Antifatigue effect of coenzyme Q10 in mice

Journal of Medicinal Food

Volumn 13, Issue 1, 2010, Pages 211-215

  Fu, Xin ^a   Ji, Rong ^b   Dam, Jorgen ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c Pharma Trade Healthcare ^*  (Sweden)

Author keywords

Bio Quinone; Endurance; Fatigue; Glycogen; Swimming; Ubiquinone

Indexed keywords

BIO QUINONE; GLYCOGEN; LACTIC ACID; NITROGEN; UBIDECARENONE; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIFATIGUE EFFECT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; ENDURANCE; EXHAUSTION; GLYCOGEN LIVER LEVEL; LACTATE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REST; SWIMMING; TIME; UREA NITROGEN BLOOD LEVEL; WEIGHT BEARING;

ANIMALS; BLOOD UREA NITROGEN; EXERCISE TOLERANCE; FATIGUE; LACTIC ACID; LIVER; LIVER GLYCOGEN; MALE; MICE; MICE, INBRED ICR; MUSCLE FATIGUE; MUSCLE, SKELETAL; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; SWIMMING; UBIQUINONE; VITAMINS;

ANIMALIA; MUS;

EID: 76649083268     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2009.0049     Document Type: Article

References (36)

1. Santos-Ocanã C, Villalba JM, Córdoba F, et al.: Genetic evidence for coenzyme Q requirement in plasma membrane electron transport. J Bioenerg Biomembr 1998;30:465-475.
2. Crane FL: Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001;20:591-598.
3. Niki E: Mechanisms and dynamics of antioxidant action of ubiquinol. Mol Aspects Med 1997;18(Suppl):S63-S70.
4. Davies KJ, Quintanilha AT, Brooks GA, Packer L: Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun 1982;107:1198-1205.
5. Jackson MJ, Edwards RHT, Symons MCR: Electron spin resonance studies of intact mammalian skeletal muscle. Biochim Biophys Acta 1985;847:185-190.
6. Reid MB: Free radicals and muscle fatigue: of ROS, canaries, and the IOC. Free Radic Biol Med 2008;44:169-179.
7. Juel C: Muscle fatigue and reactive oxygen species. J Physiol 2006;576:1.
8. Kon M, Kimura F, Akimoto T, et al.: Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats. Exerc Immunol Rev 2007;13:76-88.
9. Lakomkin VL, Konovalova GG, Kalenikova EI, et al.: Changes in antioxidant status of myocardium during oxidative stress under the influence of coenzyme Q10. Biochemistry (Mosc) 2005;70:79-84.
10. Lenaz G, D'Aurelio M, Merlo Pich M, et al.: Mitochondrial bioenergetics in aging. Biochim Biophys Acta 2000;1459:397-404.
11. Cooke M, Iosia M, Buford T, et al.: Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr 2008;5:8.
12. Mizuno K, Tanaka M, Nozaki S, et al.: Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition 2008;24:293-299.
13. Ylikoski T, Piirainen J, Hanninen O, Penttinen J: The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol Aspects Med 1997;18(Suppl):S283-S290.
14. Kon M, Tanabe K, Akimoto T, et al.: Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr 2008;20:1-7.
15. Bonetti A, Solito F, Carmosino G, Bargossi AM, Fiorella PL: Effect of ubidecarenone oral treatment on aerobic power in middle- aged trained subjects. J Sports Med Phys Fitness 2000;40: 51-57.
16. Littarru GP: Biomedical and clinical aspects of coenzyme Q. Clin Investig 1993;71:587-588.
17. Zuliani U, Bonetti A, Campana M, Cerioli G, Solito F, Novarini A: The influence of ubiquinone (Co Q10) on the metabolic response to work. J Sports Med Phys Fitness 1989;29:57-62.
18. Weston SB, Zhou S, Weatherby RP, Robson SJ: Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Int J Sport Nutr 1997;7:197-206.
19. Nielsen AN, Mizuno M, Ratkevicius A, et al.: No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Sports Med 1999;20:154-158.
20. Braun B, Clarkson PM, Freedson PS, Kohl RL: Effects of coenzyme Q10 supplementation on exercise performance, VO2- max, and lipid peroxidation in trained cyclists. Int J Sport Nutr 1991;1:353-365.
21. Skough K, Krossén C, Heiwe S, Theorell H, Borg K: Effects of resistance training in combination with coenzyme Q10 supplementation in patients with post-polio: a pilot study. J Rehabil Med 2008;40:773-775.
22. Ferrante KL, Shefner J, Zhang H, et al.: Tolerance of high-dose (3,000 mg=day) coenzyme Q10 in ALS. Neurology 2005;65: 1834-1836.
23. Kamzalov S, Sumien N, Forster MJ, Sohal RS: Coenzyme Q intake elevates the mitochondrial and tissue levels of Coenzyme Q and alpha-tocopherol in young mice. J Nutr 2003;133:3175-3180
24. Porsolt RD, Bertin A, Jalfre M: Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn 1977;229:327-336.
25. Moriura T, Matsuda H, Kubo M: Pharmacological study on Agkistrodon blomhoffii blomhoffii BOIE. V. Anti-fatigue effect of the 50% ethanol extract in acute weight-loaded forced swimming- treated rats. Biol Pharm Bull 1996;19:62-66.
26. Kim KM, Yu KW, Kang DH, Suh HJ: Anti-stress and antifatigue effect of fermented rice bran. Phytother Res 2002;16: 700-702.
27. Shulman RG, Rothman DL: The ''glycogen shunt'' in exercising muscle: a role for glycogen in muscle energetics and fatigue. Proc Natl Acad Sci U S A 2001;98:457-461.
28. Coyle EF, Coggan AR, Hemmert MK, Ivy JL: Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol 1986;6:165-172.
29. Holloszy JO, Kohrt WM, Hansen PA: The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci 1998;3:D1011-D1027.
30. Ivy JL: Role of carbohydrate in physical activity. Clin Sports Med 1999;18:469-484.
31. Edman KA, Lou F: Changes in force and stiffness induced by fatigue and intracellular acidification in frog muscle fibres. J Physiol 1990;424:133-149.
32. Halestrap AP, Griffiths EJ, Connern CP: Mitochondrial calcium handling and oxidative stress. Biochem Soc Trans 1993;21: 35335-35338.
33. Ikeuchi M, Koyama T, Takahashi J, Yazawa K: Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Biol Pharm Bull 2006;29:2106-2110.
34. Ikematsu H, Nakamura K, Harashima S, Fujii K, Fukutomi N: Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 2006;44:212-218.
35. Bentinger M, Dallner G, Chojnaki T, Swiezewska E: Distribution and breakdown of labeled Coenzyme Q10 in rat. Free Radic Biol Med 2003;34:563-575.
36. Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, Stender S: Coenzyme Q10 in health and disease. Eur J Clin Nutr 1999;53:764-770.