-
1
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
Baur, J. A. and Sinclair, D. A. (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5, 493-506
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
2
-
-
0031561513
-
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
-
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W., Fong, H. H., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G. et al. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218-220
-
(1997)
Science
, vol.275
, pp. 218-220
-
-
Jang, M.1
Cai, L.2
Udeani, G.O.3
Slowing, K.V.4
Thomas, C.F.5
Beecher, C.W.6
Fong, H.H.7
Farnsworth, N.R.8
Kinghorn, A.D.9
Mehta, R.G.10
-
3
-
-
33750839605
-
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells
-
Sexton, E., Van Themsche, C., LeBlanc, K., Parent, S., Lemoine, P. and Asselin, E. (2006) Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol. Cancer 5, 45
-
(2006)
Mol. Cancer
, vol.5
, pp. 45
-
-
Sexton, E.1
Van Themsche, C.2
LeBlanc, K.3
Parent, S.4
Lemoine, P.5
Asselin, E.6
-
4
-
-
33749991874
-
Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas
-
Faber, A. C., Dufort, F. J., Blair, D., Wagner, D., Roberts, M. F. and Chiles, T. C. (2006) Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas. Biochem. Pharmacol. 72, 1246-1256
-
(2006)
Biochem. Pharmacol
, vol.72
, pp. 1246-1256
-
-
Faber, A.C.1
Dufort, F.J.2
Blair, D.3
Wagner, D.4
Roberts, M.F.5
Chiles, T.C.6
-
5
-
-
33745654084
-
SIRT1 and endocrine signaling
-
Yang, T., Fu, M., Pestell, R. and Sauve, A. A. (2006) SIRT1 and endocrine signaling. Trends Endocrinol. Metab. 17, 186-191
-
(2006)
Trends Endocrinol. Metab
, vol.17
, pp. 186-191
-
-
Yang, T.1
Fu, M.2
Pestell, R.3
Sauve, A.A.4
-
6
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri, H., Dessain, S. K., Ng Eaton, E., Imai, S. I., Frye, R. A., Pandita, T. K., Guarente, L. and Weinberg, R. A. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
7
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y. et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
-
8
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente, L. and Kenyon, C. (2000) Genetic pathways that regulate ageing in model organisms. Nature 408, 255-262
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
9
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L. et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.L.10
-
10
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M. and Sinclair, D. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-289
-
(2004)
Nature
, vol.430
, pp. 686-289
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
Helfand, S.L.5
Tatar, M.6
Sinclair, D.7
-
11
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K. et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
-
12
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
-
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P. et al. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127, 1109-1122
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
-
13
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S. et al. (2005) Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280, 17038-17045
-
(2005)
J. Biol. Chem
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
McDonagh, T.2
Heltweg, B.3
Hixon, J.4
Westman, E.A.5
Caldwell, S.D.6
Napper, A.7
Curtis, R.8
DiStefano, P.S.9
Fields, S.10
-
14
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
Borra, M. T., Smith, B. C. and Denu, J. M. (2005) Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 280, 17187-17195
-
(2005)
J. Biol. Chem
, vol.280
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
15
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
Kaeberlein, M., Powers, III, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S. and Kennedy, B. K. (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients Science 310, 1193-1196
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers III, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
16
-
-
0035853552
-
Regulation of longevity and stress resistance by Sch9 in yeast
-
Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M. and Longo, V. D. (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-290
-
(2001)
Science
, vol.292
, pp. 288-290
-
-
Fabrizio, P.1
Pozza, F.2
Pletcher, S.D.3
Gendron, C.M.4
Longo, V.D.5
-
17
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Geloen, A., Even, P. C., Cervera, P. and Le Bouc, Y. (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Geloen, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
18
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Bluher, M., Kahn, B. B. and Kahn, C. R. (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
19
-
-
33744976074
-
-
Berdichevsky, A., Viswanathan, M., Horvitz, H. R. and Guarente, L. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177
-
Berdichevsky, A., Viswanathan, M., Horvitz, H. R. and Guarente, L. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177
-
-
-
-
20
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
-
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M. and Puigserver, P. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
21
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
-
Picard, F., Kurtev, M., Chung, N., Topark-Ngarm, A., Senawong, T., Machado De Oliveira, R., Leid, M., McBurney, M. W. and Guarente, L. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature 429, 771-776
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
22
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
-
Bordone, L., Motta, M. C., Picard, F., Robinson, A., Jhala, U. S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A. et al. (2006) Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells. PLoS Biol. 4, e31
-
(2006)
PLoS Biol
, vol.4
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
Robinson, A.4
Jhala, U.S.5
Apfeld, J.6
McDonagh, T.7
Lemieux, M.8
McBurney, M.9
Szilvasi, A.10
-
23
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan, K. A., Grimm, A. A., Plueger, M. M., Bemal-Mizrachi, E., Ford, E., Cras-Meneur, C., Permutt, M. A. and Imai, S. (2005) Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2, 105-117
-
(2005)
Cell Metab
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
Plueger, M.M.3
Bemal-Mizrachi, E.4
Ford, E.5
Cras-Meneur, C.6
Permutt, M.A.7
Imai, S.8
-
24
-
-
0042734621
-
Phosphoinositide 3-kinase signalling - which way to target?
-
Wymann, M. P., Zvelebil, M. and Laffargue, M. (2003) Phosphoinositide 3-kinase signalling - which way to target? Trends Pharmacol. Sci. 24, 366-376
-
(2003)
Trends Pharmacol. Sci
, vol.24
, pp. 366-376
-
-
Wymann, M.P.1
Zvelebil, M.2
Laffargue, M.3
-
25
-
-
0034653608
-
The PI3K-PDK1 connection: More than just a road to PKB
-
Vanhaesebroeck, B. and Alessi, D. R. (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J. 346, 561-576
-
(2000)
Biochem. J
, vol.346
, pp. 561-576
-
-
Vanhaesebroeck, B.1
Alessi, D.R.2
-
26
-
-
0038521284
-
Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells
-
Pirola, L., Bonnafous, S., Johnston, A. M., Chaussade, C., Portis, F. and Van Obberghen, E. (2003) Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells J. Biol. Chem. 278, 15641-15651
-
(2003)
J. Biol. Chem
, vol.278
, pp. 15641-15651
-
-
Pirola, L.1
Bonnafous, S.2
Johnston, A.M.3
Chaussade, C.4
Portis, F.5
Van Obberghen, E.6
-
27
-
-
0029965452
-
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
-
Wymann, M. P., Bulgarelli-Leva, G., Zvelebil, M. J., Pirola, L., Vanhaesebroeck, B., Waterfield, M. D. and Panayotou, G. (1996) Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol. Cell. Biol. 16, 1722-1733
-
(1996)
Mol. Cell. Biol
, vol.16
, pp. 1722-1733
-
-
Wymann, M.P.1
Bulgarelli-Leva, G.2
Zvelebil, M.J.3
Pirola, L.4
Vanhaesebroeck, B.5
Waterfield, M.D.6
Panayotou, G.7
-
28
-
-
0037501368
-
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ
-
Czupalla, C., Culo, M., Muller, E. C., Brock, C., Reusch, H. P., Spicher, K., Krause, E. and Nurnberg, B. (2003) Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms β and γ. J. Biol. Chem. 278, 11536-11545
-
(2003)
J. Biol. Chem
, vol.278
, pp. 11536-11545
-
-
Czupalla, C.1
Culo, M.2
Muller, E.C.3
Brock, C.4
Reusch, H.P.5
Spicher, K.6
Krause, E.7
Nurnberg, B.8
-
29
-
-
0032500730
-
Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK
-
Bondeva, T., Pirola, L., Bulgarelli-Leva, G., Rubio, I., Wetzker, R. and Wymann, M. P. (1998) Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK. Science 282, 293-296
-
(1998)
Science
, vol.282
, pp. 293-296
-
-
Bondeva, T.1
Pirola, L.2
Bulgarelli-Leva, G.3
Rubio, I.4
Wetzker, R.5
Wymann, M.P.6
-
30
-
-
0033607647
-
A phosphatidylinositol 3-kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85α regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells
-
Roques, M. and Vidal, H. (1999) A phosphatidylinositol 3-kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85α regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells. J. Biol. Chem. 274, 34005-34010
-
(1999)
J. Biol. Chem
, vol.274
, pp. 34005-34010
-
-
Roques, M.1
Vidal, H.2
-
31
-
-
0034967147
-
Construction of stable coxsackievirus and adenovirus receptor-expressing 3T3-L1 cells
-
Orlicky, D. J., DeGregori, J. and Schaack, J. (2001) Construction of stable coxsackievirus and adenovirus receptor-expressing 3T3-L1 cells. J. Lipid Res. 42, 910-915
-
(2001)
J. Lipid Res
, vol.42
, pp. 910-915
-
-
Orlicky, D.J.1
DeGregori, J.2
Schaack, J.3
-
32
-
-
0030748457
-
The insulin signalling system and the IRS proteins
-
White, M. F. (1997) The insulin signalling system and the IRS proteins. Diabetologia 40, S2-S17
-
(1997)
Diabetologia
, vol.40
-
-
White, M.F.1
-
33
-
-
0036270751
-
Regulated transport of the glucose transporter GLUT4
-
Bryant, N. J., Govers, R. and James, D. E. (2002) Regulated transport of the glucose transporter GLUT4. Nat. Rev. Mol. Cell Biol. 3, 267-277
-
(2002)
Nat. Rev. Mol. Cell Biol
, vol.3
, pp. 267-277
-
-
Bryant, N.J.1
Govers, R.2
James, D.E.3
-
34
-
-
0035089064
-
Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells
-
Park, J. B. (2001) Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells. J. Nat. Prod. 64, 381-384
-
(2001)
J. Nat. Prod
, vol.64
, pp. 381-384
-
-
Park, J.B.1
-
35
-
-
0031594188
-
14-3-3β protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3′-kinase activity in 3T3L1 adipocytes
-
Kosaki, A., Yamada, K., Suga, J., Otaka, A. and Kuzuya, H. (1998) 14-3-3β protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3′-kinase activity in 3T3L1 adipocytes. J. Biol. Chem. 273, 940-944
-
(1998)
J. Biol. Chem
, vol.273
, pp. 940-944
-
-
Kosaki, A.1
Yamada, K.2
Suga, J.3
Otaka, A.4
Kuzuya, H.5
-
36
-
-
15444344415
-
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain
-
Ogihara, T., Isobe, T., Ichimura, T., Taoka, M., Funaki, M., Sakoda, H., Onishi, Y., Inukai, K., Anai, M., Fukushima, Y. et al. (1997) 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. J. Biol. Chem. 272, 25267-25274
-
(1997)
J. Biol. Chem
, vol.272
, pp. 25267-25274
-
-
Ogihara, T.1
Isobe, T.2
Ichimura, T.3
Taoka, M.4
Funaki, M.5
Sakoda, H.6
Onishi, Y.7
Inukai, K.8
Anai, M.9
Fukushima, Y.10
-
37
-
-
0027953284
-
PI3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity
-
Dhand, R., Hiles, I., Panayotou, G., Roche, S., Fry, M. J., Gout, I., Totty, N. F., Truong, O., Vicendo, P., Yonezawa, K. et al. (1994) PI3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J. 13, 522-533
-
(1994)
EMBO J
, vol.13
, pp. 522-533
-
-
Dhand, R.1
Hiles, I.2
Panayotou, G.3
Roche, S.4
Fry, M.J.5
Gout, I.6
Totty, N.F.7
Truong, O.8
Vicendo, P.9
Yonezawa, K.10
-
38
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl- 4H-1-benzopyran-4-one (LY294002)
-
Vlahos, C. J., Matter, W. F., Hui, K. Y. and Brown, R. F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl- 4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241-5248
-
(1994)
J. Biol. Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
39
-
-
33746228121
-
Sirtuins in aging and age-related disease
-
Longo, V. D. and Kennedy, B. K. (2006) Sirtuins in aging and age-related disease. Cell 126, 257-268
-
(2006)
Cell
, vol.126
, pp. 257-268
-
-
Longo, V.D.1
Kennedy, B.K.2
-
40
-
-
31944450272
-
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
-
Valenzano, D. R., Terzibasi, E., Genade, T., Cattaneo, A., Domenici, L. and Cellerino, A. (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr. Biol. 16, 296-300
-
(2006)
Curr. Biol
, vol.16
, pp. 296-300
-
-
Valenzano, D.R.1
Terzibasi, E.2
Genade, T.3
Cattaneo, A.4
Domenici, L.5
Cellerino, A.6
-
41
-
-
5144223780
-
Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets
-
Kundu, J. K. and Surh, Y. J. (2004) Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets. Mutat, Res. 555, 65-80
-
(2004)
Mutat, Res
, vol.555
, pp. 65-80
-
-
Kundu, J.K.1
Surh, Y.J.2
-
42
-
-
33746862126
-
Resveratrol inhibits insulin responses in a SirT1-independent pathway
-
Zhang, J. (2006) Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem. J. 397, 519-527
-
(2006)
Biochem. J
, vol.397
, pp. 519-527
-
-
Zhang, J.1
-
43
-
-
0022249093
-
Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin
-
Srivastava, A. K. (1985) Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin. Biochem. Biophys. Res. Commun. 131, 1-5
-
(1985)
Biochem. Biophys. Res. Commun
, vol.131
, pp. 1-5
-
-
Srivastava, A.K.1
-
44
-
-
0033634827
-
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
-
Walker, E. H., Pacold, M. E., Perisic, O., Stephens, L., Hawkins, P. T., Wymann, M. P. and Williams, R. L. (2000) Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol. Cell 6, 909-919
-
(2000)
Mol. Cell
, vol.6
, pp. 909-919
-
-
Walker, E.H.1
Pacold, M.E.2
Perisic, O.3
Stephens, L.4
Hawkins, P.T.5
Wymann, M.P.6
Williams, R.L.7
-
45
-
-
0031034930
-
-
Sicheri, F., Moarefi, I. and Kuriyan, J. (1997) Crystal structure of the Src family tyrosine kinase Hck. Nature 385, 602-609
-
Sicheri, F., Moarefi, I. and Kuriyan, J. (1997) Crystal structure of the Src family tyrosine kinase Hck. Nature 385, 602-609
-
-
-
-
46
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy, B. T., Smith, D. L., Ram, P. T., Lu, Y. and Mills, G. B. (2005) Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 4, 988-1004
-
(2005)
Nat. Rev. Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
47
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
-
Knight, Z. A., Gonzalez, B., Feldman, M. E., Zunder, E. R., Goldenberg, D. D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B. et al. (2006) A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125, 733-747
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
Zunder, E.R.4
Goldenberg, D.D.5
Williams, O.6
Loewith, R.7
Stokoe, D.8
Balla, A.9
Toth, B.10
-
48
-
-
21044454703
-
PI3-kinase p110β: A new target for antithrombotic therapy
-
Jackson, S. P., Schoenwaelder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L., Wright, C. E., Kenche, V., Anderson, K. E., Dopheide, S. M., Yuan, Y. et al. (2005) PI3-kinase p110β: a new target for antithrombotic therapy. Nat. Med. 11, 507-514
-
(2005)
Nat. Med
, vol.11
, pp. 507-514
-
-
Jackson, S.P.1
Schoenwaelder, S.M.2
Goncalves, I.3
Nesbitt, W.S.4
Yap, C.L.5
Wright, C.E.6
Kenche, V.7
Anderson, K.E.8
Dopheide, S.M.9
Yuan, Y.10
-
49
-
-
24744435115
-
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
Camps, M., Ruckle, T., Ji, H., Ardissone, V., Rintelen, F., Shaw, J., Ferrandi, C., Chabert, C., Gillieron, C., Francon, B. et al. (2005) Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat. Med. 11, 936-943
-
(2005)
Nat. Med
, vol.11
, pp. 936-943
-
-
Camps, M.1
Ruckle, T.2
Ji, H.3
Ardissone, V.4
Rintelen, F.5
Shaw, J.6
Ferrandi, C.7
Chabert, C.8
Gillieron, C.9
Francon, B.10
|