-
1
-
-
18644376240
-
Type 2 diabetes, insulin secretion and beta-cell mass
-
Ahren B (2005) Type 2 diabetes, insulin secretion and beta-cell mass. Curr Mol Med 5:275-286.
-
(2005)
Curr Mol Med
, vol.5
, pp. 275-286
-
-
Ahren, B.1
-
2
-
-
0036224872
-
Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose
-
Greenbaum CJ, Prigeon RL, D'Alessio DA (2002) Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose. Diabetes 51:951-957.
-
(2002)
Diabetes
, vol.51
, pp. 951-957
-
-
Greenbaum, C.J.1
Prigeon, R.L.2
D'Alessio, D.A.3
-
3
-
-
0032877316
-
Impact of lack of suppression of glucagon on glucose tolerance in humans
-
Shah P, Basu A, Basu R, Rizza R (1999) Impact of lack of suppression of glucagon on glucose tolerance in humans. Am J Physiol 277:E283-290.
-
(1999)
Am J Physiol
, vol.277
-
-
Shah, P.1
Basu, A.2
Basu, R.3
Rizza, R.4
-
4
-
-
2442710176
-
Diverse causes of hypoglycemia-associated autonomic failure in diabetes
-
Cryer PE (2004) Diverse causes of hypoglycemia-associated autonomic failure in diabetes. N Engl J Med 350:2272-2279.
-
(2004)
N Engl J Med
, vol.350
, pp. 2272-2279
-
-
Cryer, P.E.1
-
5
-
-
25844492048
-
Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells
-
Diao J, Asghar Z, Chan CB, Wheeler MB (2005) Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. J Biol Chem 280:33487-33496.
-
(2005)
J Biol Chem
, vol.280
, pp. 33487-33496
-
-
Diao, J.1
Asghar, Z.2
Chan, C.B.3
Wheeler, M.B.4
-
6
-
-
44349179818
-
Investigation of Transport mechanisms and regulation of intracellular Zn2+ in pancreatic α-cells
-
Gyulkhandanyan AV, et al. (2008) Investigation of Transport mechanisms and regulation of intracellular Zn2+ in pancreatic α-cells. J Biol Chem 283:10184-10197.
-
(2008)
J Biol Chem
, vol.283
, pp. 10184-10197
-
-
Gyulkhandanyan, A.V.1
-
7
-
-
0037385959
-
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells
-
Ishihara H, et al. (2003) Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 5:330-335.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 330-335
-
-
Ishihara, H.1
-
8
-
-
0024470349
-
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels
-
Rorsman P, et al. (1989) Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature 341:233-236.
-
(1989)
Nature
, vol.341
, pp. 233-236
-
-
Rorsman, P.1
-
9
-
-
9444266572
-
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse α-cells
-
Gromada J, et al. (2004) ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse α-cells. Diabetes 53 Suppl 3:S181-189.
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Gromada, J.1
-
10
-
-
34250307235
-
A KATP channel-dependent pathway within α-cells regulates glucagon release from both rodent and human islets of Langerhans
-
Macdonald PE, et al. (2007) A KATP channel-dependent pathway within α-cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 5:e143.
-
(2007)
PLoS Biol
, vol.5
-
-
Macdonald, P.E.1
-
12
-
-
0242589945
-
Specific sequence of motifs of mitochondrial uncoupling proteins
-
Jezek P, Urbankova E (2000) Specific sequence of motifs of mitochondrial uncoupling proteins. IUBMB Life 49:63-70.
-
(2000)
IUBMB Life
, vol.49
, pp. 63-70
-
-
Jezek, P.1
Urbankova, E.2
-
14
-
-
0033667705
-
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
-
Arsenijevic D, et al. (2000) Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26:435-439.
-
(2000)
Nat Genet
, vol.26
, pp. 435-439
-
-
Arsenijevic, D.1
-
15
-
-
0034990987
-
Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
-
Chan CB, et al. (2001) Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action. Diabetes 50:1302-1310.
-
(2001)
Diabetes
, vol.50
, pp. 1302-1310
-
-
Chan, C.B.1
-
16
-
-
0034804062
-
Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal beta-cells
-
Li LX, et al. (2001) Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal beta-cells. Biochem Biophys Res Commun 282:273-277.
-
(2001)
Biochem Biophys Res Commun
, vol.282
, pp. 273-277
-
-
Li, L.X.1
-
17
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, et al. (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105:745-755.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
-
18
-
-
23944494249
-
Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly
-
Fridell YW, Sanchez-Blanco A, Silvia BA, Helfand SL (2005) Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metab 1:145-152.
-
(2005)
Cell Metab
, vol.1
, pp. 145-152
-
-
Fridell, Y.W.1
Sanchez-Blanco, A.2
Silvia, B.A.3
Helfand, S.L.4
-
19
-
-
27644448810
-
Mitochondrial uncoupling proteins in the CNS: In support of function and survival
-
Andrews ZB, Diano S, Horvath TL (2005) Mitochondrial uncoupling proteins in the CNS: In support of function and survival. Nat Rev Neurosci 6:829-840.
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 829-840
-
-
Andrews, Z.B.1
Diano, S.2
Horvath, T.L.3
-
20
-
-
24944577486
-
α-cell function in health and disease: Influence of glucagon-like peptide-1
-
Dunning BE, Foley JE, Ahren B (2005) α-cell function in health and disease: Influence of glucagon-like peptide-1. Diabetologia 48:1700-1713.
-
(2005)
Diabetologia
, vol.48
, pp. 1700-1713
-
-
Dunning, B.E.1
Foley, J.E.2
Ahren, B.3
-
21
-
-
0343986289
-
Voltage-gated and resting membrane currents recorded from β-cells in intact mouse pancreatic islets
-
Gopel S, et al. (1999) Voltage-gated and resting membrane currents recorded from β-cells in intact mouse pancreatic islets. J Physiol 521:717-728.
-
(1999)
J Physiol
, vol.521
, pp. 717-728
-
-
Gopel, S.1
-
22
-
-
0025882535
-
Use of a photolabeling technique to identify nonviable cells in fixed homologous or heterologous cell populations
-
Riedy MC, Muirhead KA, Jensen CP, Stewart CC (1991) Use of a photolabeling technique to identify nonviable cells in fixed homologous or heterologous cell populations. Cytometry 12:133-139.
-
(1991)
Cytometry
, vol.12
, pp. 133-139
-
-
Riedy, M.C.1
Muirhead, K.A.2
Jensen, C.P.3
Stewart, C.C.4
-
23
-
-
33745605166
-
Uncoupling proteins: A role in protection against reactive oxygen species-or not?
-
Cannon B, et al. (2006) Uncoupling proteins: A role in protection against reactive oxygen species-or not? Biochim Biophys Acta 1757:449-458.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 449-458
-
-
Cannon, B.1
-
24
-
-
0037039366
-
Asignificant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
-
Krauss S, Zhang CY, Lowell BB (2002)Asignificant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci USA 99:118-122.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 118-122
-
-
Krauss, S.1
Zhang, C.Y.2
Lowell, B.B.3
-
25
-
-
0030810982
-
Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
-
Schuit F, et al. (1997) Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 272:18572-18579.
-
(1997)
J Biol Chem
, vol.272
, pp. 18572-18579
-
-
Schuit, F.1
-
26
-
-
10944265062
-
Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression
-
Joseph JW, et al. (2004) Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem 279:51049-51056.
-
(2004)
J Biol Chem
, vol.279
, pp. 51049-51056
-
-
Joseph, J.W.1
-
27
-
-
21444440464
-
Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production
-
Bai Y, et al. (2005) Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. J Biol Chem 280:19062-19069.
-
(2005)
J Biol Chem
, vol.280
, pp. 19062-19069
-
-
Bai, Y.1
-
28
-
-
34547115505
-
Uncoupling Protein-2 Modulates Cell Viability in Adult Rat Cardiomyocytes
-
Bodyak N, et al. (2007) Uncoupling Protein-2 Modulates Cell Viability in Adult Rat Cardiomyocytes. Am J Physiol Heart Circ Physiol. 293:H829-H835.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
-
-
Bodyak, N.1
-
29
-
-
0032991716
-
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
-
Chan CB, et al. (1999) Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48:1482-1486.
-
(1999)
Diabetes
, vol.48
, pp. 1482-1486
-
-
Chan, C.B.1
-
30
-
-
0036829870
-
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
-
Joseph JW, et al. (2002) Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51:3211-3219.
-
(2002)
Diabetes
, vol.51
, pp. 3211-3219
-
-
Joseph, J.W.1
-
31
-
-
33845949078
-
Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species
-
Produit-Zengaffinen N, et al. (2007) Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species. Diabetologia 50:84-93.
-
(2007)
Diabetologia
, vol.50
, pp. 84-93
-
-
Produit-Zengaffinen, N.1
-
32
-
-
33846856711
-
α-cells of the endocrine pancreas: 35 years of research but the enigma remains
-
Gromada J, Franklin I, Wollheim CB (2007) α-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28:84-116.
-
(2007)
Endocr Rev
, vol.28
, pp. 84-116
-
-
Gromada, J.1
Franklin, I.2
Wollheim, C.B.3
-
33
-
-
26844556580
-
Glucose stimulates glucagon release in single rat α-cells by mechanisms that mirror the stimulus-secretion coupling in β-cells
-
Olsen HL, et al. (2005) Glucose stimulates glucagon release in single rat α-cells by mechanisms that mirror the stimulus-secretion coupling in β-cells. Endocrinology 146:4861-4870.
-
(2005)
Endocrinology
, vol.146
, pp. 4861-4870
-
-
Olsen, H.L.1
-
34
-
-
38049120264
-
Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization
-
Pecqueur C, et al. (2008) Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J 22:9-18.
-
(2008)
FASEB J
, vol.22
, pp. 9-18
-
-
Pecqueur, C.1
-
35
-
-
33847698059
-
Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages
-
Emre Y, et al. (2007) Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. Biochem J 402:271-278.
-
(2007)
Biochem J
, vol.402
, pp. 271-278
-
-
Emre, Y.1
-
36
-
-
22844442137
-
Increased expression of uncoupling protein 2 in HepG2 cells attenuates oxidative damage and apoptosis
-
Collins P, et al. (2005) Increased expression of uncoupling protein 2 in HepG2 cells attenuates oxidative damage and apoptosis. Liver Int 25:880-887.
-
(2005)
Liver Int
, vol.25
, pp. 880-887
-
-
Collins, P.1
-
37
-
-
4644298411
-
+ channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses
-
+ channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes 53:2542-2551.
-
(2004)
Diabetes
, vol.53
, pp. 2542-2551
-
-
Evans, M.L.1
-
38
-
-
9144242433
-
Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic β-cell line MIN6
-
Wang X, et al. (2004) Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic β-cell line MIN6. Diabetes 53:129-140.
-
(2004)
Diabetes
, vol.53
, pp. 129-140
-
-
Wang, X.1
-
39
-
-
0035430782
-
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
-
Cnop M, et al. (2001) Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 50:1771-1777.
-
(2001)
Diabetes
, vol.50
, pp. 1771-1777
-
-
Cnop, M.1
-
40
-
-
0037235364
-
Transgenic mice with green fluorescent protein-labeled pancreatic β-cells
-
Hara M, et al. (2003) Transgenic mice with green fluorescent protein-labeled pancreatic β-cells. Am J Physiol Endocrinol Metab 284:E177-183.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
-
-
Hara, M.1
-
41
-
-
33749873671
-
Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice
-
Saleh MC, Wheeler MB, Chan CB (2006) Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice. J Endocrinol 190:659-667.
-
(2006)
J Endocrinol
, vol.190
, pp. 659-667
-
-
Saleh, M.C.1
Wheeler, M.B.2
Chan, C.B.3
-
42
-
-
31444432477
-
Insulin resistance causes increased β-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes
-
Asghar Z, et al. (2006) Insulin resistance causes increased β-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes. Diabetologia 49:90-99.
-
(2006)
Diabetologia
, vol.49
, pp. 90-99
-
-
Asghar, Z.1
|