Coenzyme Q10 and selenium in statin-associated myopathy treatment

Canadian Journal of Physiology and Pharmacology

Volumn 91, Issue 2, 2013, Pages 165-170

  Fedacko, Jan ^a   Pella, Daniel ^a   Fedackova, Petra ^a   Hänninen, Osmo ^b   Tuomainen, Petri ^b   Jarcuska, Peter ^a   Lopuchovsky, Tomas ^a   Jedlickova, Lucia ^a   Merkovska, Lucia ^a   Littarru, Gian Paolo ^c  

^a P J AFÁRIK UNIVERSITY   (Slovakia)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Coenzyme Q10; Muscle cramps; Muscle pain; Selenium; Statin associated myopathy; Statins; Statins side effects

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; CREATINE KINASE; CREATININE; DEXTRO AMINO ACID AMINOTRANSFERASE; FLUINDOSTATIN; GAMMA GLUTAMYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; POTASSIUM; ROSUVASTATIN; SELENIUM; SIMVASTATIN; SODIUM; TRIACYLGLYCEROL; UBIDECARENONE; URIC ACID;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DRUG INDUCED DISEASE; FATIGUE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUSCLE CRAMP; MUSCLE WEAKNESS; MYALGIA; MYOPATHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATIN ASSOCIATED MYOPATHY; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

ANALYSIS OF VARIANCE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; MUSCULAR DISEASES; PILOT PROJECTS; PROSPECTIVE STUDIES; SELENIUM; TREATMENT OUTCOME; UBIQUINONE;

EID: 84874598306     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0118     Document Type: Article

References (20)

1. Boosalis, M.G. 2008. The role of selenium in chronic disease. Nutr. Clin. Pract. 23: 152-160. doi:10.1177/0884533608314532. PMID:18390782.
2. Bruckert, E., Hayem, G., Dejager, S., Yau, C., and Begaud, B. 2005. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovasc. Drugs Ther. 19: 403-414. doi:10.1007/ s10557-005-5686-z. PMID:16453090.
3. Bugel, S., Larsen, E.H., Sloth, J.J., Flytlie, K., Overvad, K., Steenberg, L.C., and Moesgaard, S. 2008. Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium. Food Nutr. Res. 52. doi:10.3402/fnr.v52i0.1642. PMID:19109661.
4. Corsini, A. 2005. Statin-related muscle complaints: an underestimated risk. Cardiovasc. Drugs Ther. 19: 379-381. doi:10.1007/s10557-005-6352-1. PMID:16453086.
5. Crane, F.L. 2001. Biochemical functions of coenzyme Q10. J. Am. Coll. Nutr. 20: 591-598. PMID:11771674.
6. Davignon, J. 2004. Beneficial cardiovascular pleiotropic effects of statins. Circulation, 109(Suppl. III): III-39-III-43. doi:10.1161/01.CIR.0000131517.20177.5a. PMID:15198965.
7. Folkers, K., Moesgaard, S., and Morita, M. 1994. A one year bioavailability study of coenzyme Q10 with 3 months withdrawal period. Mol. Aspects Med. 15(Suppl.): 281-285. doi:10.1016/0098-2997(94)90039-6. PMID:7752840.
8. Ghirlanda, G., Oradei, A., Manto, A., Lippa, S., Uccioli, L., Caputo, S., Greco, A.V., and Littarru, G.F. 1993. Evidence of plasma CoQ10-lowering effect by HMGCoA reductase inhibitor: a double-blind, placebo controlled study. J. Clin. Pharmacol. 33: 226-229. PMID:8463436.
9. Larsen, E.H., Sloth, J.J., Hansen, M., and Moesgaard, S. 2003. Selenium speciation and isotope com-position in 77Se-enriched yeast using gradient elution HPLC separation and ICP-dynamic reaction cell-MS. J. Anal. At. Spectrom. 18: 310-316. doi:10.1039/b209586f.
10. Larsen, E.H., Hansen, M., Paulin, H., Moesgaard, S., Reid, M., and Rayman, M. 2004. Speciation and bioavailability of selenium in yeast-based intervention agents used in cancer chemoprevention studies. J. AOAC Int. 87(1): 225-232. PMID:15084104.
11. Law, M., and Rudnicka, A.R. 2006. Statin safety: a systematic review. Am. J. Cardiol. 97(Suppl.): 52C-60C. doi:10.1016/j.amjcard.2005.12.010. PMID:16581329.
12. Littarru, G.P., Mosca, F., Fattorini, D., Bompadre, S., and Battino, M. 2004. Assay of coenzyme Q10 in plasma by a single dilution step. Methods Enzymol. 378: 170-176. doi:10.1016/S0076-6879(04)78014-3. PMID:15038968.
13. Moosmann, B., and Behl, C. 2004a. Selenoprotein synthesis and side effects of statins. Lancet, 363: 892-894. doi:doi:10.1016/S0140-6736(04)15739-5. PMID: 15031036.
14. Moosmann, B., and Behl, C. 2004b. Selenoproteins, cholesterol-lowering drugs, and the consequences. Revisiting of the mevalonate pathway. Trends Cardiovasc. Med. 14: 273-281. doi:10.1016/j.tcm.2004.08.003. PMID:15542379.
15. Nawrot, T.S., Staessen, J.A., Roels, H.A., Den Hond, E., Thijs, L., Fagard, R.H., Dominiczak, A.F., and Struijker-Boudier, H.A. 2007. Blood pressure and blood selenium: a cross-sectional and longitudinal population study. Eur. Heart J. 28: 628-633. doi:10.1093/eurheartj/ehl479. PMID:17242009.
16. Nordman, T., Xia, L., Björkhem-Bergman, L., Damdimopulos, A., Nalvarte, I., Arner, E.S.J., Spyrou, G., Eriksson, L.C., Bjornstedt, M., and Olsson, J.M. 2003. Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. Biofactors, 18: 45-50. doi: 10.1002/biof.5520180206. PMID:14695919.
17. Rosenson, R.S. 2004. Current overview of statin-induced myopathy. Am. J. Med. 116: 408-416. doi:10.1016/j.amjmed.2003.10.033. PMID:15006590.
18. Thompson, P.D., Clarkson, P., and Karas, R.H. 2003. Statin-associated myopathy. JAMA, 289: 1681-1690. doi:10.1001/jama.289.13.1681. PMID:12672737.
19. Vadhanavikit, S., and Ganther, H.E. 1994. Selenium deficiency and decreased coenzyme Q levels. Mol. Aspects Med. 15(Suppl.): 103-107. doi:10.1016/0098-2997(94)90019-1. PMID:7752821.
20. Weis, M., Mortensen, S.A., Rassing, M.R., Moller-Sonnergaard, J., Poulsen, G., and Rasmussen, S.N. 1994. Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers. Mol. Aspects Med. 15(Suppl.): 273-280. doi:10.1016/0098-2997(94)90038-8. PMID:7752839.