Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

Pharmacology Biochemistry and Behavior

Volumn 104, Issue 1, 2013, Pages 105-112

  Aboul Fotouh, Sawsan ^a,b  

^a Ain Shams University   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Chronic restraint stress; Coenzyme Q10; Corticosterone; DNA damage; Forced swimming test; Malondialdehyde; Nitric oxide; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; NITRIC OXIDE; UBIDECARENONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BEHAVIOR; BEHAVIOR DISORDER; CHRONIC STRESS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; DNA DAMAGE; DOSE RESPONSE; FORCED SWIMMING TEST; HIPPOCAMPUS; IMMOBILIZATION STRESS; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NITROSATIVE STRESS; NONHUMAN; OPEN FIELD TEST; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; DNA DAMAGE; HIPPOCAMPUS; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE NITROGEN SPECIES; RESTRAINT, PHYSICAL; STRESS, PHYSIOLOGICAL; UBIQUINONE;

RATTUS;

EID: 84873464437     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.12.027     Document Type: Article

References (58)

1. B.A. Abdel-Wahab, and R.H. Salama Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice Pharmacol Biochem Behav 100 2011 59 65
2. A. Abdin, and H. Hamouda Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism Neuropharmacol 55 2008 1340 1346
3. H. Aebi Catalase in vitro Meth Enzymol 105 1984 121 126
4. A. Al-Attar Hypolipidemic effects of coenzyme Q10 in experimentally induced hyper-cholesterolemic model in female rats Am J Pharmacol Toxicol 5 2010 14 23
5. M.F. Beal Coenzyme Q10 as a possible treatment for neurodegenerative diseases Free Radic Res 36 2002 455 460
6. G.A. Behr, J.C. Moreira, and B.N. Frey Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder Oxid Med Cell Longev 2012 2012 609421
7. M. Bilici, H. Efe, M.A. Koroglu, H.Á. Uydu, M. Bekaroglu, and O. Deger Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments J Affect Disorders 64 2001 43 51
8. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
9. M.G. Butler, M. Dasouki, D. Bittel, S. Hunter, A. Naini, and S. DiMauro Coenzyme Q10 levels in Prader-Willi syndrome: comparison with obese and non-obese subjects Am J Med Genet A 119A 2003 168 171
10. A.V. Calixto, F.S. Duarte, M. Duzzioni, L.P. Nascimento Häckl, M.S. Faria, and T.C. De Lima Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze Behav Brain Res 207 1 2010 112 117
11. R.K. Chaturvedi, and M.F. Beal Mitochondrial approaches for neuroprotection Ann N Y Acad Sci 1147 2008 395 412
12. G. Chew, and G. Watts Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling' hypotheses Int J Med 97 8 2004 537 548
13. S. Chiba, T. Numakawa, M. Ninomiya, M.C. Richards, C. Wakabayashi, and H. Kunugi Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex Prog Neuropsychopharmacol Biol Psychiatry 39 1 2012 112 119
14. F.L. Crane Biochemical functions of coenzyme Q10 J Am Coll Nutr 20 2001 591 598
15. R.G. Cutler Antioxidants and aging Am J Clin Nutr 50 1991 373S 379S
16. L. Ernster, and G. Dallner Biochemical, physiological and medical aspects of ubiquinone function Biochim Biophys Acta 127 1995 195 204
17. H. Esterbauer, and K.H. Cheeseman Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal Methods Enzymo 186 1990 407 421
18. R.A. Floyd Antioxidants, oxidative stress and degenerative neurological disorders Proc Soc Exp Biol Med 222 1999 236 245
19. A. Gardner, A. Johansson, R. Wibom, I. Nennesmo, U. von Dobeln, and L. Hagenfeldt Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients Affect Disord 76 1-3 2003 55 68
20. I. Guevara, J. Iwanejko, A. Dembinska-Kiec, J. Pankiewicz, A. Wanat, and P. Anna Determination of nitrite/nitrate in human biological material by the simple Griess reaction Clin Chim Acta 274 1998 177 188
21. M. Hennebelle, L. Balasse, A. Latour, G. Champeil-Potokar, and S. Denis Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress PLoS One 7 7 2012 e42142 10.1371/journal.pone.0042142
22. K. Hosoe, M. Kitano, H. Kishida, H. Kubo, K. Fujii, and M. Kitahaara Study on safety and bioavailability of ubiquinol (Kaneka QHTM) after single and 4-week multiple oral administrations to healthy volunteers Regul Toxicol Pharmacol 47 2007 19 28
23. T.N. Huynh, A.M. Krigbaum, J.J. Hanna, and C.D. Conrad Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior Behav Brain Res 222 2011 212 222
24. D.J. Jollow, J.R. Mitchel, N. Zampaglione, and J.R. Gillete Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4 bromobenzene oxide as the hepatotoxic intermediate Pharmacol 11 1974 151 169
25. S.D. Khanzode, G.N. Dakhale, S.S. Khanzode, A. Saoji, and R. Palasodkar Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors Redox Rep 8 2003 365 370
26. J. Kodydková, L. Vávrová, M. Zeman, R. Jirák, J. Macášek, and B. Staňková Antioxidative enzymes and increased oxidative stress in depressive women Int J Neuropsychopharmacol 11 2008 851 876
27. G. Li, L.Y. Zou, C.M. Cao, and E.S. Yang Coenzyme Q10 protects SHSY5Y neuronal cells from beta amyloid toxicity and oxygen-glucose deprivation by inhibiting the opening of the mitochondrial permeability transition pore Biofactors 25 2005 97 107
28. V.M. Linck, L. Costa-Campos, L.K. Pilz, C.R. Garcia, and E. Elisabetsky AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test Behav Pharmacol 23 2012 171 177
29. G. Littarru, and L. Tiano Bioenergetic and antioxidant properties of coenzyme Q10: recent developments Mol Biotechnol 37 2007 31 37
30. W. Liu, and C. Zhou Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning Psychoneuropharmacol 37 2012 1057 1070
31. K.R. Lobato, C.C. Cardoso, R.W. Binfaré, J. Budni, C.L. Wagner, and P.S. Brocardo alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression Behav Brain Res 209 2010 249 259
32. G. Lucca, C.M. Comim, S.S. Valvassori, G.Z. Réus, F. Vuolo, and F. Petronilho Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm J Psych Res 43 2009 864 869
33. G. Lucca, C.M. Comim, S.S. Valvassori, G.Z. Réus, F. Vuolo, and F. Petronilho Effects of chronic mild stress on the oxidative parameters in the rat brain Neurochem Int 54 2009 358 362
34. J.L. Madrigal, R. Olivenza, M.A. Moro, I. Lizasoain, P. Lorenzo, and J. Rodrigo Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain Neuropsychopharmacol 24 2001 420 429
35. J.L. Madrigal, B. Garcia-Bueno, J.R. Caso, B.G. Perez-Nievas, and J.C. Leza Stress-induced oxidative changes in brain CNS Neurol Disord Drug Targets 5 2006 561 568
36. M. Maes, I. Mihaylova, M. Kubera, M. Uytterhoeven, N. Vrydags, and E. Bosmans Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness Neuro Endocrinol Lett 30 2009 462 469
37. M. Maes, I. Mihaylova, M. Kubera, M. Uytterhoeven, N. Vrydags, and E. Bosmans Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis/chronic fatigue syndrome Neuro Endocrinol Lett 30 2009 715 722
38. M. Maes, P. Galecki, Y.S. Chang, and M. Berk A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness Prog Neuropsychopharmacol Biol Psychiatry 35 3 2011 676 692
39. M. Mancuso, L. Orsucc, V. Volpi, and G. Calsolaro Coenzyme Q10 in neuromuscular and neurodegenerative disorders Curr Drug Targets 11 2010 111 121
40. T.M. Michel, S. Frangou, D. Thiemeyer, S. Camara, J. Jecel, and K. Nara Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder - a postmortem study Psychiat Res 151 2007 145 150
41. K. Nosek, K. Dennis, B.M. Andrus, N. Ahmadiyeh, A.E. Baum, and L.C. Solberg Woods Context and strain-dependent behavioral response to stress Behav Brain Funct 4 2008 23 31
42. M.E. Ozcan, M. Gulec, E. Ozerol, R. Polat, and O. Akyol Antioxidant enzyme activities and oxidative stress in affective disorders Int Clin Psychopharmacol 19 2004 89 95
43. D.M. Pechlivanova, A.G. Stoynev, and J.D. Tchekalarova The effects of chronic losartan pretreatment on restraint stress-induced changes in motor activity, nociception and pentylenetetrazol generalized seizures in rats Folia Med (Plovdiv) 53 2 2011 69 73
44. R.D. Porsolt, A. Bertin, and M. Jalfre Behavioral despair in mice: a primary screening test for antidepressants Arch Int Pharmacodyn Ther 229 1977 327 336
45. T. Posser, M.P. Kaster, S.C. Baraúna, J.B. Rocha, A.L. Rodrigues, and R.B. Leal Antidepressant-like effect of the organoselenium compound ebselen in mice: evidence for the involvement of the monoaminergic system Eur J Pharmacol 602 2009 85 91
46. J.L. Quiles, J.J. Ochoa, J.R. Huertas, and J. Mataix Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet Exp Gerontol 39 2004 189 194
47. G.Z. Réus, R.B. Stringari, B. de Souza, F. Dal-Pizzol, J.E. Hallak, and A.W. Zuardi Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus Oxid Med Cell Longev 3 2010 325 331
48. G.T. Rezin, G. Amboni, A.L. Zugno, J. Quevedo, and E.L. Streck Mitochondrial dysfunction and psychiatric disorders Neurochem Res 34 2009 1021 1029
49. G.T. Rezin, M.R. Cardoso, C.L. Gonçalves, G. Scaini, D.B. Fraga, and R.E. Riegel Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression Neurochem Int 53 2008 395 400
50. P. Rojas, N. Serrano-García, O.N. Medina-Campos, J. Pedraza-Chaverri, S.O. Ogren, and C. Rojas Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress Neurochem Int 59 2011 628 636
51. A.H. Swiergiel, Y. Zhou, and A.J. Dunn Effects of chronic footshock, restraint and corticotropin-releasing factor on freezing, ultrasonic vocalization and forced swim behavior in rats Behav Brain Res 183 2007 178 187
52. M.K. Tawfik Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress Epilepsy Behav 22 2011 671 677
53. M. Tomasetti, R. Alleva, B. Borghi, and A.R. Collins In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage FASEB J 15 2001 1425 1427
54. M. Tõnisaar, T. Mällo, M. Eller, R. Häidkind, K. Kõiv, and J. Harro Rat behaviour after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram Prog Neuropsychopharmacol Biol Psychiatry 32 2008 164 177
55. A.P. West Neurobehavioral studies of forced swimming: the role of learning and memory in the forced swimming test Prog Neuropsychopharmacol Biol Psychiatry 14 1990 863 877
56. A.J. Young, S. Johnson, D.C. Steffens, and P.M. Doraiswamy Coenzyme Q10: a review of its promise as a neuroprotectant CNS Spectr 12 2007 62 68
57. A. Zafir, A. Ara, and N. Banu In vivo antioxidant status: a putative target of antidepressant action Prog Neuropsychopharmacol Biol Psychiatry 33 2009 220 228
58. J. Zhang, X.Y. Huang, M.L. Ye, C.X. Luo, H.Y. Wu, and Y. Hu Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors J Neurosci 30 7 2010 2433 2441