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Volumn 22, Issue 16, 2003, Pages 4103-4110

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

Author keywords

ANT; Hydroxynonenal; Obesity; Oxidative stress; UCP

Indexed keywords

4 HYDROXYNONENAL; ADENINE NUCLEOTIDE TRANSLOCASE; ALDEHYDE DERIVATIVE; ALKENE DERIVATIVE; BONGKREKIC ACID; CARBOXYATRACTYLIC ACID; ENZYME INHIBITOR; GUANOSINE DIPHOSPHATE; MEMBRANE PHOSPHOLIPID; REACTIVE OXYGEN METABOLITE; RETINAL; RETINOIC ACID; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

EID: 0041465009     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg412     Document Type: Article
Times cited : (518)

References (39)
  • 1
    • 0028955276 scopus 로고
    • A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene
    • Alvarez, R., de Andres, J., Yubero, P., Vinas, O., Mampel, T., Iglesias, R., Giralt, M. and Villarroya, F. (1995) A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene. J. Biol. Chem., 270, 5666-5673.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5666-5673
    • Alvarez, R.1    De Andres, J.2    Yubero, P.3    Vinas, O.4    Mampel, T.5    Iglesias, R.6    Giralt, M.7    Villarroya, F.8
  • 3
    • 0035283161 scopus 로고    scopus 로고
    • Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4
    • Bouillaud, F., Couplan, E., Pecqueur, C. and Ricquier, D. (2001) Homologues of the uncoupling protein from brown adipose tissue (UCP1): UCP2, UCP3, BMCP1 and UCP4. Biochim. Biophys. Acta, 1504, 107-119.
    • (2001) Biochim. Biophys. Acta , vol.1504 , pp. 107-119
    • Bouillaud, F.1    Couplan, E.2    Pecqueur, C.3    Ricquier, D.4
  • 4
    • 0002114258 scopus 로고
    • Measurement of mitochondrial protonmotive force
    • Brown, G.C. and Cooper, C.E. (eds). IRL Press, Oxford, UK
    • Brand, M.D. (1995) Measurement of mitochondrial protonmotive force. In Brown, G.C. and Cooper, C.E. (eds), Bioenergetics - A Practical Approach. IRL Press, Oxford, UK, pp. 39-62.
    • (1995) Bioenergetics - A Practical Approach , pp. 39-62
    • Brand, M.D.1
  • 5
    • 2242425423 scopus 로고    scopus 로고
    • Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
    • Brand, M.D., Pamplona, R., Portero-Otin, M., Requena, J.R., Roebuck, S.J., Buckingham, J.A., Clapham, J.C. and Cadenas, S. (2002) Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem. J., 368, 597-603.
    • (2002) Biochem. J. , vol.368 , pp. 597-603
    • Brand, M.D.1    Pamplona, R.2    Portero-Otin, M.3    Requena, J.R.4    Roebuck, S.J.5    Buckingham, J.A.6    Clapham, J.C.7    Cadenas, S.8
  • 6
    • 0037169484 scopus 로고    scopus 로고
    • The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3
    • Cadenas, S. et al. (2002) The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J. Biol. Chem., 277, 2773-2778.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2773-2778
    • Cadenas, S.1
  • 8
    • 0027944443 scopus 로고
    • Alterations in mitochondrial membrane fluidity by lipid peroxidation products
    • Chen, J.J. and Yu, B.P. (1994) Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic. Biol. Med., 17, 411-418.
    • (1994) Free Radic. Biol. Med. , vol.17 , pp. 411-418
    • Chen, J.J.1    Yu, B.P.2
  • 9
    • 0029165212 scopus 로고
    • Inhibition of adenine nucleotide translocator by lipid peroxidation products
    • Chen, J.J., Bertrand, H. and Yu, B.P. (1995) Inhibition of adenine nucleotide translocator by lipid peroxidation products. Free Radic. Biol. Med., 19, 583-590.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 583-590
    • Chen, J.J.1    Bertrand, H.2    Yu, B.P.3
  • 10
    • 0029986692 scopus 로고    scopus 로고
    • Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: Immunochemical detection in mitochondria exposed to oxidative stress
    • Cohn, J.A., Tsai, L., Friguet, B. and Szweda, L.I. (1996) Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: immunochemical detection in mitochondria exposed to oxidative stress. Arch. Biochem. Biophys., 328, 158-164.
    • (1996) Arch. Biochem. Biophys. , vol.328 , pp. 158-164
    • Cohn, J.A.1    Tsai, L.2    Friguet, B.3    Szweda, L.I.4
  • 11
    • 0037135559 scopus 로고    scopus 로고
    • No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria
    • Couplan, E., Del Mar Gonzalez-Barroso, M., Alves-Guerra, M.C., Ricquier, D., Goubern, M. and Bouillaud, F. (2002) No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J. Biol. Chem., 277, 26268-26275.
    • (2002) J. Biol. Chem. , vol.277 , pp. 26268-26275
    • Couplan, E.1    Del Mar Gonzalez-Barroso, M.2    Alves-Guerra, M.C.3    Ricquier, D.4    Goubern, M.5    Bouillaud, F.6
  • 13
    • 18244379331 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling proteins
    • Echtay, K.S. et al. (2002a) Superoxide activates mitochondrial uncoupling proteins. Nature, 415, 96-99.
    • (2002) Nature , vol.415 , pp. 96-99
    • Echtay, K.S.1
  • 14
    • 0037033039 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    • Echtay, K.S., Murphy, M.P., Smith, R.A., Talbot D.A. and Brand, M.D. (2002b) Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J. Biol. Chem., 277, 47129-47135.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47129-47135
    • Echtay, K.S.1    Murphy, M.P.2    Smith, R.A.3    Talbot, D.A.4    Brand, M.D.5
  • 15
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer, H., Schaur, R.J. and Zollner, H. (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med., 11, 81-128.
    • (1991) Free Radic. Biol. Med. , vol.11 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 17
    • 0035502402 scopus 로고    scopus 로고
    • Mitochondrial uncoupling as a target for drug development for the treatment of obesity
    • Harper, J.A., Dickinson, K. and Brand, M.D. (2001) Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obesity Rev., 2, 255-265.
    • (2001) Obesity Rev. , vol.2 , pp. 255-265
    • Harper, J.A.1    Dickinson, K.2    Brand, M.D.3
  • 18
    • 0032506040 scopus 로고    scopus 로고
    • Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: Reaction of lipoic acid with 4-hydroxy-2-nonenal
    • Humphries, K.M. and Szweda, L.I. (1998) Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry, 37, 15835-15841.
    • (1998) Biochemistry , vol.37 , pp. 15835-15841
    • Humphries, K.M.1    Szweda, L.I.2
  • 19
    • 0032512411 scopus 로고    scopus 로고
    • Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal
    • Humphries, K.M., Yoo, Y. and Szweda, L.I. (1998) Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Biochemistry, 37, 552-557.
    • (1998) Biochemistry , vol.37 , pp. 552-557
    • Humphries, K.M.1    Yoo, Y.2    Szweda, L.I.3
  • 20
    • 0036711708 scopus 로고    scopus 로고
    • Nucleotide binding to human uncoupling protein-2 refolded from bacterial inclusion bodies
    • Jekabsons, M.B., Echtay, K.S. and Brand, M.D. (2002) Nucleotide binding to human uncoupling protein-2 refolded from bacterial inclusion bodies. Biochem. J., 366, 565-571.
    • (2002) Biochem. J. , vol.366 , pp. 565-571
    • Jekabsons, M.B.1    Echtay, K.S.2    Brand, M.D.3
  • 21
    • 0030472065 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal-protein adducts and apoptosis in murine lung cells after acute ozone exposure
    • Kirichenko, A., Li, L., Morandi, M.T. and Holian, A. (1996) 4-hydroxy-2-nonenal-protein adducts and apoptosis in murine lung cells after acute ozone exposure. Toxicol. Appl. Pharmacol., 141, 416-424.
    • (1996) Toxicol. Appl. Pharmacol. , vol.141 , pp. 416-424
    • Kirichenko, A.1    Li, L.2    Morandi, M.T.3    Holian, A.4
  • 22
    • 0001187696 scopus 로고
    • The ADP-ATP carrier in mitochondrial membranes
    • Klingenberg, M. (1975) The ADP-ATP carrier in mitochondrial membranes. Enzymes Biol. Membr., 4, 511-553.
    • (1975) Enzymes Biol. Membr. , vol.4 , pp. 511-553
    • Klingenberg, M.1
  • 23
    • 0029866196 scopus 로고    scopus 로고
    • 4-Hydroxyhexenal is a potent inducer of the mitochondrial permeability transition
    • Kristal, B.S., Park, B.K. and Yu, B.P. (1996) 4-Hydroxyhexenal is a potent inducer of the mitochondrial permeability transition. J. Biol. Chem. 271, 6033-6038.
    • (1996) J. Biol. Chem , vol.271 , pp. 6033-6038
    • Kristal, B.S.1    Park, B.K.2    Yu, B.P.3
  • 24
    • 0037172778 scopus 로고    scopus 로고
    • Identification of bovine heart cytochrome c oxidase subunits modified by the lipid peroxidation product 4-hydroxy-2-nonenal
    • Musatov, A., Carroll, C.A., Liu, Y.C., Henderson, G.I., Weintraub, S.T. and Robinson, N.C. (2002) Identification of bovine heart cytochrome c oxidase subunits modified by the lipid peroxidation product 4-hydroxy-2-nonenal. Biochemistry, 41, 8212-8220.
    • (2002) Biochemistry , vol.41 , pp. 8212-8220
    • Musatov, A.1    Carroll, C.A.2    Liu, Y.C.3    Henderson, G.I.4    Weintraub, S.T.5    Robinson, N.C.6
  • 25
    • 0028897831 scopus 로고
    • Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal
    • Nadkarni, D.V. and Sayre, L.M. (1995) Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal. Chem. Res. Toxicol., 8, 284-291.
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 284-291
    • Nadkarni, D.V.1    Sayre, L.M.2
  • 26
    • 0019206035 scopus 로고
    • Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase
    • Nohl, N. and Kramer, R. (1980) Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase. Mech. Ageing Dev., 14, 137-144.
    • (1980) Mech. Ageing Dev. , vol.14 , pp. 137-144
    • Nohl, N.1    Kramer, R.2
  • 27
    • 0030809576 scopus 로고    scopus 로고
    • Reactive oxygen species, mitochondria, apoptosis and aging
    • Papa, S. and Skulachev, V.P. (1997) Reactive oxygen species, mitochondria, apoptosis and aging. Mol. Cell Biochem., 174, 305-319.
    • (1997) Mol. Cell Biochem. , vol.174 , pp. 305-319
    • Papa, S.1    Skulachev, V.P.2
  • 29
    • 0032731757 scopus 로고    scopus 로고
    • Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney
    • Portero-Otin, M., Pamplona, R., Ruiz, M.C., Cabiscol, E., Prat, J. and Bellmunt, M. (1999) Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney. Diabetes, 48, 2215-2220.
    • (1999) Diabetes , vol.48 , pp. 2215-2220
    • Portero-Otin, M.1    Pamplona, R.2    Ruiz, M.C.3    Cabiscol, E.4    Prat, J.5    Bellmunt, M.6
  • 31
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCPI, UCP2, UCP3, stUCP and atUCP
    • Ricquier, D. and Bouillaud, F. (2000) The uncoupling protein homologues: UCPI, UCP2, UCP3, stUCP and atUCP. Biochem. J., 345, 161-179.
    • (2000) Biochem. J. , vol.345 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 32
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre, J., Buckingham, J.A. Roebuck, S.J. and Brand, M.D. (2002) Topology of superoxide production from different sites in the mitochondrial electron transport chain. J. Biol. Chem., 277, 44784-44790.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 33
    • 0035875366 scopus 로고    scopus 로고
    • A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast
    • Stuart, J.A., Harper, J.A., Brindle, K.M., Jekabsons, M.B. and Brand, M.D. (2001) A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast. Biochem. J., 356, 779-789.
    • (2001) Biochem. J. , vol.356 , pp. 779-789
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Jekabsons, M.B.4    Brand, M.D.5
  • 34
    • 0026769469 scopus 로고
    • Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal
    • Uchida, K. and Stadtman, E.R. (1992) Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal. Proc. Natl. Acad. Sci. USA, 89, 5611-5615.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5611-5615
    • Uchida, K.1    Stadtman, E.R.2
  • 35
    • 0029924971 scopus 로고    scopus 로고
    • The effect of the lipid peroxidation product 4-hydroxynonenal and of its metabolite 4-hydroxynonenoic acid on respiration of rat kidney cortex mitochondria
    • Ullrich, O., Henke, W., Grune, T. and Siems, W.G. (1996) The effect of the lipid peroxidation product 4-hydroxynonenal and of its metabolite 4-hydroxynonenoic acid on respiration of rat kidney cortex mitochondria. Free Radic. Res., 24, 421-427.
    • (1996) Free Radic. Res. , vol.24 , pp. 421-427
    • Ullrich, O.1    Henke, W.2    Grune, T.3    Siems, W.G.4
  • 36
    • 0034717015 scopus 로고    scopus 로고
    • Energy metabolism in uncoupling protein 3 gene knockout mice
    • Vidal-Puig, A.J. et al. (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. J. Biol. Chem., 275, 16258-16266.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16258-16266
    • Vidal-Puig, A.J.1
  • 37
    • 0032573066 scopus 로고    scopus 로고
    • Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
    • Yan, L.J. and Sohal, R.S. (1998) Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc. Natl Acad. Sci. USA, 95, 12896-12901.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12896-12901
    • Yan, L.J.1    Sohal, R.S.2
  • 38
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction and type 2 diabetes
    • Zhang, C.Y. et al. (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction and type 2 diabetes. Cell, 105, 745-755.
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1
  • 39
    • 0032843441 scopus 로고    scopus 로고
    • Stress sensitive B encodes an adenine nucleotide translocase in Drosophila melanogaster
    • Zhang, Y.Q., Roote, J., Brogna, S., Davis, A.W., Barbash, D.A., Nash, D. and Ashburner, M. (1999) Stress sensitive B encodes an adenine nucleotide translocase in Drosophila melanogaster. Genetics, 153, 891-903.
    • (1999) Genetics , vol.153 , pp. 891-903
    • Zhang, Y.Q.1    Roote, J.2    Brogna, S.3    Davis, A.W.4    Barbash, D.A.5    Nash, D.6    Ashburner, M.7


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