Mitochondria in cell death: Novel targets for neuroprotection and cardioprotection

Trends in Molecular Medicine

Volumn 9, Issue 5, 2003, Pages 196-205

  Mattson, Mark P ^a   Kroemer, Guido ^b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLOPHILIN; CYCLOPHILIN D; POTASSIUM CHANNEL; PROTEIN BCL 2; PROTEIN KINASE; PROTEINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; BIOENERGY; CELL DEATH; CELL MEMBRANE; ENERGY TRANSFER; ENZYME RELEASE; HEART MUSCLE CELL; HEART PROTECTION; HUMAN; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOSIS; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SECOND MESSENGER;

EID: 0013198976     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(03)00046-7     Document Type: Review

References (74)

1. Wang, X. (2001) The expanding role of mitochondria in apoptosis. Genes Dev. 15, 2922-2933
2. Penninger, J.M. and Kroemer, G. (2003) Mitochondria, AIF and caspases: rivaling for cell death execution. Nat. Cell Biol. 5, 97-99
3. Zamzami, N. and Kroemer, G. (2003) Apoptosis: mitochondrial membrane permeabilization - the (w)hole story? Curr. Biol. 13, R71-R73
4. Shinohara, Y. et al. (2002) Permeability transition-independent release of mitochondrial cytochrome c induced by valinomycin. Eur. J. Biochem. 269, 5224-5230
5. + channels in the cardiac inner mitochondrial membrane. Science 298, 1029-1033
6. Wallace, D.C. (2002) Animal models for mitochondrial disease. Methods Mol. Biol. 197, 3-54
7. Mattson, M.P. et al. (2000) Apoptotic and antiapoptotic mechanisms in stroke. Cell Tissue Res. 301, 173-187
8. Fiskum, G. (2000) Mitochondrial participation in ischemic and traumatic neural cell death. J. Neurotrauma 17, 843-855
9. Robertson, G.S. et al. (2000) Neuroprotection by the inhibition of apoptosis. Brain Pathol. 10, 283-292
10. Culmsee, C. et al. (2001) Evidence for involvement of Par-4 in ischemic neuronal death. J. Cereb. Blood Flow Metab. 21, 334-343
11. Liu, D. et al. (2002) Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release. J. Cereb. Blood Flow Metab. 22, 431-443
12. Cao, Y.J. et al. (2002) Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model. Gene Ther. 9, 415-419
13. Xu, D. et al. (1999) Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus. J. Neurosci. 19, 5026-5033
14. Nicholls, D.G. et al. (1999) Excitotoxicity and mitochondria. Biochem. Soc. Symp. 66, 55-67
15. Gilman, C.P. and Mattson, M.P. (2002) Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility? Neuromolecular Med. 2, 197-214
16. Yu, S.W. et al. (2002) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297, 259-263
17. Springer, J.E. et al. (1999) Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat. Med. 5, 943-946
18. Yoshimoto, T. and Siesjo, B.K. (1999) Posttreatment with the immunosuppressant cyclosporine A in transient focal ischemia. Brain Res. 839, 283-291
19. Albensi, B.C. et al. (2000) Cyclosporin ameliorates traumatic brain injury-induced alterations of hippocampal synaptic plasticity. Exp. Neurol. 162, 385-389
20. Mattson, M.P. (2000) Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 1, 120-129
21. Chan, S.L. et al. (2002) Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med. 2, 167-196
22. Sherer, T.B. et al. (2002) Environment, mitochondria, and Parkinson's disease. Neuroscientist 8, 192-197
23. Sawa, A. (2001) Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria? J. Mol. Med. 79, 375-381
24. Guo, Q. et al. (1998) Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease. Nat. Med. 4, 957-962
25. Selznick, L.A. et al. (1999) In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease. J. Neuropathol. Exp. Neurol. 58, 1020-1026
26. Kruman, I. et al. (1997) Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17, 5089-5100
27. Mattson, M.P. et al. (2001) Presenilin mutations and calcium signaling defects in the nervous and immune systems. Bioessays 23, 733-744
28. ATP channel. Am. J. Physiol. Heart Circ. Physiol. 280, H2406-H2411
29. Duan, W. et al. (2002) p53 inhibitors preserve dopamine neurons and motor function in experimental Parkinsonism. Ann. Neurol. 52, 597-606
30. Mattson, M.P. (2002) Accomplices to neuronal death. Nature 415, 377-379
31. Zhang, D. et al. (2003) Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy. Cardiovasc. Res. 57, 147-157
32. Chen, Z. et al. (2001) Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am. J. Physiol. Heart Circ. Physiol. 280, H2313-H2320
33. Halestrup, A.P. et al. (1998) Elucidating the molecular mechanism of the permeability transition and its role in reperfusion injury of the heart. Biochim. Biophys. Acta 1366, 79-94
34. Yan, L.J. et al. (2002) Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J. 21, 5164-5172
35. Zhou, S. et al. (2001) Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin. Cancer Res. 61, 771-777
36. Chen, M. et al. (2002) Calpain and mitochondria in ischemia/reperfusion injury. J. Biol. Chem. 277, 29181-29186
37. Kubasiak, L.A. et al. (2002) Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc. Natl. Acad. Sci. U. S. A. 99, 12825-12830
38. Regula, K.M. et al. (2002) Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes. Circ. Res. 91, 226-231
39. Yussman, M.G. et al. (2002) Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat. Med. 8, 725-730
40. Cassarino, D.S. et al. (1998) Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochem. Biophys. Res. Commun. 248, 168-173
41. Matsuura, K. et al. (1997) Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons and in striatal dopamine content in rats with intrastriatal injection of 6-hydroxydopamine. Exp. Neurol. 146, 526-535
42. Liu, D. et al. Inhibition of mitochondrial potassium channels reduces focal ischemic brain damage and suppresses oxyradical production and apoptotic cascades. J. Neurosci.
43. Culmsee, C. et al. (2001) A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β-peptide. J. Neurochem. 77, 220-228
44. Lawrence, M.S. (1997) Herpes simplex viral vectors expressing Bcl-2 are neuroprotective when delivered after a stroke. J. Cereb. Blood Flow Metab. 17, 740-744
45. Mattson, M.P. et al. (2002) Modification of brain aging and neurodegenerative disorders by genes, diet and behavior. Physiol. Rev. 82, 637-672
46. Duan, W. et al. (2003) Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression and increases survival in huntingtin mutant mice. Proc. Natl. Acad. Sci. U. S. A. 100, 2911-2916
47. Long, P. et al. (2002) Caloric restriction restores the cardioprotective effect of preconditioning in the rat heart. Mech. Ageing Dev. 123, 1411-1413
48. Yu, Z.F. and Mattson, M.P. (1999) Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism. J. Neurosci. Res. 57, 830-839
49. Tirosh, O. et al. (2000) Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death. Neuroscience 97, 531-541
50. Beal, M.F. et al. (1998) Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 783, 109-114
51. Bastianetto, S. et al. (2000) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br. J. Pharmacol. 131, 711-720
52. Mattson, M.P. and Shea, T.B. (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 26, 137-146
53. Korge, P. et al. (2002) Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning. Proc. Natl. Acad. Sci. U. S. A. 99, 3312-3317
54. Liu, Y. et al. (1999) Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning. Ann. N. Y. Acad. Sci. 874, 27-37
55. Akao, M. et al. (2003) Differential actions of cardioprotective agents on the mitochondrial death pathway. Circ. Res. 92, 195-202
56. ATP channels via multiple signaling pathways. Anesthesiology 97, 4-14
57. Sato, T. et al. (2000) Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels. J. Am. Coll. Cardiol. 35, 514-518
58. ATP channel gene expression is induced by urocortin and mediates its cardioprotective effect. Circulation 106, 1556-1562
59. Malhotra, R. et al. (1997) Cardioprotective effects of diltiazem infusion in the perioperative period. Eur. J. Cardiothorac. Surg. 12, 420-427
60. Chatterjee, S. et al. (2002) Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure. Circulation 106, S212-S217
61. Shimizu, S. et al. (2000) BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc. Natl. Acad. Sci. U. S. A. 97, 3100-3105
62. + and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J. Biol. Chem. 276, 2571-2575
63. Clarke, S.J. et al. (2002) Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin D at a different site from cyclosporin A. J. Biol. Chem. 277, 34793-34799
64. Leventhal, L. et al. (2000) Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity. J. Comp. Neurol. 425, 471-478
65. + channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity. Brain Res. 706, 328-332
66. Park, J.B. et al. (2002) Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats. Am. J. Hypertens. 15, 78-84
67. Pong, K. et al. (2000) Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain Res. 881, 182-189
68. Wakiyama, H. et al. (2002) Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis. Eur. J. Cardiothorac. Surg. 21, 424-433
69. Fauvel, H. et al. (2002) Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats. Am. J. Respir. Crit. Care Med. 165, 449-455
70. Masters, T.N. et al. (2000) Extending myocardial viability during heart preservation with cyclosporine. A. J. Card. Surg. 15, 392-402
71. Morin, D. et al. (2001) Mitochondria as target for antiischemic drugs. Adv. Drug Deliv. Rev. 49, 151-174
72. Opie, L.H. and Sack, M.N. (2002) Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning. J. Mol. Cell. Cardiol. 34, 1077-1089
73. Suzuki, K. et al. (2002) Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation 106, 1270-1276
74. Lu, C. et al. (2001) Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurode-generative disorders. Neurobiol. Dis. 8, 194-206