-
1
-
-
66949152096
-
Parkinson's disease
-
Lees, A.J.; Hardy, J.; Revesz, T. Parkinson's disease. Lancet 2009, 373, 2055-2066.
-
(2009)
Lancet
, vol.373
, pp. 2055-2066
-
-
Lees, A.J.1
Hardy, J.2
Revesz, T.3
-
2
-
-
77953666105
-
Genetic animal models of Parkinson's disease
-
Dawson, T.M.; Ko, H.S.; Dawson, V.L. Genetic animal models of Parkinson's disease. Neuron 2010, 66, 646-661.
-
(2010)
Neuron
, vol.66
, pp. 646-661
-
-
Dawson, T.M.1
Ko, H.S.2
Dawson, V.L.3
-
3
-
-
84864928966
-
Oxidative stress in genetic mouse models of Parkinson's disease
-
2012, doi:10.1155/2012/624925
-
Varcin, M.; Bentea, E.; Michotte, Y.; Sarre, S. Oxidative stress in genetic mouse models of Parkinson's disease. Oxid. Med. Cell. Longev. 2012, 2012, doi:10.1155/2012/624925.
-
(2012)
Oxid. Med. Cell. Longev
-
-
Varcin, M.1
Bentea, E.2
Michotte, Y.3
Sarre, S.4
-
4
-
-
0034708183
-
Mpp+-induced mitochondrial dysfunction is potentiated by dopamine
-
Boada, J.; Cutillas, B.; Roig, T.; Bermudez, J.; Ambrosio, S. Mpp+-induced mitochondrial dysfunction is potentiated by dopamine. Biochem. Biophys. Res. Commun. 2000, 268, 916-920.
-
(2000)
Biochem. Biophys. Res. Commun
, vol.268
, pp. 916-920
-
-
Boada, J.1
Cutillas, B.2
Roig, T.3
Bermudez, J.4
Ambrosio, S.5
-
5
-
-
79955066685
-
Mitochondrial dysfunction in Parkinson's disease
-
2011, doi:10.4061/2011/716871
-
Keane, P.C.; Kurzawa, M.; Blain, P.G.; Morris, C.M. Mitochondrial dysfunction in Parkinson's disease. Parkinson's Dis. 2011, 2011, doi:10.4061/2011/716871.
-
(2011)
Parkinson's Dis
-
-
Keane, P.C.1
Kurzawa, M.2
Blain, P.G.3
Morris, C.M.4
-
6
-
-
84863644562
-
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems
-
2012, doi:10.1155/2012/240146
-
Cacciatore, I.; Baldassarre, L.; Fornasari, E.; Mollica, A.; Pinnen, F. Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. Oxid. Med. Cell. Longev. 2012, 2012, doi:10.1155/2012/240146.
-
(2012)
Oxid. Med. Cell. Longev
-
-
Cacciatore, I.1
Baldassarre, L.2
Fornasari, E.3
Mollica, A.4
Pinnen, F.5
-
7
-
-
0016766336
-
Dopaminergic neurons in the nematode Caenorhabditis elegans
-
Sulston, J.; Dew, M.; Brenner, S. Dopaminergic neurons in the nematode Caenorhabditis elegans. J. Comp. Neurol. 1975, 163, 215-226.
-
(1975)
J. Comp. Neurol
, vol.163
, pp. 215-226
-
-
Sulston, J.1
Dew, M.2
Brenner, S.3
-
8
-
-
0031754719
-
The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter
-
Jayanthi, L.D.; Apparsundaram, S.; Malone, M.D.; Ward, E.; Miller, D.M.; Eppler, M.; Blakely, R.D. The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter. Mol. Pharmacol. 1998, 54, 601-609.
-
(1998)
Mol. Pharmacol
, vol.54
, pp. 601-609
-
-
Jayanthi, L.D.1
Apparsundaram, S.2
Malone, M.D.3
Ward, E.4
Miller, D.M.5
Eppler, M.6
Blakely, R.D.7
-
9
-
-
0032958758
-
The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors
-
Duerr, J.S.; Frisby, D.L.; Gaskin, J.; Duke, A.; Asermely, K.; Huddleston, D.; Eiden, L.E.; Rand, J.B. The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors. J. Neurosci. 1999, 19, 72-84.
-
(1999)
J. Neurosci
, vol.19
, pp. 72-84
-
-
Duerr, J.S.1
Frisby, D.L.2
Gaskin, J.3
Duke, A.4
Asermely, K.5
Huddleston, D.6
Eiden, L.E.7
Rand, J.B.8
-
10
-
-
0033714116
-
C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
-
Sawin, E.R.; Ranganathan, R.; Horvitz, H.R. C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 2000, 26, 619-631.
-
(2000)
Neuron
, vol.26
, pp. 619-631
-
-
Sawin, E.R.1
Ranganathan, R.2
Horvitz, H.R.3
-
11
-
-
38449105755
-
Biogenic amine neurotransmitters in C. elegans
-
doi:10.1895/wormbook.1.132.1
-
Chase, D.L.; Koelle, M.R. Biogenic amine neurotransmitters in C. elegans. WormBook 2007, doi:10.1895/wormbook.1.132.1.
-
(2007)
WormBook
-
-
Chase, D.L.1
Koelle, M.R.2
-
12
-
-
0037022668
-
Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
-
Nass, R.; Hall, D.H.; Miller, D.M., 3rd; Blakely, R.D. Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 2002, 99, 3264-3269.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 3264-3269
-
-
Nass, R.1
Hall, D.H.2
Miller III, D.M.3
Blakely, R.D.4
-
13
-
-
0032509302
-
Genome sequence of the nematode C. elegans: A platform for investigating biology
-
Consortium, C.E.S. Genome sequence of the nematode C. elegans: A platform for investigating biology. Science 1998, 282, 2012-2018.
-
(1998)
Science
, vol.282
, pp. 2012-2018
-
-
Consortium,, C.E.S.1
-
14
-
-
79952502868
-
Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases
-
Martinez-Finley, E.J.; Avila, D.S.; Chakraborty, S.; Aschner, M. Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases. Metallomics Integr. Biomet. Sci. 2011, 3, 271-279.
-
(2011)
Metallomics Integr. Biomet. Sci
, vol.3
, pp. 271-279
-
-
Martinez-Finley, E.J.1
Avila, D.S.2
Chakraborty, S.3
Aschner, M.4
-
16
-
-
84870485773
-
Biolistic transformation of Caenorhabditis elegans
-
Isik, M.; Berezikov, E. Biolistic transformation of Caenorhabditis elegans. Methods Mol. Biol. 2013, 940, 77-86.
-
(2013)
Methods Mol. Biol
, vol.940
, pp. 77-86
-
-
Isik, M.1
Berezikov, E.2
-
17
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A.; Xu, S.; Montgomery, M.K.; Kostas, S.A.; Driver, S.E.; Mello, C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391, 806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
18
-
-
0037031152
-
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi
-
Simmer, F.; Tijsterman, M.; Parrish, S.; Koushika, S.P.; Nonet, M.L.; Fire, A.; Ahringer, J.; Plasterk, R.H. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr. Biol. 2002, 12, 1317-1319.
-
(2002)
Curr. Biol
, vol.12
, pp. 1317-1319
-
-
Simmer, F.1
Tijsterman, M.2
Parrish, S.3
Koushika, S.P.4
Nonet, M.L.5
Fire, A.6
Ahringer, J.7
Plasterk, R.H.8
-
19
-
-
0035941485
-
Ingestion of bacterially expressed dsrnas can produce specific and potent genetic interference in Caenorhabditis elegans
-
Timmons, L.; Court, D.L.; Fire, A. Ingestion of bacterially expressed dsrnas can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 2001, 263, 103-112.
-
(2001)
Gene
, vol.263
, pp. 103-112
-
-
Timmons, L.1
Court, D.L.2
Fire, A.3
-
20
-
-
0032538391
-
RNAi in C. elegans: Soaking in the genome sequence
-
Tabara, H.; Grishok, A.; Mello, C.C. RNAi in C. elegans: Soaking in the genome sequence. Science 1998, 282, 430-431.
-
(1998)
Science
, vol.282
, pp. 430-431
-
-
Tabara, H.1
Grishok, A.2
Mello, C.C.3
-
21
-
-
3342880124
-
Endogenous inhibitors of RNA interference in Caenorhabditis elegans
-
Timmons, L. Endogenous inhibitors of RNA interference in Caenorhabditis elegans. BioEssays 2004, 26, 715-718.
-
(2004)
BioEssays
, vol.26
, pp. 715-718
-
-
Timmons, L.1
-
22
-
-
77952993846
-
Targeted gene deletions in C. elegans using transposon excision
-
Frokjaer-Jensen, C.; Davis, M.W.; Hollopeter, G.; Taylor, J.; Harris, T.W.; Nix, P.; Lofgren, R.; Prestgard-Duke, M.; Bastiani, M.; Moerman, D.G.; et al. Targeted gene deletions in C. elegans using transposon excision. Nat. Methods 2010, 7, 451-453.
-
(2010)
Nat. Methods
, vol.7
, pp. 451-453
-
-
Frokjaer-Jensen, C.1
Davis, M.W.2
Hollopeter, G.3
Taylor, J.4
Harris, T.W.5
Nix, P.6
Lofgren, R.7
Prestgard-Duke, M.8
Bastiani, M.9
Moerman, D.G.10
-
23
-
-
34250697119
-
The versatile worm: Genetic and genomic resources for Caenorhabditis elegans research
-
Antoshechkin, I.; Sternberg, P.W. The versatile worm: Genetic and genomic resources for Caenorhabditis elegans research. Nat. Rev. Genet. 2007, 8, 518-532.
-
(2007)
Nat. Rev. Genet
, vol.8
, pp. 518-532
-
-
Antoshechkin, I.1
Sternberg, P.W.2
-
24
-
-
84859108554
-
Animal models of Parkinson's disease
-
Blandini, F.; Armentero, M.T. Animal models of Parkinson's disease. FEBS J. 2012, 279, 1156-1166.
-
(2012)
FEBS J
, vol.279
, pp. 1156-1166
-
-
Blandini, F.1
Armentero, M.T.2
-
25
-
-
84859732716
-
Classic and new animal models of Parkinson's disease
-
2012, doi:10.1155/2012/845618
-
Blesa, J.; Phani, S.; Jackson-Lewis, V.; Przedborski, S. Classic and new animal models of Parkinson's disease. J. Biomed. Biotechnol. 2012, 2012, doi:10.1155/2012/845618.
-
(2012)
J. Biomed. Biotechnol
-
-
Blesa, J.1
Phani, S.2
Jackson-Lewis, V.3
Przedborski, S.4
-
26
-
-
84870733873
-
Further characterisation of the LPS model of parkinson's disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat
-
Hoban, D.B.; Connaughton, E.; Connaughton, C.; Hogan, G.; Thornton, C.; Mulcahy, P.; Moloney, T.C.; Dowd, E. Further characterisation of the LPS model of parkinson's disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat. Brain Behav. Immun. 2013, 27, 91-100.
-
(2013)
Brain Behav. Immun
, vol.27
, pp. 91-100
-
-
Hoban, D.B.1
Connaughton, E.2
Connaughton, C.3
Hogan, G.4
Thornton, C.5
Mulcahy, P.6
Moloney, T.C.7
Dowd, E.8
-
27
-
-
80054737700
-
Modeling dopamine neuron degeneration in Caenorhabditis elegans
-
Tucci, M.L.; Harrington, A.J.; Caldwell, G.A.; Caldwell, K.A. Modeling dopamine neuron degeneration in Caenorhabditis elegans. Methods Mol. Biol. 2011, 793, 129-148.
-
(2011)
Methods Mol. Biol
, vol.793
, pp. 129-148
-
-
Tucci, M.L.1
Harrington, A.J.2
Caldwell, G.A.3
Caldwell, K.A.4
-
28
-
-
84875035898
-
Elicitation of dopaminergic features of Parkinson's disease in C. elegans by monocrotophos, an organophosphorous insecticide
-
Ali, S.J.; Rajini, P.S. Elicitation of dopaminergic features of Parkinson's disease in C. elegans by monocrotophos, an organophosphorous insecticide. CNS Neurol. Disord. Drug Targets 2012, 11, 993-1000.
-
(2012)
CNS Neurol. Disord. Drug Targets
, vol.11
, pp. 993-1000
-
-
Ali, S.J.1
Rajini, P.S.2
-
29
-
-
38149111218
-
ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in α-synuclein transgenic C. elegans
-
Wang, Y.M.; Pu, P.; Le, W.D. ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in α-synuclein transgenic C. elegans. Neurosci. Bull. 2007, 23, 329-335.
-
(2007)
Neurosci. Bull
, vol.23
, pp. 329-335
-
-
Wang, Y.M.1
Pu, P.2
Le, W.D.3
-
30
-
-
77957363643
-
Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans
-
Benedetto, A.; Au, C.; Avila, D.S.; Milatovic, D.; Aschner, M. Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans. PLoS Genet. 2010, 6, e1001084.
-
(2010)
PLoS Genet
, vol.6
-
-
Benedetto, A.1
Au, C.2
Avila, D.S.3
Milatovic, D.4
Aschner, M.5
-
31
-
-
84984535652
-
Organotellurium and organoselenium compounds attenuate mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress
-
Avila, D.S.; Benedetto, A.; Au, C.; Manarin, F.; Erikson, K.; Soares, F.A.; Rocha, J.B.; Aschner, M. Organotellurium and organoselenium compounds attenuate mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress. Free Radic. Biol. Med. 2012, 52, 1903-1910.
-
(2012)
Free Radic. Biol. Med
, vol.52
, pp. 1903-1910
-
-
Avila, D.S.1
Benedetto, A.2
Au, C.3
Manarin, F.4
Erikson, K.5
Soares, F.A.6
Rocha, J.B.7
Aschner, M.8
-
32
-
-
0029414750
-
Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease
-
Jellinger, K.; Linert, L.; Kienzl, E.; Herlinger, E.; Youdim, M.B. Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease. J. Neural Transm. Suppl. 1995, 46, 297-314.
-
(1995)
J. Neural Transm. Suppl
, vol.46
, pp. 297-314
-
-
Jellinger, K.1
Linert, L.2
Kienzl, E.3
Herlinger, E.4
Youdim, M.B.5
-
33
-
-
0022398587
-
Hydroxyl radical attack on dopamine
-
Slivka, A.; Cohen, G. Hydroxyl radical attack on dopamine. J. Biol. Chem. 1985, 260, 15466-15472.
-
(1985)
J. Biol. Chem
, vol.260
, pp. 15466-15472
-
-
Slivka, A.1
Cohen, G.2
-
34
-
-
0016378870
-
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
-
Cohen, G.; Heikkila, R.E. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem. 1974, 249, 2447-2452.
-
(1974)
J. Biol. Chem
, vol.249
, pp. 2447-2452
-
-
Cohen, G.1
Heikkila, R.E.2
-
35
-
-
0018148688
-
Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro
-
Graham, D.G.; Tiffany, S.M.; Bell, W.R., Jr.; Gutknecht, W.F. Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol. Pharmacol. 1978, 14, 644-653.
-
(1978)
Mol. Pharmacol
, vol.14
, pp. 644-653
-
-
Graham, D.G.1
Tiffany, S.M.2
Bell Jr., W.R.3
Gutknecht, W.F.4
-
36
-
-
0028918841
-
Inhibition of mitochondrial complexes I{cyrillic, ukrainian} and I{cyrillic, ukrainian}I{cyrillic, ukrainian} by 6-hydroxydopamine
-
Glinka, Y.Y.; Youdim, M.B. Inhibition of mitochondrial complexes I{cyrillic, ukrainian} and I{cyrillic, ukrainian}I{cyrillic, ukrainian} by 6-hydroxydopamine. Eur. J. Pharmacol. 1995, 292, 329-332.
-
(1995)
Eur. J. Pharmacol
, vol.292
, pp. 329-332
-
-
Glinka, Y.Y.1
Youdim, M.B.2
-
37
-
-
0030614642
-
Mechanism of 6-hydroxydopamine neurotoxicity
-
Glinka, Y.; Gassen, M.; Youdim, M.B. Mechanism of 6-hydroxydopamine neurotoxicity. J. Neural Transm. Suppl. 1997, 50, 55-66.
-
(1997)
J. Neural Transm. Suppl
, vol.50
, pp. 55-66
-
-
Glinka, Y.1
Gassen, M.2
Youdim, M.B.3
-
38
-
-
0031899172
-
Oxidative mechanisms in nigral cell death in Parkinson's disease
-
Jenner, P. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov. Disord. 1998, 13, 24-34.
-
(1998)
Mov. Disord
, vol.13
, pp. 24-34
-
-
Jenner, P.1
-
39
-
-
0026671035
-
Parkinsonism-inducing neurotoxin MPP+: Uptake and toxicity in nonneuronal cos cells expressing dopamine transporter cdna
-
Kitayama, S.; Shimada, S.; Uhl, G.R. Parkinsonism-inducing neurotoxin MPP+: Uptake and toxicity in nonneuronal cos cells expressing dopamine transporter cdna. Ann. Neurol. 1992, 32, 109-111.
-
(1992)
Ann. Neurol
, vol.32
, pp. 109-111
-
-
Kitayama, S.1
Shimada, S.2
Uhl, G.R.3
-
40
-
-
76049115685
-
Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans
-
Dingley, S.; Polyak, E.; Lightfoot, R.; Ostrovsky, J.; Rao, M.; Greco, T.; Ischiropoulos, H.; Falk, M.J. Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans. Mitochondrion 2010, 10, 125-136.
-
(2010)
Mitochondrion
, vol.10
, pp. 125-136
-
-
Dingley, S.1
Polyak, E.2
Lightfoot, R.3
Ostrovsky, J.4
Rao, M.5
Greco, T.6
Ischiropoulos, H.7
Falk, M.J.8
-
41
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz, T.J.; Zarse, K.; Voigt, A.; Urban, N.; Birringer, M.; Ristow, M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007, 6, 280-293.
-
(2007)
Cell Metab
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
42
-
-
0030087733
-
Rate of aerobic metabolism and superoxide production rate potential in the nematode Caenorhabditis elegans
-
Vanfleteren, J.R.; de Vreese, A. Rate of aerobic metabolism and superoxide production rate potential in the nematode Caenorhabditis elegans. J. Exp. Zool. 1996, 274, 93-100.
-
(1996)
J. Exp. Zool
, vol.274
, pp. 93-100
-
-
Vanfleteren, J.R.1
de Vreese, A.2
-
43
-
-
0034816698
-
Cytochrome C is a potent catalyst of dichlorofluorescin oxidation: Implications for the role of reactive oxygen species in apoptosis
-
Burkitt, M.J.; Wardman, P. Cytochrome C is a potent catalyst of dichlorofluorescin oxidation: Implications for the role of reactive oxygen species in apoptosis. Biochem. Biophys. Res. Commun. 2001, 282, 329-333.
-
(2001)
Biochem. Biophys. Res. Commun
, vol.282
, pp. 329-333
-
-
Burkitt, M.J.1
Wardman, P.2
-
44
-
-
33644872102
-
The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy?
-
Bonini, M.G.; Rota, C.; Tomasi, A.; Mason, R.P. The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy? Free Radic. Biol. Med. 2006, 40, 968-975.
-
(2006)
Free Radic. Biol. Med
, vol.40
, pp. 968-975
-
-
Bonini, M.G.1
Rota, C.2
Tomasi, A.3
Mason, R.P.4
-
45
-
-
0032783532
-
Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
-
Hempel, S.L.; Buettner, G.R.; O'Malley, Y.Q.; Wessels, D.A.; Flaherty, D.M. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic. Biol. Med. 1999, 27, 146-159.
-
(1999)
Free Radic. Biol. Med
, vol.27
, pp. 146-159
-
-
Hempel, S.L.1
Buettner, G.R.2
O'Malley, Y.Q.3
Wessels, D.A.4
Flaherty, D.M.5
-
46
-
-
64749107070
-
Kinetics of reaction of nitrogen dioxide with dihydrorhodamine and the reaction of the dihydrorhodamine radical with oxygen: Implications for quantifying peroxynitrite formation in cells
-
Folkes, L.K.; Patel, K.B.; Wardman, P.; Wrona, M. Kinetics of reaction of nitrogen dioxide with dihydrorhodamine and the reaction of the dihydrorhodamine radical with oxygen: Implications for quantifying peroxynitrite formation in cells. Arch. Biochem. Biophys. 2009, 484, 122-126.
-
(2009)
Arch. Biochem. Biophys
, vol.484
, pp. 122-126
-
-
Folkes, L.K.1
Patel, K.B.2
Wardman, P.3
Wrona, M.4
-
47
-
-
84655163961
-
Measuring reactive oxygen and nitrogen species with fluorescent probes: Challenges and limitations
-
Kalyanaraman, B.; Darley-Usmar, V.; Davies, K.J.; Dennery, P.A.; Forman, H.J.; Grisham, M.B.; Mann, G.E.; Moore, K.; Roberts, L.J., 2nd; Ischiropoulos, H. Measuring reactive oxygen and nitrogen species with fluorescent probes: Challenges and limitations. Free Radic. Biol. Med. 2012, 52, 1-6.
-
(2012)
Free Radic. Biol. Med
, vol.52
, pp. 1-6
-
-
Kalyanaraman, B.1
Darley-Usmar, V.2
Davies, K.J.3
Dennery, P.A.4
Forman, H.J.5
Grisham, M.B.6
Mann, G.E.7
Moore, K.8
Roberts II, L.J.9
Ischiropoulos, H.10
-
48
-
-
84856716910
-
Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans
-
Back, P.; de Vos, W.H.; Depuydt, G.G.; Matthijssens, F.; Vanfleteren, J.R.; Braeckman, B.P. Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans. Free Radic. Biol. Med. 2012, 52, 850-859.
-
(2012)
Free Radic. Biol. Med
, vol.52
, pp. 850-859
-
-
Back, P.1
de Vos, W.H.2
Depuydt, G.G.3
Matthijssens, F.4
Vanfleteren, J.R.5
Braeckman, B.P.6
-
49
-
-
84866272849
-
Quantitative in vivo redox sensors uncover oxidative stress as an early event in life
-
Knoefler, D.; Thamsen, M.; Koniczek, M.; Niemuth, N.J.; Diederich, A.K.; Jakob, U. Quantitative in vivo redox sensors uncover oxidative stress as an early event in life. Mol. Cell 2012, 47, 767-776.
-
(2012)
Mol. Cell
, vol.47
, pp. 767-776
-
-
Knoefler, D.1
Thamsen, M.2
Koniczek, M.3
Niemuth, N.J.4
Diederich, A.K.5
Jakob, U.6
-
50
-
-
33645283923
-
Genetically encoded fluorescent indicator for intracellular hydrogen peroxide
-
Belousov, V.V.; Fradkov, A.F.; Lukyanov, K.A.; Staroverov, D.B.; Shakhbazov, K.S.; Terskikh, A.V.; Lukyanov, S. Genetically encoded fluorescent indicator for intracellular hydrogen peroxide. Nat. Methods 2006, 3, 281-286.
-
(2006)
Nat. Methods
, vol.3
, pp. 281-286
-
-
Belousov, V.V.1
Fradkov, A.F.2
Lukyanov, K.A.3
Staroverov, D.B.4
Shakhbazov, K.S.5
Terskikh, A.V.6
Lukyanov, S.7
-
51
-
-
0032994431
-
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status
-
Aslund, F.; Zheng, M.; Beckwith, J.; Storz, G. Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status. Proc. Natl. Acad. Sci. USA 1999, 96, 6161-6165.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6161-6165
-
-
Aslund, F.1
Zheng, M.2
Beckwith, J.3
Storz, G.4
-
52
-
-
2942585126
-
Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone
-
De Castro, E.; Hegi de Castro, S.; Johnson, T.E. Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone. Free Radic. Biol. Med. 2004, 37, 139-145.
-
(2004)
Free Radic. Biol. Med
, vol.37
, pp. 139-145
-
-
de Castro, E.1
de Castro, H.S.2
Johnson, T.E.3
-
53
-
-
1642498276
-
Cytotoxic action of juglone and plumbagin: A mechanistic study using HaCaT keratinocytes
-
Inbaraj, J.J.; Chignell, C.F. Cytotoxic action of juglone and plumbagin: A mechanistic study using HaCaT keratinocytes. Chem. Res. Toxicol. 2004, 17, 55-62.
-
(2004)
Chem. Res. Toxicol
, vol.17
, pp. 55-62
-
-
Inbaraj, J.J.1
Chignell, C.F.2
-
54
-
-
77953338484
-
Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis
-
Hartwig, K.; Heidler, T.; Moch, J.; Daniel, H.; Wenzel, U. Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis. Genes Nutr. 2009, 4, 59-67.
-
(2009)
Genes Nutr
, vol.4
, pp. 59-67
-
-
Hartwig, K.1
Heidler, T.2
Moch, J.3
Daniel, H.4
Wenzel, U.5
-
55
-
-
67349276677
-
Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone
-
Przybysz, A.J.; Choe, K.P.; Roberts, L.J.; Strange, K. Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Mechan. Ageing Dev. 2009, 130, 357-369.
-
(2009)
Mechan. Ageing Dev
, vol.130
, pp. 357-369
-
-
Przybysz, A.J.1
Choe, K.P.2
Roberts, L.J.3
Strange, K.4
-
56
-
-
0025185977
-
A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans
-
Ishii, N.; Takahashi, K.; Tomita, S.; Keino, T.; Honda, S.; Yoshino, K.; Suzuki, K. A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. Mutat. Res. 1990, 237, 165-171.
-
(1990)
Mutat. Res
, vol.237
, pp. 165-171
-
-
Ishii, N.1
Takahashi, K.2
Tomita, S.3
Keino, T.4
Honda, S.5
Yoshino, K.6
Suzuki, K.7
-
57
-
-
70349411509
-
Defective responses to oxidative stress in protein L-isoaspartyl repair-deficient Caenorhabditis elegans
-
Khare, S.; Gomez, T.; Linster, C.L.; Clarke, S.G. Defective responses to oxidative stress in protein L-isoaspartyl repair-deficient Caenorhabditis elegans. Mech. Ageing Dev. 2009, 130, 670-680.
-
(2009)
Mech. Ageing Dev
, vol.130
, pp. 670-680
-
-
Khare, S.1
Gomez, T.2
Linster, C.L.3
Clarke, S.G.4
-
58
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim, S.C.; Sprung, R.; Chen, Y.; Xu, Y.; Ball, H.; Pei, J.; Cheng, T.; Kho, Y.; Xiao, H.; Xiao, L.; et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 2006, 23, 607-618.
-
(2006)
Mol. Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
-
59
-
-
0027197284
-
Oxidative stress and ageing in Caenorhabditis elegans
-
Vanfleteren, J.R. Oxidative stress and ageing in Caenorhabditis elegans. Biochem. J. 1993, 292, 605-608.
-
(1993)
Biochem. J
, vol.292
, pp. 605-608
-
-
Vanfleteren, J.R.1
-
60
-
-
0020526823
-
Superoxide, hydrogen peroxide, and oxygen toxicity in two free-living nematode species
-
Blum, J.; Fridovich, I. Superoxide, hydrogen peroxide, and oxygen toxicity in two free-living nematode species. Arch. Biochem. Biophys. 1983, 222, 35-43.
-
(1983)
Arch. Biochem. Biophys
, vol.222
, pp. 35-43
-
-
Blum, J.1
Fridovich, I.2
-
61
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
Lee, S.S.; Lee, R.Y.; Fraser, A.G.; Kamath, R.S.; Ahringer, J.; Ruvkun, G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 2003, 33, 40-48.
-
(2003)
Nat. Genet
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Ruvkun, G.6
-
62
-
-
22144462536
-
Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans
-
Ventura, N.; Rea, S.; Henderson, S.T.; Condo, I.; Johnson, T.E.; Testi, R. Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans. Aging Cell 2005, 4, 109-112.
-
(2005)
Aging Cell
, vol.4
, pp. 109-112
-
-
Ventura, N.1
Rea, S.2
Henderson, S.T.3
Condo, I.4
Johnson, T.E.5
Testi, R.6
-
63
-
-
0002004749
-
Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans
-
Yamamoto, K.; Honda, S.; Ishii, N. Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans. Mutat. Res. 1996, 358, 1-6.
-
(1996)
Mutat. Res
, vol.358
, pp. 1-6
-
-
Yamamoto, K.1
Honda, S.2
Ishii, N.3
-
64
-
-
0035515923
-
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
-
Feng, J.; Bussiere, F.; Hekimi, S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev. Cell 2001, 1, 633-644.
-
(2001)
Dev. Cell
, vol.1
, pp. 633-644
-
-
Feng, J.1
Bussiere, F.2
Hekimi, S.3
-
65
-
-
0842346368
-
Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases
-
Montine, K.S.; Quinn, J.F.; Zhang, J.; Fessel, J.P.; Roberts, L.J., 2nd; Morrow, J.D.; Montine, T.J. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chem. Phys. Lipids 2004, 128, 117-124.
-
(2004)
Chem. Phys. Lipids
, vol.128
, pp. 117-124
-
-
Montine, K.S.1
Quinn, J.F.2
Zhang, J.3
Fessel, J.P.4
Roberts II, L.J.5
Morrow, J.D.6
Montine, T.J.7
-
66
-
-
80054080478
-
Isoprostane generation and function
-
Milne, G.L.; Yin, H.; Hardy, K.D.; Davies, S.S.; Roberts, L.J., 2nd. Isoprostane generation and function. Chem. Rev. 2011, 111, 5973-5996.
-
(2011)
Chem. Rev
, vol.111
, pp. 5973-5996
-
-
Milne, G.L.1
Yin, H.2
Hardy, K.D.3
Davies, S.S.4
Roberts II, L.J.5
-
67
-
-
33744933226
-
Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid
-
Gao, L.; Yin, H.; Milne, G.L.; Porter, N.A.; Morrow, J.D. Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid. J. Biol. Chem. 2006, 281, 14092-14099.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 14092-14099
-
-
Gao, L.1
Yin, H.2
Milne, G.L.3
Porter, N.A.4
Morrow, J.D.5
-
68
-
-
84878950143
-
Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement
-
Labuschagne, C.F.; Stigter, E.C.; Hendriks, M.M.; Berger, R.; Rokach, J.; Korswagen, H.C.; Brenkman, A.B. Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement. Aging Cell 2013, 12, 214-223.
-
(2013)
Aging Cell
, vol.12
, pp. 214-223
-
-
Labuschagne, C.F.1
Stigter, E.C.2
Hendriks, M.M.3
Berger, R.4
Rokach, J.5
Korswagen, H.C.6
Brenkman, A.B.7
-
69
-
-
0031904566
-
Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans
-
Adachi, H.; Fujiwara, Y.; Ishii, N. Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans. J. Gerontol. A Biol. Sci. Med. Sci. 1998, 53, B240-B244.
-
(1998)
J. Gerontol. a Biol. Sci. Med. Sci
, vol.53
-
-
Adachi, H.1
Fujiwara, Y.2
Ishii, N.3
-
70
-
-
2442421023
-
Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans
-
Petriv, O.I.; Rachubinski, R.A. Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. J. Biol. Chem. 2004, 279, 19996-20001.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 19996-20001
-
-
Petriv, O.I.1
Rachubinski, R.A.2
-
71
-
-
0036860964
-
Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span
-
Yanase, S.; Yasuda, K.; Ishii, N. Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span. Mech. Ageing Dev. 2002, 123, 1579-1587.
-
(2002)
Mech. Ageing Dev
, vol.123
, pp. 1579-1587
-
-
Yanase, S.1
Yasuda, K.2
Ishii, N.3
-
72
-
-
2942598255
-
The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans
-
Kayser, E.B.; Sedensky, M.M.; Morgan, P.G. The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Mech. Ageing Dev. 2004, 125, 455-464.
-
(2004)
Mech. Ageing Dev
, vol.125
, pp. 455-464
-
-
Kayser, E.B.1
Sedensky, M.M.2
Morgan, P.G.3
-
73
-
-
67349139149
-
The effect of different ubiquinones on lifespan in Caenorhabditis elegans
-
Yang, Y.Y.; Gangoiti, J.A.; Sedensky, M.M.; Morgan, P.G. The effect of different ubiquinones on lifespan in Caenorhabditis elegans. Mech. Ageing Dev. 2009, 130, 370-376.
-
(2009)
Mech. Ageing Dev
, vol.130
, pp. 370-376
-
-
Yang, Y.Y.1
Gangoiti, J.A.2
Sedensky, M.M.3
Morgan, P.G.4
-
74
-
-
1842785821
-
Localization of isoketal adducts in vivo using a single-chain antibody
-
Davies, S.S.; Talati, M.; Wang, X.; Mernaugh, R.L.; Amarnath, V.; Fessel, J.; Meyrick, B.O.; Sheller, J.; Roberts, L.J., 2nd. Localization of isoketal adducts in vivo using a single-chain antibody. Free Rad. Biol. Med. 2004, 36, 1163-1174.
-
(2004)
Free Rad. Biol. Med
, vol.36
, pp. 1163-1174
-
-
Davies, S.S.1
Talati, M.2
Wang, X.3
Mernaugh, R.L.4
Amarnath, V.5
Fessel, J.6
Meyrick, B.O.7
Sheller, J.8
Roberts II, L.J.9
-
75
-
-
66349105688
-
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans
-
Choe, K.P.; Przybysz, A.J.; Strange, K. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol. Cell. Biol. 2009, 29, 2704-2715.
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 2704-2715
-
-
Choe, K.P.1
Przybysz, A.J.2
Strange, K.3
-
76
-
-
80355128983
-
High-throughput screening and biosensing with fluorescent C. elegans strains
-
doi:10.3791/2745
-
Leung, C.K.; Deonarine, A.; Strange, K.; Choe, K.P. High-throughput screening and biosensing with fluorescent C. elegans strains. J. Vis. Exp. 2011, doi:10.3791/2745.
-
(2011)
J. Vis. Exp
-
-
Leung, C.K.1
Deonarine, A.2
Strange, K.3
Choe, K.P.4
-
77
-
-
84856752547
-
Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf/SKN-1 and p53/CEP-1
-
Leung, C.K.; Empinado, H.; Choe, K.P. Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf/SKN-1 and p53/CEP-1. Free Radic. Biol. Med. 2012, 52, 937-950.
-
(2012)
Free Radic. Biol. Med
, vol.52
, pp. 937-950
-
-
Leung, C.K.1
Empinado, H.2
Choe, K.P.3
-
78
-
-
2942589064
-
Evolutionary and functional relationships within the DJ1 superfamily
-
Bandyopadhyay, S.; Cookson, M.R. Evolutionary and functional relationships within the DJ1 superfamily. BMC Evol. Biol. 2004, 4, 6.
-
(2004)
BMC Evol. Biol
, vol.4
, pp. 6
-
-
Bandyopadhyay, S.1
Cookson, M.R.2
-
79
-
-
0037428241
-
Mutations in the dj-1 gene associated with autosomal recessive early-onset parkinsonism
-
Bonifati, V.; Rizzu, P.; van Baren, M.J.; Schaap, O.; Breedveld, G.J.; Krieger, E.; Dekker, M.C.; Squitieri, F.; Ibanez, P.; Joosse, M.; et al. Mutations in the dj-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003, 299, 256-259.
-
(2003)
Science
, vol.299
, pp. 256-259
-
-
Bonifati, V.1
Rizzu, P.2
van Baren, M.J.3
Schaap, O.4
Breedveld, G.J.5
Krieger, E.6
Dekker, M.C.7
Squitieri, F.8
Ibanez, P.9
Joosse, M.10
-
80
-
-
0141704202
-
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
-
Miller, D.W.; Ahmad, R.; Hague, S.; Baptista, M.J.; Canet-Aviles, R.; McLendon, C.; Carter, D.M.; Zhu, P.P.; Stadler, J.; Chandran, J.; et al. L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. J. Biol. Chem. 2003, 278, 36588-36595.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 36588-36595
-
-
Miller, D.W.1
Ahmad, R.2
Hague, S.3
Baptista, M.J.4
Canet-Aviles, R.5
McLendon, C.6
Carter, D.M.7
Zhu, P.P.8
Stadler, J.9
Chandran, J.10
-
81
-
-
0242524434
-
The DJ-1l166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes
-
Macedo, M.G.; Anar, B.; Bronner, I.F.; Cannella, M.; Squitieri, F.; Bonifati, V.; Hoogeveen, A.; Heutink, P.; Rizzu, P. The DJ-1l166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes. Hum. Mol. Genet. 2003, 12, 2807-2816.
-
(2003)
Hum. Mol. Genet
, vol.12
, pp. 2807-2816
-
-
Macedo, M.G.1
Anar, B.2
Bronner, I.F.3
Cannella, M.4
Squitieri, F.5
Bonifati, V.6
Hoogeveen, A.7
Heutink, P.8
Rizzu, P.9
-
82
-
-
13944267769
-
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
-
Shendelman, S.; Jonason, A.; Martinat, C.; Leete, T.; Abeliovich, A. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol. 2004, 2, e362.
-
(2004)
PLoS Biol
, vol.2
-
-
Shendelman, S.1
Jonason, A.2
Martinat, C.3
Leete, T.4
Abeliovich, A.5
-
83
-
-
0035692636
-
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin
-
Mitsumoto, A.; Nakagawa, Y. DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radic. Res. 2001, 35, 885-893.
-
(2001)
Free Radic. Res
, vol.35
, pp. 885-893
-
-
Mitsumoto, A.1
Nakagawa, Y.2
-
84
-
-
0034906096
-
Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat
-
Mitsumoto, A.; Nakagawa, Y.; Takeuchi, A.; Okawa, K.; Iwamatsu, A.; Takanezawa, Y. Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic. Res. 2001, 35, 301-310.
-
(2001)
Free Radic. Res
, vol.35
, pp. 301-310
-
-
Mitsumoto, A.1
Nakagawa, Y.2
Takeuchi, A.3
Okawa, K.4
Iwamatsu, A.5
Takanezawa, Y.6
-
85
-
-
84860539187
-
Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
-
Wang, X.; Petrie, T.G.; Liu, Y.; Liu, J.; Fujioka, H.; Zhu, X. Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. J. Neurochem. 2012, 121, 830-839.
-
(2012)
J. Neurochem
, vol.121
, pp. 830-839
-
-
Wang, X.1
Petrie, T.G.2
Liu, Y.3
Liu, J.4
Fujioka, H.5
Zhu, X.6
-
86
-
-
59849104963
-
DJ-1 protects against dopamine toxicity
-
Lev, N.; Ickowicz, D.; Barhum, Y.; Lev, S.; Melamed, E.; Offen, D. DJ-1 protects against dopamine toxicity. J. Neural Transm. 2009, 116, 151-160.
-
(2009)
J. Neural Transm
, vol.116
, pp. 151-160
-
-
Lev, N.1
Ickowicz, D.2
Barhum, Y.3
Lev, S.4
Melamed, E.5
Offen, D.6
-
87
-
-
84873665618
-
DJ-1 protects against dopamine toxicity: Implications for Parkinson's disease and aging
-
Lev, N.; Barhum, Y.; Pilosof, N.S.; Ickowicz, D.; Cohen, H.Y.; Melamed, E.; Offen, D. DJ-1 protects against dopamine toxicity: Implications for Parkinson's disease and aging. J. Gerontol. A Biol. Sci. Med. Sci. 2013, 68, 215-225.
-
(2013)
J. Gerontol. a Biol. Sci. Med. Sci
, vol.68
, pp. 215-225
-
-
Lev, N.1
Barhum, Y.2
Pilosof, N.S.3
Ickowicz, D.4
Cohen, H.Y.5
Melamed, E.6
Offen, D.7
-
88
-
-
35548972027
-
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
-
Andres-Mateos, E.; Perier, C.; Zhang, L.; Blanchard-Fillion, B.; Greco, T.M.; Thomas, B.; Ko, H.S.; Sasaki, M.; Ischiropoulos, H.; Przedborski, S.; et al. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc. Natl. Acad. Sci. USA 2007, 104, 14807-14812.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 14807-14812
-
-
Andres-Mateos, E.1
Perier, C.2
Zhang, L.3
Blanchard-Fillion, B.4
Greco, T.M.5
Thomas, B.6
Ko, H.S.7
Sasaki, M.8
Ischiropoulos, H.9
Przedborski, S.10
-
89
-
-
2942684871
-
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
-
Canet-Aviles, R.M.; Wilson, M.A.; Miller, D.W.; Ahmad, R.; McLendon, C.; Bandyopadhyay, S.; Baptista, M.J.; Ringe, D.; Petsko, G.A.; Cookson, M.R. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl. Acad. Sci. USA 2004, 101, 9103-9108.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 9103-9108
-
-
Canet-Aviles, R.M.1
Wilson, M.A.2
Miller, D.W.3
Ahmad, R.4
McLendon, C.5
Bandyopadhyay, S.6
Baptista, M.J.7
Ringe, D.8
Petsko, G.A.9
Cookson, M.R.10
-
90
-
-
33646826619
-
Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
-
Choi, J.; Sullards, M.C.; Olzmann, J.A.; Rees, H.D.; Weintraub, S.T.; Bostwick, D.E.; Gearing, M.; Levey, A.I.; Chin, L.S.; Li, L. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J. Biol. Chem. 2006, 281, 10816-10824.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10816-10824
-
-
Choi, J.1
Sullards, M.C.2
Olzmann, J.A.3
Rees, H.D.4
Weintraub, S.T.5
Bostwick, D.E.6
Gearing, M.7
Levey, A.I.8
Chin, L.S.9
Li, L.10
-
91
-
-
1642527499
-
DJ-1 has a role in antioxidative stress to prevent cell death
-
Taira, T.; Saito, Y.; Niki, T.; Iguchi-Ariga, S.M.; Takahashi, K.; Ariga, H. DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep. 2004, 5, 213-218.
-
(2004)
EMBO Rep
, vol.5
, pp. 213-218
-
-
Taira, T.1
Saito, Y.2
Niki, T.3
Iguchi-Ariga, S.M.4
Takahashi, K.5
Ariga, H.6
-
92
-
-
84878775802
-
Structure and function of parkin, PINK1, and DJ-1, the three musketeers of neuroprotection
-
Trempe, J.F.; Fon, E.A. Structure and function of parkin, PINK1, and DJ-1, the three musketeers of neuroprotection. Front Neurol 2013, 4, 38.
-
(2013)
Front Neurol
, vol.4
, pp. 38
-
-
Trempe, J.F.1
Fon, E.A.2
-
93
-
-
84861561345
-
Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53
-
Girotto, S.; Sturlese, M.; Bellanda, M.; Tessari, I.; Cappellini, R.; Bisaglia, M.; Bubacco, L.; Mammi, S. Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53. J. Biol. Chem. 2012, 287, 18738-18749.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 18738-18749
-
-
Girotto, S.1
Sturlese, M.2
Bellanda, M.3
Tessari, I.4
Cappellini, R.5
Bisaglia, M.6
Bubacco, L.7
Mammi, S.8
-
94
-
-
84879984546
-
DJ-1 expression modulates astrocyte-mediated protection against neuronal oxidative stress
-
Mullett, S.J.; di Maio, R.; Greenamyre, J.T.; Hinkle, D.A. DJ-1 expression modulates astrocyte-mediated protection against neuronal oxidative stress. J. Mol. Neurosci. 2013, 49, 507-511.
-
(2013)
J. Mol. Neurosci
, vol.49
, pp. 507-511
-
-
Mullett, S.J.1
di Maio, R.2
Greenamyre, J.T.3
Hinkle, D.A.4
-
95
-
-
24044472010
-
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
-
Meulener, M.; Whitworth, A.J.; Armstrong-Gold, C.E.; Rizzu, P.; Heutink, P.; Wes, P.D.; Pallanck, L.J.; Bonini, N.M. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 2005, 15, 1572-1577.
-
(2005)
Curr. Biol
, vol.15
, pp. 1572-1577
-
-
Meulener, M.1
Whitworth, A.J.2
Armstrong-Gold, C.E.3
Rizzu, P.4
Heutink, P.5
Wes, P.D.6
Pallanck, L.J.7
Bonini, N.M.8
-
96
-
-
79961207215
-
The antioxidant trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells
-
Shim, J.H.; Yoon, S.H.; Kim, K.H.; Han, J.Y.; Ha, J.Y.; Hyun, D.H.; Paek, S.H.; Kang, U.J.; Zhuang, X.; Son, J.H. The antioxidant trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. Mitochondrion 2011, 11, 707-715.
-
(2011)
Mitochondrion
, vol.11
, pp. 707-715
-
-
Shim, J.H.1
Yoon, S.H.2
Kim, K.H.3
Han, J.Y.4
Ha, J.Y.5
Hyun, D.H.6
Paek, S.H.7
Kang, U.J.8
Zhuang, X.9
Son, J.H.10
-
97
-
-
84865036938
-
Involvement and interplay of parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders
-
Wilhelmus, M.M.; Nijland, P.G.; Drukarch, B.; de Vries, H.E.; van Horssen, J. Involvement and interplay of parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders. Free Radic. Biol. Med. 2012, 53, 983-992.
-
(2012)
Free Radic. Biol. Med
, vol.53
, pp. 983-992
-
-
Wilhelmus, M.M.1
Nijland, P.G.2
Drukarch, B.3
de Vries, H.E.4
van Horssen, J.5
-
98
-
-
20144389422
-
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
-
Kim, R.H.; Smith, P.D.; Aleyasin, H.; Hayley, S.; Mount, M.P.; Pownall, S.; Wakeham, A.; You-Ten, A.J.; Kalia, S.K.; Horne, P.; et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl. Acad. Sci. USA 2005, 102, 5215-5220.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 5215-5220
-
-
Kim, R.H.1
Smith, P.D.2
Aleyasin, H.3
Hayley, S.4
Mount, M.P.5
Pownall, S.6
Wakeham, A.7
You-Ten, A.J.8
Kalia, S.K.9
Horne, P.10
-
99
-
-
77953084081
-
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
-
Hao, L.Y.; Giasson, B.I.; Bonini, N.M. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc. Natl. Acad. Sci. USA 2010, 107, 9747-9752.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 9747-9752
-
-
Hao, L.Y.1
Giasson, B.I.2
Bonini, N.M.3
-
100
-
-
84868087279
-
ROS-dependent regulation of parkin and DJ-1 localization during oxidative stress in neurons
-
Joselin, A.P.; Hewitt, S.J.; Callaghan, S.M.; Kim, R.H.; Chung, Y.H.; Mak, T.W.; Shen, J.; Slack, R.S.; Park, D.S. ROS-dependent regulation of parkin and DJ-1 localization during oxidative stress in neurons. Hum. Mol. Genet. 2012, 21, 4888-4903.
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 4888-4903
-
-
Joselin, A.P.1
Hewitt, S.J.2
Callaghan, S.M.3
Kim, R.H.4
Chung, Y.H.5
Mak, T.W.6
Shen, J.7
Slack, R.S.8
Park, D.S.9
-
101
-
-
65649118917
-
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
-
Xiong, H.; Wang, D.; Chen, L.; Choo, Y.S.; Ma, H.; Tang, C.; Xia, K.; Jiang, W.; Ronai, Z.; Zhuang, X.; et al. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 2009, 119, 650-660.
-
(2009)
J. Clin. Invest
, vol.119
, pp. 650-660
-
-
Xiong, H.1
Wang, D.2
Chen, L.3
Choo, Y.S.4
Ma, H.5
Tang, C.6
Xia, K.7
Jiang, W.8
Ronai, Z.9
Zhuang, X.10
-
102
-
-
79956323688
-
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
-
Thomas, K.J.; McCoy, M.K.; Blackinton, J.; Beilina, A.; van der Brug, M.; Sandebring, A.; Miller, D.; Maric, D.; Cedazo-Minguez, A.; Cookson, M.R. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Hum. Mol. Genet. 2011, 20, 40-50.
-
(2011)
Hum. Mol. Genet
, vol.20
, pp. 40-50
-
-
Thomas, K.J.1
McCoy, M.K.2
Blackinton, J.3
Beilina, A.4
van der Brug, M.5
Sandebring, A.6
Miller, D.7
Maric, D.8
Cedazo-Minguez, A.9
Cookson, M.R.10
-
103
-
-
24944534660
-
Mitochondrial localization of the Parkinson's disease related protein DJ-1: Implications for pathogenesis
-
Zhang, L.; Shimoji, M.; Thomas, B.; Moore, D.J.; Yu, S.W.; Marupudi, N.I.; Torp, R.; Torgner, I.A.; Ottersen, O.P.; Dawson, T.M.; et al. Mitochondrial localization of the Parkinson's disease related protein DJ-1: Implications for pathogenesis. Hum. Mol. Genet. 2005, 14, 2063-2073.
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 2063-2073
-
-
Zhang, L.1
Shimoji, M.2
Thomas, B.3
Moore, D.J.4
Yu, S.W.5
Marupudi, N.I.6
Torp, R.7
Torgner, I.A.8
Ottersen, O.P.9
Dawson, T.M.10
-
104
-
-
33846849338
-
A new evolutionary paradigm for the parkinson disease gene DJ-1
-
Lucas, J.I.; Marin, I. A new evolutionary paradigm for the parkinson disease gene DJ-1. Mol. Biol. Evol. 2007, 24, 551-561.
-
(2007)
Mol. Biol. Evol
, vol.24
, pp. 551-561
-
-
Lucas, J.I.1
Marin, I.2
-
105
-
-
84864021706
-
Human DJ-1 and its homologs are novel glyoxalases
-
Lee, J.Y.; Song, J.; Kwon, K.; Jang, S.; Kim, C.; Baek, K.; Kim, J.; Park, C. Human DJ-1 and its homologs are novel glyoxalases. Hum. Mol. Genet. 2012, 21, 3215-3225.
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 3215-3225
-
-
Lee, J.Y.1
Song, J.2
Kwon, K.3
Jang, S.4
Kim, C.5
Baek, K.6
Kim, J.7
Park, C.8
-
106
-
-
30044434872
-
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
-
Ved, R.; Saha, S.; Westlund, B.; Perier, C.; Burnam, L.; Sluder, A.; Hoener, M.; Rodrigues, C.M.; Alfonso, A.; Steer, C.; et al. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J. Biol. Chem. 2005, 280, 42655-42668.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 42655-42668
-
-
Ved, R.1
Saha, S.2
Westlund, B.3
Perier, C.4
Burnam, L.5
Sluder, A.6
Hoener, M.7
Rodrigues, C.M.8
Alfonso, A.9
Steer, C.10
-
107
-
-
84878652654
-
DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state
-
Lee, J.Y.; Kim, C.; Kim, J.; Park, C. DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state. Gene 2013, 524, 373-376.
-
(2013)
Gene
, vol.524
, pp. 373-376
-
-
Lee, J.Y.1
Kim, C.2
Kim, J.3
Park, C.4
-
108
-
-
0034700158
-
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
-
Zhang, Y.; Gao, J.; Chung, K.K.; Huang, H.; Dawson, V.L.; Dawson, T.M. Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc. Natl. Acad. Sci. USA 2000, 97, 13354-13359.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13354-13359
-
-
Zhang, Y.1
Gao, J.2
Chung, K.K.3
Huang, H.4
Dawson, V.L.5
Dawson, T.M.6
-
109
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada, T.; Asakawa, S.; Hattori, N.; Matsumine, H.; Yamamura, Y.; Minoshima, S.; Yokochi, M.; Mizuno, Y.; Shimizu, N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998, 392, 605-608.
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
110
-
-
0032693422
-
Identification and distribution of parkin in rat brain
-
Horowitz, J.M.; Myers, J.; Stachowiak, M.K.; Torres, G. Identification and distribution of parkin in rat brain. Neuroreport 1999, 10, 3393-3397.
-
(1999)
Neuroreport
, vol.10
, pp. 3393-3397
-
-
Horowitz, J.M.1
Myers, J.2
Stachowiak, M.K.3
Torres, G.4
-
111
-
-
0035854437
-
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease
-
Shimura, H.; Schlossmacher, M.G.; Hattori, N.; Frosch, M.P.; Trockenbacher, A.; Schneider, R.; Mizuno, Y.; Kosik, K.S.; Selkoe, D.J. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: Implications for Parkinson's disease. Science 2001, 293, 263-269.
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H.1
Schlossmacher, M.G.2
Hattori, N.3
Frosch, M.P.4
Trockenbacher, A.5
Schneider, R.6
Mizuno, Y.7
Kosik, K.S.8
Selkoe, D.J.9
-
112
-
-
0034776095
-
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for lewy-body formation in Parkinson disease
-
Chung, K.K.; Zhang, Y.; Lim, K.L.; Tanaka, Y.; Huang, H.; Gao, J.; Ross, C.A.; Dawson, V.L.; Dawson, T.M. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for lewy-body formation in Parkinson disease. Nat. Med. 2001, 7, 1144-1150.
-
(2001)
Nat. Med
, vol.7
, pp. 1144-1150
-
-
Chung, K.K.1
Zhang, Y.2
Lim, K.L.3
Tanaka, Y.4
Huang, H.5
Gao, J.6
Ross, C.A.7
Dawson, V.L.8
Dawson, T.M.9
-
113
-
-
0035967883
-
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin
-
Imai, Y.; Soda, M.; Inoue, H.; Hattori, N.; Mizuno, Y.; Takahashi, R. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin. Cell 2001, 105, 891-902.
-
(2001)
Cell
, vol.105
, pp. 891-902
-
-
Imai, Y.1
Soda, M.2
Inoue, H.3
Hattori, N.4
Mizuno, Y.5
Takahashi, R.6
-
114
-
-
24144470504
-
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin
-
Sriram, S.R.; Li, X.; Ko, H.S.; Chung, K.K.; Wong, E.; Lim, K.L.; Dawson, V.L.; Dawson, T.M. Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. Hum. Mol. Genet. 2005, 14, 2571-2586.
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 2571-2586
-
-
Sriram, S.R.1
Li, X.2
Ko, H.S.3
Chung, K.K.4
Wong, E.5
Lim, K.L.6
Dawson, V.L.7
Dawson, T.M.8
-
115
-
-
0141891953
-
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
-
Goldberg, M.S.; Fleming, S.M.; Palacino, J.J.; Cepeda, C.; Lam, H.A.; Bhatnagar, A.; Meloni, E.G.; Wu, N.; Ackerson, L.C.; Klapstein, G.J.; et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 2003, 278, 43628-43635.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 43628-43635
-
-
Goldberg, M.S.1
Fleming, S.M.2
Palacino, J.J.3
Cepeda, C.4
Lam, H.A.5
Bhatnagar, A.6
Meloni, E.G.7
Wu, N.8
Ackerson, L.C.9
Klapstein, G.J.10
-
116
-
-
11144232015
-
Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter
-
Jiang, H.; Jiang, Q.; Feng, J. Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. J. Biol. Chem. 2004, 279, 54380-54386.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 54380-54386
-
-
Jiang, H.1
Jiang, Q.2
Feng, J.3
-
117
-
-
67649479622
-
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice
-
Kitada, T.; Pisani, A.; Karouani, M.; Haburcak, M.; Martella, G.; Tscherter, A.; Platania, P.; Wu, B.; Pothos, E.N.; Shen, J. Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. J.Neurochem. 2009, 110, 613-621.
-
(2009)
J.Neurochem
, vol.110
, pp. 613-621
-
-
Kitada, T.1
Pisani, A.2
Karouani, M.3
Haburcak, M.4
Martella, G.5
Tscherter, A.6
Platania, P.7
Wu, B.8
Pothos, E.N.9
Shen, J.10
-
118
-
-
58049209715
-
Pruning and loss of excitatory synapses by the parkin ubiquitin ligase
-
Helton, T.D.; Otsuka, T.; Lee, M.C.; Mu, Y.; Ehlers, M.D. Pruning and loss of excitatory synapses by the parkin ubiquitin ligase. Proc. Natl. Acad. Sci. USA 2008, 105, 19492-19497.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19492-19497
-
-
Helton, T.D.1
Otsuka, T.2
Lee, M.C.3
Mu, Y.4
Ehlers, M.D.5
-
119
-
-
33846804056
-
A drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine
-
Sang, T.K.; Chang, H.Y.; Lawless, G.M.; Ratnaparkhi, A.; Mee, L.; Ackerson, L.C.; Maidment, N.T.; Krantz, D.E.; Jackson, G.R. A drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine. J. Neurosci. 2007, 27, 981-992.
-
(2007)
J. Neurosci
, vol.27
, pp. 981-992
-
-
Sang, T.K.1
Chang, H.Y.2
Lawless, G.M.3
Ratnaparkhi, A.4
Mee, L.5
Ackerson, L.C.6
Maidment, N.T.7
Krantz, D.E.8
Jackson, G.R.9
-
120
-
-
60849106352
-
Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein
-
Lu, X.H.; Fleming, S.M.; Meurers, B.; Ackerson, L.C.; Mortazavi, F.; Lo, V.; Hernandez, D.; Sulzer, D.; Jackson, G.R.; Maidment, N.T.; et al. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. J. Neurosci. 2009, 29, 1962-1976.
-
(2009)
J. Neurosci
, vol.29
, pp. 1962-1976
-
-
Lu, X.H.1
Fleming, S.M.2
Meurers, B.3
Ackerson, L.C.4
Mortazavi, F.5
Lo, V.6
Hernandez, D.7
Sulzer, D.8
Jackson, G.R.9
Maidment, N.T.10
-
121
-
-
3042656791
-
Parkin attenuates manganese-induced dopaminergic cell death
-
Higashi, Y.; Asanuma, M.; Miyazaki, I.; Hattori, N.; Mizuno, Y.; Ogawa, N. Parkin attenuates manganese-induced dopaminergic cell death. J. Neurochem. 2004, 89, 1490-1497.
-
(2004)
J. Neurochem
, vol.89
, pp. 1490-1497
-
-
Higashi, Y.1
Asanuma, M.2
Miyazaki, I.3
Hattori, N.4
Mizuno, Y.5
Ogawa, N.6
-
122
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente, E.M.; Abou-Sleiman, P.M.; Caputo, V.; Muqit, M.M.; Harvey, K.; Gispert, S.; Ali, Z.; del Turco, D.; Bentivoglio, A.R.; Healy, D.G.; et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004, 304, 1158-1160.
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
-
123
-
-
25144433763
-
Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome
-
Kessler, K.R.; Hamscho, N.; Morales, B.; Menzel, C.; Barrero, F.; Vives, F.; Gispert, S.; Auburger, G. Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome. J. Neural Transm. 2005, 112, 1345-1353.
-
(2005)
J. Neural Transm
, vol.112
, pp. 1345-1353
-
-
Kessler, K.R.1
Hamscho, N.2
Morales, B.3
Menzel, C.4
Barrero, F.5
Vives, F.6
Gispert, S.7
Auburger, G.8
-
124
-
-
34547489872
-
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
-
Kitada, T.; Pisani, A.; Porter, D.R.; Yamaguchi, H.; Tscherter, A.; Martella, G.; Bonsi, P.; Zhang, C.; Pothos, E.N.; Shen, J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc. Natl. Acad. Sci. USA 2007, 104, 11441-11446.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 11441-11446
-
-
Kitada, T.1
Pisani, A.2
Porter, D.R.3
Yamaguchi, H.4
Tscherter, A.5
Martella, G.6
Bonsi, P.7
Zhang, C.8
Pothos, E.N.9
Shen, J.10
-
125
-
-
33745087689
-
PINK1 protein in normal human brain and Parkinson's disease
-
Gandhi, S.; Muqit, M.M.; Stanyer, L.; Healy, D.G.; Abou-Sleiman, P.M.; Hargreaves, I.; Heales, S.; Ganguly, M.; Parsons, L.; Lees, A.J.; et al. PINK1 protein in normal human brain and Parkinson's disease. Brain J. Neurol. 2006, 129, 1720-1731.
-
(2006)
Brain J. Neurol
, vol.129
, pp. 1720-1731
-
-
Gandhi, S.1
Muqit, M.M.2
Stanyer, L.3
Healy, D.G.4
Abou-Sleiman, P.M.5
Hargreaves, I.6
Heales, S.7
Ganguly, M.8
Parsons, L.9
Lees, A.J.10
-
126
-
-
33750220194
-
Cheng, H.C. C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
-
Sim, C.H.; Lio, D.S.; Mok, S.S.; Masters, C.L.; Hill, A.F.; Culvenor, J.G.; Cheng, H.C. C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. Hum. Mol. Genet. 2006, 15, 3251-3262.
-
(2006)
Hum. Mol. Genet
, vol.15
, pp. 3251-3262
-
-
Sim, C.H.1
Lio, D.S.2
Mok, S.S.3
Masters, C.L.4
Hill, A.F.5
Culvenor, J.G.6
-
127
-
-
39449098267
-
Cytoplasmic PINK1 activity protects neurons from dopaminergic neurotoxin MPTP
-
Haque, M.E.; Thomas, K.J.; D'Souza, C.; Callaghan, S.; Kitada, T.; Slack, R.S.; Fraser, P.; Cookson, M.R.; Tandon, A.; Park, D.S. Cytoplasmic PINK1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc. Natl. Acad. Sci. USA 2008, 105, 1716-1721.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1716-1721
-
-
Haque, M.E.1
Thomas, K.J.2
D'Souza, C.3
Callaghan, S.4
Kitada, T.5
Slack, R.S.6
Fraser, P.7
Cookson, M.R.8
Tandon, A.9
Park, D.S.10
-
128
-
-
26644440926
-
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
-
Petit, A.; Kawarai, T.; Paitel, E.; Sanjo, N.; Maj, M.; Scheid, M.; Chen, F.; Gu, Y.; Hasegawa, H.; Salehi-Rad, S.; et al. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J. Biol. Chem. 2005, 280, 34025-34032.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 34025-34032
-
-
Petit, A.1
Kawarai, T.2
Paitel, E.3
Sanjo, N.4
Maj, M.5
Scheid, M.6
Chen, F.7
Gu, Y.8
Hasegawa, H.9
Salehi-Rad, S.10
-
129
-
-
33846288002
-
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6
-
Hoepken, H.H.; Gispert, S.; Morales, B.; Wingerter, O.; del Turco, D.; Mulsch, A.; Nussbaum, R.L.; Muller, K.; Drose, S.; Brandt, U.; et al. Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol. Dis. 2007, 25, 401-411.
-
(2007)
Neurobiol. Dis
, vol.25
, pp. 401-411
-
-
Hoepken, H.H.1
Gispert, S.2
Morales, B.3
Wingerter, O.4
del Turco, D.5
Mulsch, A.6
Nussbaum, R.L.7
Muller, K.8
Drose, S.9
Brandt, U.10
-
130
-
-
56049091236
-
PINK1 controls mitochondrial localization of parkin through direct phosphorylation
-
Kim, Y.; Park, J.; Kim, S.; Song, S.; Kwon, S.K.; Lee, S.H.; Kitada, T.; Kim, J.M.; Chung, J. PINK1 controls mitochondrial localization of parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 2008, 377, 975-980.
-
(2008)
Biochem. Biophys. Res. Commun
, vol.377
, pp. 975-980
-
-
Kim, Y.1
Park, J.2
Kim, S.3
Song, S.4
Kwon, S.K.5
Lee, S.H.6
Kitada, T.7
Kim, J.M.8
Chung, J.9
-
131
-
-
84881260124
-
Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation
-
Iguchi, M.; Kujuro, Y.; Okatsu, K.; Koyano, F.; Kosako, H.; Kimura, M.; Suzuki, N.; Uchiyama, S.; Tanaka, K.; Matsuda, N. Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation. J. Biol. Chem. 2013, 288, 22019-22032.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 22019-22032
-
-
Iguchi, M.1
Kujuro, Y.2
Okatsu, K.3
Koyano, F.4
Kosako, H.5
Kimura, M.6
Suzuki, N.7
Uchiyama, S.8
Tanaka, K.9
Matsuda, N.10
-
132
-
-
33745602748
-
Mitochondrial dysfunction in drosophila PINK1 mutants is complemented by parkin
-
Park, J.; Lee, S.B.; Lee, S.; Kim, Y.; Song, S.; Kim, S.; Bae, E.; Kim, J.; Shong, M.; Kim, J.M.; et al. Mitochondrial dysfunction in drosophila PINK1 mutants is complemented by parkin. Nature 2006, 441, 1157-1161.
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
Kim, S.6
Bae, E.7
Kim, J.8
Shong, M.9
Kim, J.M.10
-
133
-
-
55749090654
-
The Parkinson's disease genes PINK1 and parkin promote mitochondrial fission and/or inhibit fusion in drosophila
-
Deng, H.; Dodson, M.W.; Huang, H.; Guo, M. The Parkinson's disease genes PINK1 and parkin promote mitochondrial fission and/or inhibit fusion in drosophila. Proc. Natl. Acad. Sci. USA 2008, 105, 14503-14508.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
134
-
-
84866072587
-
PINK1 autophosphorylation upon membrane potential dissipation is essential for parkin recruitment to damaged mitochondria
-
Okatsu, K.; Oka, T.; Iguchi, M.; Imamura, K.; Kosako, H.; Tani, N.; Kimura, M.; Go, E.; Koyano, F.; Funayama, M.; et al. PINK1 autophosphorylation upon membrane potential dissipation is essential for parkin recruitment to damaged mitochondria. Nat. Commun. 2012, 3, 1016.
-
(2012)
Nat. Commun
, vol.3
, pp. 1016
-
-
Okatsu, K.1
Oka, T.2
Iguchi, M.3
Imamura, K.4
Kosako, H.5
Tani, N.6
Kimura, M.7
Go, E.8
Koyano, F.9
Funayama, M.10
-
135
-
-
75949098487
-
PINK1-dependent recruitment of parkin to mitochondria in mitophagy
-
Vives-Bauza, C.; Zhou, C.; Huang, Y.; Cui, M.; de Vries, R.L.; Kim, J.; May, J.; Tocilescu, M.A.; Liu, W.; Ko, H.S.; et al. PINK1-dependent recruitment of parkin to mitochondria in mitophagy. Proc. Natl. Acad. Sci. USA 2010, 107, 378-383.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 378-383
-
-
Vives-Bauza, C.1
Zhou, C.2
Huang, Y.3
Cui, M.4
de Vries, R.L.5
Kim, J.6
May, J.7
Tocilescu, M.A.8
Liu, W.9
Ko, H.S.10
-
136
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D.; Tanaka, A.; Suen, D.F.; Youle, R.J. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 2008, 183, 795-803.
-
(2008)
J. Cell Biol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
137
-
-
77950371695
-
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
-
Kawajiri, S.; Saiki, S.; Sato, S.; Sato, F.; Hatano, T.; Eguchi, H.; Hattori, N. PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett. 2010, 584, 1073-1079.
-
(2010)
FEBS Lett
, vol.584
, pp. 1073-1079
-
-
Kawajiri, S.1
Saiki, S.2
Sato, S.3
Sato, F.4
Hatano, T.5
Eguchi, H.6
Hattori, N.7
-
138
-
-
84876531457
-
PINK1-phosphorylated mitofusin 2 is a parkin receptor for culling damaged mitochondria
-
Chen, Y.; Dorn, G.W., 2nd. PINK1-phosphorylated mitofusin 2 is a parkin receptor for culling damaged mitochondria. Science 2013, 340, 471-475.
-
(2013)
Science
, vol.340
, pp. 471-475
-
-
Chen, Y.1
Dorn II, G.W.2
-
139
-
-
84868110583
-
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons
-
Lee, S.; Sterky, F.H.; Mourier, A.; Terzioglu, M.; Cullheim, S.; Olson, L.; Larsson, N.G. Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Hum. Mol. Genet. 2012, 21, 4827-4835.
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 4827-4835
-
-
Lee, S.1
Sterky, F.H.2
Mourier, A.3
Terzioglu, M.4
Cullheim, S.5
Olson, L.6
Larsson, N.G.7
-
140
-
-
84870013071
-
Voltage-dependent anion channels (VDACS) recruit parkin to defective mitochondria to promote mitochondrial autophagy
-
Sun, Y.; Vashisht, A.A.; Tchieu, J.; Wohlschlegel, J.A.; Dreier, L. Voltage-dependent anion channels (VDACS) recruit parkin to defective mitochondria to promote mitochondrial autophagy. J. Biol. Chem. 2012, 287, 40652-40660.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 40652-40660
-
-
Sun, Y.1
Vashisht, A.A.2
Tchieu, J.3
Wohlschlegel, J.A.4
Dreier, L.5
-
141
-
-
27944506923
-
A Caenorhabditis elegans parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress
-
Springer, W.; Hoppe, T.; Schmidt, E.; Baumeister, R. A Caenorhabditis elegans parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum. Mol. Genet. 2005, 14, 3407-3423.
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 3407-3423
-
-
Springer, W.1
Hoppe, T.2
Schmidt, E.3
Baumeister, R.4
-
142
-
-
67650233672
-
Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth
-
Samann, J.; Hegermann, J.; von Gromoff, E.; Eimer, S.; Baumeister, R.; Schmidt, E. Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth. J. Biol. Chem. 2009, 284, 16482-16491.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 16482-16491
-
-
Samann, J.1
Hegermann, J.2
von Gromoff, E.3
Eimer, S.4
Baumeister, R.5
Schmidt, E.6
-
143
-
-
84879689165
-
Early-life exposure to methylmercury in wildtype and PDR-1/parkin knockout C. elegans
-
Martinez-Finley, E.J.; Chakraborty, S.; Slaughter, J.C.; Aschner, M. Early-life exposure to methylmercury in wildtype and PDR-1/parkin knockout C. elegans. Neurochem. Res. 2013, 38, 1543-1552.
-
(2013)
Neurochem. Res
, vol.38
, pp. 1543-1552
-
-
Martinez-Finley, E.J.1
Chakraborty, S.2
Slaughter, J.C.3
Aschner, M.4
-
144
-
-
84888177824
-
-
Vanderbilt University, Nashville, MI. Personal communication
-
Chakraborty, S.; Aschner, M. Vanderbilt University, Nashville, MI. Personal communication, 2013.
-
(2013)
-
-
Chakraborty, S.1
Aschner, M.2
-
145
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
Zimprich, A.; Biskup, S.; Leitner, P.; Lichtner, P.; Farrer, M.; Lincoln, S.; Kachergus, J.; Hulihan, M.; Uitti, R.J.; Calne, D.B.; et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004, 44, 601-607.
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
-
146
-
-
0036196860
-
A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1
-
Funayama, M.; Hasegawa, K.; Kowa, H.; Saito, M.; Tsuji, S.; Obata, F. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1. Ann. Neurol. 2002, 51, 296-301.
-
(2002)
Ann. Neurol
, vol.51
, pp. 296-301
-
-
Funayama, M.1
Hasegawa, K.2
Kowa, H.3
Saito, M.4
Tsuji, S.5
Obata, F.6
-
147
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
West, A.B.; Moore, D.J.; Biskup, S.; Bugayenko, A.; Smith, W.W.; Ross, C.A.; Dawson, V.L.; Dawson, T.M. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc. Natl. Acad. Sci. USA 2005, 102, 16842-16847.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
Bugayenko, A.4
Smith, W.W.5
Ross, C.A.6
Dawson, V.L.7
Dawson, T.M.8
-
148
-
-
78650025189
-
Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2
-
Mortiboys, H.; Johansen, K.K.; Aasly, J.O.; Bandmann, O. Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2. Neurology 2010, 75, 2017-2020.
-
(2010)
Neurology
, vol.75
, pp. 2017-2020
-
-
Mortiboys, H.1
Johansen, K.K.2
Aasly, J.O.3
Bandmann, O.4
-
149
-
-
29444437871
-
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
-
Smith, W.W.; Pei, Z.; Jiang, H.; Moore, D.J.; Liang, Y.; West, A.B.; Dawson, V.L.; Dawson, T.M.; Ross, C.A. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc. Natl. Acad. Sci. USA 2005, 102, 18676-18681.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18676-18681
-
-
Smith, W.W.1
Pei, Z.2
Jiang, H.3
Moore, D.J.4
Liang, Y.5
West, A.B.6
Dawson, V.L.7
Dawson, T.M.8
Ross, C.A.9
-
150
-
-
84872691988
-
Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons
-
Cherra, S.J., 3rd; Steer, E.; Gusdon, A.M.; Kiselyov, K.; Chu, C.T. Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Am. J. Pathol. 2013, 182, 474-484.
-
(2013)
Am. J. Pathol
, vol.182
, pp. 474-484
-
-
Cherra III, S.J.1
Steer, E.2
Gusdon, A.M.3
Kiselyov, K.4
Chu, C.T.5
-
151
-
-
70350683754
-
Leucine-rich repeat kinase 2 interacts with parkin, DJ-1 and PINK-1 in a drosophila melanogaster model of Parkinson's disease
-
Venderova, K.; Kabbach, G.; Abdel-Messih, E.; Zhang, Y.; Parks, R.J.; Imai, Y.; Gehrke, S.; Ngsee, J.; Lavoie, M.J.; Slack, R.S.; et al. Leucine-rich repeat kinase 2 interacts with parkin, DJ-1 and PINK-1 in a drosophila melanogaster model of Parkinson's disease. Hum. Mol. Genet. 2009, 18, 4390-4404.
-
(2009)
Hum. Mol. Genet
, vol.18
, pp. 4390-4404
-
-
Venderova, K.1
Kabbach, G.2
Abdel-Messih, E.3
Zhang, Y.4
Parks, R.J.5
Imai, Y.6
Gehrke, S.7
Ngsee, J.8
Lavoie, M.J.9
Slack, R.S.10
-
152
-
-
70349103837
-
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in drosophila
-
Ng, C.H.; Mok, S.Z.; Koh, C.; Ouyang, X.; Fivaz, M.L.; Tan, E.K.; Dawson, V.L.; Dawson, T.M.; Yu, F.; Lim, K.L. Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in drosophila. J. Neurosci. 2009, 29, 11257-11262.
-
(2009)
J. Neurosci
, vol.29
, pp. 11257-11262
-
-
Ng, C.H.1
Mok, S.Z.2
Koh, C.3
Ouyang, X.4
Fivaz, M.L.5
Tan, E.K.6
Dawson, V.L.7
Dawson, T.M.8
Yu, F.9
Lim, K.L.10
-
153
-
-
33947663512
-
LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins
-
Sakaguchi-Nakashima, A.; Meir, J.Y.; Jin, Y.; Matsumoto, K.; Hisamoto, N. LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Curr. Biol. 2007, 17, 592-598.
-
(2007)
Curr. Biol
, vol.17
, pp. 592-598
-
-
Sakaguchi-Nakashima, A.1
Meir, J.Y.2
Jin, Y.3
Matsumoto, K.4
Hisamoto, N.5
-
154
-
-
67651171368
-
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans
-
Saha, S.; Guillily, M.D.; Ferree, A.; Lanceta, J.; Chan, D.; Ghosh, J.; Hsu, C.H.; Segal, L.; Raghavan, K.; Matsumoto, K.; et al. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J. Neurosci. 2009, 29, 9210-9218.
-
(2009)
J. Neurosci
, vol.29
, pp. 9210-9218
-
-
Saha, S.1
Guillily, M.D.2
Ferree, A.3
Lanceta, J.4
Chan, D.5
Ghosh, J.6
Hsu, C.H.7
Segal, L.8
Raghavan, K.9
Matsumoto, K.10
-
155
-
-
84866663422
-
Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: Relevance to Parkinson disease
-
Di Domenico, F.; Sultana, R.; Ferree, A.; Smith, K.; Barone, E.; Perluigi, M.; Coccia, R.; Pierce, W.; Cai, J.; Mancuso, C.; et al. Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: Relevance to Parkinson disease. Antioxid. Redox Signal. 2012, 17, 1490-1506.
-
(2012)
Antioxid. Redox Signal
, vol.17
, pp. 1490-1506
-
-
Di Domenico, F.1
Sultana, R.2
Ferree, A.3
Smith, K.4
Barone, E.5
Perluigi, M.6
Coccia, R.7
Pierce, W.8
Cai, J.9
Mancuso, C.10
-
156
-
-
84871581831
-
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
-
Yao, C.; Johnson, W.M.; Gao, Y.; Wang, W.; Zhang, J.; Deak, M.; Alessi, D.R.; Zhu, X.; Mieyal, J.J.; Roder, H.; et al. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Hum. Mol. Genet. 2013, 22, 328-344.
-
(2013)
Hum. Mol. Genet
, vol.22
, pp. 328-344
-
-
Yao, C.1
Johnson, W.M.2
Gao, Y.3
Wang, W.4
Zhang, J.5
Deak, M.6
Alessi, D.R.7
Zhu, X.8
Mieyal, J.J.9
Roder, H.10
-
157
-
-
33748052967
-
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
-
Kobayashi, M.; Yamamoto, M. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzym. Regul. 2006, 46, 113-140.
-
(2006)
Adv. Enzym. Regul
, vol.46
, pp. 113-140
-
-
Kobayashi, M.1
Yamamoto, M.2
-
158
-
-
21744445077
-
Nrf2, a multi-organ protector?
-
Lee, J.M.; Li, J.; Johnson, D.A.; Stein, T.D.; Kraft, A.D.; Calkins, M.J.; Jakel, R.J.; Johnson, J.A. Nrf2, a multi-organ protector? FASEB J. 2005, 19, 1061-1066.
-
(2005)
FASEB J
, vol.19
, pp. 1061-1066
-
-
Lee, J.M.1
Li, J.2
Johnson, D.A.3
Stein, T.D.4
Kraft, A.D.5
Calkins, M.J.6
Jakel, R.J.7
Johnson, J.A.8
-
159
-
-
78751703950
-
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
-
Taguchi, K.; Motohashi, H.; Yamamoto, M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011, 16, 123-140.
-
(2011)
Genes Cells
, vol.16
, pp. 123-140
-
-
Taguchi, K.1
Motohashi, H.2
Yamamoto, M.3
-
160
-
-
0035836698
-
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
-
Chan, K.; Han, X.D.; Kan, Y.W. An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen. Proc. Natl. Acad. Sci. USA 2001, 98, 4611-4616.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4611-4616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
161
-
-
0042626242
-
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
-
An, J.H.; Blackwell, T.K. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 2003, 17, 1882-1893.
-
(2003)
Genes Dev
, vol.17
, pp. 1882-1893
-
-
An, J.H.1
Blackwell, T.K.2
-
162
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop, N.A.; Guarente, L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 2007, 447, 545-549.
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
163
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet, J.M.; Hertweck, M.; An, J.H.; Baker, J.; Hwang, J.Y.; Liu, S.; Oliveira, R.P.; Baumeister, R.; Blackwell, T.K. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 2008, 132, 1025-1038.
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
164
-
-
34248593492
-
Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2
-
Pi, J.; Bai, Y.; Reece, J.M.; Williams, J.; Liu, D.; Freeman, M.L.; Fahl, W.E.; Shugar, D.; Liu, J.; Qu, W.; et al. Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2. Free Radic. Biol. Med. 2007, 42, 1797-1806.
-
(2007)
Free Radic. Biol. Med
, vol.42
, pp. 1797-1806
-
-
Pi, J.1
Bai, Y.2
Reece, J.M.3
Williams, J.4
Liu, D.5
Freeman, M.L.6
Fahl, W.E.7
Shugar, D.8
Liu, J.9
Qu, W.10
-
165
-
-
70349843323
-
Nrf2:INrf2 (Keap1) signaling in oxidative stress
-
Kaspar, J.W.; Niture, S.K.; Jaiswal, A.K. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic. Biol. Med. 2009, 47, 1304-1309.
-
(2009)
Free Radic. Biol. Med
, vol.47
, pp. 1304-1309
-
-
Kaspar, J.W.1
Niture, S.K.2
Jaiswal, A.K.3
-
166
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
-
Itoh, K.; Wakabayashi, N.; Katoh, Y.; Ishii, T.; O'Connor, T.; Yamamoto, M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 2003, 8, 379-391.
-
(2003)
Genes Cells
, vol.8
, pp. 379-391
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
O'Connor, T.5
Yamamoto, M.6
-
167
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon, M.; Itoh, K.; Yamamoto, M.; Hayes, J.D. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem. 2003, 278, 21592-21600.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
168
-
-
66149175591
-
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1
-
Park, S.K.; Tedesco, P.M.; Johnson, T.E. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 2009, 8, 258-269.
-
(2009)
Aging Cell
, vol.8
, pp. 258-269
-
-
Park, S.K.1
Tedesco, P.M.2
Johnson, T.E.3
-
169
-
-
70350625466
-
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
-
Oliveira, R.P.; Porter Abate, J.; Dilks, K.; Landis, J.; Ashraf, J.; Murphy, C.T.; Blackwell, T.K. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 2009, 8, 524-541.
-
(2009)
Aging Cell
, vol.8
, pp. 524-541
-
-
Oliveira, R.P.1
Porter Abate, J.2
Dilks, K.3
Landis, J.4
Ashraf, J.5
Murphy, C.T.6
Blackwell, T.K.7
-
170
-
-
77957583314
-
Rnai screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition
-
Wang, J.; Robida-Stubbs, S.; Tullet, J.M.; Rual, J.F.; Vidal, M.; Blackwell, T.K. Rnai screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet 2010, 6, e1001048.
-
(2010)
PLoS Genet
, vol.6
-
-
Wang, J.1
Robida-Stubbs, S.2
Tullet, J.M.3
Rual, J.F.4
Vidal, M.5
Blackwell, T.K.6
-
171
-
-
0036279460
-
Reporter transgenes for study of oxidant stress in Caenorhabditis elegans
-
Link, C.D.; Johnson, C.J. Reporter transgenes for study of oxidant stress in Caenorhabditis elegans. Methods Enzymol. 2002, 353, 497-505.
-
(2002)
Methods Enzymol
, vol.353
, pp. 497-505
-
-
Link, C.D.1
Johnson, C.J.2
-
172
-
-
84861215311
-
A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans
-
Papp, D.; Csermely, P.; Soti, C. A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans. PLoS Pathog. 2012, 8, e1002673.
-
(2012)
PLoS Pathog
, vol.8
-
-
Papp, D.1
Csermely, P.2
Soti, C.3
-
173
-
-
84855263820
-
Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C
-
Hoeven, R.; McCallum, K.C.; Cruz, M.R.; Garsin, D.A. Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans. PLoS Pathog. 2011, 7, e1002453.
-
(2011)
Elegans. PLoS Pathog
, vol.7
-
-
Hoeven, R.1
McCallum, K.C.2
Cruz, M.R.3
Garsin, D.A.4
-
174
-
-
28044446334
-
Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3
-
An, J.H.; Vranas, K.; Lucke, M.; Inoue, H.; Hisamoto, N.; Matsumoto, K.; Blackwell, T.K. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc. Natl. Acad. Sci. USA 2005, 102, 16275-16280.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 16275-16280
-
-
An, J.H.1
Vranas, K.2
Lucke, M.3
Inoue, H.4
Hisamoto, N.5
Matsumoto, K.6
Blackwell, T.K.7
-
175
-
-
84877013110
-
MRI and CT appearances in metabolic encephalopathies due to systemic diseases in adults
-
Bathla, G.; Hegde, A.N. MRI and CT appearances in metabolic encephalopathies due to systemic diseases in adults. Clin. Radiol. 2013, 68, 545-554.
-
(2013)
Clin. Radiol
, vol.68
, pp. 545-554
-
-
Bathla, G.1
Hegde, A.N.2
-
176
-
-
0030016523
-
Oxidative damage caused by free radicals produced during catecholamine autoxidation: Protective effects of o-methylation and melatonin
-
Miller, J.W.; Selhub, J.; Joseph, J.A. Oxidative damage caused by free radicals produced during catecholamine autoxidation: Protective effects of o-methylation and melatonin. Free Radic. Biol. Med. 1996, 21, 241-249.
-
(1996)
Free Radic. Biol. Med
, vol.21
, pp. 241-249
-
-
Miller, J.W.1
Selhub, J.2
Joseph, J.A.3
-
177
-
-
57449092273
-
Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
-
Salazar, J.; Mena, N.; Hunot, S.; Prigent, A.; Alvarez-Fischer, D.; Arredondo, M.; Duyckaerts, C.; Sazdovitch, V.; Zhao, L.; Garrick, L.M.; et al. Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc. Natl. Acad. Sci. USA 2008, 105, 18578-18583.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18578-18583
-
-
Salazar, J.1
Mena, N.2
Hunot, S.3
Prigent, A.4
Alvarez-Fischer, D.5
Arredondo, M.6
Duyckaerts, C.7
Sazdovitch, V.8
Zhao, L.9
Garrick, L.M.10
-
178
-
-
84884529657
-
How to treat Parkinson's disease in 2013
-
Worth, P.F. How to treat Parkinson's disease in 2013. Clin. Med. 2013, 13, 93-96.
-
(2013)
Clin. Med
, vol.13
, pp. 93-96
-
-
Worth, P.F.1
|