Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis

Proceedings of the Society for Experimental Biology and Medicine

Volumn 226, Issue 2, 2001, Pages 78-84

  Himms Hagen, Jean ^a   Harper, Mary Ellen ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Acyl CoA thioesterase; Brown adipose tissue; Cold; Fatty acids; Mitochondrial carrier proteins; Skeletal muscle; Thermogenesis; Uncoupling proteins

Indexed keywords

ACYL COENZYME A; CARRIER PROTEIN; FATTY ACID; PALMITOYL COENZYME A HYDROLASE; UNCOUPLING PROTEIN 3;

BROWN ADIPOSE TISSUE; CITRIC ACID CYCLE; CYTOSOL; DIET RESTRICTION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GENE EXPRESSION; HYDROLYSIS; HYPOTHESIS; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; SHORT SURVEY; SKELETAL MUSCLE; THERMOGENESIS;

EID: 0035133171     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020122600204     Document Type: Short Survey

References (67)

1. A history of the first uncoupling protein, UCP1
2. Brown adipose tissue
3. UCP1: The original uncoupling protein - And perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice
4. The bioenergetics of brown fat mitochondria from UCP1-ablated mice. UCP1 is not involved in fatty acid-induced de-energization ("uncoupling")
5. Thermogenic responses in brown-fat cells are fully UCP1-dependent. UCP2 or UCP3 cannot substitute for UCP1 in adrenergically or fatty acid induced thermogenesis
6. The mechanism of proton transport mediated by mitochondrial uncoupling proteins
7. Mammalian mitochondrial uncoupling proteins
8. Fatty acid cycling mechanism and mitochondrial uncoupling proteins
9. Transport function and regulation of mitochondrial uncoupling proteins 2 and 3
10. Structure-function relationship in UCP1
11. Structure and function of the uncoupling protein from brown adipose tissue
12. The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter
13. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
14. Brown adipose tissue thermogenesis and obesity
15. Biochemical aspects of the uncoupling proteins: View from the chair
16. Uncoupling protein-2: A novel gene linked to obesity and hyper-insulinemia
17. Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
18. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
19. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
20. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
21. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
22. Molecular cloning of rat brain mitochondrial carrier protein-1 cDNA and its up-regulation during postnatal development
23. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
24. Characterization of novel UCP5/BMCP1 isoforms, and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
25. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
26. The significance and mechanism of mitochondrial proton conductance
27. Mitochondrial proton leak and the uncoupling proteins
28. Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism
29. Contribution to the identification and analysis of the mitochondrial uncoupling proteins
30. Uncoupling protein-3 (UCP3): A mitochondrial carrier in search of a function
31. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
32. Energy metabolism in uncoupling protein 3 gene knockout mice
33. The uncoupling proteins, a review
34. Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
35. Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in skeletal muscle by cold
36. Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone
37. Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats
38. Tissue-specific expression of the uncoupling protein family in streptozotocin-induced diabetic rats
39. Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats
40. Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats
41. Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia
42. Skeletal muscle UCP 2 and UCP3 gene expression in a rat cancer cachexia model
43. Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation
44. Effect of endurance training on mRNA expression of uncoupling proteins 1, 2, and 3 in the rat
45. Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle
46. Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise training and down-regulation of UCP 3 by denervation in skeletal muscles
47. Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids
48. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: A potential explanation for the effect of fasting
49. Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue
50. Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?
51. Downregulation of skeletal muscle UCP-3 gene expression during refeeding is prevented by cold exposure
52. Effects of fasting and refeeding on the level of uncoupling protein mRNA in rat brown adipose tissue: Evidence for diet-induced and cold-induced responses
53. UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
54. Fasting and leptin modulate adipose and muscle uncoupling protein: Divergent effects between messenger ribonucleic acid and protein expression
55. Uncoupling protein 3: Its possible biological role and mode of regulation in rodents and humans
56. Differential regulation of uncoupling protein-1, -2 and -3 gene expression by sympathetic innervation in brown adipose tissue of thermoneutral or cold-exposed rats
57. Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation
58. Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: Is there a role for circulating free fatty acids?
59. Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver
60. Molecular cloning of the peroxisome proliferator-induced 46-kDa cytosolic acyl-CoA thioesterase from mouse and rat liver - Recombinant expression in Escherichia coli, tissue expression, and nutritional regulation
61. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism
62. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase
63. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor-alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
64. Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: A potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth
65. Intracellular localization of long-chain acyl-coenzyme A hydrolase and acyl-L-carnitine in brown adipose tissue from guinea pigs
66. A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria
67. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean