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Volumn 9, Issue 12, 2003, Pages 522-525

Uncoupling protein 2: A novel player in neuroprotection

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2;

EID: 0345732183     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2003.10.009     Document Type: Article
Times cited : (49)

References (27)
  • 1
    • 0021451717 scopus 로고
    • Proton and calcium circuits across the mitochondrial inner membrane
    • Nicholls, D.G. et al. (1984) Proton and calcium circuits across the mitochondrial inner membrane. Biochem. Soc. Trans. 12, 388-390
    • (1984) Biochem. Soc. Trans. , vol.12 , pp. 388-390
    • Nicholls, D.G.1
  • 2
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
    • Fleury, C. et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15, 269-272
    • (1997) Nat. Genet. , vol.15 , pp. 269-272
    • Fleury, C.1
  • 3
    • 0032504772 scopus 로고    scopus 로고
    • Distribution of the uncoupling protein 2 mRNA in the mouse brain
    • Richard, D. et al. (1998) Distribution of the uncoupling protein 2 mRNA in the mouse brain. J. Comp. Neurol. 397, 549-560
    • (1998) J. Comp. Neurol. , vol.397 , pp. 549-560
    • Richard, D.1
  • 4
    • 0035214180 scopus 로고    scopus 로고
    • Uncoupling protein 2 in the brain: Distribution and function
    • Richard, D. et al. (2001) Uncoupling protein 2 in the brain: distribution and function. Biochem. Soc. Trans. 29, 812-817
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 812-817
    • Richard, D.1
  • 5
    • 0038168520 scopus 로고    scopus 로고
    • Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10
    • Jaburek, M. and Garlid, K.D. (2003) Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10. J. Biol. Chem. 278, 25825-25831
    • (2003) J. Biol. Chem. , vol.278 , pp. 25825-25831
    • Jaburek, M.1    Garlid, K.D.2
  • 6
    • 0037039366 scopus 로고    scopus 로고
    • A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
    • Krauss, S. et al. (2002) A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc. Natl. Acad. Sci. U. S. A. 99, 118-122
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 118-122
    • Krauss, S.1
  • 7
    • 18244379331 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling proteins
    • Echtay, K.S. et al. (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415, 96-99
    • (2002) Nature , vol.415 , pp. 96-99
    • Echtay, K.S.1
  • 8
    • 0037135559 scopus 로고    scopus 로고
    • No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria
    • Couplan, E. et al. (2002) No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J. Biol. Chem. 277, 26268-26275
    • (2002) J. Biol. Chem. , vol.277 , pp. 26268-26275
    • Couplan, E.1
  • 9
    • 0033667705 scopus 로고    scopus 로고
    • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    • Arsenijevic, D. et al. (2000) Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat. Genet. 26, 435-439
    • (2000) Nat. Genet. , vol.26 , pp. 435-439
    • Arsenijevic, D.1
  • 10
    • 0038061012 scopus 로고    scopus 로고
    • A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
    • Negre-Salvayre, A. et al. (1997) A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J. 11, 809-815
    • (1997) FASEB J. , vol.11 , pp. 809-815
    • Negre-Salvayre, A.1
  • 11
    • 0030670765 scopus 로고    scopus 로고
    • Membrane-linked systems preventing superoxide formation
    • Skulachev, V.P. (1997) Membrane-linked systems preventing superoxide formation. Biosci. Rep. 17, 347-366
    • (1997) Biosci. Rep. , vol.17 , pp. 347-366
    • Skulachev, V.P.1
  • 12
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • Zhang, C.Y. et al. (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105, 745-755
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1
  • 13
    • 0037469183 scopus 로고    scopus 로고
    • Protective role of uncoupling protein 2 in atherosclerosis
    • Blanc, J. et al. (2003) Protective role of uncoupling protein 2 in atherosclerosis. Circulation 107, 388-390
    • (2003) Circulation , vol.107 , pp. 388-390
    • Blanc, J.1
  • 14
    • 0041464712 scopus 로고    scopus 로고
    • Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
    • Mattiasson, G. et al. (2003) Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat. Med. 9, 1062-1068
    • (2003) Nat. Med. , vol.9 , pp. 1062-1068
    • Mattiasson, G.1
  • 15
    • 85030934599 scopus 로고    scopus 로고
    • Kainic acid upregulated uncoupling protein-2 mRNA expression in the mouse brain
    • in press
    • Clavel, S. et al. Kainic acid upregulated uncoupling protein-2 mRNA expression in the mouse brain. Neuroreport (in press)
    • Neuroreport
    • Clavel, S.1
  • 16
    • 0038443821 scopus 로고    scopus 로고
    • Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death
    • Sullivan, P. G. et al. (2003) Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann. Neurol. 53, 711-717
    • (2003) Ann. Neurol. , vol.53 , pp. 711-717
    • Sullivan, P.G.1
  • 17
    • 0036683694 scopus 로고    scopus 로고
    • Brain mitochondrial uncoupling protein 2 (UCP2): A protective stress signal in neuronal injury
    • Bechmann, I. et al. (2002) Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem. Pharmacol. 64, 363-367
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 363-367
    • Bechmann, I.1
  • 18
    • 0034736001 scopus 로고    scopus 로고
    • Distinct regulation of brain mitochondrial carrier-protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging
    • Mizuno, T. et al. (2000) Distinct regulation of brain mitochondrial carrier-protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging. Biochem. Biophys. Res. Commun. 278, 691-697
    • (2000) Biochem. Biophys. Res. Commun. , vol.278 , pp. 691-697
    • Mizuno, T.1
  • 19
    • 85030934504 scopus 로고    scopus 로고
    • Uncoupling protein 2 prevents neuronal death including that occurring during seizures: A mechanism for pre-conditioning
    • in press
    • Diano, S. et al. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for pre-conditioning. Endocrinology (in press)
    • Endocrinology
    • Diano, S.1
  • 20
    • 0037025256 scopus 로고    scopus 로고
    • Mitochondria, Ca(2+) and neurodegenerative disease
    • Krieger, C. and Duchen, M.R. (2002) Mitochondria, Ca(2+) and neurodegenerative disease. Eur. J. Pharmacol. 447, 177-188
    • (2002) Eur. J. Pharmacol. , vol.447 , pp. 177-188
    • Krieger, C.1    Duchen, M.R.2
  • 21
    • 0042526012 scopus 로고    scopus 로고
    • Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes
    • Teshima, Y. et al. (2003) Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ. Res. 93, 192-200
    • (2003) Circ. Res. , vol.93 , pp. 192-200
    • Teshima, Y.1
  • 22
    • 0037169484 scopus 로고    scopus 로고
    • The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3
    • Cadenas, S. et al. (2002) The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J. Biol. Chem. 277, 2773-2778
    • (2002) J. Biol. Chem. , vol.277 , pp. 2773-2778
    • Cadenas, S.1
  • 23
    • 0037088649 scopus 로고    scopus 로고
    • Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes
    • Nakatani, T. et al. (2002) Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes. J. Biol. Chem. 277, 9562-9569
    • (2002) J. Biol. Chem. , vol.277 , pp. 9562-9569
    • Nakatani, T.1
  • 24
    • 85030934588 scopus 로고    scopus 로고
    • Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and non immune cells during inflammation
    • in press
    • Alves-Guerra, M.C. et al. Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and non immune cells during inflammation. J. Biol. Chem. (in press)
    • J. Biol. Chem.
    • Alves-Guerra, M.C.1
  • 25
    • 0041465009 scopus 로고    scopus 로고
    • A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
    • Echtay, K.S. et al. (2003) A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 22, 4103-4110
    • (2003) EMBO J. , vol.22 , pp. 4103-4110
    • Echtay, K.S.1
  • 26
    • 0037047142 scopus 로고    scopus 로고
    • Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages
    • Kizaki, T. et al. (2002) Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages, Proc. Natl. Acad. Sci. U. S. A. 99, 9392-9397
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 9392-9397
    • Kizaki, T.1
  • 27
    • 0035937856 scopus 로고    scopus 로고
    • Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation
    • Pecqueur, C. (2001) Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J. Biol. Chem. 276, 8705-8712
    • (2001) J. Biol. Chem. , vol.276 , pp. 8705-8712
    • Pecqueur, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.