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Volumn 48, Issue 3, 2013, Pages 883-903

Coenzyme Q10 depletion in medical and neuropsychiatric disorders: Potential repercussions and therapeutic implications

Author keywords

Coenzyme Q10; Cytokines; Inflammation; Mitochondria; Oxidative and nitrosative stress

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; 8 HYDROXYDEOXYGUANOSINE; ALPHA TOCOPHEROL; AMITRIPTYLINE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOPROSTANE DERIVATIVE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UBIDECARENONE; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; ZINC;

EID: 84888206003     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8477-8     Document Type: Review
Times cited : (95)

References (337)
  • 3
    • 33746848052 scopus 로고    scopus 로고
    • Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: A randomised trial
    • 16872244 1:CAS:528:DC%2BD28XhtVWksL%2FE
    • Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, Gouni-Berthold I (2006) Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 29(8):703-712
    • (2006) Drug Saf , vol.29 , Issue.8 , pp. 703-712
    • Berthold, H.K.1    Naini, A.2    Di Mauro, S.3    Hallikainen, M.4    Gylling, H.5    Krone, W.6    Gouni-Berthold, I.7
  • 4
    • 35848963373 scopus 로고    scopus 로고
    • Bioenergetic and antioxidant properties of coenzyme Q10: Recent developments
    • 17914161 1:CAS:528:DC%2BD2sXhtVais7%2FJ
    • Littarru GP, Tiano L (2007) Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 37(1):31-37
    • (2007) Mol Biotechnol , vol.37 , Issue.1 , pp. 31-37
    • Littarru, G.P.1    Tiano, L.2
  • 5
    • 33645854921 scopus 로고    scopus 로고
    • Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: A double-blind, randomized, placebo-controlled trial
    • 16431002 1:CAS:528:DC%2BD28XjtFaiu78%3D
    • Ikematsu H, Nakamura K, Harashima S, Fujii K, Fukutomi N (2006) Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 44(3):212-218
    • (2006) Regul Toxicol Pharmacol , vol.44 , Issue.3 , pp. 212-218
    • Ikematsu, H.1    Nakamura, K.2    Harashima, S.3    Fujii, K.4    Fukutomi, N.5
  • 6
    • 58149387526 scopus 로고    scopus 로고
    • The evolution of coenzyme Q
    • 19096095 1:CAS:528:DC%2BD1cXhsV2iur3L
    • Crane FL (2008) The evolution of coenzyme Q. Biofactors 32(1-4):5-11
    • (2008) Biofactors , vol.32 , Issue.1-4 , pp. 5-11
    • Crane, F.L.1
  • 7
    • 1342265414 scopus 로고    scopus 로고
    • Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver
    • 15036389
    • De Cabo R, Cabello R, Rios M, López-Lluch G, Ingram DK, Lane MA, Navas P (2004) Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver. Exp Gerontol 39(3):297-304
    • (2004) Exp Gerontol , vol.39 , Issue.3 , pp. 297-304
    • De Cabo, R.1    Cabello, R.2    Rios, M.3    López-Lluch, G.4    Ingram, D.K.5    Lane, M.A.6    Navas, P.7
  • 8
    • 0029083107 scopus 로고
    • A phospholipid-dependent NADH-coenzyme Q reductase from liver plasma membrane
    • 7611997 1:CAS:528:DyaK2MXmslemtb4%3D
    • Navarro F, Villalba JM, Crane FL, Mackellar WC, Navas P (1995) A phospholipid-dependent NADH-coenzyme Q reductase from liver plasma membrane. Biochem Biophys Res Commun 212(1):138-143
    • (1995) Biochem Biophys Res Commun , vol.212 , Issue.1 , pp. 138-143
    • Navarro, F.1    Villalba, J.M.2    Crane, F.L.3    Mackellar, W.C.4    Navas, P.5
  • 9
    • 0032555066 scopus 로고    scopus 로고
    • Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
    • 9671775 1:CAS:528:DyaK1cXkvFalt7s%3D
    • Matthews RT, Yang L, Browne S, Baik M, Beal MF (1998) Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A 95(15):8892-8897
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.15 , pp. 8892-8897
    • Matthews, R.T.1    Yang, L.2    Browne, S.3    Baik, M.4    Beal, M.F.5
  • 10
    • 0035667921 scopus 로고    scopus 로고
    • Biochemical functions of coenzyme Q10
    • 11771674 1:CAS:528:DC%2BD38XmvVKqtA%3D%3D
    • Crane FL (2001) Biochemical functions of coenzyme Q10. J Am Coll Nutr 20(6):591-598
    • (2001) J Am Coll Nutr , vol.20 , Issue.6 , pp. 591-598
    • Crane, F.L.1
  • 11
    • 67849094517 scopus 로고    scopus 로고
    • Qualitative electron microscopic analysis of cultured chick embryonic cardiac and skeletal muscle cells: The cellular effect of coenzyme q10 after exposure to triton x-100
    • 19479649
    • Potgieter M, Pretorius E, Oberholzer HM (2009) Qualitative electron microscopic analysis of cultured chick embryonic cardiac and skeletal muscle cells: the cellular effect of coenzyme q10 after exposure to triton x-100. Ultrastruct Pathol 33(3):93-101
    • (2009) Ultrastruct Pathol , vol.33 , Issue.3 , pp. 93-101
    • Potgieter, M.1    Pretorius, E.2    Oberholzer, H.M.3
  • 12
    • 58149387518 scopus 로고    scopus 로고
    • Functions of coenzyme Q10 in inflammation and gene expression
    • 19096114 1:CAS:528:DC%2BD1cXhsV2iur3J
    • Schmelzer C, Lindner I, Rimbach G, Niklowitz P, Menke T, Doring F (2008) Functions of coenzyme Q10 in inflammation and gene expression. Biofactors 32(1-4):179-183
    • (2008) Biofactors , vol.32 , Issue.1-4 , pp. 179-183
    • Schmelzer, C.1    Lindner, I.2    Rimbach, G.3    Niklowitz, P.4    Menke, T.5    Doring, F.6
  • 13
    • 77952300148 scopus 로고    scopus 로고
    • Coenzyme Q - Biosynthesis and functions
    • 20494114 1:CAS:528:DC%2BC3cXmsVGlsLY%3D
    • Bentinger M, Tekle M, Dallner G (2010) Coenzyme Q - biosynthesis and functions. Biochem Biophys Res Commun 396(1):74-79
    • (2010) Biochem Biophys Res Commun , vol.396 , Issue.1 , pp. 74-79
    • Bentinger, M.1    Tekle, M.2    Dallner, G.3
  • 14
    • 15044348677 scopus 로고    scopus 로고
    • Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells
    • 15778085 1:CAS:528:DC%2BD2MXitlChtb0%3D
    • Groneberg DA, Kindermann B, Althammer M, Klapper M, Vormann J, Littarru GP, Döring F (2005) Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Int J Biochem Cell Biol 37(6):1208-1218
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.6 , pp. 1208-1218
    • Groneberg, D.A.1    Kindermann, B.2    Althammer, M.3    Klapper, M.4    Vormann, J.5    Littarru, G.P.6    Döring, F.7
  • 15
    • 77955751471 scopus 로고    scopus 로고
    • Identification of LPS-inducible genes downregulated by ubiquinone in human THP-1 monocytes
    • 20533395 1:CAS:528:DC%2BC3cXht1entrnM
    • Schmelzer C, Döring F (2010) Identification of LPS-inducible genes downregulated by ubiquinone in human THP-1 monocytes. Biofactors 36(3):222-228
    • (2010) Biofactors , vol.36 , Issue.3 , pp. 222-228
    • Schmelzer, C.1    Döring, F.2
  • 16
    • 1642588198 scopus 로고    scopus 로고
    • The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice
    • 15059645 1:CAS:528:DC%2BD2cXis1Wnsbc%3D
    • Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA (2004) The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med 36(8):1043-1057
    • (2004) Free Radic Biol Med , vol.36 , Issue.8 , pp. 1043-1057
    • Lee, C.K.1    Pugh, T.D.2    Klopp, R.G.3    Edwards, J.4    Allison, D.B.5    Weindruch, R.6    Prolla, T.A.7
  • 17
    • 77954685883 scopus 로고    scopus 로고
    • Coenzyme Q10: A therapy for hypertension and statin-induced myalgia?
    • 20601617
    • Wyman M, Leonard M, Morledge T (2010) Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? Cleve Clin J Med 77(7):435-442
    • (2010) Cleve Clin J Med , vol.77 , Issue.7 , pp. 435-442
    • Wyman, M.1    Leonard, M.2    Morledge, T.3
  • 18
    • 34648828494 scopus 로고    scopus 로고
    • Functional connections and pathways of coenzyme Q10-inducible genes: An in-silico study
    • 17852568
    • Schmelzer C, Lindner I, Vock C, Fujii K, Döring F (2007) Functional connections and pathways of coenzyme Q10-inducible genes: an in-silico study. IUBMB Life 59(10):628-633
    • (2007) IUBMB Life , vol.59 , Issue.10 , pp. 628-633
    • Schmelzer, C.1    Lindner, I.2    Vock, C.3    Fujii, K.4    Döring, F.5
  • 19
    • 57349102400 scopus 로고    scopus 로고
    • Influence of coenzyme Q{10} on release of pro-inflammatory chemokines in the human monocytic cell line THP-1
    • 18997284 1:CAS:528:DC%2BD1cXhsVChtLjI
    • Schmelzer C, Lorenz G, Rimbach G, Döring F (2007) Influence of coenzyme Q{10} on release of pro-inflammatory chemokines in the human monocytic cell line THP-1. Biofactors 31(3-4):211-217
    • (2007) Biofactors , vol.31 , Issue.3-4 , pp. 211-217
    • Schmelzer, C.1    Lorenz, G.2    Rimbach, G.3    Döring, F.4
  • 20
    • 60849106971 scopus 로고    scopus 로고
    • In vitro effects of the reduced form of coenzyme Q(10) on secretion levels of TNF-alpha and chemokines in response to LPS in the human monocytic cell line THP-1
    • 19177190 1:CAS:528:DC%2BD1MXjt1eqsLw%3D
    • Schmelzer C, Lorenz G, Rimbach G, Döring F (2009) In vitro effects of the reduced form of coenzyme Q(10) on secretion levels of TNF-alpha and chemokines in response to LPS in the human monocytic cell line THP-1. J Clin Biochem Nutr 44(1):62-66
    • (2009) J Clin Biochem Nutr , vol.44 , Issue.1 , pp. 62-66
    • Schmelzer, C.1    Lorenz, G.2    Rimbach, G.3    Döring, F.4
  • 21
    • 0030866907 scopus 로고    scopus 로고
    • Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal
    • 9298711 1:CAS:528:DyaK2sXlslyku7w%3D
    • Barroso MP, Gómez-Díaz C, Villalba JM, Burón MI, López-Lluch G, Navas P (1997) Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. J Bioenerg Biomembr 29(3):259-267
    • (1997) J Bioenerg Biomembr , vol.29 , Issue.3 , pp. 259-267
    • Barroso, M.P.1    Gómez-Díaz, C.2    Villalba, J.M.3    Burón, M.I.4    López-Lluch, G.5    Navas, P.6
  • 24
    • 77956087373 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 or combined with micronutrients on antioxidant defense system in rats
    • 18646530 1:CAS:528:DC%2BD1cXhtVSlurfM
    • Wang H, Zhao X, Yin S (2008) Effects of coenzyme Q10 or combined with micronutrients on antioxidant defense system in rats. Wei Sheng Yan Jiu 37(3):311-313
    • (2008) Wei Sheng Yan Jiu , vol.37 , Issue.3 , pp. 311-313
    • Wang, H.1    Zhao, X.2    Yin, S.3
  • 26
    • 84888203343 scopus 로고    scopus 로고
    • Application of coenzyme Q10 in clinical practice
    • 10.5580/2b24
    • Hiebert JB, Shen Q, Pierce JD (2012) Application of coenzyme Q10 in clinical practice. Int J Intern Med. doi: 10.5580/2b24
    • (2012) Int J Intern Med
    • Hiebert, J.B.1    Shen, Q.2    Pierce, J.D.3
  • 27
    • 31544480133 scopus 로고    scopus 로고
    • A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency
    • 16400613 1:CAS:528:DC%2BD28XptlGqsQ%3D%3D
    • Quinzii C, Naini A, Salviati L, Trevisson E, Navas P, Dimauro S, Hirano M (2006) A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. Am J Hum Genet 78(2):345-349
    • (2006) Am J Hum Genet , vol.78 , Issue.2 , pp. 345-349
    • Quinzii, C.1    Naini, A.2    Salviati, L.3    Trevisson, E.4    Navas, P.5    Dimauro, S.6    Hirano, M.7
  • 28
    • 33845232634 scopus 로고    scopus 로고
    • Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations
    • 17186472
    • López LC, Schuelke M, Quinzii CM, Kanki T, Rodenburg RJ, Naini A, Dimauro S, Hirano M (2006) Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum Genet 79(6):1125-1129
    • (2006) Am J Hum Genet , vol.79 , Issue.6 , pp. 1125-1129
    • López, L.C.1    Schuelke, M.2    Quinzii, C.M.3    Kanki, T.4    Rodenburg, R.J.5    Naini, A.6    Dimauro, S.7    Hirano, M.8
  • 29
    • 33847404036 scopus 로고    scopus 로고
    • Mutations in coenzyme Q10 biosynthetic genes
    • 17332886 1:CAS:528:DC%2BD2sXis12htrs%3D
    • DiMauro S, Quinzii CM, Hirano M (2007) Mutations in coenzyme Q10 biosynthetic genes. J Clin Invest 117(3):587-589
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 587-589
    • Dimauro, S.1    Quinzii, C.M.2    Hirano, M.3
  • 30
    • 79960557093 scopus 로고    scopus 로고
    • Association between genetic variants in the coenzyme Q10 metabolism and coenzyme Q10 status in humans
    • 21774831 1:CAS:528:DC%2BC3MXhtVGhtLrM
    • Fischer A, Schmelzer C, Rimbach G, Niklowitz P, Menke T, Döring F (2011) Association between genetic variants in the coenzyme Q10 metabolism and coenzyme Q10 status in humans. BMC Res Notes 4:245
    • (2011) BMC Res Notes , vol.4 , pp. 245
    • Fischer, A.1    Schmelzer, C.2    Rimbach, G.3    Niklowitz, P.4    Menke, T.5    Döring, F.6
  • 31
    • 0025754439 scopus 로고
    • Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)
    • 1887756 1:STN:280:DyaK3MzmtFOqsw%3D%3D
    • Abe K, Fujimura H, Nishikawa Y, Yorifuji S, Mezaki T, Hirono N, Nishitani N, Kameyama M (1991) Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Acta Neurol Scand 83(6):356-359
    • (1991) Acta Neurol Scand , vol.83 , Issue.6 , pp. 356-359
    • Abe, K.1    Fujimura, H.2    Nishikawa, Y.3    Yorifuji, S.4    Mezaki, T.5    Hirono, N.6    Nishitani, N.7    Kameyama, M.8
  • 32
    • 0023899584 scopus 로고
    • Clinical and biochemical correlations in mitochondrial myopathies treated with coenzyme Q10
    • 3368070 1:STN:280:DyaL1c3hs12ktw%3D%3D
    • Bresolin N, Bet L, Binda A, Moggio M, Comi G, Nador F, Ferrante C, Carenzi A, Scarlato G (1988) Clinical and biochemical correlations in mitochondrial myopathies treated with coenzyme Q10. Neurology 38(6):892-899
    • (1988) Neurology , vol.38 , Issue.6 , pp. 892-899
    • Bresolin, N.1    Bet, L.2    Binda, A.3    Moggio, M.4    Comi, G.5    Nador, F.6    Ferrante, C.7    Carenzi, A.8    Scarlato, G.9
  • 33
    • 0024317560 scopus 로고
    • Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy
    • 2554297 1:CAS:528:DyaL1MXmtFarurw%3D
    • Shoffner JM, Lott MT, Voljavec AS, Soueidan SA, Costigan DA, Wallace DC (1989) Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc Natl Acad Sci U S A 86(20):7952-7956
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.20 , pp. 7952-7956
    • Shoffner, J.M.1    Lott, M.T.2    Voljavec, A.S.3    Soueidan, S.A.4    Costigan, D.A.5    Wallace, D.C.6
  • 34
    • 0142043477 scopus 로고    scopus 로고
    • Isoprenoid pathway dysfunction in chronic fatigue syndrome
    • Kurup RK, Kurup PA (2003) Isoprenoid pathway dysfunction in chronic fatigue syndrome. Acta Neuropsychiatr 15(5):266-273
    • (2003) Acta Neuropsychiatr , vol.15 , Issue.5 , pp. 266-273
    • Kurup, R.K.1    Kurup, P.A.2
  • 35
    • 77649266722 scopus 로고    scopus 로고
    • Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis/chronic fatigue syndrome
    • 20035260 1:CAS:528:DC%2BC3cXktVShtbY%3D
    • Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2009) Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis/chronic fatigue syndrome. Neuro Endocrinol Lett 30(6):715-722
    • (2009) Neuro Endocrinol Lett , vol.30 , Issue.6 , pp. 715-722
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Uytterhoeven, M.4    Vrydags, N.5    Bosmans, E.6
  • 36
    • 76049126501 scopus 로고    scopus 로고
    • Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder
    • 20010505 1:CAS:528:DC%2BC3cXitlWhtb0%3D
    • Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2009) Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 30(4):470-476
    • (2009) Neuro Endocrinol Lett , vol.30 , Issue.4 , pp. 470-476
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Uytterhoeven, M.4    Vrydags, N.5    Bosmans, E.6
  • 38
    • 84867220756 scopus 로고    scopus 로고
    • Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient
    • 22898267 1:CAS:528:DC%2BC38XhsFSls7jO
    • Cordero MD, Cotán D, del-Pozo-Martín Y, Carrión AM, de Miguel M, Bullón P, Sánchez-Alcazar JA (2012) Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Nutrition 28(11-12):1200-1203
    • (2012) Nutrition , vol.28 , Issue.11-12 , pp. 1200-1203
    • Cordero, M.D.1    Cotán, D.2    Del-Pozo-Martín, Y.3    Carrión, A.M.4    De Miguel, M.5    Bullón, P.6    Sánchez-Alcazar, J.A.7
  • 40
    • 0030612117 scopus 로고    scopus 로고
    • Coenzyme Q10 levels correlate with the activities of complexes i and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
    • 9266740 1:CAS:528:DyaK2sXls1ynsbk%3D
    • Shults CW, Haas RH, Passov D, Beal MF (1997) Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol 42(2):261-264
    • (1997) Ann Neurol , vol.42 , Issue.2 , pp. 261-264
    • Shults, C.W.1    Haas, R.H.2    Passov, D.3    Beal, M.F.4
  • 41
    • 0036525567 scopus 로고    scopus 로고
    • Coenzyme Q10 as a possible treatment for neurodegenerative diseases
    • 12069110
    • Beal MF (2002) Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Radic Res 36(4):455-460
    • (2002) Free Radic Res , vol.36 , Issue.4 , pp. 455-460
    • Beal, M.F.1
  • 42
    • 1242274617 scopus 로고    scopus 로고
    • Therapeutic effects of coenzyme Q10 in neurodegenerative diseases
    • 15047118 1:CAS:528:DC%2BD2cXjtVWkt7g%3D
    • Beal MF (2004) Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. Methods Enzymol 382:473-487
    • (2004) Methods Enzymol , vol.382 , pp. 473-487
    • Beal, M.F.1
  • 43
    • 29044438880 scopus 로고    scopus 로고
    • The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus
    • 16375724 1:CAS:528:DC%2BD28XntVCqug%3D%3D
    • Dhanasekaran M, Ren J (2005) The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res 2(5):447-459
    • (2005) Curr Neurovasc Res , vol.2 , Issue.5 , pp. 447-459
    • Dhanasekaran, M.1    Ren, J.2
  • 44
    • 79953744583 scopus 로고    scopus 로고
    • Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    • 21455120 1:CAS:528:DC%2BC3MXhtFSlsr3I
    • Maes M, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2011) Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS). Med Sci Monit 17(4):SC11-SC15
    • (2011) Med Sci Monit , vol.17 , Issue.4
    • Maes, M.1    Kubera, M.2    Uytterhoeven, M.3    Vrydags, N.4    Bosmans, E.5
  • 46
    • 84893443403 scopus 로고    scopus 로고
    • TRYCAT pathways link peripheral inflammation, nicotine, somatization and depression in the etiology and course of Parkinson's disease
    • (in press).
    • Anderson G, Maes M (2013) TRYCAT pathways link peripheral inflammation, nicotine, somatization and depression in the etiology and course of Parkinson's disease. CNS Neurolog Dis (in press).
    • (2013) CNS Neurolog Dis
    • Anderson, G.1    Maes, M.2
  • 48
    • 84873888319 scopus 로고    scopus 로고
    • Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development
    • 22711881
    • Nierenberg AA, Kansky C, Brennan BP, Shelton RC, Perlis R, Iosifescu DV (2013) Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development. Aust N Z J Psychiatry 47(1):26-42
    • (2013) Aust N Z J Psychiatry , vol.47 , Issue.1 , pp. 26-42
    • Nierenberg, A.A.1    Kansky, C.2    Brennan, B.P.3    Shelton, R.C.4    Perlis, R.5    Iosifescu, D.V.6
  • 49
    • 0141761467 scopus 로고    scopus 로고
    • Coenzyme Q10 in neurodegenerative diseases
    • 12871093 1:CAS:528:DC%2BD3sXnslyqtLc%3D
    • Shults CW (2003) Coenzyme Q10 in neurodegenerative diseases. Curr Med Chem 10(19):1917-1921
    • (2003) Curr Med Chem , vol.10 , Issue.19 , pp. 1917-1921
    • Shults, C.W.1
  • 50
    • 77949440226 scopus 로고    scopus 로고
    • Coenzyme Q10 in neuromuscular and neurodegenerative disorders
    • 20017723 1:CAS:528:DC%2BC3cXisVCitrg%3D
    • Mancuso M, Orsucci D, Volpi L, Calsolaro V, Siciliano G (2010) Coenzyme Q10 in neuromuscular and neurodegenerative disorders. Curr Drug Targets 11(1):111-121
    • (2010) Curr Drug Targets , vol.11 , Issue.1 , pp. 111-121
    • Mancuso, M.1    Orsucci, D.2    Volpi, L.3    Calsolaro, V.4    Siciliano, G.5
  • 53
    • 0035668056 scopus 로고    scopus 로고
    • Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase
    • 11709394 1:CAS:528:DC%2BD3MXptlKgurs%3D
    • Turko IV, Marcondes S, Murad F (2001) Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase. Am J Physiol Heart Circ Physiol 281(6):H2289-H2294
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , Issue.6
    • Turko, I.V.1    Marcondes, S.2    Murad, F.3
  • 54
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
    • 12372842 1:CAS:528:DC%2BD38XosVejsbg%3D
    • Evans JL, Goldfine ID, Maddux BA, Grodsky GM (2002) Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23(5):599-622
    • (2002) Endocr Rev , vol.23 , Issue.5 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 55
    • 1342325376 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease
    • 14989367
    • Vega-López S, Devaraj S, Jialal I (2004) Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease. J Investig Med 52(1):24-32
    • (2004) J Investig Med , vol.52 , Issue.1 , pp. 24-32
    • Vega-López, S.1    Devaraj, S.2    Jialal, I.3
  • 56
    • 18544371009 scopus 로고    scopus 로고
    • Metals, toxicity and oxidative stress
    • 15892631 1:CAS:528:DC%2BD2MXktlant7g%3D
    • Valko M, Morris H, Cronin MT (2005) Metals, toxicity and oxidative stress. Curr Med Chem 12(10):1161-1208
    • (2005) Curr Med Chem , vol.12 , Issue.10 , pp. 1161-1208
    • Valko, M.1    Morris, H.2    Cronin, M.T.3
  • 57
    • 0033062973 scopus 로고    scopus 로고
    • Effects of dietary polyunsaturated fatty acids on neuronal function
    • 10102242 1:CAS:528:DyaK1MXhvFaqu7g%3D
    • Fernstrom JD (1999) Effects of dietary polyunsaturated fatty acids on neuronal function. Lipids 34(2):161-169
    • (1999) Lipids , vol.34 , Issue.2 , pp. 161-169
    • Fernstrom, J.D.1
  • 58
  • 59
    • 0032764519 scopus 로고    scopus 로고
    • The effect of increased intakes of polyunsaturated fatty acids and vitamin e on DNA damage in human lymphocytes
    • 10593860 1:CAS:528:DyaK1MXotVKitL4%3D
    • Jenkinson AM, Collins AR, Duthie SJ, Wahle KW, Duthie GG (1999) The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes. FASEB J 13(15):2138-2142
    • (1999) FASEB J , vol.13 , Issue.15 , pp. 2138-2142
    • Jenkinson, A.M.1    Collins, A.R.2    Duthie, S.J.3    Wahle, K.W.4    Duthie, G.G.5
  • 60
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: Where are we now?
    • 1:CAS:528:DC%2BD28Xnt1Ons7g%3D
    • Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochemistry 97(6):1634-1658
    • (2006) J Neurochemistry , vol.97 , Issue.6 , pp. 1634-1658
    • Halliwell, B.1
  • 61
    • 84875725411 scopus 로고    scopus 로고
    • Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration
    • 10.1016/j.neuint.2013.02.013 23422879 Epub ahead of print
    • Smith JA, Park S, Krause JS, Banik NL (2013) Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochem Int. doi: 10.1016/j.neuint.2013.02.013, Epub ahead of print
    • (2013) Neurochem Int
    • Smith, J.A.1    Park, S.2    Krause, J.S.3    Banik, N.L.4
  • 62
    • 39349105603 scopus 로고    scopus 로고
    • The role for oxidative stress in neurodegenerative diseases
    • 18306664 1:CAS:528:DC%2BD1cXkvFWmu78%3D
    • Shibata N, Kobayashi M (2008) The role for oxidative stress in neurodegenerative diseases. Brain Nerve 60(2):157-170
    • (2008) Brain Nerve , vol.60 , Issue.2 , pp. 157-170
    • Shibata, N.1    Kobayashi, M.2
  • 63
    • 79953272320 scopus 로고    scopus 로고
    • Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease
    • Farooqui T, Farooqui AA (2011) Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease. Park Dis 2011:247467
    • (2011) Park Dis , vol.2011 , pp. 247467
    • Farooqui, T.1    Farooqui, A.A.2
  • 64
    • 78649983205 scopus 로고    scopus 로고
    • Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: Potential implications for Alzheimer's and Parkinson's diseases
    • 20177970 1:CAS:528:DC%2BC3cXhsVWqtr%2FF
    • Nakamura T, Lipton SA (2010) Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases. Apoptosis 15(11):1354-1363
    • (2010) Apoptosis , vol.15 , Issue.11 , pp. 1354-1363
    • Nakamura, T.1    Lipton, S.A.2
  • 66
    • 33845577972 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy in aging and neurodegeneration: Lessons from alpha-synuclein
    • 16860504
    • Bandyopadhyay U, Cuervo AM (2007) Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein. Exp Gerontol 42(1-2):120-128
    • (2007) Exp Gerontol , vol.42 , Issue.1-2 , pp. 120-128
    • Bandyopadhyay, U.1    Cuervo, A.M.2
  • 67
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • 17051204 1:CAS:528:DC%2BD28XhtVyktbbN
    • Rubinsztein DC (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443(7113):780-786
    • (2006) Nature , vol.443 , Issue.7113 , pp. 780-786
    • Rubinsztein, D.C.1
  • 68
    • 4344618623 scopus 로고    scopus 로고
    • Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain
    • 15325579 1:CAS:528:DC%2BD2cXmvFemurc%3D
    • Keller JN, Dimayuga E, Chen Q, Thorpe J, Gee J, Ding Q (2004) Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. Int J Biochem Cell Biol 36(12):2376-2391
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.12 , pp. 2376-2391
    • Keller, J.N.1    Dimayuga, E.2    Chen, Q.3    Thorpe, J.4    Gee, J.5    Ding, Q.6
  • 69
    • 0028912676 scopus 로고
    • Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome
    • 7836468 1:CAS:528:DyaK2MXjsV2kt7Y%3D
    • Grune T, Reinheckel T, Joshi M, Davies KJ (1995) Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome. J Biol Chem 270(5):2344-2351
    • (1995) J Biol Chem , vol.270 , Issue.5 , pp. 2344-2351
    • Grune, T.1    Reinheckel, T.2    Joshi, M.3    Davies, K.J.4
  • 70
    • 0032080117 scopus 로고    scopus 로고
    • Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome
    • 9556559 1:CAS:528:DyaK1cXjtFGktrg%3D
    • Grune T, Blasig IE, Sitte N, Roloff B, Haseloff R, Davies KJ (1998) Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome. J Biol Chem 273(18):10857-10862
    • (1998) J Biol Chem , vol.273 , Issue.18 , pp. 10857-10862
    • Grune, T.1    Blasig, I.E.2    Sitte, N.3    Roloff, B.4    Haseloff, R.5    Davies, K.J.6
  • 71
    • 0032867796 scopus 로고    scopus 로고
    • Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome
    • 10490267 1:CAS:528:DyaK1MXls12nt74%3D
    • Ullrich O, Reinheckel T, Sitte N, Grune T (1999) Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome. Free Radic Biol Med 27(5-6):487-492
    • (1999) Free Radic Biol Med , vol.27 , Issue.5-6 , pp. 487-492
    • Ullrich, O.1    Reinheckel, T.2    Sitte, N.3    Grune, T.4
  • 72
    • 68149156531 scopus 로고    scopus 로고
    • Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: How neurons are lost in the Bermuda triangle
    • 19500376
    • Malkus KA, Tsika E, Ischiropoulos H (2009) Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener 4:24
    • (2009) Mol Neurodegener , vol.4 , pp. 24
    • Malkus, K.A.1    Tsika, E.2    Ischiropoulos, H.3
  • 73
    • 0030977793 scopus 로고    scopus 로고
    • Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein
    • 9094417 1:CAS:528:DyaK2sXhvFWgs7g%3D
    • Friguet B, Szweda LI (1997) Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein. FEBS Lett 405(1):21-25
    • (1997) FEBS Lett , vol.405 , Issue.1 , pp. 21-25
    • Friguet, B.1    Szweda, L.I.2
  • 74
    • 0027990369 scopus 로고
    • Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease
    • 8063806 1:CAS:528:DyaK2cXlslKisrc%3D
    • Friguet B, Stadtman ER, Szweda LI (1994) Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease. J Biol Chem 269(34):21639-21643
    • (1994) J Biol Chem , vol.269 , Issue.34 , pp. 21639-21643
    • Friguet, B.1    Stadtman, E.R.2    Szweda, L.I.3
  • 75
    • 0033673408 scopus 로고    scopus 로고
    • Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: Part i - Effects of proliferative senescence
    • 11099467 1:CAS:528:DC%2BD3MXht1SntL4%3D
    • Sitte N, Merker K, Von Zglinicki T, Grune T, Davies KJ (2000) Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I - effects of proliferative senescence. FASEB J 14(15):2495-2502
    • (2000) FASEB J , vol.14 , Issue.15 , pp. 2495-2502
    • Sitte, N.1    Merker, K.2    Von Zglinicki, T.3    Grune, T.4    Davies, K.J.5
  • 76
    • 0033870001 scopus 로고    scopus 로고
    • Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
    • 10928983 1:CAS:528:DC%2BD3cXlslaqtrk%3D
    • Sitte N, Huber M, Grune T, Ladhoff A, Doecke WD, Von Zglinicki T, Davies KJ (2000) Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts. FASEB J 14(11):1490-1498
    • (2000) FASEB J , vol.14 , Issue.11 , pp. 1490-1498
    • Sitte, N.1    Huber, M.2    Grune, T.3    Ladhoff, A.4    Doecke, W.D.5    Von Zglinicki, T.6    Davies, K.J.7
  • 78
    • 0035607509 scopus 로고    scopus 로고
    • The influence of oxidation of membrane thiol groups on lysosomal proton permeability
    • 11716763 1:CAS:528:DC%2BD3MXpt1Ghsb8%3D
    • Wan FY, Wang YN, Zhang GJ (2001) The influence of oxidation of membrane thiol groups on lysosomal proton permeability. Biochem J 360(Pt 2):355-362
    • (2001) Biochem J , vol.360 , Issue.PART 2 , pp. 355-362
    • Wan, F.Y.1    Wang, Y.N.2    Zhang, G.J.3
  • 79
    • 0030757986 scopus 로고    scopus 로고
    • Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
    • 9215807 1:CAS:528:DyaK2sXksFajsLk%3D
    • Brunk UT, Dalen H, Roberg K, Hellquist HB (1997) Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic Biol Med 23(4):616-626
    • (1997) Free Radic Biol Med , vol.23 , Issue.4 , pp. 616-626
    • Brunk, U.T.1    Dalen, H.2    Roberg, K.3    Hellquist, H.B.4
  • 80
    • 0036710928 scopus 로고    scopus 로고
    • Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
    • 12208347 1:CAS:528:DC%2BD38Xms1ymtLc%3D
    • Brunk UT, Terman A (2002) Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 33(5):611-619
    • (2002) Free Radic Biol Med , vol.33 , Issue.5 , pp. 611-619
    • Brunk, U.T.1    Terman, A.2
  • 81
    • 0035110055 scopus 로고    scopus 로고
    • Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease
    • 11162237 1:CAS:528:DC%2BD3MXpvVSqsw%3D%3D
    • Ditaranto K, Tekirian TL, Yang AJ (2001) Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease. Neurobiol Dis 8(1):19-31
    • (2001) Neurobiol Dis , vol.8 , Issue.1 , pp. 19-31
    • Ditaranto, K.1    Tekirian, T.L.2    Yang, A.J.3
  • 82
    • 0028260509 scopus 로고
    • One- and two-electron reduction of quinones by rat liver subcellular fractions
    • 7982895 1:CAS:528:DyaK2cXlvFyltrs%3D
    • Nakamura M, Hayashi T (1994) One- and two-electron reduction of quinones by rat liver subcellular fractions. J Biochem 115(6):1141-1147
    • (1994) J Biochem , vol.115 , Issue.6 , pp. 1141-1147
    • Nakamura, M.1    Hayashi, T.2
  • 83
    • 0029042393 scopus 로고
    • Biochemical, physiological and medical aspects of ubiquinone function
    • 7599208
    • Ernster L, Dallner G (1995) Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271(1):195-204
    • (1995) Biochim Biophys Acta , vol.1271 , Issue.1 , pp. 195-204
    • Ernster, L.1    Dallner, G.2
  • 84
    • 33645099245 scopus 로고    scopus 로고
    • Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
    • 16551570 1:CAS:528:DC%2BD28Xis1CjtbY%3D
    • Bhagavan HN, Chopra RK (2006) Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 40(5):445-453
    • (2006) Free Radic Res , vol.40 , Issue.5 , pp. 445-453
    • Bhagavan, H.N.1    Chopra, R.K.2
  • 86
    • 0030823103 scopus 로고    scopus 로고
    • The diversity of coenzyme Q function
    • 9266500 1:CAS:528:DyaK2sXlvVakurs%3D
    • Crane FL, Navas P (1997) The diversity of coenzyme Q function. Mol Aspects Med 18(Suppl):S1-S6
    • (1997) Mol Aspects Med , vol.18 , Issue.SUPPL.
    • Crane, F.L.1    Navas, P.2
  • 87
    • 0028028302 scopus 로고
    • Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells
    • 7982910 1:CAS:528:DyaK2cXmslOntb0%3D
    • Larm JA, Vaillant F, Linnane AW, Lawen A (1994) Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells. J Biol Chem 269(48):30097-30100
    • (1994) J Biol Chem , vol.269 , Issue.48 , pp. 30097-30100
    • Larm, J.A.1    Vaillant, F.2    Linnane, A.W.3    Lawen, A.4
  • 88
    • 0034122558 scopus 로고    scopus 로고
    • Surface oxidase and oxidative stress propagation in aging
    • 10769214
    • Morré DM, Lenaz G, Morré DJ (2000) Surface oxidase and oxidative stress propagation in aging. J Exp Biol 203(Pt 10):1513-1521
    • (2000) J Exp Biol , vol.203 , Issue.PART 10 , pp. 1513-1521
    • Morré, D.M.1    Lenaz, G.2    Morré, D.J.3
  • 89
    • 0022495724 scopus 로고
    • The mitochondrial site of superoxide formation
    • 3017331 1:CAS:528:DyaL28XlvVGqtLs%3D
    • Nohl H, Jordan W (1986) The mitochondrial site of superoxide formation. Biochem Biophys Res Commun 138(2):533-539
    • (1986) Biochem Biophys Res Commun , vol.138 , Issue.2 , pp. 533-539
    • Nohl, H.1    Jordan, W.2
  • 90
    • 0021996572 scopus 로고
    • Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
    • 2983613 1:CAS:528:DyaL2MXht1Ontrg%3D
    • Turrens JF, Alexandre A, Lehninger AL (1985) Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys 237(2):408-414
    • (1985) Arch Biochem Biophys , vol.237 , Issue.2 , pp. 408-414
    • Turrens, J.F.1    Alexandre, A.2    Lehninger, A.L.3
  • 91
    • 0025609342 scopus 로고
    • The oxidation of ubiquinol by the isolated Rieske iron-sulfur protein in solution
    • DegliEsposti M, Ballester F, Timoneda J, Crimi M, Lenaz G (1990) The oxidation of ubiquinol by the isolated Rieske iron-sulfur protein in solution. Arch Biochem Biophys 28(2):258-265
    • (1990) Arch Biochem Biophys , vol.28 , Issue.2 , pp. 258-265
    • Degliesposti, M.1    Ballester, F.2    Timoneda, J.3    Crimi, M.4    Lenaz, G.5
  • 92
    • 0019558007 scopus 로고
    • New concepts on the role of ubiquinone in the mitochondrial respiratory chain
    • 7014553 1:CAS:528:DyaL3MXhvVKqtL4%3D
    • Trumpower BL (1981) New concepts on the role of ubiquinone in the mitochondrial respiratory chain. J Bioenerg Biomembr 13(1-2):1-24
    • (1981) J Bioenerg Biomembr , vol.13 , Issue.1-2 , pp. 1-24
    • Trumpower, B.L.1
  • 93
    • 0032504657 scopus 로고    scopus 로고
    • Role of mitochondria in oxidative stress and ageing
    • 9714734 1:CAS:528:DyaK1cXltFWksL8%3D
    • Lenaz G (1998) Role of mitochondria in oxidative stress and ageing. Biochim Biophys Acta 1366(1-2):53-67
    • (1998) Biochim Biophys Acta , vol.1366 , Issue.1-2 , pp. 53-67
    • Lenaz, G.1
  • 94
    • 34248195909 scopus 로고    scopus 로고
    • The importance of plasma membrane coenzyme Q in aging and stress responses
    • 17482527 1:CAS:528:DC%2BD2sXlt1aktrs%3D
    • Navas P, Villalba JM, de Cabo R (2007) The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 7(Suppl):S34-S40
    • (2007) Mitochondrion , vol.7 , Issue.SUPPL.
    • Navas, P.1    Villalba, J.M.2    De Cabo, R.3
  • 95
    • 0037192846 scopus 로고    scopus 로고
    • Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants
    • 11788608
    • Santos-Ocaña C, Do TQ, Padilla S, Navas P, Clarke CF (2002) Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. J Biol Chem 277(13):10973-10981
    • (2002) J Biol Chem , vol.277 , Issue.13 , pp. 10973-10981
    • Santos-Ocaña, C.1    Do, T.Q.2    Padilla, S.3    Navas, P.4    Clarke, C.F.5
  • 98
    • 1642341366 scopus 로고    scopus 로고
    • Mitochondriopathies
    • 15009163 1:STN:280:DC%2BD2c7hvFegsg%3D%3D
    • Finsterer J (2004) Mitochondriopathies. Eur J Neurol 11(3):163-186
    • (2004) Eur J Neurol , vol.11 , Issue.3 , pp. 163-186
    • Finsterer, J.1
  • 99
    • 0035987272 scopus 로고    scopus 로고
    • Combined partial deficiencies of carnitine palmitoyltransferase II and mitochondrial complex i presenting as increased serum creatine kinase level
    • 12088089
    • Tsao CY, Mendell JR (2002) Combined partial deficiencies of carnitine palmitoyltransferase II and mitochondrial complex I presenting as increased serum creatine kinase level. J Child Neurol 17(4):304-306
    • (2002) J Child Neurol , vol.17 , Issue.4 , pp. 304-306
    • Tsao, C.Y.1    Mendell, J.R.2
  • 101
    • 4043181369 scopus 로고    scopus 로고
    • Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases
    • 15298157
    • Steele PE, Tang PH, DeGrauw AJ, Miles MV (2004) Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases. Am J Clin Pathol 121(Suppl):S113-S120
    • (2004) Am J Clin Pathol , vol.121 , Issue.SUPPL.
    • Steele, P.E.1    Tang, P.H.2    Degrauw, A.J.3    Miles, M.V.4
  • 102
    • 3242775520 scopus 로고    scopus 로고
    • Targeting energy metabolism in Huntington's disease
    • 15276373
    • Walker FO, Raymond LA (2004) Targeting energy metabolism in Huntington's disease. Lancet 364(9431):312-313
    • (2004) Lancet , vol.364 , Issue.9431 , pp. 312-313
    • Walker, F.O.1    Raymond, L.A.2
  • 103
    • 0034050603 scopus 로고    scopus 로고
    • Nutritional strategies for treating chronic fatigue syndrome
    • 10767667 1:STN:280:DC%2BD3c3jt1WktQ%3D%3D
    • Werbach MR (2000) Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 5(2):93-108
    • (2000) Altern Med Rev , vol.5 , Issue.2 , pp. 93-108
    • Werbach, M.R.1
  • 104
    • 0015882341 scopus 로고
    • The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
    • 4749271 1:CAS:528:DyaE3sXltFansLk%3D
    • Boveris A, Chance B (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 134(3):707-716
    • (1973) Biochem J , vol.134 , Issue.3 , pp. 707-716
    • Boveris, A.1    Chance, B.2
  • 105
    • 0002532996 scopus 로고
    • The antioxidant role of Coenzyme Q
    • G. Lenaz O. Barnobei A. Robbi M. Battino (eds) Taylor & Francis London
    • Beyer RE, Ernster L (1990) The antioxidant role of Coenzyme Q. In: Lenaz G, Barnobei O, Robbi A, Battino M (eds) Highlights of ubiquinone research. Taylor & Francis, London, pp 191-213
    • (1990) Highlights of Ubiquinone Research , pp. 191-213
    • Beyer, R.E.1    Ernster, L.2
  • 106
    • 34250869614 scopus 로고    scopus 로고
    • Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin
    • 18398496 1:CAS:528:DC%2BD2sXovFajs78%3D
    • Kettawan A, Takahashi T, Kongkachuichai R, Charoenkiatkul S, Kishi T, Okamoto T (2007) Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin. J Clin Biochem Nutr 40(3):194-202
    • (2007) J Clin Biochem Nutr , vol.40 , Issue.3 , pp. 194-202
    • Kettawan, A.1    Takahashi, T.2    Kongkachuichai, R.3    Charoenkiatkul, S.4    Kishi, T.5    Okamoto, T.6
  • 107
    • 0025369150 scopus 로고
    • Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling
    • 2114108 1:CAS:528:DyaK3cXksFCmsr8%3D
    • Kagan V, Serbinova E, Packer L (1990) Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun 169(3):851-857
    • (1990) Biochem Biophys Res Commun , vol.169 , Issue.3 , pp. 851-857
    • Kagan, V.1    Serbinova, E.2    Packer, L.3
  • 108
    • 0026580678 scopus 로고
    • The mode of action of lipid-soluble antioxidants in biological membranes: Relationship between the effects of ubiquinol and vitamin e as inhibitors of lipid peroxidation in submitochondrial particles
    • 1605833 1:CAS:528:DyaK38XksVSgur4%3D
    • Ernster L, Forsmark P, Nordenbrand K (1992) The mode of action of lipid-soluble antioxidants in biological membranes: relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles. Biofactors 3(4):241-248
    • (1992) Biofactors , vol.3 , Issue.4 , pp. 241-248
    • Ernster, L.1    Forsmark, P.2    Nordenbrand, K.3
  • 109
    • 0025611704 scopus 로고
    • Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome
    • 2097322 1:CAS:528:DyaK3MXht1Snsrw%3D (Tokyo)
    • Yamamoto Y, Komuro E, Niki E (1990) Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome. J Nutr Sci Vitaminol 36(5):505-511 (Tokyo)
    • (1990) J Nutr Sci Vitaminol , vol.36 , Issue.5 , pp. 505-511
    • Yamamoto, Y.1    Komuro, E.2    Niki, E.3
  • 110
    • 0026563848 scopus 로고
    • The antioxidant activity of ubiquinol-3 in homogeneous solution and in liposomes
    • 1511485 1:CAS:528:DyaK38XktVagtLw%3D
    • Landi L, Cabrini L, Fiorentini D, Stefanelli C, Pedulli GF (1992) The antioxidant activity of ubiquinol-3 in homogeneous solution and in liposomes. Chem Phys Lipids 61(2):121-130
    • (1992) Chem Phys Lipids , vol.61 , Issue.2 , pp. 121-130
    • Landi, L.1    Cabrini, L.2    Fiorentini, D.3    Stefanelli, C.4    Pedulli, G.F.5
  • 111
    • 34248194299 scopus 로고    scopus 로고
    • The antioxidant role of coenzyme Q
    • 17482888 1:CAS:528:DC%2BD2sXlt1aktrg%3D
    • Bentinger M, Brismar K, Dallner G (2007) The antioxidant role of coenzyme Q. Mitochondrion 7(Suppl):S41-S50
    • (2007) Mitochondrion , vol.7 , Issue.SUPPL.
    • Bentinger, M.1    Brismar, K.2    Dallner, G.3
  • 112
    • 1042278892 scopus 로고    scopus 로고
    • Antioxidant and prooxidant properties of mitochondrial coenzyme Q
    • 14989264 1:CAS:528:DC%2BD2cXhtV2hsrY%3D
    • James AM, Smith RA, Murphy MP (2004) Antioxidant and prooxidant properties of mitochondrial coenzyme Q. Arch Biochem Biophys 423(1):47-56
    • (2004) Arch Biochem Biophys , vol.423 , Issue.1 , pp. 47-56
    • James, A.M.1    Smith, R.A.2    Murphy, M.P.3
  • 113
    • 0028981291 scopus 로고
    • The roles of coenzyme Q10 and vitamin e on the peroxidation of human low density lipoprotein subfractions
    • 7568138 1:CAS:528:DyaK2MXosVWlurY%3D
    • Alleva R, Tomasetti M, Battino M, Curatola G, Littarru GP, Folkers K (1995) The roles of coenzyme Q10 and vitamin E on the peroxidation of human low density lipoprotein subfractions. Proc Natl Acad Sci U S A 92(20):9388-9391
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.20 , pp. 9388-9391
    • Alleva, R.1    Tomasetti, M.2    Battino, M.3    Curatola, G.4    Littarru, G.P.5    Folkers, K.6
  • 114
    • 34547166634 scopus 로고    scopus 로고
    • Coenzyme Q10 supplementation and heart failure
    • 17605305
    • Singh U, Devaraj S, Jialal I (2007) Coenzyme Q10 supplementation and heart failure. Nutr Rev 65(6 Pt 1):286-293
    • (2007) Nutr Rev , vol.65 , Issue.6 PART 1 , pp. 286-293
    • Singh, U.1    Devaraj, S.2    Jialal, I.3
  • 115
    • 84862323191 scopus 로고    scopus 로고
    • The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease
    • 22645453
    • Lee BJ, Lin YC, Huang YC, Ko YW, Hsia S, Lin PT (2012) The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease. Scientific World Journal 2012:792756
    • (2012) Scientific World Journal , vol.2012 , pp. 792756
    • Lee, B.J.1    Lin, Y.C.2    Huang, Y.C.3    Ko, Y.W.4    Hsia, S.5    Lin, P.T.6
  • 116
    • 0025327523 scopus 로고
    • Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations
    • 2352956 1:CAS:528:DyaK3cXltFWjs7s%3D
    • Frei B, Kim MC, Ames BN (1990) Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A 87(12):4879-4883
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.12 , pp. 4879-4883
    • Frei, B.1    Kim, M.C.2    Ames, B.N.3
  • 118
    • 0027234508 scopus 로고
    • Ubiquinol: An endogenous antioxidant in aerobic organisms
    • 8241707 1:CAS:528:DyaK2cXmvFOqtb0%3D
    • Ernster L, Forsmark-Andrée P (1993) Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Investig 71(8 Suppl):S60-S65
    • (1993) Clin Investig , vol.71 , Issue.8 SUPPL.
    • Ernster, L.1    Forsmark-Andrée, P.2
  • 119
    • 0028630747 scopus 로고
    • Effect of dietary coenzyme Q10 as an antioxidant in human plasma
    • 7752850 1:CAS:528:DyaK2MXktlyms70%3D
    • Weber C, Jakobsen TS, Mortensen SA, Paulsen G, Hølmer G (1994) Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Mol Aspects Med 15(Suppl):S97-S102
    • (1994) Mol Aspects Med , vol.15 , Issue.SUPPL.
    • Weber, C.1    Jakobsen, T.S.2    Mortensen, S.A.3    Paulsen, G.4    Hølmer, G.5
  • 120
    • 46449129625 scopus 로고    scopus 로고
    • Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome
    • 18544898 1:CAS:528:DC%2BD1cXotVyhsr0%3D
    • Kunitomo M, Yamaguchi Y, Kagota S, Otsubo K (2008) Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome. J Pharmacol Sci 107(2):128-137
    • (2008) J Pharmacol Sci , vol.107 , Issue.2 , pp. 128-137
    • Kunitomo, M.1    Yamaguchi, Y.2    Kagota, S.3    Otsubo, K.4
  • 121
    • 84868644255 scopus 로고    scopus 로고
    • Amelioration of altered antioxidant enzymes activity and glomerulosclerosis by coenzyme Q10 in alloxan-induced diabetic rats
    • 22795334
    • Ahmadvand H, Tavafi M, Khosrowbeygi A (2012) Amelioration of altered antioxidant enzymes activity and glomerulosclerosis by coenzyme Q10 in alloxan-induced diabetic rats. J Diabetes Complications 26(6):476-482
    • (2012) J Diabetes Complications , vol.26 , Issue.6 , pp. 476-482
    • Ahmadvand, H.1    Tavafi, M.2    Khosrowbeygi, A.3
  • 123
    • 84864401965 scopus 로고    scopus 로고
    • Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
    • 22848760 1:CAS:528:DC%2BC38XhtFCgtbjE
    • Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ (2012) Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One 7(7):e42357
    • (2012) PLoS One , vol.7 , Issue.7 , pp. 42357
    • Massudi, H.1    Grant, R.2    Braidy, N.3    Guest, J.4    Farnsworth, B.5    Guillemin, G.J.6
  • 124
    • 33744477074 scopus 로고    scopus 로고
    • Cellular redox regulation and prooxidant signaling systems: A new perspective on the free radical theory of aging
    • 16803970 1:CAS:528:DC%2BD28Xms1Oks7w%3D
    • Linnane AW, Eastwood H (2006) Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging. Ann N Y Acad Sci 1067:47-55
    • (2006) Ann N y Acad Sci , vol.1067 , pp. 47-55
    • Linnane, A.W.1    Eastwood, H.2
  • 125
    • 10644272512 scopus 로고    scopus 로고
    • Cellular redox poise modulation; The role of coenzyme Q10, gene and metabolic regulation
    • 16120432 1:CAS:528:DC%2BD2cXhtVCgsL7L
    • Linnane AW, Eastwood H (2004) Cellular redox poise modulation; the role of coenzyme Q10, gene and metabolic regulation. Mitochondrion 4(5-6):779-789
    • (2004) Mitochondrion , vol.4 , Issue.5-6 , pp. 779-789
    • Linnane, A.W.1    Eastwood, H.2
  • 126
    • 0036009574 scopus 로고    scopus 로고
    • Cellular coenzyme Q10 redox poise constitutes a major cell metabolic and gene regulatory system
    • 12014838 1:CAS:528:DC%2BD38XjsF2mu74%3D
    • Linnane AW (2002) Cellular coenzyme Q10 redox poise constitutes a major cell metabolic and gene regulatory system. Biogerontology 3(1-2):3-6
    • (2002) Biogerontology , vol.3 , Issue.1-2 , pp. 3-6
    • Linnane, A.W.1
  • 127
    • 0034326430 scopus 로고    scopus 로고
    • Sensing electrons: Protein phosphatase redox regulation
    • 11084359 1:CAS:528:DC%2BD3cXotVKqtLk%3D
    • Rusnak F, Reiter T (2000) Sensing electrons: protein phosphatase redox regulation. Trends Biochem Sci 25(11):527-529
    • (2000) Trends Biochem Sci , vol.25 , Issue.11 , pp. 527-529
    • Rusnak, F.1    Reiter, T.2
  • 128
    • 0034735799 scopus 로고    scopus 로고
    • Coenzyme Q is an obligatory cofactor for uncoupling protein function
    • 11117751 1:CAS:528:DC%2BD3cXovFajtr0%3D
    • Echtay KS, Winkler E, Klingenberg M (2000) Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408(6812):609-613
    • (2000) Nature , vol.408 , Issue.6812 , pp. 609-613
    • Echtay, K.S.1    Winkler, E.2    Klingenberg, M.3
  • 132
    • 0025894922 scopus 로고
    • On the nature of the mitochondrial proton leak
    • 1651764 1:CAS:528:DyaK3MXmtVWhurk%3D
    • Brown GC, Brand MD (1991) On the nature of the mitochondrial proton leak. Biochim Biophys Acta 1059(1):55-62
    • (1991) Biochim Biophys Acta , vol.1059 , Issue.1 , pp. 55-62
    • Brown, G.C.1    Brand, M.D.2
  • 133
    • 0028884511 scopus 로고
    • Causes of differences in respiration rate of hepatocytes from mammals of different body mass
    • 7503313 1:CAS:528:DyaK2MXpslOkt7s%3D
    • Porter RK, Brand MD (1995) Causes of differences in respiration rate of hepatocytes from mammals of different body mass. Am J Physiol 269(5 Pt 2):R1213-R1224
    • (1995) Am J Physiol , vol.269 , Issue.5 PART 2
    • Porter, R.K.1    Brand, M.D.2
  • 134
    • 0032953969 scopus 로고    scopus 로고
    • Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR
    • 10069997 1:CAS:528:DyaK1MXit1Srtbk%3D
    • Rolfe DF, Newman JM, Buckingham JA, Clark MG, Brand MD (1999) Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR. Am J Physiol 276(3 Pt 1):C692-C699
    • (1999) Am J Physiol , vol.276 , Issue.3 PART 1
    • Rolfe, D.F.1    Newman, J.M.2    Buckingham, J.A.3    Clark, M.G.4    Brand, M.D.5
  • 136
    • 37649024444 scopus 로고    scopus 로고
    • Role of uncoupling protein UCP2 in cell-mediated immunity: How macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes
    • 18006654 1:CAS:528:DC%2BD2sXhsVSlu7fK
    • Emre Y, Hurtaud C, Karaca M, Nubel T, Zavala F, Ricquier D (2007) Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes. Proc Natl Acad Sci U S A 104(48):19085-19090
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.48 , pp. 19085-19090
    • Emre, Y.1    Hurtaud, C.2    Karaca, M.3    Nubel, T.4    Zavala, F.5    Ricquier, D.6
  • 138
    • 0345732183 scopus 로고    scopus 로고
    • Uncoupling protein 2: A novel player in neuroprotection
    • 14659466 1:CAS:528:DC%2BD3sXptlyhsrk%3D
    • Paradis E, Clavel S, Bouillaud F, Ricquier D, Richard D (2003) Uncoupling protein 2: a novel player in neuroprotection. Trends Mol Med 9(12):522-525
    • (2003) Trends Mol Med , vol.9 , Issue.12 , pp. 522-525
    • Paradis, E.1    Clavel, S.2    Bouillaud, F.3    Ricquier, D.4    Richard, D.5
  • 141
    • 33750518197 scopus 로고    scopus 로고
    • The uncoupling protein 2 modulates the cytokine balance in innate immunity
    • 16971137 1:CAS:528:DC%2BD28XhtFKmt7%2FK
    • Rousset S, Emre Y, Join-Lambert O, Hurtaud C, Ricquier D, Cassard-Doulcier AM (2006) The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine 35(3-4):135-142
    • (2006) Cytokine , vol.35 , Issue.3-4 , pp. 135-142
    • Rousset, S.1    Emre, Y.2    Join-Lambert, O.3    Hurtaud, C.4    Ricquier, D.5    Cassard-Doulcier, A.M.6
  • 146
    • 0344926417 scopus 로고    scopus 로고
    • Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus)
    • 14651968 1:CAS:528:DC%2BD3sXpsVSjsro%3D
    • Talbot DA, Hanuise N, Rey B, Rouanet JL, Duchamp C, Brand MD (2003) Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus). Biochem Biophys Res Commun 312(4):983-1038
    • (2003) Biochem Biophys Res Commun , vol.312 , Issue.4 , pp. 983-1038
    • Talbot, D.A.1    Hanuise, N.2    Rey, B.3    Rouanet, J.L.4    Duchamp, C.5    Brand, M.D.6
  • 150
    • 58049127212 scopus 로고    scopus 로고
    • Upregulation of uncoupling protein-3 in skeletal muscle during exercise: A potential antioxidant function
    • 18977294 1:CAS:528:DC%2BD1MXhsFSjug%3D%3D
    • Jiang N, Zhang G, Bo H, Qu J, Ma G, Cao D, Wen L, Liu S, Ji LL, Zhang Y (2009) Upregulation of uncoupling protein-3 in skeletal muscle during exercise: a potential antioxidant function. Free Radic Biol Med 46(2):138-145
    • (2009) Free Radic Biol Med , vol.46 , Issue.2 , pp. 138-145
    • Jiang, N.1    Zhang, G.2    Bo, H.3    Qu, J.4    Ma, G.5    Cao, D.6    Wen, L.7    Liu, S.8    Ji, L.L.9    Zhang, Y.10
  • 151
    • 20444500563 scopus 로고    scopus 로고
    • Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation
    • 15814607 1:CAS:528:DC%2BD2MXkvVagu7o%3D
    • Bezaire V, Spriet LL, Campbell S, Sabet N, Gerrits M, Bonen A, Harper ME (2005) Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation. FASEB J 19(8):977-979
    • (2005) FASEB J , vol.19 , Issue.8 , pp. 977-979
    • Bezaire, V.1    Spriet, L.L.2    Campbell, S.3    Sabet, N.4    Gerrits, M.5    Bonen, A.6    Harper, M.E.7
  • 152
    • 0035133171 scopus 로고    scopus 로고
    • Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
    • 1:CAS:528:DC%2BD3MXpvFykug%3D%3D
    • Himms-Hagen J, Harper ME (2001) Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (Maywood) 226(2):78-84
    • (2001) Exp Biol Med (Maywood) , vol.226 , Issue.2 , pp. 78-84
    • Himms-Hagen, J.1    Harper, M.E.2
  • 153
    • 31644440526 scopus 로고    scopus 로고
    • Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?
    • 16384603 1:CAS:528:DC%2BD28XhtV2ksbs%3D
    • Schrauwen P, Hoeks J, Hesselink MK (2006) Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism? Prog Lipid Res 45(1):17-41
    • (2006) Prog Lipid Res , vol.45 , Issue.1 , pp. 17-41
    • Schrauwen, P.1    Hoeks, J.2    Hesselink, M.K.3
  • 154
    • 0013198976 scopus 로고    scopus 로고
    • Mitochondria in cell death: Novel targets for neuroprotection and cardioprotection
    • 12763524 1:CAS:528:DC%2BD3sXjvFWnsro%3D
    • Mattson MP, Kroemer G (2003) Mitochondria in cell death: novel targets for neuroprotection and cardioprotection. Trends Mol Med 9(5):196-205
    • (2003) Trends Mol Med , vol.9 , Issue.5 , pp. 196-205
    • Mattson, M.P.1    Kroemer, G.2
  • 155
    • 0037427415 scopus 로고    scopus 로고
    • Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death
    • 12729589 1:CAS:528:DC%2BD3sXjt1Kis7o%3D
    • Mattson MP, Liu D (2003) Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem Biophys Res Commun 304(3):539-549
    • (2003) Biochem Biophys Res Commun , vol.304 , Issue.3 , pp. 539-549
    • Mattson, M.P.1    Liu, D.2
  • 156
    • 0042160141 scopus 로고    scopus 로고
    • The role of uncoupling proteins in the regulation of metabolism
    • 12864746 1:CAS:528:DC%2BD3sXmt1Crt7s%3D
    • Erlanson-Albertsson C (2003) The role of uncoupling proteins in the regulation of metabolism. Acta Physiol Scand 178(4):405-412
    • (2003) Acta Physiol Scand , vol.178 , Issue.4 , pp. 405-412
    • Erlanson-Albertsson, C.1
  • 157
    • 43549101948 scopus 로고    scopus 로고
    • Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria
    • 18251717 1:CAS:528:DC%2BD1cXltVykurs%3D
    • Parker N, Affourtit C, Vidal-Puig A, Brand MD (2008) Energization- dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J 412(1):131-139
    • (2008) Biochem J , vol.412 , Issue.1 , pp. 131-139
    • Parker, N.1    Affourtit, C.2    Vidal-Puig, A.3    Brand, M.D.4
  • 159
    • 33646251863 scopus 로고    scopus 로고
    • Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria
    • 16451125 1:CAS:528:DC%2BD28XjtlCgtrw%3D
    • Esteves TC, Parker N, Brand MD (2006) Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. Biochem J 395(3):619-628
    • (2006) Biochem J , vol.395 , Issue.3 , pp. 619-628
    • Esteves, T.C.1    Parker, N.2    Brand, M.D.3
  • 160
    • 0034804062 scopus 로고    scopus 로고
    • Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal beta-cells
    • 11264003 1:CAS:528:DC%2BD3MXitFeitb8%3D
    • Li LX, Skorpen F, Egeberg K, Jørgensen IH, Grill V (2001) Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal beta-cells. Biochem Biophys Res Commun 282(1):273-277
    • (2001) Biochem Biophys Res Commun , vol.282 , Issue.1 , pp. 273-277
    • Li, L.X.1    Skorpen, F.2    Egeberg, K.3    Jørgensen, I.H.4    Grill, V.5
  • 161
    • 38549120705 scopus 로고    scopus 로고
    • Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages
    • 18082129 1:CAS:528:DC%2BD1cXhtV2it7o%3D
    • Giardina TM, Steer JH, Lo SZ, Joyce DA (2008) Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages. Biochim Biophys Acta 1777(2):118-129
    • (2008) Biochim Biophys Acta , vol.1777 , Issue.2 , pp. 118-129
    • Giardina, T.M.1    Steer, J.H.2    Lo, S.Z.3    Joyce, D.A.4
  • 162
    • 67349227115 scopus 로고    scopus 로고
    • Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke
    • 19240738 1:CAS:528:DC%2BD1MXntVykurY%3D
    • Mehta SL, Li PA (2009) Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke. J Cereb Blood Flow Metab 29(6):1069-1078
    • (2009) J Cereb Blood Flow Metab , vol.29 , Issue.6 , pp. 1069-1078
    • Mehta, S.L.1    Li, P.A.2
  • 163
    • 0035852755 scopus 로고    scopus 로고
    • Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
    • 11171965 1:CAS:528:DC%2BD3MXhsVWjt74%3D
    • Echtay KS, Winkler E, Frischmuth K, Klingenberg M (2001) Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc Natl Acad Sci U S A 98(4):1416-1421
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.4 , pp. 1416-1421
    • Echtay, K.S.1    Winkler, E.2    Frischmuth, K.3    Klingenberg, M.4
  • 165
    • 33745215883 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in mitochondrial biogenesis
    • 16709637 1:CAS:528:DC%2BD28XnsVyju78%3D
    • Reznick RM, Shulman GI (2006) The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol 574:33-39
    • (2006) J Physiol , vol.574 , pp. 33-39
    • Reznick, R.M.1    Shulman, G.I.2
  • 166
    • 0035941492 scopus 로고    scopus 로고
    • Animal mitochondrial biogenesis and function: A regulatory cross-talk between two genomes
    • 11223238 1:CAS:528:DC%2BD3MXht1Okur0%3D
    • Garesse R, Vallejo CG (2001) Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes. Gene 263(1-2):1-16
    • (2001) Gene , vol.263 , Issue.1-2 , pp. 1-16
    • Garesse, R.1    Vallejo, C.G.2
  • 167
    • 34248589911 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease
    • 17502589
    • Finck BN, Kelly DP (2007) Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 115(19):2540-2548
    • (2007) Circulation , vol.115 , Issue.19 , pp. 2540-2548
    • Finck, B.N.1    Kelly, D.P.2
  • 168
    • 34250811284 scopus 로고    scopus 로고
    • Mitochondrial-nuclear communications
    • 17227225 1:CAS:528:DC%2BD2sXhtVehtbzL
    • Ryan MT, Hoogenraad NJ (2007) Mitochondrial-nuclear communications. Annu Rev Biochem 76:701-722
    • (2007) Annu Rev Biochem , vol.76 , pp. 701-722
    • Ryan, M.T.1    Hoogenraad, N.J.2
  • 169
    • 84862278866 scopus 로고    scopus 로고
    • A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells
    • 22655115 1:STN:280:DC%2BC38notFSisQ%3D%3D
    • Wagner AE, Ernst IM, Birringer M, Sancak O, Barella L, Rimbach G (2012) A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells. Oxid Med Cell Longev 2012:835970
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 835970
    • Wagner, A.E.1    Ernst, I.M.2    Birringer, M.3    Sancak, O.4    Barella, L.5    Rimbach, G.6
  • 170
    • 70349780391 scopus 로고    scopus 로고
    • Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-β1 expression
    • 19647758 1:CAS:528:DC%2BD1MXht1GmtbzK
    • Choi HK, Pokharel YR, Lim SC, Han HK, Ryu CS, Kim SK, Kwak MK, Kang KW (2009) Inhibition of liver fibrosis by solubilized coenzyme Q10: role of Nrf2 activation in inhibiting transforming growth factor-β1 expression. Toxicol Appl Pharmacol 240(3):377-384
    • (2009) Toxicol Appl Pharmacol , vol.240 , Issue.3 , pp. 377-384
    • Choi, H.K.1    Pokharel, Y.R.2    Lim, S.C.3    Han, H.K.4    Ryu, C.S.5    Kim, S.K.6    Kwak, M.K.7    Kang, K.W.8
  • 171
    • 11244315114 scopus 로고    scopus 로고
    • Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle
    • 15629894 1:CAS:528:DC%2BD2MXitVyluw%3D%3D
    • Garnier A, Fortin D, Zoll J, N'Guessan B, Mettauer B, Lampert E, Veksler V, Ventura-Clapier R (2005) Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle. FASEB J 19(1):43-52
    • (2005) FASEB J , vol.19 , Issue.1 , pp. 43-52
    • Garnier, A.1    Fortin, D.2    Zoll, J.3    N'Guessan, B.4    Mettauer, B.5    Lampert, E.6    Veksler, V.7    Ventura-Clapier, R.8
  • 172
    • 0035112481 scopus 로고    scopus 로고
    • Invited review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle
    • 11181630 1:CAS:528:DC%2BD3MXjsVWmu7s%3D
    • Hood DA (2001) Invited review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 90(3):1137-1157
    • (2001) J Appl Physiol , vol.90 , Issue.3 , pp. 1137-1157
    • Hood, D.A.1
  • 173
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • 16054085
    • Lin J, Handschin C, Spiegelman BM (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1(6):361-370
    • (2005) Cell Metab , vol.1 , Issue.6 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 174
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • 18391175 1:CAS:528:DC%2BD1cXls1KhsLw%3D
    • Scarpulla RC (2008) Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88(2):611-638
    • (2008) Physiol Rev , vol.88 , Issue.2 , pp. 611-638
    • Scarpulla, R.C.1
  • 176
    • 0025036216 scopus 로고
    • Behavior of mitochondria in the living cell
    • 2246114 1:STN:280:DyaK3M%2FmtVensw%3D%3D
    • Bereiter-Hahn J (1990) Behavior of mitochondria in the living cell. Int Rev Cytol 122:1-63
    • (1990) Int Rev Cytol , vol.122 , pp. 1-63
    • Bereiter-Hahn, J.1
  • 177
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator
    • 12588810 1:CAS:528:DC%2BD3sXhslOgsbo%3D
    • Puigserver P, Spiegelman BM (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24(1):78-90
    • (2003) Endocr Rev , vol.24 , Issue.1 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 178
    • 35348969404 scopus 로고    scopus 로고
    • Targeting PGC-1 alpha to control energy homeostasis
    • 17907962 1:CAS:528:DC%2BD2sXhtFSgsbjN
    • Wu Z, Boss O (2007) Targeting PGC-1 alpha to control energy homeostasis. Expert Opin Ther Targets 11(10):1329-1338
    • (2007) Expert Opin Ther Targets , vol.11 , Issue.10 , pp. 1329-1338
    • Wu, Z.1    Boss, O.2
  • 179
    • 64549127790 scopus 로고    scopus 로고
    • PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    • 19276888
    • Cantó C, Auwerx J (2009) PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 20(2):98-105
    • (2009) Curr Opin Lipidol , vol.20 , Issue.2 , pp. 98-105
    • Cantó, C.1    Auwerx, J.2
  • 180
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1alpha: A key regulator of energy metabolism
    • 17108241
    • Liang H, Ward WF (2006) PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ 30(4):145-151
    • (2006) Adv Physiol Educ , vol.30 , Issue.4 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 181
    • 0037036115 scopus 로고    scopus 로고
    • Nuclear activators and coactivators in mammalian mitochondrial biogenesis
    • 12031478 1:CAS:528:DC%2BD38XjvVejsrw%3D
    • Scarpulla RC (2002) Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim Biophys Acta 1576(1-2):1-14
    • (2002) Biochim Biophys Acta , vol.1576 , Issue.1-2 , pp. 1-14
    • Scarpulla, R.C.1
  • 182
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • 15004004 1:CAS:528:DC%2BD2cXitlWnurg%3D
    • Kelly DP, Scarpulla RC (2004) Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 18(4):357-368
    • (2004) Genes Dev , vol.18 , Issue.4 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 183
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • 20933024 1:CAS:528:DC%2BC3MXntV2lsL4%3D
    • Scarpulla RC (2011) Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 1813(7):1269-1278
    • (2011) Biochim Biophys Acta , vol.1813 , Issue.7 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 184
    • 77957298139 scopus 로고    scopus 로고
    • Transactivation of genes encoding for phase II enzymes and phase III transporters by phytochemical antioxidants
    • 10.3390/molecules15096332 20877225 1:CAS:528:DC%2BC3cXhtFKrs7%2FI
    • Yang YM, Noh K, Han CY, Kim SG (2010) Transactivation of genes encoding for phase II enzymes and phase III transporters by phytochemical antioxidants. Molecules 15(9):6332-6348. doi: 10.3390/molecules15096332
    • (2010) Molecules , vol.15 , Issue.9 , pp. 6332-6348
    • Yang, Y.M.1    Noh, K.2    Han, C.Y.3    Kim, S.G.4
  • 185
    • 84866900065 scopus 로고    scopus 로고
    • Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: Therapeutic modulation via fumaric acid esters
    • 23109883 1:CAS:528:DC%2BC38XhsVCmt7zK
    • Lee DH, Gold R, Linker RA (2012) Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters. Int J Mol Sci 13(9):11783-11803
    • (2012) Int J Mol Sci , vol.13 , Issue.9 , pp. 11783-11803
    • Lee, D.H.1    Gold, R.2    Linker, R.A.3
  • 186
    • 84867421023 scopus 로고    scopus 로고
    • A possible involvement of Nrf2-mediated heme oxygenase-1 up-regulation in protective effect of the proton pump inhibitor pantoprazole against indomethacin-induced gastric damage in rats
    • 23066659
    • Hahm KB, Lee HJ, Han Y, Kim EH, Kim YJ (2012) A possible involvement of Nrf2-mediated heme oxygenase-1 up-regulation in protective effect of the proton pump inhibitor pantoprazole against indomethacin-induced gastric damage in rats. BMC Gastroenterol 12(1):143
    • (2012) BMC Gastroenterol , vol.12 , Issue.1 , pp. 143
    • Hahm, K.B.1    Lee, H.J.2    Han, Y.3    Kim, E.H.4    Kim, Y.J.5
  • 187
    • 37549050907 scopus 로고    scopus 로고
    • Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1
    • 17942419 1:CAS:528:DC%2BD1cXhtFGrtw%3D%3D
    • Reichard JF, Motz GT, Puga A (2007) Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic Acids Res 35(21):7074-7086
    • (2007) Nucleic Acids Res , vol.35 , Issue.21 , pp. 7074-7086
    • Reichard, J.F.1    Motz, G.T.2    Puga, A.3
  • 188
    • 20444381360 scopus 로고    scopus 로고
    • Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury
    • 15896789 1:CAS:528:DC%2BD2MXltVKgtrw%3D
    • Zhu H, Itoh K, Yamamoto M, Zweier JL, Li Y (2005) Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Lett 579(14):3029-3036
    • (2005) FEBS Lett , vol.579 , Issue.14 , pp. 3029-3036
    • Zhu, H.1    Itoh, K.2    Yamamoto, M.3    Zweier, J.L.4    Li, Y.5
  • 189
    • 67650229881 scopus 로고    scopus 로고
    • Nrf2-dependent upregulation of antioxidative enzymes: A novel pathway for proteasome inhibitor-mediated cardioprotection
    • 19351736 1:CAS:528:DC%2BD1MXnvVOks7c%3D
    • Dreger H, Westphal K, Weller A, Baumann G, Stangl V, Meiners S, Stangl K (2009) Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovasc Res 83(2):354-361
    • (2009) Cardiovasc Res , vol.83 , Issue.2 , pp. 354-361
    • Dreger, H.1    Westphal, K.2    Weller, A.3    Baumann, G.4    Stangl, V.5    Meiners, S.6    Stangl, K.7
  • 190
    • 79951974148 scopus 로고    scopus 로고
    • Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans
    • 21280176 1:CAS:528:DC%2BC3MXhtFKrsb4%3D
    • Schmelzer C, Niklowitz P, Okun JG, Haas D, Menke T, Döring F (2011) Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. IUBMB Life 63(1):42-48
    • (2011) IUBMB Life , vol.63 , Issue.1 , pp. 42-48
    • Schmelzer, C.1    Niklowitz, P.2    Okun, J.G.3    Haas, D.4    Menke, T.5    Döring, F.6
  • 191
    • 84862830701 scopus 로고    scopus 로고
    • Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation
    • 22252298 1:CAS:528:DC%2BC38XhsVeisLk%3D
    • Moon HJ, Ko WK, Han SW, Kim DS, Hwang YS, Park HK, Kwon IK (2012) Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. Biochem Biophys Res Commun 418(2):247-253
    • (2012) Biochem Biophys Res Commun , vol.418 , Issue.2 , pp. 247-253
    • Moon, H.J.1    Ko, W.K.2    Han, S.W.3    Kim, D.S.4    Hwang, Y.S.5    Park, H.K.6    Kwon, I.K.7
  • 192
    • 84886596028 scopus 로고    scopus 로고
    • Elucidation of molecular mechanism involved in neuroprotective effect of coenzyme Q10 in alcohol-induced neuropathic pain
    • 10.1111/fcp.12003 23057828
    • Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL (2012) Elucidation of molecular mechanism involved in neuroprotective effect of coenzyme Q10 in alcohol-induced neuropathic pain. Fundam Clin Pharmacol. doi: 10.1111/fcp.12003
    • (2012) Fundam Clin Pharmacol
    • Kandhare, A.D.1    Ghosh, P.2    Ghule, A.E.3    Bodhankar, S.L.4
  • 193
    • 0014963570 scopus 로고
    • Coenzymes Q: Stimulants of the phagocytic activity in rats and immune response in mice
    • Bliznakov E, Casey A, Premuzic E (1970) Coenzymes Q: stimulants of the phagocytic activity in rats and immune response in mice. Experientia 26(9):253-254
    • (1970) Experientia , vol.26 , Issue.9 , pp. 253-254
    • Bliznakov, E.1    Casey, A.2    Premuzic, E.3
  • 194
    • 0018134446 scopus 로고
    • Enhancing effect of coenzyme Q10 on immunorestoration with Mycobacterium bovis BCG in tumor-bearing mice
    • 101414 1:CAS:528:DyaE1cXls1Wgu7o%3D
    • Kawase I, Niitani H, Saijo N, Sasaki H, Morita T (1978) Enhancing effect of coenzyme Q10 on immunorestoration with Mycobacterium bovis BCG in tumor-bearing mice. Gann 69(4):493-497
    • (1978) Gann , vol.69 , Issue.4 , pp. 493-497
    • Kawase, I.1    Niitani, H.2    Saijo, N.3    Sasaki, H.4    Morita, T.5
  • 196
    • 0025921725 scopus 로고
    • Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex
    • 1673841 1:CAS:528:DyaK3MXisVGrs7g%3D
    • Folkers K, Hanioka T, Xia LJ, McRee JT Jr, Langsjoen P (1991) Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex. Biochem Biophys Res Commun 176(2):786-791
    • (1991) Biochem Biophys Res Commun , vol.176 , Issue.2 , pp. 786-791
    • Folkers, K.1    Hanioka, T.2    Xia, L.J.3    McRee, Jr.J.T.4    Langsjoen, P.5
  • 197
    • 0032588778 scopus 로고    scopus 로고
    • Coenzyme Q10 administration increases antibody titer in hepatitis B vaccinated volunteers - A single blind placebo-controlled and randomized clinical study
    • 10416052 1:CAS:528:DyaK1MXkt12mt70%3D
    • Barbieri B, Lund B, Lundström B, Scaglione F (1999) Coenzyme Q10 administration increases antibody titer in hepatitis B vaccinated volunteers - a single blind placebo-controlled and randomized clinical study. Biofactors 9(2-4):351-357
    • (1999) Biofactors , vol.9 , Issue.2-4 , pp. 351-357
    • Barbieri, B.1    Lund, B.2    Lundström, B.3    Scaglione, F.4
  • 198
    • 0015577789 scopus 로고
    • Effect of stimulation of the host defense system by coenzyme Q10 on dibenzpyrene-induced tumors and infection with friend leukemia virus in mice
    • 4510283 1:CAS:528:DyaE3sXhtF2ns78%3D
    • Bliznakov EG (1973) Effect of stimulation of the host defense system by coenzyme Q10 on dibenzpyrene-induced tumors and infection with friend leukemia virus in mice. Proc Natl Acad Sci U S A 70(2):390-394
    • (1973) Proc Natl Acad Sci U S A , vol.70 , Issue.2 , pp. 390-394
    • Bliznakov, E.G.1
  • 199
    • 0348168452 scopus 로고
    • Coenzyme Q in experimental infections and neoplasia
    • K. Folkers Y. Yamamura (eds) Elsevier Amsterdam, The Netherlands
    • Bliznakov EG (1977) Coenzyme Q in experimental infections and neoplasia. In: Folkers K, Yamamura Y (eds) Biomedical and clinical aspects of coenzyme Q. Elsevier, Amsterdam, The Netherlands, pp 73-83
    • (1977) Biomedical and Clinical Aspects of Coenzyme Q , pp. 73-83
    • Bliznakov, E.G.1
  • 200
    • 0015443498 scopus 로고
    • Nonlinear response of the reticuloendothelial system upon stimulation
    • 1:CAS:528:DyaE3sXltlersA%3D%3D
    • Bliznakov EG, Adler AD (1972) Nonlinear response of the reticuloendothelial system upon stimulation. Pathol Microbiol (Basel) 38(6):393-410
    • (1972) Pathol Microbiol (Basel) , vol.38 , Issue.6 , pp. 393-410
    • Bliznakov, E.G.1    Adler, A.D.2
  • 201
    • 0006355346 scopus 로고    scopus 로고
    • Plasma membrane redox system and their role in biological stress and disease
    • H. Asard A. Berczi R.J. Caubergs (eds) Vol 1
    • Villalba JM, Crane FL, Navas P (1998) Plasma membrane redox system and their role in biological stress and disease. In: Asard H, Berczi A, Caubergs RJ (eds) Kluwer, Dordrecht, vol 1, Vol.; pp 247-265
    • (1998) Kluwer, Dordrecht , pp. 247-265
    • Villalba, J.M.1    Crane, F.L.2    Navas, P.3
  • 203
    • 0032524667 scopus 로고    scopus 로고
    • Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex i
    • 9575229 1:CAS:528:DyaK1cXjtlSnsrs%3D
    • Fontaine E, Eriksson O, Ichas F, Bernardi P (1998) Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex i. J Biol Chem 273(20):12662-12668
    • (1998) J Biol Chem , vol.273 , Issue.20 , pp. 12662-12668
    • Fontaine, E.1    Eriksson, O.2    Ichas, F.3    Bernardi, P.4
  • 204
    • 0033575255 scopus 로고    scopus 로고
    • Suicidal tendencies: Apoptotic cell death by caspase family proteinases
    • 10400609 1:CAS:528:DyaK1MXks1Kqur0%3D
    • Wolf BB, Green DR (1999) Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 274(29):20049-20052
    • (1999) J Biol Chem , vol.274 , Issue.29 , pp. 20049-20052
    • Wolf, B.B.1    Green, D.R.2
  • 205
    • 33845967496 scopus 로고    scopus 로고
    • Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins
    • 17159817 1:CAS:528:DC%2BD2sXhsVOksbc%3D
    • Maes M, Mihaylova I, Leunis JC (2006) Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins. Neuro Endocrinol Lett 27(5):615-621
    • (2006) Neuro Endocrinol Lett , vol.27 , Issue.5 , pp. 615-621
    • Maes, M.1    Mihaylova, I.2    Leunis, J.C.3
  • 206
    • 0035896246 scopus 로고    scopus 로고
    • Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome
    • 11388705 1:CAS:528:DC%2BD3MXks1CitLg%3D
    • Manuel y Keenoy B, Moorkens G, Vertommen J, De Leeuw I (2001) Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome. Life Sci 68(17):2037-2049
    • (2001) Life Sci , vol.68 , Issue.17 , pp. 2037-2049
    • Manuel Keenoy Y, B.1    Moorkens, G.2    Vertommen, J.3    De Leeuw, I.4
  • 208
    • 0038303501 scopus 로고    scopus 로고
    • Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients
    • 12870659 1:CAS:528:DC%2BD3sXksFWnsLo%3D
    • Smirnova IV, Pall ML (2003) Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients. Mol Cell Biochem 248(1-2):93-95
    • (2003) Mol Cell Biochem , vol.248 , Issue.1-2 , pp. 93-95
    • Smirnova, I.V.1    Pall, M.L.2
  • 209
    • 67650727423 scopus 로고    scopus 로고
    • Increased oxidative stress suggested by low serum vitamin e concentrations in patients with chronic fatigue syndrome
    • 18684522
    • Miwa K, Fujita M (2009) Increased oxidative stress suggested by low serum vitamin E concentrations in patients with chronic fatigue syndrome. Int J Cardiol 136(2):238-239
    • (2009) Int J Cardiol , vol.136 , Issue.2 , pp. 238-239
    • Miwa, K.1    Fujita, M.2
  • 210
    • 80053900289 scopus 로고    scopus 로고
    • Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome
    • 21549189 1:CAS:528:DC%2BC3MXht12itrzO
    • Jason L, Sorenson M, Sebally K, Alkazemi D, Lerch A, Porter N, Kubow S (2011) Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome. Brain Behav Immun 25(8):1544-1554
    • (2011) Brain Behav Immun , vol.25 , Issue.8 , pp. 1544-1554
    • Jason, L.1    Sorenson, M.2    Sebally, K.3    Alkazemi, D.4    Lerch, A.5    Porter, N.6    Kubow, S.7
  • 211
    • 79751481710 scopus 로고    scopus 로고
    • Lipid peroxidation is elevated in female patients with chronic fatigue syndrome
    • 21119582 1:CAS:528:DC%2BC3MXhvV2ntLk%3D
    • Brkic S, Tomic S, Maric D, Novakov Mikic A, Turkulov V (2010) Lipid peroxidation is elevated in female patients with chronic fatigue syndrome. Med Sci Monit 16(12):CR628-CR632
    • (2010) Med Sci Monit , vol.16 , Issue.12
    • Brkic, S.1    Tomic, S.2    Maric, D.3    Novakov Mikic, A.4    Turkulov, V.5
  • 212
    • 23444438707 scopus 로고    scopus 로고
    • Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
    • 16085177 1:CAS:528:DC%2BD2MXns1Wiu7Y%3D
    • Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ (2005) Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med 39(5):584-589
    • (2005) Free Radic Biol Med , vol.39 , Issue.5 , pp. 584-589
    • Kennedy, G.1    Spence, V.A.2    McLaren, M.3    Hill, A.4    Underwood, C.5    Belch, J.J.6
  • 213
    • 0342368655 scopus 로고    scopus 로고
    • Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: Effects of supplementation with magnesium
    • 10872900 1:CAS:528:DC%2BD3cXksVGgt7o%3D
    • Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Neve J, De Leeuw I (2000) Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr 19(3):374-382
    • (2000) J Am Coll Nutr , vol.19 , Issue.3 , pp. 374-382
    • Manuel Keenoy Y, B.1    Moorkens, G.2    Vertommen, J.3    Noe, M.4    Neve, J.5    De Leeuw, I.6
  • 214
    • 0034129715 scopus 로고    scopus 로고
    • Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome
    • 10905542 1:CAS:528:DC%2BD3cXltlKrs74%3D
    • Richards RS, Roberts TK, McGregor NR, Dunstan RH, Butt HL (2000) Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome. Redox Rep 5(1):35-41
    • (2000) Redox Rep , vol.5 , Issue.1 , pp. 35-41
    • Richards, R.S.1    Roberts, T.K.2    McGregor, N.R.3    Dunstan, R.H.4    Butt, H.L.5
  • 215
    • 33845424640 scopus 로고    scopus 로고
    • Erythrocyte oxidative damage in chronic fatigue syndrome
    • 17174731 1:CAS:528:DC%2BD28XhtlaktLbL
    • Richards RS, Wang L, Jelinek H (2007) Erythrocyte oxidative damage in chronic fatigue syndrome. Arch Med Res 38(1):94-98
    • (2007) Arch Med Res , vol.38 , Issue.1 , pp. 94-98
    • Richards, R.S.1    Wang, L.2    Jelinek, H.3
  • 216
    • 77956051292 scopus 로고    scopus 로고
    • Fluctuation of serum vitamin e (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome
    • 20676841
    • Miwa K, Fujita M (2010) Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. Heart Vessels 25(4):319-323
    • (2010) Heart Vessels , vol.25 , Issue.4 , pp. 319-323
    • Miwa, K.1    Fujita, M.2
  • 217
    • 35348868081 scopus 로고    scopus 로고
    • Not in the mind but in the cell: Increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome
    • 17693978 1:CAS:528:DC%2BD2sXht12rt7vN
    • Maes M, Mihaylova I, Kubera M, Bosmans E (2007) Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett 28(4):463-469
    • (2007) Neuro Endocrinol Lett , vol.28 , Issue.4 , pp. 463-469
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Bosmans, E.4
  • 218
    • 84857359512 scopus 로고    scopus 로고
    • Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin
    • 21975140 1:CAS:528:DC%2BC38XisFWmt7s%3D
    • Maes M, Twisk FNM, Kubera M, Ringel K (2012) Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin. J Affect Disord 136(3):933-939
    • (2012) J Affect Disord , vol.136 , Issue.3 , pp. 933-939
    • Maes, M.1    Twisk, F.N.M.2    Kubera, M.3    Ringel, K.4
  • 219
    • 14844315700 scopus 로고    scopus 로고
    • Chronic fatigue syndrome: Assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise
    • 15715687 1:STN:280:DC%2BD2M7js1Kmtg%3D%3D
    • Jammes Y, Steinberg JG, Mambrini O, Bregeon F, Delliaux S (2005) Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. J Intern Med 257(3):299-310
    • (2005) J Intern Med , vol.257 , Issue.3 , pp. 299-310
    • Jammes, Y.1    Steinberg, J.G.2    Mambrini, O.3    Bregeon, F.4    Delliaux, S.5
  • 220
    • 67650485309 scopus 로고    scopus 로고
    • Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses
    • 19457057 1:CAS:528:DC%2BD1MXhtVGisrfO
    • Jammes Y, Steinberg JG, Delliaux S, Bregeon F (2009) Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. J Intern Med 266(2):196-206
    • (2009) J Intern Med , vol.266 , Issue.2 , pp. 196-206
    • Jammes, Y.1    Steinberg, J.G.2    Delliaux, S.3    Bregeon, F.4
  • 221
    • 84862640024 scopus 로고    scopus 로고
    • Chronic fatigue syndrome: Acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins
    • Jammes Y, Steinberg JG, Delliaux S (2011) Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins. J Intern Med 272(1):74-84
    • (2011) J Intern Med , vol.272 , Issue.1 , pp. 74-84
    • Jammes, Y.1    Steinberg, J.G.2    Delliaux, S.3
  • 222
    • 41049087200 scopus 로고    scopus 로고
    • Specific correlations between muscle oxidative stress and chronic fatigue syndrome: A working hypothesis
    • 18274865 1:CAS:528:DC%2BD1cXjsFGitLg%3D
    • Fulle S, Pietrangelo T, Mancinelli R, Saggini R, Fano G (2007) Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis. J Muscle Res Cell Motil 28(6):355-362
    • (2007) J Muscle Res Cell Motil , vol.28 , Issue.6 , pp. 355-362
    • Fulle, S.1    Pietrangelo, T.2    Mancinelli, R.3    Saggini, R.4    Fano, G.5
  • 223
    • 84865296409 scopus 로고    scopus 로고
    • Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology
    • 22281935 1:CAS:528:DC%2BC38XhtFOqsrzL
    • Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ (2012) Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 25(9):1073-1087
    • (2012) NMR Biomed , vol.25 , Issue.9 , pp. 1073-1087
    • Shungu, D.C.1    Weiduschat, N.2    Murrough, J.W.3    Mao, X.4    Pillemer, S.5    Dyke, J.P.6    Medow, M.S.7    Natelson, B.H.8    Stewart, J.M.9    Mathew, S.J.10
  • 224
    • 37849046499 scopus 로고    scopus 로고
    • Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: Evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression
    • 18063934
    • Maes M, Mihaylova I, Leunis JC (2007) Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression. Neuro Endocrinol Lett 28(6):861-867
    • (2007) Neuro Endocrinol Lett , vol.28 , Issue.6 , pp. 861-867
    • Maes, M.1    Mihaylova, I.2    Leunis, J.C.3
  • 225
    • 84888204772 scopus 로고    scopus 로고
    • Treatment study of methylation cycle support in patients with chronic fatigue syndrome and fibromyalgia
    • Reno, Nevada
    • Nathan N, Van Konynenburg RA (2009) Treatment study of methylation cycle support in patients with chronic fatigue syndrome and fibromyalgia. 9th International IACFS/ME Conference, Reno, Nevada
    • (2009) 9th International IACFS/ME Conference
    • Nathan, N.1    Van Konynenburg, R.A.2
  • 226
    • 84874377185 scopus 로고    scopus 로고
    • A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome
    • doi: 10.1007/s11011-012-9324-8
    • Morris G, Maes M (2012) A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome. Metab Brain Dis. doi: 10.1007/s11011-012-9324-8
    • (2012) Metab Brain Dis
    • Morris, G.1    Maes, M.2
  • 227
    • 84867334006 scopus 로고    scopus 로고
    • Increased nuclear factor-κB and loss of p53 are key mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    • 10.1016/j.mehy.2012.07.034 22951418 1:CAS:528:DC%2BC38XhsFSlsrnF
    • Morris G, Maes M (2012) Increased nuclear factor-κB and loss of p53 are key mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Med Hypotheses 79(5):607-613. doi: 10.1016/j.mehy.2012.07.034
    • (2012) Med Hypotheses , vol.79 , Issue.5 , pp. 607-613
    • Morris, G.1    Maes, M.2
  • 228
    • 77957679024 scopus 로고    scopus 로고
    • Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity
    • 10.1186/1479-5876-8-93 20937116
    • Vermeulen RC, Kurk RM, Visser FC, Sluiter W, Scholte HR (2010) Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med 8:93. doi: 10.1186/1479-5876-8-93
    • (2010) J Transl Med , vol.8 , pp. 93
    • Vermeulen, R.C.1    Kurk, R.M.2    Visser, F.C.3    Sluiter, W.4    Scholte, H.R.5
  • 229
    • 0033067518 scopus 로고    scopus 로고
    • Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome
    • 10209352 1:STN:280:DC%2BD3c3osVajtA%3D%3D
    • Paul L, Wood L, Behan WM, Maclaren WM (1999) Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome. Eur J Neurol 6(1):63-69
    • (1999) Eur J Neurol , vol.6 , Issue.1 , pp. 63-69
    • Paul, L.1    Wood, L.2    Behan, W.M.3    Maclaren, W.M.4
  • 230
    • 0021239002 scopus 로고
    • Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion/fatigue syndrome
    • 6145831 1:STN:280:DyaL2c3ksVKlsQ%3D%3D
    • Arnold DL, Bore PJ, Radda GK, Styles P, Taylor DJ (1984) Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion/fatigue syndrome. Lancet 1(8391):1367-1369
    • (1984) Lancet , vol.1 , Issue.8391 , pp. 1367-1369
    • Arnold, D.L.1    Bore, P.J.2    Radda, G.K.3    Styles, P.4    Taylor, D.J.5
  • 231
    • 0025985435 scopus 로고
    • Mitochondrial abnormalities in the postviral fatigue syndrome
    • 1792865 1:STN:280:DyaK387ntVejsw%3D%3D
    • Behan WM, More IA, Behan PO (1991) Mitochondrial abnormalities in the postviral fatigue syndrome. Acta Neuropathol 83(1):61-65
    • (1991) Acta Neuropathol , vol.83 , Issue.1 , pp. 61-65
    • Behan, W.M.1    More, I.A.2    Behan, P.O.3
  • 232
    • 0032077922 scopus 로고    scopus 로고
    • Heterogeneity in chronic fatigue syndrome: Evidence from magnetic resonance spectroscopy of muscle
    • 9631403 1:STN:280:DyaK1c3psVyltg%3D%3D
    • Lane RJ, Barrett MC, Taylor DJ, Kemp GJ, Lodi R (1998) Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle. Neuromuscul Disord 8(3-4):204-209
    • (1998) Neuromuscul Disord , vol.8 , Issue.3-4 , pp. 204-209
    • Lane, R.J.1    Barrett, M.C.2    Taylor, D.J.3    Kemp, G.J.4    Lodi, R.5
  • 233
    • 0028803859 scopus 로고
    • Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome
    • 8587699 1:STN:280:DyaK287lvF2htA%3D%3D
    • Plioplys AV, Plioplys S (1995) Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome. Neuropsychobiology 32(4):175-181
    • (1995) Neuropsychobiology , vol.32 , Issue.4 , pp. 175-181
    • Plioplys, A.V.1    Plioplys, S.2
  • 234
    • 0031920213 scopus 로고    scopus 로고
    • Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome
    • 9527150 1:STN:280:DyaK1c7os1ersg%3D%3D
    • Lane RJM, Barrett MC, Woodrow D, Moss J, Fletcher R, Archard LC (1998) Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 64(3):362-367
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , Issue.3 , pp. 362-367
    • Lane, R.J.M.1    Barrett, M.C.2    Woodrow, D.3    Moss, J.4    Fletcher, R.5    Archard, L.C.6
  • 235
    • 38349048508 scopus 로고    scopus 로고
    • Skeletal muscle fatigue: Cellular mechanisms
    • 18195089 1:CAS:528:DC%2BD1cXitVKgtrg%3D
    • Allen DG, Lamb GD, Westerbland H (2008) Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 88(1):287-332
    • (2008) Physiol Rev , vol.88 , Issue.1 , pp. 287-332
    • Allen, D.G.1    Lamb, G.D.2    Westerbland, H.3
  • 236
    • 77955283596 scopus 로고    scopus 로고
    • Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function
    • 20649547 1:CAS:528:DC%2BC3cXhtFegsLvN
    • Wu I-C, Ohsawa I, Fuku N, Tanaka M (2010) Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function. Ann NY Acad Sci 1201:111-120
    • (2010) Ann NY Acad Sci , vol.1201 , pp. 111-120
    • Wu, I.-C.1    Ohsawa, I.2    Fuku, N.3    Tanaka, M.4
  • 238
    • 33645847273 scopus 로고    scopus 로고
    • Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: Etiologic and therapeutic concerns
    • 16283318 1:CAS:528:DC%2BD28XjsVeksLs%3D
    • Ozgocmen S, Ozyurt H, Sogut S, Akyol O, Ardicoglu O, Yildizhan H (2006) Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns. Rheumatol Int 26(7):598-603
    • (2006) Rheumatol Int , vol.26 , Issue.7 , pp. 598-603
    • Ozgocmen, S.1    Ozyurt, H.2    Sogut, S.3    Akyol, O.4    Ardicoglu, O.5    Yildizhan, H.6
  • 239
    • 33746364521 scopus 로고    scopus 로고
    • Total antioxidant capacity and the severity of the pain in patients with fibromyalgia
    • 16805968 1:CAS:528:DC%2BD28XmsFersb0%3D
    • Altindag O, Celik H (2006) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia. Redox Rep 11(3):131-135
    • (2006) Redox Rep , vol.11 , Issue.3 , pp. 131-135
    • Altindag, O.1    Celik, H.2
  • 240
    • 63349091068 scopus 로고    scopus 로고
    • Serum antioxidants and nitric oxide levels in fibromyalgia: A controlled study
    • 18853166 1:CAS:528:DC%2BD1MXjsFymu7o%3D
    • Sendur OF, Turan Y, Tastaban E, Yenisey C, Serter M (2009) Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study. Rheumatol Int 29(6):629-633
    • (2009) Rheumatol Int , vol.29 , Issue.6 , pp. 629-633
    • Sendur, O.F.1    Turan, Y.2    Tastaban, E.3    Yenisey, C.4    Serter, M.5
  • 241
    • 80052963983 scopus 로고    scopus 로고
    • Oxidative stress in fibromyalgia: Pathophysiology and clinical implications
    • 21925443
    • Cordero MD (2011) Oxidative stress in fibromyalgia: pathophysiology and clinical implications. Reumatol Clin 7(5):281-283
    • (2011) Reumatol Clin , vol.7 , Issue.5 , pp. 281-283
    • Cordero, M.D.1
  • 242
    • 84877653812 scopus 로고    scopus 로고
    • Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia
    • S0303-8467 2
    • Neyal M, Yimenicioglu F, Aydeniz A, Taskin A, Saglam S, Cekmen M, Neyal A, Gursoy S, Erel O, Balat A (2012) Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia. Clin Neurol Neurosurg S0303-8467(12):00453, 2
    • (2012) Clin Neurol Neurosurg , Issue.12 , pp. 00453
    • Neyal, M.1    Yimenicioglu, F.2    Aydeniz, A.3    Taskin, A.4    Saglam, S.5    Cekmen, M.6    Neyal, A.7    Gursoy, S.8    Erel, O.9    Balat, A.10
  • 244
    • 79952316649 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in fibromyalgia and its implication in the pathogenesis of disease
    • Cordero MD, de Miguel M, Moreno-Fernández AM (2011) Mitochondrial dysfunction in fibromyalgia and its implication in the pathogenesis of disease. Med Clin (Barc) 136(6):252-256
    • (2011) Med Clin (Barc.) , vol.136 , Issue.6 , pp. 252-256
    • Cordero, M.D.1    De Miguel, M.2    Moreno-Fernández, A.M.3
  • 245
    • 84876670027 scopus 로고    scopus 로고
    • The neuroprogressive nature of major depressive disorder: Pathways to disease evolution and resistance, and therapeutic implications
    • 10.1038/mp.2012.33 22525486
    • Moylan S, Maes M, Wray NR, Berk M (2012) The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications. Mol Psychiatry. doi: 10.1038/mp.2012.33
    • (2012) Mol Psychiatry
    • Moylan, S.1    Maes, M.2    Wray, N.R.3    Berk, M.4
  • 246
    • 84855801183 scopus 로고    scopus 로고
    • Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
    • 22197082 1:CAS:528:DC%2BC38Xht1Wgs7Y%3D
    • Leonard B, Maes M (2012) Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 36(2):764-785
    • (2012) Neurosci Biobehav Rev , vol.36 , Issue.2 , pp. 764-785
    • Leonard, B.1    Maes, M.2
  • 247
    • 79954568978 scopus 로고    scopus 로고
    • A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
    • 20471444 1:CAS:528:DC%2BC3MXkvVWgt70%3D
    • Maes M, Galecki P, Chang YS, Berk M (2011) A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry 35(3):676-692
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , Issue.3 , pp. 676-692
    • Maes, M.1    Galecki, P.2    Chang, Y.S.3    Berk, M.4
  • 248
    • 84861856558 scopus 로고    scopus 로고
    • Antioxidants as antidepressants: Fact or fiction?
    • 22668245 1:CAS:528:DC%2BC38XhtFKnsbrP
    • Scapagnini G, Davinelli S, Drago F, De Lorenzo A, Oriani G (2012) Antioxidants as antidepressants: fact or fiction? CNS Drugs 26(6):477-490
    • (2012) CNS Drugs , vol.26 , Issue.6 , pp. 477-490
    • Scapagnini, G.1    Davinelli, S.2    Drago, F.3    De Lorenzo, A.4    Oriani, G.5
  • 250
    • 0031962268 scopus 로고    scopus 로고
    • Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay
    • 9422371 1:CAS:528:DyaK1cXmt1Wg
    • Floor E, Wetzel MG (1998) Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. J Neurochem 70(1):268-275
    • (1998) J Neurochem , vol.70 , Issue.1 , pp. 268-275
    • Floor, E.1    Wetzel, M.G.2
  • 252
    • 0022475372 scopus 로고
    • Lipid peroxidation as cause of nigral cell death in Parkinson's disease
    • 2875360 1:STN:280:DyaL28zgvFyrtQ%3D%3D
    • Dexter D, Carter C, Agid F, Agid Y, Lees AJ, Jenner P, Marsden CD (1986) Lipid peroxidation as cause of nigral cell death in Parkinson's disease. Lancet 2(8507):639-640
    • (1986) Lancet , vol.2 , Issue.8507 , pp. 639-640
    • Dexter, D.1    Carter, C.2    Agid, F.3    Agid, Y.4    Lees, A.J.5    Jenner, P.6    Marsden, C.D.7
  • 254
    • 78449282609 scopus 로고    scopus 로고
    • Metals, oxidative stress and neurodegenerative disorders
    • 20730621 1:CAS:528:DC%2BC3cXhtlOrurzM
    • Jomova K, Vondrakova D, Lawson M, Valko M (2010) Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem 345(1-2):91-104
    • (2010) Mol Cell Biochem , vol.345 , Issue.1-2 , pp. 91-104
    • Jomova, K.1    Vondrakova, D.2    Lawson, M.3    Valko, M.4
  • 256
    • 73349108757 scopus 로고    scopus 로고
    • Do mtDNA mutations participate in the pathogenesis of sporadic Parkinson's disease?
    • 20514220 1:CAS:528:DC%2BD1MXhsFWisb%2FJ
    • Kirches E (2009) Do mtDNA mutations participate in the pathogenesis of sporadic Parkinson's disease? Curr Genomics 10(8):585-593
    • (2009) Curr Genomics , vol.10 , Issue.8 , pp. 585-593
    • Kirches, E.1
  • 257
    • 37349004102 scopus 로고    scopus 로고
    • Parkinson's disease
    • 17911161 1:CAS:528:DC%2BD2sXht1KntLfN
    • Thomas B, Beal MF (2007) Parkinson's disease. Hum Mol Genet 16(2):R183-R194
    • (2007) Hum Mol Genet , vol.16 , Issue.2
    • Thomas, B.1    Beal, M.F.2
  • 258
    • 34250716407 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease
    • 17464321 1:CAS:528:DC%2BD2sXms1Sqs7w%3D
    • Schapira AH (2007) Mitochondrial dysfunction in Parkinson's disease. Cell Death Differ 14(7):1261-1266
    • (2007) Cell Death Differ , vol.14 , Issue.7 , pp. 1261-1266
    • Schapira, A.H.1
  • 259
    • 49349106093 scopus 로고    scopus 로고
    • Redox imbalance in Parkinson's disease
    • 18358848 1:CAS:528:DC%2BD1cXhtVartr7O
    • Chinta SJ, Andersen JK (2008) Redox imbalance in Parkinson's disease. Biochim Biophys Acta 1780(11):1362-1367
    • (2008) Biochim Biophys Acta , vol.1780 , Issue.11 , pp. 1362-1367
    • Chinta, S.J.1    Andersen, J.K.2
  • 261
  • 263
    • 0025640845 scopus 로고
    • Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease
    • 2121905 1:CAS:528:DyaK3MXpvFeltw%3D%3D
    • Schapira AH, Mann VM, Cooper JM, Dexter D, Daniel SE, Jenner P, Clark JB, Marsden CD (1990) Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J Neurochem 55(6):2142-2145
    • (1990) J Neurochem , vol.55 , Issue.6 , pp. 2142-2145
    • Schapira, A.H.1    Mann, V.M.2    Cooper, J.M.3    Dexter, D.4    Daniel, S.E.5    Jenner, P.6    Clark, J.B.7    Marsden, C.D.8
  • 264
    • 33646948530 scopus 로고    scopus 로고
    • Parkinson's disease brain mitochondrial complex i has oxidatively damaged subunits and is functionally impaired and misassembled
    • 16687518 1:CAS:528:DC%2BD28Xlt1Cisrk%3D
    • Keeney PM, Xie J, Capaldi RA, Bennett JP Jr (2006) Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci 26(19):5256-5264
    • (2006) J Neurosci , vol.26 , Issue.19 , pp. 5256-5264
    • Keeney, P.M.1    Xie, J.2    Capaldi, R.A.3    Bennett, Jr.J.P.4
  • 265
    • 0026544129 scopus 로고
    • Mitochondrial complex i and II activities of lymphocytes and platelets in Parkinson's disease
    • 1347219 1:STN:280:DyaK387nt1Wqtg%3D%3D
    • Yoshino H, Nakagawa-Hattori Y, Kondo T, Mizuno Y (1992) Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease. J Neural Transm Park Dis Dement Sect 4(1):27-34
    • (1992) J Neural Transm Park Dis Dement Sect , vol.4 , Issue.1 , pp. 27-34
    • Yoshino, H.1    Nakagawa-Hattori, Y.2    Kondo, T.3    Mizuno, Y.4
  • 266
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • 2557792
    • Parker WD Jr, Boyson SJ, Parks JK (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26(6):719-723
    • (1989) Ann Neurol , vol.26 , Issue.6 , pp. 719-723
    • Parker, Jr.W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 267
    • 0026091344 scopus 로고
    • Mitochondrial oxidative phosphorylation defects in Parkinson's disease
    • 1952821 1:CAS:528:DyaK38Xls1Knuw%3D%3D
    • Shoffner JM, Watts RL, Juncos JL, Torroni A, Wallace DC (1991) Mitochondrial oxidative phosphorylation defects in Parkinson's disease. Ann Neurol 30(3):332-339
    • (1991) Ann Neurol , vol.30 , Issue.3 , pp. 332-339
    • Shoffner, J.M.1    Watts, R.L.2    Juncos, J.L.3    Torroni, A.4    Wallace, D.C.5
  • 269
    • 70350630733 scopus 로고    scopus 로고
    • The emerging role of autophagy in Parkinson's disease
    • 19754977
    • Cheung ZH, Ip NY (2009) The emerging role of autophagy in Parkinson's disease. Mol Brain 2:29
    • (2009) Mol Brain , vol.2 , pp. 29
    • Cheung, Z.H.1    Ip, N.Y.2
  • 270
    • 84869041395 scopus 로고    scopus 로고
    • Development and characterization of a new Parkinson's disease model resulting from impaired autophagy
    • 23152632 1:CAS:528:DC%2BC38XhslagurvP
    • Ahmed I, Liang Y, Schools S, Dawson VL, Dawson TM, Savitt JM (2012) Development and characterization of a new Parkinson's disease model resulting from impaired autophagy. J Neurosci 32(46):16503-16509
    • (2012) J Neurosci , vol.32 , Issue.46 , pp. 16503-16509
    • Ahmed, I.1    Liang, Y.2    Schools, S.3    Dawson, V.L.4    Dawson, T.M.5    Savitt, J.M.6
  • 272
    • 79955685287 scopus 로고    scopus 로고
    • Allostery in a disordered protein: Oxidative modifications to α-synuclein act distally to regulate membrane binding
    • 21491910 1:CAS:528:DC%2BC3MXkslemsbc%3D
    • Sevcsik E, Trexler AJ, Dunn JM, Rhoades E (2011) Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding. J Am Chem Soc 133(18):7152-7158
    • (2011) J Am Chem Soc , vol.133 , Issue.18 , pp. 7152-7158
    • Sevcsik, E.1    Trexler, A.J.2    Dunn, J.M.3    Rhoades, E.4
  • 274
    • 84863683962 scopus 로고    scopus 로고
    • α-Synuclein and mitochondrial dysfunction: A pathogenic partnership in Parkinson's disease?
    • Protter D, Lang C, Cooper AA (2012) α-Synuclein and mitochondrial dysfunction: a pathogenic partnership in Parkinson's disease? Park Dis 2012:829207
    • (2012) Park Dis , vol.2012 , pp. 829207
    • Protter, D.1    Lang, C.2    Cooper, A.A.3
  • 278
    • 70349640049 scopus 로고    scopus 로고
    • Protein turnover and inclusion body formation
    • 19838079 1:CAS:528:DC%2BC3cXmt1Cgtg%3D%3D
    • Mitra S, Tsvetkov AS, Finkbeiner S (2009) Protein turnover and inclusion body formation. Autophagy 5(7):1037-1038
    • (2009) Autophagy , vol.5 , Issue.7 , pp. 1037-1038
    • Mitra, S.1    Tsvetkov, A.S.2    Finkbeiner, S.3
  • 279
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • 18305538 1:CAS:528:DC%2BD1cXisFWjt78%3D
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451(7182):1069-1075
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 283
    • 70350343178 scopus 로고    scopus 로고
    • Chronic fatigue syndrome: La bête noire of the Belgian Health Care System
    • 19855351
    • Maes M, Twisk FN (2009) Chronic fatigue syndrome: la bête noire of the Belgian Health Care System. Neuro Endocrinol Lett 30(3):300-311
    • (2009) Neuro Endocrinol Lett , vol.30 , Issue.3 , pp. 300-311
    • Maes, M.1    Twisk, F.N.2
  • 285
    • 84873971565 scopus 로고    scopus 로고
    • Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: Amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation
    • 23394493 1:CAS:528:DC%2BC3sXis1GlsLw%3D
    • Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y, Yokota S, Yamamoto Y (2013) Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation. Redox Rep 18(1):12-19
    • (2013) Redox Rep , vol.18 , Issue.1 , pp. 12-19
    • Miyamae, T.1    Seki, M.2    Naga, T.3    Uchino, S.4    Asazuma, H.5    Yoshida, T.6    Iizuka, Y.7    Kikuchi, M.8    Imagawa, T.9    Natsumeda, Y.10    Yokota, S.11    Yamamoto, Y.12
  • 286
    • 33746083600 scopus 로고    scopus 로고
    • Treatment of statin adverse effects with supplemental coenzyme Q10 and statin drug discontinuation
    • 16873939 1:CAS:528:DC%2BD28XmvFWksLg%3D
    • Langsjoen PH, Langsjoen JO, Langsjoen AM, Lucas LA (2005) Treatment of statin adverse effects with supplemental coenzyme Q10 and statin drug discontinuation. Biofactors 25(1-4):147-152
    • (2005) Biofactors , vol.25 , Issue.1-4 , pp. 147-152
    • Langsjoen, P.H.1    Langsjoen, J.O.2    Langsjoen, A.M.3    Lucas, L.A.4
  • 287
    • 0347419370 scopus 로고    scopus 로고
    • Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA
    • 14695926 1:CAS:528:DC%2BD3sXpsFenurg%3D
    • Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP (2003) Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Biofactors 18(1-4):113-124
    • (2003) Biofactors , vol.18 , Issue.1-4 , pp. 113-124
    • Passi, S.1    Stancato, A.2    Aleo, E.3    Dmitrieva, A.4    Littarru, G.P.5
  • 291
    • 34250354742 scopus 로고    scopus 로고
    • Effect of atorvastatin withdrawal on circulating coenzyme Q10 concentration in patients with hypercholesterolemia
    • 17473378 1:CAS:528:DC%2BD2sXksVCjtLw%3D
    • Chu CS, Kou HS, Lee CJ, Lee KT, Chen SH, Voon WC, Sheu SH, Lai WT (2006) Effect of atorvastatin withdrawal on circulating coenzyme Q10 concentration in patients with hypercholesterolemia. Biofactors 28(3-4):177-184
    • (2006) Biofactors , vol.28 , Issue.3-4 , pp. 177-184
    • Chu, C.S.1    Kou, H.S.2    Lee, C.J.3    Lee, K.T.4    Chen, S.H.5    Voon, W.C.6    Sheu, S.H.7    Lai, W.T.8
  • 292
    • 0041320849 scopus 로고    scopus 로고
    • Coenzyme Q10 levels in Prader-Willi syndrome: Comparison with obese and non-obese subjects
    • 12749057
    • Butler MG, Dasouki M, Bittel D, Hunter S, Naini A, DiMauro S (2003) Coenzyme Q10 levels in Prader-Willi syndrome: comparison with obese and non-obese subjects. Am J Med Genet A 119A(2):168-171
    • (2003) Am J Med Genet A , vol.119 , Issue.2 , pp. 168-171
    • Butler, M.G.1    Dasouki, M.2    Bittel, D.3    Hunter, S.4    Naini, A.5    Dimauro, S.6
  • 293
    • 56049088295 scopus 로고    scopus 로고
    • Coenzyme Q10 and vitamin e deficiency in Friedreich's ataxia: Predictor of efficacy of vitamin e and coenzyme Q10 therapy
    • 19049556 1:STN:280:DC%2BD1cjotFyitw%3D%3D
    • Cooper JM, Korlipara LV, Hart PE, Bradley JL, Schapira AH (2008) Coenzyme Q10 and vitamin E deficiency in Friedreich's ataxia: predictor of efficacy of vitamin E and coenzyme Q10 therapy. Eur J Neurol 15(12):1371-1379
    • (2008) Eur J Neurol , vol.15 , Issue.12 , pp. 1371-1379
    • Cooper, J.M.1    Korlipara, L.V.2    Hart, P.E.3    Bradley, J.L.4    Schapira, A.H.5
  • 295
    • 76049090965 scopus 로고    scopus 로고
    • Lower plasma coenzyme Q10 in depression: A marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness
    • 20010493 1:CAS:528:DC%2BC3cXitlWhtb8%3D
    • Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2009) Lower plasma coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Neuro Endocrinol Lett 30(4):462-469
    • (2009) Neuro Endocrinol Lett , vol.30 , Issue.4 , pp. 462-469
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Uytterhoeven, M.4    Vrydags, N.5    Bosmans, E.6
  • 297
    • 0001115172 scopus 로고
    • Serum coenzyme Q-10 level in Parkinson syndrome
    • K. Folkers Littarru T. Yamagami (eds) Elsevier Amsterdam
    • Matsubara T, Azuma T, Yoshida S, Yamagami T (1991) Serum coenzyme Q-10 level in Parkinson syndrome. In: Folkers K, Littarru P, Yamagami T (eds) Biomedical and clinical aspects of coenzyme Q. Elsevier, Amsterdam, pp 159-166
    • (1991) Biomedical and Clinical Aspects of Coenzyme Q , pp. 159-166
    • Matsubara, T.1    Azuma, T.2    Yoshida, S.3    Yamagami, T.4
  • 299
    • 77949431709 scopus 로고    scopus 로고
    • The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men
    • 19644406
    • Gökbel H, Gül I, Belviranl M, Okudan N (2010) The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 24(1):97-102
    • (2010) J Strength Cond Res , vol.24 , Issue.1 , pp. 97-102
    • Gökbel, H.1    Gül, I.2    Belviranl, M.3    Okudan, N.4
  • 301
    • 84870240506 scopus 로고    scopus 로고
    • Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise
    • 21990004
    • Díaz-Castro J, Guisado R, Kajarabille N, García C, Guisado IM, de Teresa C, Ochoa JJ (2012) Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise. Eur J Nutr 51(7):791-799
    • (2012) Eur J Nutr , vol.51 , Issue.7 , pp. 791-799
    • Díaz-Castro, J.1    Guisado, R.2    Kajarabille, N.3    García, C.4    Guisado, I.M.5    De Teresa, C.6    Ochoa, J.J.7
  • 303
    • 0038755531 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
    • 12841346 1:CAS:528:DC%2BD3sXjtFKmt7s%3D
    • Singh RB, Neki NS, Kartikey K, Pella D, Kumar A, Niaz MA, Thakur AS (2003) Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 246(1-2):75-82
    • (2003) Mol Cell Biochem , vol.246 , Issue.1-2 , pp. 75-82
    • Singh, R.B.1    Neki, N.S.2    Kartikey, K.3    Pella, D.4    Kumar, A.5    Niaz, M.A.6    Thakur, A.S.7
  • 304
    • 34247639532 scopus 로고    scopus 로고
    • Effect of coenzyme q10 on myopathic symptoms in patients treated with statins
    • 17493470 1:CAS:528:DC%2BD2sXlt1equr4%3D
    • Caso G, Kelly P, McNurlan MA, Lawson WE (2007) Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. Am J Cardiol 99(10):1409-1412
    • (2007) Am J Cardiol , vol.99 , Issue.10 , pp. 1409-1412
    • Caso, G.1    Kelly, P.2    McNurlan, M.A.3    Lawson, W.E.4
  • 306
    • 0035092874 scopus 로고    scopus 로고
    • Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma
    • 11291836 1:CAS:528:DC%2BD3MXisFyqsL0%3D
    • Kim WS, Kim MM, Choi HJ, Yoon SS, Lee MH, Park K, Park CH, Kang WK (2001) Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma. Invest New Drugs 19(1):81-83
    • (2001) Invest New Drugs , vol.19 , Issue.1 , pp. 81-83
    • Kim, W.S.1    Kim, M.M.2    Choi, H.J.3    Yoon, S.S.4    Lee, M.H.5    Park, K.6    Park, C.H.7    Kang, W.K.8
  • 308
    • 0036012822 scopus 로고    scopus 로고
    • An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome
    • 12025528 1:CAS:528:DC%2BD38Xkt1Sgur4%3D
    • Lister RE (2002) An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. J Int Med Res 30(2):195-199
    • (2002) J Int Med Res , vol.30 , Issue.2 , pp. 195-199
    • Lister, R.E.1
  • 309
    • 76649083268 scopus 로고    scopus 로고
    • Antifatigue effect of coenzyme Q10 in mice
    • 20136457 1:CAS:528:DC%2BC3cXhs1Kgsr8%3D
    • Fu X, Ji R, Dam J (2010) Antifatigue effect of coenzyme Q10 in mice. J Med Food 13(1):211-215
    • (2010) J Med Food , vol.13 , Issue.1 , pp. 211-215
    • Fu, X.1    Ji, R.2    Dam, J.3
  • 310
    • 84884913935 scopus 로고    scopus 로고
    • Can coenzyme Q10 improve clinical and molecular parameter in fibromyalgia
    • doi: 10.1089/ars.2013.5260
    • Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, Bullón P, Battino M, Fernández- Rodríguez A, Sánchez-Alcazar JA (2013) Can coenzyme Q10 improve clinical and molecular parameter in fibromyalgia? Antioxid Redox Signal. doi: 10.1089/ars.2013.5260
    • (2013) Antioxid Redox Signal
    • Cordero Md, A.1
  • 311
    • 0141498663 scopus 로고    scopus 로고
    • Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy
    • 9298596 1:CAS:528:DyaK2sXlvVejsLw%3D
    • Barbiroli B, Frassineti C, Martinelli P, Iotti S, Lodi R, Cortelli P, Montagna P (1997) Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy. Cell Mol Biol 43(5):741-749
    • (1997) Cell Mol Biol , vol.43 , Issue.5 , pp. 741-749
    • Barbiroli, B.1    Frassineti, C.2    Martinelli, P.3    Iotti, S.4    Lodi, R.5    Cortelli, P.6    Montagna, P.7
  • 313
    • 0031757804 scopus 로고    scopus 로고
    • Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy
    • 9776469 1:STN:280:DyaK1cvksleltg%3D%3D
    • Chan A, Reichmann H, Kogel A, Beck A, Gold R (1998) Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy. J Neurol 245(10):681-685
    • (1998) J Neurol , vol.245 , Issue.10 , pp. 681-685
    • Chan, A.1    Reichmann, H.2    Kogel, A.3    Beck, A.4    Gold, R.5
  • 314
    • 0036710515 scopus 로고    scopus 로고
    • Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat
    • 12208349 1:CAS:528:DC%2BD38Xms1ymtb8%3D
    • Kwong LK, Kamzalov S, Rebrin I, Bayne AC, Jana CK, Morris P, Forster MJ, Sohal RS (2002) Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med 33(5):627-638
    • (2002) Free Radic Biol Med , vol.33 , Issue.5 , pp. 627-638
    • Kwong, L.K.1    Kamzalov, S.2    Rebrin, I.3    Bayne, A.C.4    Jana, C.K.5    Morris, P.6    Forster, M.J.7    Sohal, R.S.8
  • 315
    • 0141639911 scopus 로고    scopus 로고
    • Coenzyme Q intake elevates the mitochondrial and tissue levels of coenzyme Q and alpha-tocopherol in young mice
    • 14519806 1:CAS:528:DC%2BD3sXotFKrt70%3D
    • Kamzalov S, Sumien N, Forster MJ, Sohal RS (2003) Coenzyme Q intake elevates the mitochondrial and tissue levels of coenzyme Q and alpha-tocopherol in young mice. J Nutr 133(10):3175-3180
    • (2003) J Nutr , vol.133 , Issue.10 , pp. 3175-3180
    • Kamzalov, S.1    Sumien, N.2    Forster, M.J.3    Sohal, R.S.4
  • 316
    • 0023619281 scopus 로고
    • Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes with recurrent abdominal symptoms and coenzyme Q10 administration
    • 2826704 1:STN:280:DyaL1c%2FovFKqsw%3D%3D
    • Yamamoto M, Sato T, Anno M, Ujike H, Takemoto M (1987) Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes with recurrent abdominal symptoms and coenzyme Q10 administration. J Neurol Neurosurg Psychiatry 50:1475-1481
    • (1987) J Neurol Neurosurg Psychiatry , vol.50 , pp. 1475-1481
    • Yamamoto, M.1    Sato, T.2    Anno, M.3    Ujike, H.4    Takemoto, M.5
  • 317
    • 0024561803 scopus 로고
    • Mitochondrial encephalomyopathy (MELAS): Pathological study and successful therapy with coenzyme Q10 and idebenone
    • 2738608 1:STN:280:DyaL1M3ptlWnug%3D%3D
    • Ihara Y, Namba R, Kuroda S, Sato T, Shirabe T (1989) Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone. J Neurol Sci 90(3):263-271
    • (1989) J Neurol Sci , vol.90 , Issue.3 , pp. 263-271
    • Ihara, Y.1    Namba, R.2    Kuroda, S.3    Sato, T.4    Shirabe, T.5
  • 318
    • 0023267038 scopus 로고
    • Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy
    • 3819789 1:STN:280:DyaL2s7ktVWksA%3D%3D
    • Goda S, Hamada T, Ishimoto S, Kobayashi T, Goto I, Kuroiwa Y (1987) Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy. J Neurol 234(1):62-63
    • (1987) J Neurol , vol.234 , Issue.1 , pp. 62-63
    • Goda, S.1    Hamada, T.2    Ishimoto, S.3    Kobayashi, T.4    Goto, I.5    Kuroiwa, Y.6
  • 319
    • 0032944976 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 in patients with mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS): Evaluation by noninvasive tissue oximetry
    • 10064171 1:CAS:528:DyaK1MXhs1yltL8%3D
    • Abe K, Matsuo Y, Kadekawa J, Inoue S, Yanagihara T (1999) Effect of coenzyme Q10 in patients with mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS): evaluation by noninvasive tissue oximetry. J Neurol Sci 162(1):65-68
    • (1999) J Neurol Sci , vol.162 , Issue.1 , pp. 65-68
    • Abe, K.1    Matsuo, Y.2    Kadekawa, J.3    Inoue, S.4    Yanagihara, T.5
  • 321
    • 0024549140 scopus 로고
    • Longterm coenzyme Q10 therapy for a mitochondrial encephalomyopathy with cytochrome c oxidase deficiency: A 31P NMR study
    • 2538775 1:STN:280:DyaL1M7ot1CrtQ%3D%3D
    • Nishikawa Y, Takahashi M, Yorifuji S, Nakamura Y, Ueno S, Tarui S, Kozuka T, Nishimura T (1989) Longterm coenzyme Q10 therapy for a mitochondrial encephalomyopathy with cytochrome c oxidase deficiency: a 31P NMR study. Neurology 39(3):399-403
    • (1989) Neurology , vol.39 , Issue.3 , pp. 399-403
    • Nishikawa, Y.1    Takahashi, M.2    Yorifuji, S.3    Nakamura, Y.4    Ueno, S.5    Tarui, S.6    Kozuka, T.7    Nishimura, T.8
  • 322
    • 0029069148 scopus 로고
    • Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies
    • 7599221 1:CAS:528:DyaK2MXmvVSlsL8%3D
    • Folkers K, Simonsen R (1995) Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochim Biophys Acta 1271(1):281-286
    • (1995) Biochim Biophys Acta , vol.1271 , Issue.1 , pp. 281-286
    • Folkers, K.1    Simonsen, R.2
  • 323
    • 0030612535 scopus 로고    scopus 로고
    • Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study
    • 9208260 1:STN:280:DyaK2szltF2kug%3D%3D
    • Chen RS, Huang CC, Chu NS (1997) Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study. Eur Neurol 37(4):212-218
    • (1997) Eur Neurol , vol.37 , Issue.4 , pp. 212-218
    • Chen, R.S.1    Huang, C.C.2    Chu, N.S.3
  • 324
    • 0030823110 scopus 로고    scopus 로고
    • The effect of coenzyme Q10 on blood glucose and insulin requirement in patients with insulin dependent diabetes mellitus
    • 9266541 1:CAS:528:DyaK2sXlvVarsLo%3D
    • Andersen CB, Henriksen JE, Hother-Nielsen O, Vaag A, Mortensen SA, BeckNielsen H (1997) The effect of coenzyme Q10 on blood glucose and insulin requirement in patients with insulin dependent diabetes mellitus. Mol Aspects Med 18(Suppl):S307-S309
    • (1997) Mol Aspects Med , vol.18 , Issue.SUPPL.
    • Andersen, C.B.1    Henriksen, J.E.2    Hother-Nielsen, O.3    Vaag, A.4    Mortensen, S.A.5    Becknielsen, H.6
  • 326
    • 84873464437 scopus 로고    scopus 로고
    • Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats
    • 23313551 1:CAS:528:DC%2BC3sXjtFSqsb4%3D
    • Aboul-Fotouh S (2013) Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. Pharmacol Biochem Behav 104:105-112
    • (2013) Pharmacol Biochem Behav , vol.104 , pp. 105-112
    • Aboul-Fotouh, S.1
  • 328
    • 84863314750 scopus 로고    scopus 로고
    • Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease
    • 22747840
    • Chao J, Leung Y, Wang M, Chang RC (2012) Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease. Nutr Rev 70(7):373-386
    • (2012) Nutr Rev , vol.70 , Issue.7 , pp. 373-386
    • Chao, J.1    Leung, Y.2    Wang, M.3    Chang, R.C.4
  • 330
    • 84862509879 scopus 로고    scopus 로고
    • New agents promote neuroprotection in Parkinson's disease models
    • 22483311 1:CAS:528:DC%2BC38XptFertrw%3D
    • Santos CM (2012) New agents promote neuroprotection in Parkinson's disease models. CNS Neurol Disord Drug Targets 11(4):410-418
    • (2012) CNS Neurol Disord Drug Targets , vol.11 , Issue.4 , pp. 410-418
    • Santos, C.M.1
  • 332
    • 0347419379 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 in Huntington's disease and early Parkinson's disease
    • 14695931 1:CAS:528:DC%2BD3sXpsFenu7w%3D
    • Beal MF, Shults CW (2003) Effects of coenzyme Q10 in Huntington's disease and early Parkinson's disease. Biofactors 18(1-4):153-161
    • (2003) Biofactors , vol.18 , Issue.1-4 , pp. 153-161
    • Beal, M.F.1    Shults, C.W.2
  • 333
    • 84858611748 scopus 로고    scopus 로고
    • Prospective study of statin use and risk of Parkinson disease
    • 22410446
    • Gao X, Simon KC, Schwarzschild MA, Ascherio A (2012) Prospective study of statin use and risk of Parkinson disease. Arch Neurol 69(3):380-384
    • (2012) Arch Neurol , vol.69 , Issue.3 , pp. 380-384
    • Gao, X.1    Simon, K.C.2    Schwarzschild, M.A.3    Ascherio, A.4
  • 334
    • 0036392326 scopus 로고    scopus 로고
    • Ubiquinol inhibition of neutral sphingomyelinase in liver plasma membrane: Specific inhibition of the Mg(2+)-dependent enzyme and role of isoprenoid chain
    • 12270134
    • Martín SF, Gómez-Díaz C, Navas P, Villalba JM (2002) Ubiquinol inhibition of neutral sphingomyelinase in liver plasma membrane: specific inhibition of the Mg(2+)-dependent enzyme and role of isoprenoid chain. Biochem Biophys Res Commun 297(3):581-586
    • (2002) Biochem Biophys Res Commun , vol.297 , Issue.3 , pp. 581-586
    • Martín, S.F.1    Gómez-Díaz, C.2    Navas, P.3    Villalba, J.M.4
  • 335
    • 4444307109 scopus 로고    scopus 로고
    • Effect of melatonin cotreatment against kainic acid on coenzyme Q10, lipid peroxidation and Trx mRNA in rat hippocampus
    • 15370175 1:CAS:528:DC%2BD2cXhtVahs77E
    • Yalcin A, Kilinc E, Kocturk S, Resmi H, Sozmen EY (2004) Effect of melatonin cotreatment against kainic acid on coenzyme Q10, lipid peroxidation and Trx mRNA in rat hippocampus. Int J Neurosci 114(9):1085-1097
    • (2004) Int J Neurosci , vol.114 , Issue.9 , pp. 1085-1097
    • Yalcin, A.1    Kilinc, E.2    Kocturk, S.3    Resmi, H.4    Sozmen, E.Y.5
  • 336
    • 20444365828 scopus 로고    scopus 로고
    • Therapeutic role of coenzyme Q(10) in Parkinson's disease
    • 15963354 1:CAS:528:DC%2BD2MXlt1Ghurs%3D
    • Shults CW (2005) Therapeutic role of coenzyme Q(10) in Parkinson's disease. Pharmacol Ther 107(1):120-130
    • (2005) Pharmacol Ther , vol.107 , Issue.1 , pp. 120-130
    • Shults, C.W.1
  • 337
    • 3042717908 scopus 로고    scopus 로고
    • Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease
    • 15246848 1:CAS:528:DC%2BD2cXlsFyns7w%3D
    • Shults CW, Flint Beal M, Song D, Fontaine D (2004) Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp Neurol 188(2):491-494
    • (2004) Exp Neurol , vol.188 , Issue.2 , pp. 491-494
    • Shults, C.W.1    Flint Beal, M.2    Song, D.3    Fontaine, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.