메뉴 건너뛰기




Volumn 144, Issue 7, 2003, Pages 2757-2760

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; SUPEROXIDE; UBIQUINONE; UNCOUPLING PROTEIN;

EID: 0038336912     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0163     Document Type: Article
Times cited : (107)

References (31)
  • 1
    • 0036325531 scopus 로고    scopus 로고
    • Genetic approaches to studying energy balance: Perception and integration
    • Barsh GS, Schwartz MW 2002 Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 3:589-600
    • (2002) Nat Rev Genet , vol.3 , pp. 589-600
    • Barsh, G.S.1    Schwartz, M.W.2
  • 2
    • 0342334561 scopus 로고
    • Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein
    • Bouillaud F, Ricquier D, Thibault J, Weissenbach J 1985 Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein. Proc Natl Acad Sci USA 82:445-448
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 445-448
    • Bouillaud, F.1    Ricquier, D.2    Thibault, J.3    Weissenbach, J.4
  • 5
    • 0031560941 scopus 로고    scopus 로고
    • UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
    • Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB 1997 UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 235:79-82
    • (1997) Biochem Biophys Res Commun , vol.235 , pp. 79-82
    • Vidal-Puig, A.1    Solanes, G.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 6
    • 0032998265 scopus 로고    scopus 로고
    • UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
    • Mao W, Yu XX, Zhong A, Li W, Brush J, Sherwood SW, Adams SH, Pan G 1999 UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett 443:326-330
    • (1999) FEBS Lett , vol.443 , pp. 326-330
    • Mao, W.1    Yu, X.X.2    Zhong, A.3    Li, W.4    Brush, J.5    Sherwood, S.W.6    Adams, S.H.7    Pan, G.8
  • 8
    • 0021322138 scopus 로고
    • Thermogenic mechanism in brown fat
    • Nicholls DG, Locke RM 1984 Thermogenic mechanism in brown fat. Physiol Rev 64:1-64
    • (1984) Physiol Rev , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 11
    • 0033492873 scopus 로고    scopus 로고
    • Brain uncoupling protein 2: Uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers
    • Horvath TL, Warden CH, Hajos M, Lombardi A, Goglia F, Diano S 1999 Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J Neurosci 19:10417-10427
    • (1999) J Neurosci , vol.19 , pp. 10417-10427
    • Horvath, T.L.1    Warden, C.H.2    Hajos, M.3    Lombardi, A.4    Goglia, F.5    Diano, S.6
  • 16
    • 0031594295 scopus 로고    scopus 로고
    • Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1, 2, 3, tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice
    • Beal MF, Matthews RT, Tieleman A, Shults CW 1998 Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1, 2, 3, tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res 783:109-114
    • (1998) Brain Res , vol.783 , pp. 109-114
    • Beal, M.F.1    Matthews, R.T.2    Tieleman, A.3    Shults, C.W.4
  • 17
    • 0034735799 scopus 로고    scopus 로고
    • Coenzyme Q is an obligatory cofactor for uncoupling protein function
    • Echtay KS, Winkler E, Klingenberg M 2000 Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408:609-613
    • (2000) Nature , vol.408 , pp. 609-613
    • Echtay, K.S.1    Winkler, E.2    Klingenberg, M.3
  • 18
    • 0035852755 scopus 로고    scopus 로고
    • Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
    • Echtay KS, Winkler E, Frischmuth K, Klingenberg M 2001 Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc Natl Acad Sci USA 98:1416-1421
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1416-1421
    • Echtay, K.S.1    Winkler, E.2    Frischmuth, K.3    Klingenberg, M.4
  • 22
    • 0037033039 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling protein 2 from the matrix side: Studies using targeted antioxidants
    • Echtay KS, Murphy MP, Smith RA, Talbot DA, Brand MD 2002 Superoxide activates mitochondrial uncoupling protein 2 from the matrix side: studies using targeted antioxidants. J Biol Chem 277:47129-47135
    • (2002) J Biol Chem , vol.277 , pp. 47129-47135
    • Echtay, K.S.1    Murphy, M.P.2    Smith, R.A.3    Talbot, D.A.4    Brand, M.D.5
  • 23
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
    • Gong DW, He Y, Karas M, Reitman M 1997 Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin. J Biol Chem 272:24129-24132
    • (1997) J Biol Chem , vol.272 , pp. 24129-24132
    • Gong, D.W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 28
  • 29
    • 0345451597 scopus 로고    scopus 로고
    • Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients
    • Shults CW, Beal MF, Fontaine D, Nakano K, Haas RH 1998 Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology 50:793-795
    • (1998) Neurology , vol.50 , pp. 793-795
    • Shults, C.W.1    Beal, M.F.2    Fontaine, D.3    Nakano, K.4    Haas, R.H.5
  • 30
    • 0030612117 scopus 로고    scopus 로고
    • Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
    • Shults CW, Haas RH, Passov D, Beal MF 1997 Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol 42:261-264
    • (1997) Ann Neurol , vol.42 , pp. 261-264
    • Shults, C.W.1    Haas, R.H.2    Passov, D.3    Beal, M.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.