, trans-3,5,4'-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. J. Cell. Biochem. 2010, 109:339-346.
2. Anastasiadi M., Pratsinis H., Kletsas D., Skaltsounis A.L., Haroutounian S.A. Grape stem extracts: polyphenolic content and assessment of their in vitro antioxidant properties. Lwt-Food Sci. Technol. 2012, 48:316-322.
3. Anisimova N.Y., Kiselevsky M.V., Sosnov A.V., Sadovnikov S.V., Stankov I.N., Gakh A.A. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem. Cent. J. 2011, 5:88.
4. Asensi M., Ortega A., Mena S., Feddi F., Estrela J.M. Natural polyphenols in cancer therapy. Crit. Rev. Cl Lab. Sci. 2011, 48:197-216.
5. Athar M., Back J.H., Kopelovich L., Bickers D.R., Kim A.L. Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Arch. Biochem. Biophys. 2009, 486:95-102.
6. Atten M.J., Godoy-Romero E., Attar B.M., Milson T., Zopel M., Holian O. Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. Invest. New Drugs 2005, 23:111-119.
7. Barger J.L., Kayo T., Vann J.M., Arias E.B., Wang J., Hacker T.A., Wang Y., Raederstorff D., Morrow J.D., Leeuwenburgh C., Allison D.B., Saupe K.W., Cartee G.D., Weindruch R., Prolla T.A. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 2008, 3:e2264.
8. Bass T.M., Weinkove D., Houthoofd K., Gems D., Partridge L. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 2007, 128:546-552.
9. Bauer J.H., Goupil S., Garber G.B., Helfand S.L. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 2004, 101:12980-12985.
10. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., Sinclair D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
11. Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5:493-506.
12. Benova B., Adam M., Pavlikova P., Fischer J. Supercritical fluid extraction of piceid, resveratrol and emodin from Japanese knotweed. J. Supercrit. Fluid 2010, 51:325-330.
13. Bernhaus A., Ozsvar-Kozma M., Saiko P., Jaschke M., Lackner A., Grusch M., Horvath Z., Madlener S., Krupitza G., Handler N., Erker T., Jaeger W., Fritzer-Szekeres M., Szekeres T. Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells. Invest New Drug 2009, 27:393-401.
14. Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev. Res. 2009, 2:409-418.
15. Bordone L., Cohen D., Robinson A., Motta M.C., van Veen E., Czopik A., Steele A.D., Crowe H., Marmor S., Luo J., Gu W., Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007, 6:759-767.
16. Borra M.T., Smith B.C., Denu J.M. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 2005, 280:17187-17195.
17. Brakenhielm E., Cao R.H., Cao Y.H. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. Faseb J. 2001, 15. 1798-+.
18. Braumann C., Tangermann J., Jacobi C.A., Muller J.M., Dubiel W. Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini-Rev. Med. Chem. 2008, 8:421-428.
19. Brizzi A., Brizzi V., Corradini D. Identification and quantification of trans-resveratrol in dietary supplements by a rapid and straightforward RP-HPLC method. J. Liq. Chromatogr. R T 2008, 31:2089-2100.
20. Cai W.Q., Zhang L.W., Song Y.L., Zhang B.X., Cui X.M., Hu G.M., Fang J.G. 3,4,4'-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent. Free Radical Res. 2011, 45:1379-1387.
21. Calabrese E.J., Mattson M.P., Calabrese V. Resveratrol commonly displays hormesis: occurrence and biomedical significance. Hum. Exp. Toxicol. 2010, 29:980-1015.
22. Calabrese G. Nonalcoholic compounds of wine: the phytoestrogen resveratrol and moderate red wine consumption during menopause. Drugs Exp. Clin. Res. 1999, 25:111-114.
23. Calamini B., Ratia K., Malkowski M.G., Cuendet M., Pezzuto J.M., Santarsiero B.D., Mesecar A.D. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem. J. 2010, 429:273-282.
24. Cao Z., Fang J., Xia C., Shi X., Jiang B.H. Trans-3,4,5'-trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells. Clin. Cancer Res. 2004, 10:5253-5263.
25. Carrera C., Ruiz-Rodriguez A., Palma M., Barroso C.G. Ultrasound assisted extraction of phenolic compounds from grapes. Anal. Chim. Acta 2012, 732:100-104.
26. Chen T., Shen L., Yu J., Wan H., Guo A., Chen J., Long Y., Zhao J., Pei G. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell 2011, 10:908-911.
27. Chen Y., Tseng S.H. Review. Pro- and anti-angiogenesis effects of resveratrol. In Vivo 2007, 21:365-370.
28. Chung J.H., Manganiello V., Dyck J.R. Resveratrol as a calorie restriction mimetic: therapeutic implications. Trends Cell Biol. 2012, 22:546-554.
29. de la Lastra C.A., Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol. Nutr. Food Res. 2005, 49:405-430.
30. de la Lastra C.A., Villegas I. Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem. Soc. Trans. 2007, 35:1156-1160.
31. Delmas D., Jannin B., Latruffe N. Resveratrol: preventing properties against vascular alterations and ageing. Mol. Nutr. Food Res. 2005, 49:377-395.
32. Dias P.F., Berti F.V., Siqueira J.M., Maraschin M., Gagliardi A.R., do Valle R.M. Trans-resveratrol inhibits early blood vessel formation (Vasculogenesis) without impairment of embryonic growth. J. Pharmacol. Sci. 2008, 107:118-127.
33. Fang Y., Yu Y., Hou Q., Zheng X., Zhang M., Zhang D., Li J., Wu X.R., Huang C. The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP. J. Biol. Chem. 2012, 287:35234-35243.
34. Fernandez-Marin M.I., Guerrero R.F., Garcia-Parrilla M.C., Puertas B., Richard T., Rodriguez-Werner M.A., Winterhalter P., Monti J.P., Cantos-Villar E. Isorhapontigenin: a novel bioactive stilbene from wine grapes. Food Chem. 2012, 135:1353-1359.
35. Folkman J., Bach M., Rowe J.W., Davidoff F., Lambert P., Hirsch C., Goldberg A., Hiatt H.H., Glass J., Henshaw E. Tumor angiogenesis - therapeutic implications. New Engl. J. Med. 1971, 285. 1182-&.
36. Frojdo S., Cozzone D., Vidal H., Pirola L. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. Biochem. J. 2007, 406:511-518.
37. Frojdo S., Durand C., Molin L., Carey A.L., El-Osta A., Kingwell B.A., Febbraio M.A., Solari F., Vidal H., Pirola L. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1. Mol. Cell. Endocrinol. 2011, 335:166-176.
38. Frombaum M., Le Clanche S., Bonnefont-Rousselot D., Borderie D. Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: Potential benefits to cardiovascular diseases. Biochimie 2012, 94:269-276.
39. Fujita Y., Islam R., Sakai K., Kaneda H., Kudo K., Tamura D., Aomatsu K., Nagai T., Kimura H., Matsumoto K., de Velasco M.A., Arao T., Okawara T., Nishio K. Aza-derivatives of resveratrol are potent macrophage migration inhibitory factor inhibitors. Invest. New Drug 2012, 30:1878-1886.
40. Fukuda S., Kaga S., Zhan L., Bagchi D., Das D.K., Bertelli A., Maulik N. Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1. Cell Biochem. Biophys. 2006, 44:43-49.
41. Fulda S. Resveratrol and derivatives for the prevention and treatment of cancer. Drug Discov. Today 2010, 15:757-765.
42. Fulda S., Debatin K.M. Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review. Cancer Detect. Prev. 2006, 30:217-223.
43. Geldenhuys W.J., Bishayee A., Darvesh A.S., Carroll R.T. Natural products of dietary origin as lead compounds in virtual screening and drug design. Curr. Pharm. Des. 2012, 13:117-124.
44. Gerhardt E., Graber S., Szego E.M., Moisoi N., Martins L.M., Outeiro T.F., Kermer P. Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice. PLoS ONE 2011, 6:e28855.
45. Gertz M., Nguyen G.T., Fischer F., Suenkel B., Schlicker C., Franzel B., Tomaschewski J., Aladini F., Becker C., Wolters D., Steegborn C. A molecular mechanism for direct sirtuin activation by resveratrol. PLoS ONE 2012, 7:e49761.
46. Gollücke A.P.B., Ribeiro D.A. Use of grape polyphenols for promoting human health: a review of patents. Rec. Patents Food, Nutri. Agric. 2012, 4:26-30.
47. Goncalves J., Camara J.S. New method for determination of (E)-resveratrol in wine based on microextraction using packed sorbent and ultra-performance liquid chromatography. J. Sep. Sci. 2011, 34:2376-2384.
48. Gruber J., Tang S.Y., Halliwell B. Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. Ann. N. Y. Acad. Sci. 2007, 1100:530-542.
49. Guerrero R.F., Garcia-Parrilla M.C., Puertas B., Cantos-Villar E. Wine, resveratrol and health: a review. Nat. Prod. Commun. 2009, 4:635-658.
50. Guillarme D., Casetta C., Bicchi C., Veuthey J.L. High throughput qualitative analysis of polyphenols in tea samples by ultra-high pressure liquid chromatography coupled to UV and mass spectrometry detectors. J. Chromatogr. A 2010, 1217:6882-6890.
51. Hagemann T., Robinson S.C., Thompson R.G., Charles K., Kulbe H., Balkwill F.R. Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis. Mol. Cancer Ther. 2007, 6:1993-2002.
52. Handler N., Brunhofer G., Studenik C., Leisser K., Jaeger W., Parth S., Erker T. 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorgan. Med. Chem. 2007, 15:6109-6118.
53. Handley A.J. Extraction Methods in Organic Analysis 1999, Sheffield Academic Press, Sheffield.
54. Ho S.M. Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates. J. Cell. Biochem. 2004, 91:491-503.
55. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425:191-196.
56. Hsieh T.C., Wu J.M. Resveratrol: biological and pharmaceutical properties as anticancer molecule. BioFactors 2010, 36:360-369.
57. Hu Y., Liu J., Wang J., Liu Q. The controversial links among calorie restriction, SIRT1, and resveratrol. Free Radic. Biol. Med. 2011, 51:250-256.
58. Huang X., Mazza G. Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry. J. Chromatogr. A 2011, 1218:3890-3899.
59. Hussain S., Slevin M., Ahmed N., West D., Choudhary M.I., Naz H., Gaffney J. Stilbene glycosides are natural product inhibitors of FGF-2-induced angiogenesis. BMC Cell Biol. 2009, 10:30.
60. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., Fong H.H., Farnsworth N.R., Kinghorn A.D., Mehta R.G., Moon R.C., Pezzuto J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275:218-220.
61. Jeong S.J., Koh W., Kim B., Kim S.H. Are there new therapeutic options for treating lung cancer based on herbal medicines and their metabolites?. J. Ethnopharmacol. 2011, 138:652-661.
62. Jung D.B., Lee H.J., Jeong S.J., Lee H.J., Lee E.O., Kim Y.C., Ahn K.S., Chen C.Y., Kim S.H. Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells. Biol. Pharm. Bull. 2011, 34:850-855.
63. Kaeberlein M., McDonagh T., Heltweg B., Hixon J., Westman E.A., Caldwell S.D., Napper A., Curtis R., DiStefano P.S., Fields S., Bedalov A., Kennedy B.K. Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 2005, 280:17038-17045.
64. Kaga S., Zhan L., Matsumoto M., Maulik N. Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor. J. Mol. Cell. Cardiol. 2005, 39:813-822.
65. Kelly G. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: Part 1. Altern. Med. Rev. 2010, 15:245-263.
66. Kim H.B., Kim M.J., Lee S.H., Lee J.W., Bae J.H., Kim D.W., Dao T.T., Oh W.K., Kang C.D., Kim S.H. Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis. Biochem. Pharmacol. 2012, 84:402-410.
67. Kimura Y., Baba K., Okuda H. Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (part 2). Anticancer Res. 2000, 20:2923-2930.
68. Kimura Y., Sumiyoshi M., Baba K. Antitumor activities of synthetic and natural stilbenes through antiangiogenic action. Cancer Sci. 2008, 99:2083-2096.
69. Klinge C.M., Blankenship K.A., Risinger K.E., Bhatnagar S., Noisin E.L., Sumanasekera W.K., Zhao L., Brey M., Keynton R.S. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J. Biol. Chem. 2005, 280:7460-7468.
70. Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?. Eur. J. Endocrinol. 1998, 138:619-620.
71. Koubova J., Guarente L. How does calorie restriction work?. Genes Dev. 2003, 17:313-321.
72. Kovacic P., Somanathan R. Multifaceted approach to resveratrol bioactivity: focus on antioxidant action, cell signaling and safety. Oxid. Med. Cell Longev. 2010, 3:86-100.
73. Kundu J.K., Surh Y.J. Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett. 2008, 269:243-261.
74. Kunimasa K., Ohta T., Tani H., Kato E., Eguchi R., Kaji K., Ikeda K., Mori H., Mori M., Tatefuji T., Yamori Y. Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis. Mol. Nutr. Food Res. 2011, 55:1730-1734.
75. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127:1109-1122.
76. Lee S.K., Nam K.A., Hoe Y.H., Min H.Y., Kim E.Y., Ko H., Song S., Lee T., Kim S. Synthesis and evaluation of cytotoxicity of stilbene analogues. Arch Pharm. Res. 2003, 26:253-257.
77. Levi F., Pasche C., Lucchini F., Ghidoni R., Ferraroni M., La Vecchia C. Resveratrol and breast cancer risk. Eur. J. Cancer Prev. 2005, 14:139-142.
78. Li Y., Skouroumounis G.K., Elsey G.M., Taylor D.K. Microwave-assistance provides very rapid and efficient extraction of grape seed polyphenols. Food Chem. 2011, 129:570-576.
79. Lin H.Y., Tang H.Y., Davis F.B., Davis P.J. Resveratrol and apoptosis. Ann. N. Y. Acad. Sci. 2011, 1215:79-88.
80. Lin J.K., Chen P.C., Ho C.T., Lin-Shiau S.Y. Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate. J. Agric. Food Chem. 2000, 48:2736-2743.
81. Liu J.C., Chen J.J., Chan P., Cheng C.F., Cheng T.H. Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol. Hypertension 2003, 42:1198-1205.
82. Liu Z., Li Y., Yang R. Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation. Oncol. Lett. 2012, 4:837-839.
83. Llorach R., Urpi-Sarda M., Rotches-Ribalta M., Rabassa M., Andres-Lacueva C. Resveratrol From dietary intake to promising therapeutic molecule. Agro Food Ind. Hi Tec 2010, 21:42-44.
84. Maccario C., Savio M., Ferraro D., Bianchi L., Pizzala R., Pretali L., Forti L., Stivala L.A. The resveratrol analog 4,4'-dihydroxy-trans-stilbene suppresses transformation in normal mouse fibroblasts and inhibits proliferation and invasion of human breast cancer cells. Carcinogenesis 2012, 33:2172-2180.
85. Marchal J., Blanc S., Epelbaum J., Aujard F., Pifferi F. Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus. PLoS ONE 2012, 7:e34289.
86. Michishita E., Park J.Y., Burneskis J.M., Barrett J.C., Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 2005, 16:4623-4635.
87. Mikula-Pietrasik J., Kuczmarska A., Kucinska M., Murias M., Wierzchowski M., Winckiewicz M., Staniszewski R., Breborowicz A., Ksiazek K. Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8. Angiogenesis 2012, 15:361-376.
88. Miller R.A., Harrison D.E., Astle C.M., Baur J.A., Boyd A.R., de Cabo R., Fernandez E., Flurkey K., Javors M.A., Nelson J.F., Orihuela C.J., Pletcher S., Sharp Z.D., Sinclair D., Starnes J.W., Wilkinson J.E., Nadon N.L., Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 2011, 66:191-201.
89. Milne J.C., Lambert P.D., Schenk S., Carney D.P., Smith J.J., Gagne D.J., Jin L., Boss O., Perni R.B., Vu C.B., Bemis J.E., Xie R., Disch J.S., Ng P.Y., Nunes J.J., Lynch A.V., Yang H., Galonek H., Israelian K., Choy W., Iffland A., Lavu S., Medvedik O., Sinclair D.A., Olefsky J.M., Jirousek M.R., Elliott P.J., Westphal C.H. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450:712-716.
90. Montes R., Garcia-Lopez M., Rodriguez I., Cela R. Mixed-mode solid-phase extraction followed by acetylation and gas chromatography mass spectrometry for the reliable determination of trans-resveratrol in wine samples. Anal. Chim. Acta 2010, 673:47-53.
91. Moran B.W., Anderson F.P., Devery A., Cloonan S., Butler W.E., Varughese S., Draper S.M., Kenny P.T.M. Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol. Bioorgan. Med. Chem. 2009, 17:4510-4522.
92. Mukherjee S., Dudley J.I., Das D.K. Dose-dependency of resveratrol in providing health benefits. Dose Response 2010, 8:478-500.
93. Murias M., Handler N., Erker T., Pleban K., Ecker G., Saiko P., Szekeres T., Jager W. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorgan. Med. Chem. 2004, 12:5571-5578.
94. Ndiaye M., Kumar R., Ahmad N. Resveratrol in cancer management: where are we and where we go from here?. Ann. N. Y. Acad. Sci. 2011, 1215:144-149.
95. Nicholson S.K., Tucker G.A., Brameld J.M. Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. Br. J. Nutr. 2010, 103:1398-1403.
96. Nishida N., Yano H., Nishida T., Kamura T., Kojiro M. Angiogenesis in cancer. Vasc. Health Risk Manage. 2006, 2:213-219.
97. Oh W.K., Cho K.B., Hien T.T., Kim T.H., Kim H.S., Dao T.T., Han H.K., Kwon S.M., Ahn S.G., Yoon J.H., Kim T.H., Kim Y.G., Kang K.W. Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol. Pharmacol. 2010, 78:855-864.
98. Pardo A., Mespouille L., Dubois P., Duez P., Blankert B. Targeted extraction of active compounds from natural products by molecularly imprinted polymers. Cent. Eur. J. Chem. 2012, 10:751-765.
99. Paulitschke V., Schicher N., Szekeres T., Jager W., Elbling L., Riemer A.B., Scheiner O., Trimurtulu G., Venkateswarlu S., Mikula M., Swoboda A., Fiebiger E., Gerner C., Pehamberger H., Kunstfeld R. 3,3',4,4',5,5'-Hexahydroxystilbene impairs melanoma progression in a metastatic mouse model. J. Invest. Dermatol. 2010, 130:1668-1679.
100. Pearson K.J., Baur J.A., Lewis K.N., Peshkin L., Price N.L., Labinskyy N., Swindell W.R., Kamara D., Minor R.K., Perez E., Jamieson H.A., Zhang Y., Dunn S.R., Sharma K., Pleshko N., Woollett L.A., Csiszar A., Ikeno Y., Le Couteur D., Elliott P.J., Becker K.G., Navas P., Ingram D.K., Wolf N.S., Ungvari Z., Sinclair D.A., de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008, 8:157-168.
101. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004, 429:771-776.
102. Poussier B., Cordova A.C., Becquemin J.P., Sumpio B.E. Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. J. Vasc. Surg. 2005, 42:1190-1197.
103. Puntumchai A., Kittakoop P., Rajviroongit S., Vimuttipong S., Likhitwitayawuid K., Thebtaranonth Y. Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha. J. Nat. Prod. 2004, 67:485-486.
104. Raczkowska J., Mielcarz G., Howard A., Raczkowski M. UPLC and spectrophotometric analysis of polyphenols in wines available in the polish market. Int. J. Food Prop. 2011, 14:514-522.
105. Rascon B., Hubbard B.P., Sinclair D.A., Amdam G.V. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY) 2012, 4:499-508.
106. Roberti M., Pizzirani D., Simoni D., Rondanin R., Baruchello R., Bonora C., Buscemi F., Grimaudo S., Tolomeo M. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J. Med. Chem. 2003, 46:3546-3554.
107. Rodriguez-Cabo T., Rodriguez I., Cela R. Determination of hydroxylated stilbenes in wine by dispersive liquid-liquid microextraction followed by gas chromatography mass spectrometry. J. Chromatogr. A 2012, 1258:21-29.
108. Saiko P., Ozsvar-Kozma M., Bernhaus A., Jaschke M., Graser G., Lackner A., Grusch M., Horvath Z., Madlener S., Krupitza G., Handler N., Erker T., Jaeger W., Fritzer-Szekeres M., Szekeres T. N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxybenzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine. Int. J. Oncol. 2007, 31:1261-1266.
109. Scott E., Steward W.P., Gescher A.J., Brown K. Resveratrol in human cancer chemoprevention - choosing the 'right' dose. Mol. Nutr. Food Res. 2012, 56:7-13.
110. Sebastia N., Montoro A., Manes J., Soriano J.M. A preliminary study of presence of resveratrol in skins and pulps of European and Japanese plum cultivars. J. Sci. Food Agric. 2012, 92:3091-3094.
111. Shen M., Zhao L., Wu R.X., Yue S.Q., Pei J.M. The vasorelaxing effect of resveratrol on abdominal aorta from rats and its underlying mechanisms. Vascul. Pharmacol. 2012.
112. Shen T., Wang X.N., Lou H.X. Natural stilbenes: an overview. Nat. Prod. Rep. 2009, 26:916-935.
113. Signorelli P., Ghidoni R. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J. Nutr. Biochem. 2005, 16:449-466.
114. Soto M.E., Bernal J., Martin M.T., Higes M., Bernal J.L., Nozal M.J. Liquid chromatographic determination of resveratrol and piceid isomers in honey. Food Anal. Method 2012, 5:162-171.
115. Srivastava R.K., Unterman T.G., Shankar S. FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol. Mol. Cell. Biochem. 2010, 337:201-212.
116. Stagos D., Umstead T.M., Phelps D.S., Skaltsounis L., Haroutounian S., Floros J., Kouretas D. Inhibition of ozone-induced SP - a oxidation by plant polyphenols. Free Radic. Res. 2007, 41:357-366.
117. Stark T., Wollmann N., Losch S., Hofmann T. Quantitation of resveratrol in red wines by means of stable isotope dilution analysis-ultra-performance liquid chromatography-quan-time-of-flight mass spectrometry and cross validation. Anal. Chem. 2011, 83:3398-3405.
118. Stefani M., Markus M.A., Lin R.C., Pinese M., Dawes I.W., Morris B.J. The effect of resveratrol on a cell model of human aging. Ann. N. Y. Acad. Sci. 2007, 1114:407-418.
119. Stivala L.A., Savio M., Carafoli F., Perucca P., Bianchi L., Maga G., Forti L., Pagnoni U.M., Albini A., Prosperi E., Vannini V. Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. J. Biol. Chem. 2001, 276:22586-22594.
120. Szekeres T., Fritzer-Szekeres M., Saiko P., Jager W. Resveratrol and resveratrol analogues-structure-activity relationship. Pharm. Res.-Dordr. 2010, 27:1042-1048.
121. Trapp V., Parmakhtiar B., Papazian V., Willmott L., Fruehauf J.P. Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture. Angiogenesis 2010, 13:305-315.
122. Udenigwe C.C., Ramprasath V.R., Aluko R.E., Jones P.J. Potential of resveratrol in anticancer and anti-inflammatory therapy. Nutr. Rev. 2008, 66:445-454.
123. Valenzano D.R., Terzibasi E., Genade T., Cattaneo A., Domenici L., Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr. Biol. 2006, 16:296-300.
124. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. HSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001, 107:149-159.
125. Vinas P., Campillo N., Hernandez-Perez M., Hernandez-Cordoba M. A comparison of solid-phase microextraction and stir bar sorptive extraction coupled to liquid chromatography for the rapid analysis of resveratrol isomers in wines, musts and fruit juices. Anal. Chim. Acta 2008, 611:119-125.
126. Wallerath T., Deckert G., Ternes T., Anderson H., Li H., Witte K., Forstermann U. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002, 106:1652-1658.
127. Walter A., Etienne-Selloum N., Brasse D., Khallouf H., Bronner C., Rio M.C., Beretz A., Schini-Kerth V.B. Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. Faseb. J. 2010, 24:3360-3369.
128. Wang C., Wheeler C.T., Alberico T., Sun X., Seeberger J., Laslo M., Spangler E., Kern B., de Cabo R., Zou S. The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr.) 2011.
129. Wang G.Q., Chen Y.L., Han M.S., Sun L., Wang Q.A. Synthesis and biological activity of pterostilbene and 3'-methoxy pterostilbene and their glucosides derivatives. Chin. J. Org. Chem. 2011, 31:2114-2120.
130. Wang H., Zhou H.B., Zou Y.X., Liu Q.A., Guo C.H., Gao G.M., Shao C.S., Gong Y.Q. Resveratrol modulates angiogenesis through the GSK3 beta/beta-catenin/TCF-dependent pathway in human endothelial cells. Biochem. Pharmacol. 2010, 80:1386-1395.
131. Wenzel E., Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol. Nutr. Food Res. 2005, 49:472-481.
132. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004, 430:686-689.
133. Yao C.S., Lin M., Yang Q.Y. A new resveratrol trimer derivative from Gnetum brunonianum. J. Asian Nat. Prod. Res. 2012, 14:918-922.
134. Yuan H.F., Zhai C., Yan X.L., Zhao D.D., Wang J.X., Zeng Q., Chen L., Nan X., He L.J., Li S.T., Yue W., Pei X.T. SIRT1 is required for long-term growth of human mesenchymal stem cells. J. Mol. Med. (Berl.) 2012, 90:389-400.
135. 2-induced oxidative stress in human endothelial cells. Pharmacol. Rep. 2011, 63:1469-1480.
136. Zhang Q.F., Guo Y.X., Zheng G.D., Wang W.J. Chemical constituents comparison between Rhizoma Smilacis Glabrae and Rhizoma Smilacis Chinae by HPLC-DAD-MS/MS. Nat. Prod. Res. 2013, 27:277-281.
137. Zou S., Carey J.R., Liedo P., Ingram D.K., Muller H.G., Wang J.L., Yao F., Yu B., Zhou A. The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Exp. Gerontol. 2009, 44:472-476.