Cytoprotective effects of CSTMP, a novel stilbene derivative, against H2O2-induced oxidative stress in human endothelial cells

Pharmacological Reports

Volumn 63, Issue 6, 2011, Pages 1469-1480

  Zhai, Li ^a,b   Zhang, Peng ^a   Sun, Ren Yuan ^a   Liu, Xin Yong ^a   Liu, Wei Guo ^c   Guo, Xiu Li ^a  

^a SHANDONG UNIVERSITY   (China)

^b QINGDAO UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

(E) 2 (2 chlorostyryl) 3,5,6 trimethylpyrazine; Antioxidation; Apoptosis; Caspase 3; MAPK; NO; Oxidative stress

Indexed keywords

2 (2 CHLOROSTYRYL) 3,5,6 TRIMETHYLPYRAZINE; CASPASE 3; GLUTATHIONE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STILBENE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MICROVASCULAR ENDOTHELIAL CELL; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

EID: 84863181086     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(11)70711-3     Document Type: Article

References (29)

1. Berra E, Diaz-Meco MT, Moscat J: The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J Biol Chem, 1998, 273, 10792-10797. (Pubitemid 28227697)
2. Choi YJ, Jeong YJ, Lee YJ, Kwon HM, Kang YH: (-)Epigallocatechin gallate and quercetin enhance survival signaling in response to oxidant-induced human endothelial apoptosis. J Nutr, 2005, 135, 707-713.
3. Dimmeler S, Zeiher AM: Endothelial cell apoptosis in angiogenesis and vessel regression. Circ Res, 2000, 87, 434-439.
4. Dimmeler S, Zeiher AM: Nitric oxide-an endothelial cell survival factor. Cell Death Differ, 1999, 6, 964-968. (Pubitemid 29520797)
5. Dugan LL, Creedon DJ, Johnson EM Jr, Holtzman DM: Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway. Proc Natl Acad Sci USA, 1997, 94, 4086-4091. (Pubitemid 27180503)
6. Gonzalez MA, Selwyn AP: Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med, 2003, 115, Suppl 8A, 99S-106S.
7. Guo S, Bezard E, Zhao B: Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway. Free Radic Biol Med, 2005, 39, 682-695. (Pubitemid 41112109)
8. 2, role in cell survival following oxidative injury. J Biol Chem, 1996, 271, 4138-4142.
9. Haendeler J, Zeiher AM, Dimmeler S: Nitric oxide and apoptosis. Vitam Horm, 1999, 57, 49-77.
10. Heo JM, Kim HJ, Ha YM, Park MK, Kang YJ, Lee YS, Seo HG et al.: YS 51, 1- (-naphthylmethyl)-6,7- dihydroxy-1,2,3,4-tetrahydroisoquinoline, protects endothelial cells against hydrogen peroxide-induced injury via carbon monoxide derived from heme oxygenase-1. Biochem Pharmacol, 2007, 74, 1361-1370. (Pubitemid 47445447)
11. 2+transients in isolated adult rat ventricular myocytes. Vascul Pharmacol, 2003, 40, 213-217.
12. Hou YZ, Zhao GR, Yang J, Yuan YJ, Zhu GG, Hiltunen R: Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide. Life Sci, 2004, 75, 1775-1786. (Pubitemid 38961800)
13. Hu XZ, Xu Y, Hu DC, Hui Y, Yang FX: Apoptosis induction on human hepatoma cells Hep G2 of decabrominated diphenyl ether (PBDE-209). Toxicol Lett, 2007, 171, 19-28. (Pubitemid 46990665)
14. Kao TK, Ou YC, Kuo JS, Chen WY, Liao SL, Wu CW, Chen CJ et al.: Neuroprotection by tetramethylpyrazine against ischemiac brain injury in rats. Neurochem Int, 2006, 48, 166-176.
15. Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC, Walsh K: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med, 2000, 6, 1004-1010.
16. Kwon SH, Hong SI, Kim JA, Jung YH, Kim SY, Kim HC, Lee SY, Jang CG: The neuroprotective effects of Lonicera japonica THUNB against hydrogen peroxide-induced apoptosis via phosphorylation of MAPKs and PI3K/Akt in SH-SY5Y cells. Food Chem Toxicol, 2011, 49, 1011-1019.
17. Lum H, Roebuck KA: Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol, 2001, 280, C719-741.
18. Martindale JL and Holbrook NJ: Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol, 2002, 192, 1-15. (Pubitemid 34587382)
19. Petrovski G, Gurusamy N, Das DK: Resveratrol in cardiovascular health and disease. Ann NY Acad Sci, 2011, 1215, 22-33.
20. Piechota A, Polańczyk A, Gora̧ca A: Role of endothelin-1 receptor blockers on hemodynamic parameters and oxidative stress. Pharmacol Rep, 2010, 62, 28-34.
21. Rácz B, Gasz B, Borsiczky B, Gallyas Jr F, Tamás A, Józsa R, Lubics A et al.: Protective effects of pituitary adenylate cyclase activating polypeptide in endothelial cells against oxidative stress-induced apoptosis. Gen Comp Endocrinol, 2007, 153, 115-123. (Pubitemid 47103325)
22. Rössig L, Fichtlscherer B, Breitschopf K, Haendeler J, Zeiher AM, Mülsch A, Dimmeler S: Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem, 1999, 274, 6823-6826.
23. Somjen D, Knoll E, Kohen F, Stern N: Effects of phytoestrogens on DNAsynthesis and creatine kinase activity in vascular cells. Am J Hypertens, 2001, 14, 1256-1262. (Pubitemid 33151483)
24. Spasova M, Philipov S, Nikolaeva-Glomb L, Galabov AS, Milkova T: Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities. Bioorg Med Chem, 2008, 16, 7457-7461.
25. Sugawara T, Chan PH: Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal, 2003, 5, 597-607. (Pubitemid 37315148)
26. Wang B, Peng L, Zhu L, Ren P: Protective effect of total flavonoids from Spirodela polyrrhiza (L.) Schleid on human umbilical vein endothelial cell damage induced by hydrogen peroxide. Colloids Surf B Biointerfaces, 2007, 60, 36-40. (Pubitemid 47302293)
27. Yamagishi S, Nakamura K, Matsui T: Role of oxidative stress in the development of vascular injury and its therapeutic intervention by nifedipine. Curr Med Chem, 2008, 15, 172-177. (Pubitemid 351234620)
28. Ye Y, Wang S, Jiang J: Studies on the metabolites of tetramethylpyrazine in human urine. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 1996, 18, 288-291.
29. Yu J, Eto M, Kozaki K, Akishita M, Okabe T, Ouchi Y: Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway. Eur J Pharmacol, 2008, 589, 32-36.