Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Gerhardt, Ellen ^a   Gräber, Simone ^b   Szego, Éva M ^a   Moisoi, Nicoleta ^c   Martins, L Miguel ^c   Outeiro, Tiago F ^a   Kermer, Pawel ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IDEBENONE; PROTEIN BAX; RESVERATROL; SERINE PROTEINASE OMI; DDIT3 PROTEIN, MOUSE; DRUG DERIVATIVE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOCHONDRIAL PROTEIN; SERINE PROTEINASE; STILBENE DERIVATIVE; UBIQUINONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; CONTROLLED STUDY; CORPUS STRIATUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG MECHANISM; FEMALE; GENE SILENCING; KNOCKOUT MOUSE; LIFESPAN; MALE; MOTOR PERFORMANCE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; STRESS; ANIMAL; CELL COUNT; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; LONGEVITY; METABOLISM; MOTOR ACTIVITY; NEOSTRIATUM; OXIDATIVE STRESS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL COUNT; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; LONGEVITY; MICE; MITOCHONDRIAL PROTEINS; MOTOR ACTIVITY; NEOSTRIATUM; OXIDATIVE STRESS; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; STILBENES; TRANSCRIPTION FACTOR CHOP; UBIQUINONE;

EID: 83655183720     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028855     Document Type: Article

References (41)

1. Bueler H, (2009) Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Exp Neurol 218: 235-246.
2. Kieper N, Holmstrom KM, Ciceri D, Fiesel FC, Wolburg H, et al. (2010) Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Exp Cell Res 316: 1213-1224.
3. Branco DM, Arduino DM, Esteves AR, Silva DF, Cardoso SM, et al. (2010) Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis. Front Aging Neurosci 2: 17.
4. Torii H, Yoshida K, Kobayashi T, Tsukamoto T, Tanayama S, (1985) Disposition of idebenone (CV-2619), a new cerebral metabolism improving agent, in rats and dogs. J Pharmacobiodyn 8: 457-467.
5. Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol 24: 9848-9862.
6. Moisoi N, Klupsch K, Fedele V, East P, Sharma S, et al. (2009) Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death Differ 16: 449-464.
7. Kruger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, et al. (2011) A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Neurobiol Aging 32: 548 e549-518.
8. Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, et al. (2003) Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 425: 721-727.
9. Geromel V, Darin N, Chretien D, Benit P, DeLonlay P, et al. (2002) Coenzyme Q(10) and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits. Mol Genet Metab 77: 21-30.
10. de la Lastra CA, Villegas I, (2005) Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 49: 405-430.
11. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
12. Grieb P, Ryba MS, Debicki GS, Gordon-Krajcer W, Januszewski S, et al. (1998) Changes in oxidative stress in the rat brain during post-cardiac arrest reperfusion, and the effect of treatment with the free radical scavenger idebenone. Resuscitation 39: 107-113.
13. Quincozes-Santos A, Gottfried C, (2011) Resveratrol modulates astroglial functions: neuroprotective hypothesis. Ann N Y Acad Sci 1215: 72-78.
14. Becker C, Bray-French K, Drewe J, (2010) Pharmacokinetic evaluation of idebenone. Expert Opin Drug Metab Toxicol 6: 1437-1444.
15. Tillerson JL, Miller GW, (2003) Grid performance test to measure behavioral impairment in the MPTP-treated-mouse model of parkinsonism. J Neurosci Methods 123: 189-200.
16. Szego{double acute} ÉM, Barabas K, Balog J, Szilagyi N, Korach KS, et al. (2006) Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo. J Neurosci 26: 4104-4110.
17. Paxinos G, Franklin KBJ, (2001) The mouse brain in stereotaxic coordinates San Diego Academic Press.
18. Szego{double acute} ÉM, Gerhardt E, Outeiro TF, Kermer P, (2011) Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice. J Neurol Sci.
19. Kowsky S, Poppelmeyer C, Kramer ER, Falkenburger BH, Kruse A, et al. (2007) RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals. Proc Natl Acad Sci U S A 104: 20049-20054.
20. Szegezdi E, Logue SE, Gorman AM, Samali A, (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7: 880-885.
21. Ron D, (2002) Translational control in the endoplasmic reticulum stress response. J Clin Invest 110: 1383-1388.
22. Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S, (2006) 3,3′-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis 27: 717-728.
23. Yamaguchi H, Wang HG, (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279: 45495-45502.
24. Yoshida T, Shiraishi T, Nakata S, Horinaka M, Wakada M, et al. (2005) Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein. Cancer Res 65: 5662-5667.
25. Li B, Hu Q, Wang H, Man N, Ren H, et al. (2010) Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death Differ 17: 1773-1784.
26. Fulda S, Debatin KM, (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25: 4798-4811.
27. MacFarlane M, Williams AC, (2004) Apoptosis and disease: a life or death decision. EMBO Rep 5: 674-678.
28. Oyadomari S, Mori M, (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389.
29. Myers L, Farmer JM, Wilson RB, Friedman L, Tsou A, et al. (2008) Antioxidant use in Friedreich ataxia. J Neurol Sci 267: 174-176.
30. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, et al. (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 1053-1058.
31. Roth W, Kermer P, Krajewska M, Welsh K, Davis S, et al. (2003) Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways. Cell Death Differ 10: 1178-1187.
32. Ashkenazi A, (2002) Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer 2: 420-430.
33. Gonzalvez F, Ashkenazi A, (2010) New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29: 4752-4765.
34. Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, et al. (2001) BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8: 705-711.
35. Mukherjee S, Dudley JI, Das DK, (2010) Dose-dependency of resveratrol in providing health benefits. Dose Response 8: 478-500.
36. Lu KT, Ko MC, Chen BY, Huang JC, Hsieh CW, et al. (2008) Neuroprotective effects of resveratrol on MPTP-induced neuron loss mediated by free radical scavenging. J Agric Food Chem 56: 6910-6913.
37. Kapetanovic IM, Muzzio M, Huang Z, Thompson TN, McCormick DL, (2010) Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother Pharmacol.
38. Long J, Gao H, Sun L, Liu J, Zhao-Wilson X, (2009) Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Res 12: 321-331.
39. Kelly G, (2010) A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1. Altern Med Rev 15: 245-263.
40. Anekonda TS, Adamus G, (2008) Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70. BMC Res Notes 1: 122.
41. Schulz JB, Weller M, Klockgether T, (1996) Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species. J Neurosci 16: 4696-4706.