Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1

Cell Biochemistry and Biophysics

Volumn 44, Issue 1, 2006, Pages 43-49

  Fukuda, Shoji ^a   Kaga, Shigeaki ^a   Zhan, Lijun ^a   Bagchi, Debasis ^b   Das, Dipak K ^a   Bertelli, Aldo ^c   Maulik, Nilanjana ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b InterHealth Nutraceuticals Inc   (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Angiogenesis; eNOS; Flk 1; iNOS; Myocardium; Resveratrol; VEGF

Indexed keywords

RATTUS;

EID: 30744441162     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/cbb:44:1:043     Document Type: Article

References (28)

1. Criqui, M. H. and Ringel, B. L. (1994) Does diet or alcohol explain the French paradox? Lancet 344, 1719-1723.
2. Goldberg, D. M., Tsang, E., Karumanchiri, A., Diamandis, E., Soleas, G., and Ng, E. (1996) Method to assay the concentrations of phenolic constituents of biological interest in wines. Anal. Chem. 68, 1688-1694.
3. Gonzalez-Candelas, L., Gil, J. V., Lamuela-Raventos, R. M., and Ramon, D. (2000) The use of transgenic yeasts expressing a gene encoding a glycosyl-hydrolase as a tool to increase resveratrol content in wine. Int. J. Food Microbiol. 59, 179-183.
4. Ray, P. S., Maulik, G., Cordis, G. A., Bertelli, A. A., Bertelli, A., and Das, D. K. (1999) The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radic. Biol. Med. 27, 160-169.
5. Hattori, R., Otani, H., Maulik, N., and Das, D. K. (2002) Pharmacological preconditioning with resveratrol: role of nitric oxide. Am. J. Physiol. 282, H1988-H1995.
6. Parenti, A., Morbidelli, L., Cui, X. L., et al. (1998) Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J. Biol. Chem. 273, 4220-4226.
7. Morbidelli, L., Chang, C. H., Douglas, J. G., Granger, H. J., Ledda, F., and Ziche, M. (1996) Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am. J. Physiol. 270, H411-H415.
8. Ziche, M., Morbidelli, L., Choudhuri, R., et al. (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Investig. 99, 2625-2634.
9. Maruyama, K., Mori, Y., Murasawa, S., et al. (1999) Interleukin-1 β upregulates cardiac expression of vascular endothelial growth factor and its receptor KDR/flk-1 via activation of protein tyrosine kinases. J. Mol. Cell. Cardiol. 31, 607-617.
10. Banai, S., Shweiki, D., Pinson, A., Chandra, M., Lazarovici, G., and Keshet, E. (1994) Upregulation of vascular endothelial growth factor expression induced by myocardial ischemia: implication for coronary angiogenesis. Cardiovasc. Res. 28, 1176-1179.
11. Hashimoto, E., Ogita, T., Nakaoka, T., Matsuoka, R., Takao, A., and Kira, Y. (1994) Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am. J. Physiol. 267, H1948-H1954.
12. Fukuda, S., Kaga, S., Sasaki, H., et al. (2004) Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction. J. Mol. Cell. Cardiol. 36, 547-559.
13. Sasaki, H., Fukuda, S., Otani, H., et al. (2002) Hypoxic preconditioning triggers myocardial angiogenesis: a novel approach to enhance contractile functional reserve in rat with myocardial infarction. J. Mol. Cell. Cardiol. 34, 335-348.
14. Zhu, L., Fukuda, S., Cordis, G., Das, D. K., and Maulik, N. (2001) Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett. 508, 369-374.
15. Sasaki, H., Ray, P. S., Zhu, L., Otani, H., Asahara, T., and Maulik, N. (2001) Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF κB-dependent mechanism in a rat model of chronic myocardial infarction. J. Mol. Cell. Cardiol. 33, 283-294.
16. Kelly, R. A., Balligand, J. L., and Smith, T. W. (1996) Nitric oxisde and cardiac function. Circ. Res. 79, 363-380.
17. Wildhirt, S. M., Suzuki, H., Horstman, D., et al. (1997) Selective modulation of inducible nitric oxide synthase isozyme in myocardial infarction. Circulation 96, 1616-1623.
18. Gaballa, M. A., Raya, T. E., Hoover, C. A., and Goldman, S. (1999) Effects of endothelial and inducible nitric oxide syntheses inhibition on circulatory function in rats after myocardial infarction. Cardiovasc. Res. 42, 627-635.
19. Rossig, L., Haendeler, J., Hermann, C., et al. (2000) Nitric oxide down-regulates MKP-3 mRNA levels: involvement in endothelial cell protection from apoptosis. J. Biol. Chem. 275, 25,502-25,507.
20. Dimmeler, S., Haendeler, J., Nehls, M., and Zeiher, A. M. (1997) Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β- converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J. Exp. Med. 185, 601-607.
21. van der Zee, R., Murohara, T., Luo, Z., et al. (1997) Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95, 1030-1037.
22. Papapetropoulos, A., Garcia-Cardena, G., Madri, J. A., and Sessa, W. C. (1997) Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J. Clin. Investig. 100, 3131-3139.
23. Le Cras, T. D., Xue, C., Rengasamy, A., and Johns, R. A. (1996) Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol. 270, L164-L170.
24. Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C. H. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269, 26,988-26,995.
25. Kroll, J., and Waltenberger, J. (1998) VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem. Biophys. Res. Commun. 252, 743-746.
26. Bussolati, B., Dunk, C., Grohman, M., Kontos, C. D., Mason, J., and Ahmed, A. (2001) Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide. Am. J. Pathol. 159, 993-1008.
27. Zhuang, H., Kim, Y. S., Koehler, R. C., and Dore, S. (2003) Potential mechanism by which resveratrol, a red wine constituent, protects neurons. Ann. N.Y. Acad. Sci. 993, 276-278.
28. Juan, S. H., Cheng, T. H., Lin, H. C., Chu, Y. L., and Lee, W. S. (2005) Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells. Biochem. Pharmacol. 69, 41-48.