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Volumn 68, Issue 3, 2013, Pages 215-225

DJ-1 protects against dopamine toxicity: Implications for parkinson's disease and aging

Author keywords

DJ 1; Dopamine; Oxidative stress; Parkinson's disease; Reactive oxygen species; VMAT2

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; DJ 1 PROTEIN, MOUSE; DJ-1 PROTEIN, MOUSE; DOPAMINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOPROTEIN; OXIDOPAMINE; REACTIVE OXYGEN METABOLITE; SLC18A2 PROTEIN, MOUSE; SMALL INTERFERING RNA; VESICULAR MONOAMINE TRANSPORTER;

EID: 84873665618     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls147     Document Type: Article
Times cited : (41)

References (35)
  • 1
    • 79958035799 scopus 로고    scopus 로고
    • Dopamine-derived biological reactive intermediates and protein modifications: Implications for Parkinson's disease
    • doi:10.1016/j.cbi.2011.01.006
    • Jinsmaa Y, Florang VR, Rees JN, et al. Dopamine-derived biological reactive intermediates and protein modifications: implications for Parkinson's disease. Chem Biol Interact. 2011;192:118-121. doi:10.1016/j.cbi.2011.01.006.
    • (2011) Chem Biol Interact , vol.192 , pp. 118-121
    • Jinsmaa, Y.1    Florang, V.R.2    Rees, J.N.3
  • 2
    • 0037208510 scopus 로고    scopus 로고
    • The molecular mechanisms of dopamine toxicity
    • Barzilai A, Daily D, Zilkha-Falb R, et al. The molecular mechanisms of dopamine toxicity. Adv Neurol. 2003;91:73-82.
    • (2003) Adv Neurol , vol.91 , pp. 73-82
    • Barzilai, A.1    Daily, D.2    Zilkha-Falb, R.3
  • 3
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • doi:10.1016/S0301-0082(01)00003-X
    • Blum D, Torch S, Lambeng N, et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol. 2001;65:135-172. doi:10.1016/S0301- 0082(01)00003-X.
    • (2001) Prog Neurobiol , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3
  • 4
    • 0035664746 scopus 로고    scopus 로고
    • Alpha-synuclein and cytosolic dopamine: Stabilizing a bad situation
    • doi:10.1038/nm1201-1280
    • Sulzer D. Alpha-synuclein and cytosolic dopamine: stabilizing a bad situation. Nat Med. 2001;7:1280-1282. doi:10.1038/nm1201-1280.
    • (2001) Nat Med , vol.7 , pp. 1280-1282
    • Sulzer, D.1
  • 5
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner P, Olanow CW. Understanding cell death in Parkinson's disease. Ann Neurol. 1998;44:S72-S84.
    • (1998) Ann Neurol , vol.44
    • Jenner, P.1    Olanow, C.W.2
  • 6
    • 0030249286 scopus 로고    scopus 로고
    • Prevention of dopamine-induced cell death by thiol antioxidants: Possible implications for treatment of Parkinson's disease
    • doi:10.1006/exnr.1996.0136
    • Offen D, Ziv I, Sternin H, Melamed E, Hochman A. Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease. Exp Neurol. 1996;141:32-39. doi:10.1006/exnr.1996.0136.
    • (1996) Exp Neurol , vol.141 , pp. 32-39
    • Offen, D.1    Ziv, I.2    Sternin, H.3    Melamed, E.4    Hochman, A.5
  • 8
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • doi:10.1126/science.1087753
    • Dawson TM, Dawson VL. Molecular pathways of neurodegeneration in Parkinson's disease. Science 2003;302:819-822. doi:10.1126/science.1087753.
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 9
    • 0001672745 scopus 로고    scopus 로고
    • Intraneuronal dopamine-quinone syn thesis: A review
    • doi:10.1007/BF03033289
    • Sulzer D, Zecca L. Intraneuronal dopamine-quinone synthesis: a review. Neurotox Res. 2000;3:181-195. doi:10.1007/BF03033289.
    • (2000) Neurotox Res , vol.3 , pp. 181-195
    • Sulzer, D.1    Zecca, L.2
  • 10
    • 78751691004 scopus 로고    scopus 로고
    • Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity
    • doi:10.1002/glia.21112
    • Miyazaki I, Asanuma M, Kikkawa Y, et al. Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia. 2011;59:435-451. doi:10.1002/glia.21112.
    • (2011) Glia , vol.59 , pp. 435-451
    • Miyazaki, I.1    Asanuma, M.2    Kikkawa, Y.3
  • 11
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • doi:10.1126/science.1077209
    • Bonifati V, Rizzu P, van Baren MJ, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003;299:256-259. doi:10.1126/science.1077209.
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1    Rizzu, P.2    Van Baren, M.J.3
  • 12
    • 0042232353 scopus 로고    scopus 로고
    • The role of pathogenic DJ-1 mutations in Parkinson's disease
    • doi:10.1002/ana.10675
    • Abou-Sleiman PM, Healy DG, Quinn N, Lees AJ, Wood NW. The role of pathogenic DJ-1 mutations in Parkinson's disease. Ann Neurol. 2003;54:283-286. doi:10.1002/ana.10675.
    • (2003) Ann Neurol , vol.54 , pp. 283-286
    • Abou-Sleiman, P.M.1    Healy, D.G.2    Quinn, N.3    Lees, A.J.4    Wood, N.W.5
  • 13
    • 2942684871 scopus 로고    scopus 로고
    • The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
    • doi:10.1073/pnas.0402959101
    • Canet-Aviles RM, Wilson MA, Miller DW, et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA. 2004;101:9103-9108. doi:10.1073/pnas.0402959101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9103-9108
    • Canet-Aviles, R.M.1    Wilson, M.A.2    Miller, D.W.3
  • 14
    • 67649771389 scopus 로고    scopus 로고
    • Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase1
    • doi:10.1074/jbc.M806902200
    • Waak J, Weber SS, Görner K, et al. Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase1. J Biol Chem. 2009;284:14245-14257. doi:10.1074/jbc.M806902200.
    • (2009) J Biol Chem , vol.284 , pp. 14245-14257
    • Waak, J.1    Weber, S.S.2    Görner, K.3
  • 15
    • 33646826619 scopus 로고    scopus 로고
    • Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    • doi:10.1074/jbc.M509079200
    • Choi J, Sullards MC, Olzmann JA, et al. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem. 2006;281:10816-10824. doi:10.1074/jbc.M509079200.
    • (2006) J Biol Chem , vol.281 , pp. 10816-10824
    • Choi, J.1    Sullards, M.C.2    Olzmann, J.A.3
  • 16
    • 70349784928 scopus 로고    scopus 로고
    • Differential DJ-1 gene expression in Parkinson's disease
    • doi:10.1016/j.nbd.2009.08.011
    • Kumaran R, Vandrovcova J, Luk C, et al. Differential DJ-1 gene expression in Parkinson's disease. Neurobiol Dis. 2009;36:393-400. doi:10.1016/j.nbd.2009. 08.011.
    • (2009) Neurobiol Dis , vol.36 , pp. 393-400
    • Kumaran, R.1    Vandrovcova, J.2    Luk, C.3
  • 17
    • 34548645355 scopus 로고    scopus 로고
    • Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease
    • doi:10.1016/j.neulet.2007.08.010
    • Waragai M, Nakai M, Wei J, et al. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease. Neurosci Lett. 2007;425:18-22. doi:10.1016/j.neulet.2007.08.010.
    • (2007) Neurosci Lett , vol.425 , pp. 18-22
    • Waragai, M.1    Nakai, M.2    Wei, J.3
  • 18
    • 77950223687 scopus 로고    scopus 로고
    • DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    • doi:10.1093/brain/awq008
    • Hong Z, Shi M, Chung KA, et al. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain. 2010;133:713-726. doi:10.1093/brain/awq008.
    • (2010) Brain , vol.133 , pp. 713-726
    • Hong, Z.1    Shi, M.2    Chung, K.A.3
  • 19
    • 79953283868 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    • doi:10.1002/ana.22311
    • Shi M, Bradner J, Hancock AM, et al. Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol. 2011;69:570-580. doi:10.1002/ana.22311.
    • (2011) Ann Neurol , vol.69 , pp. 570-580
    • Shi, M.1    Bradner, J.2    Hancock, A.M.3
  • 20
    • 77956283357 scopus 로고    scopus 로고
    • Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals
    • doi:10.1016/j. neulet.2010.08.007
    • Akazawa YO, Saito Y, Hamakubo T, et al. Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals. Neurosci Lett. 2010;483:201-205. doi:10.1016/j. neulet.2010.08.007.
    • (2010) Neurosci Lett , vol.483 , pp. 201-205
    • Akazawa, Y.O.1    Saito, Y.2    Hamakubo, T.3
  • 21
    • 44649188448 scopus 로고    scopus 로고
    • Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection
    • doi:10.1016/j. neuro.2008
    • Lev N, Ickowicz D, Melamed E, Offen D. Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection. Neurotoxicology. 2008;29:397-405. doi:10.1016/j. neuro.2008.01.007.
    • (2008) Neurotoxicology , vol.29 , pp. 397-405
    • Lev, N.1    Ickowicz, D.2    Melamed, E.3    Offen, D.4
  • 22
    • 29144514762 scopus 로고    scopus 로고
    • Vesicular monoamine transporter-2 and aromatic l-amino acid decarboxylase gene therapy prevents development of motor complications in parkinsonian rats after chronic intermittent l-3,4-dihydroxyphenylalanine administration
    • doi:10.1016/j. expneurol.2005
    • Lee WY, Lee EA, Jeon MY, Kang HY, Park YG. Vesicular monoamine transporter-2 and aromatic l-amino acid decarboxylase gene therapy prevents development of motor complications in parkinsonian rats after chronic intermittent l-3,4-dihydroxyphenylalanine administration. Exp Neurol. 2006;197:215-224. doi:10.1016/j. expneurol.2005.09.012.
    • (2006) Exp Neurol , vol.197 , pp. 215-224
    • Lee, W.Y.1    Lee, E.A.2    Jeon, M.Y.3    Kang, H.Y.4    Park, Y.G.5
  • 23
    • 66149143952 scopus 로고    scopus 로고
    • Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons
    • doi:10.1007/s12035-009-8059-y
    • Guillot TS, Miller GW. Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons. Mol Neurobiol. 2009;39:149-170. doi:10.1007/s12035-009-8059-y.
    • (2009) Mol Neurobiol , vol.39 , pp. 149-170
    • Guillot, T.S.1    Miller, G.W.2
  • 24
    • 0037064078 scopus 로고    scopus 로고
    • Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line
    • doi:10.1074/jbc.M205518200
    • Lotharius J, Barg S, Wiekop P, Lundberg C, Raymon HK, Brundin P. Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem. 2002;277: 38884-38894. doi:10.1074/jbc.M205518200.
    • (2002) J Biol Chem , vol.277 , pp. 38884-38894
    • Lotharius, J.1    Barg, S.2    Wiekop, P.3    Lundberg, C.4    Raymon, H.K.5    Brundin, P.6
  • 25
    • 33846953556 scopus 로고    scopus 로고
    • Selective enrichment of DJ-1 protein in primate striatal neuronal processes: Implications for Parkinson's disease
    • doi:10.1002/cne.21191
    • Olzmann JA, Bordelon JR, Muly EC, et al. Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease. J Comp Neurol. 2007;500:585-599. doi:10.1002/cne.21191.
    • (2007) J Comp Neurol , vol.500 , pp. 585-599
    • Olzmann, J.A.1    Bordelon, J.R.2    Muly, E.C.3
  • 26
    • 20944437573 scopus 로고    scopus 로고
    • The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    • doi:10.1093/hmg/ddi134
    • Xu J, Zhong N, Wang H, et al. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet. 2005;14:1231-1241. doi:10.1093/hmg/ddi134.
    • (2005) Hum Mol Genet , vol.14 , pp. 1231-1241
    • Xu, J.1    Zhong, N.2    Wang, H.3
  • 27
    • 78650065962 scopus 로고    scopus 로고
    • Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene
    • doi:10.1074/jbc.M110.137034
    • Ishikawa S, Taira T, Takahashi-Niki K, Niki T, Ariga H, Iguchi-Ariga SM. Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene. J Biol Chem. 2010;285:39718-39731. doi:10.1074/jbc.M110.137034.
    • (2010) J Biol Chem , vol.285 , pp. 39718-39731
    • Ishikawa, S.1    Taira, T.2    Takahashi-Niki, K.3    Niki, T.4    Ariga, H.5    Iguchi-Ariga, S.M.6
  • 28
    • 0030931721 scopus 로고    scopus 로고
    • VMAT2 knockout mice: Heterozygotes display reduced amphetamine- conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity
    • doi:10.1073/pnas.94.18.9938
    • Takahashi N, Miner LL, Sora I, et al. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proc Natl Acad Sci USA. 1997;94:9938-9994. doi:10.1073/pnas.94.18.9938.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9938-9994
    • Takahashi, N.1    Miner, L.L.2    Sora, I.3
  • 29
    • 0033664390 scopus 로고    scopus 로고
    • The VMAT2 gene in mice and humans: Amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins
    • doi:10.1096/fj.00-0205rev
    • Uhl GR, Li S, Takahashi N, et al. The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins. FASEB J. 2000;14: 2459-2465. doi:10.1096/fj.00-0205rev.
    • (2000) FASEB J , vol.14 , pp. 2459-2465
    • Uhl, G.R.1    Li, S.2    Takahashi, N.3
  • 30
    • 0034736180 scopus 로고    scopus 로고
    • Pharmacological inactivation of the vesicular monoamine transporter can enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of midbrain dopaminergic neurons, but not locus coeruleus noradrenergic neurons
    • doi:10.1016/S0306-4522(00)00385-7
    • German DC, Liang CL, Manaye KF, Lane K, Sonsalla PK. Pharmacological inactivation of the vesicular monoamine transporter can enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of midbrain dopaminergic neurons, but not locus coeruleus noradrenergic neurons. Neuroscience. 2000;101:1063-1069. doi:10.1016/S0306-4522(00)00385-7.
    • (2000) Neuroscience , vol.101 , pp. 1063-1069
    • German, D.C.1    Liang, C.L.2    Manaye, K.F.3    Lane, K.4    Sonsalla, P.K.5
  • 31
    • 31144476794 scopus 로고    scopus 로고
    • Gainof-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women
    • doi:10.1093/hmg/ddi445
    • Glatt CE, Wahner AD, White DJ, Ruiz-Linares A, Ritz B. Gainof-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women. Hum Mol Genet. 2006;15:299-305. doi:10.1093/hmg/ ddi445.
    • (2006) Hum Mol Genet , vol.15 , pp. 299-305
    • Glatt, C.E.1    Wahner, A.D.2    White, D.J.3    Ruiz-Linares, A.4    Ritz, B.5
  • 32
    • 20144389422 scopus 로고    scopus 로고
    • Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrindine (MPTP) and oxidative stress
    • doi:10.1073/pnas.0501282102
    • Kim RH, Smith PD, Aleyasin H, et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci USA. 2005;102: 5215-5220. doi:10.1073/pnas. 0501282102.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5215-5220
    • Kim, R.H.1    Smith, P.D.2    Aleyasin, H.3
  • 33
    • 33947282153 scopus 로고    scopus 로고
    • DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice
    • doi:10.1038/sj.mt.6300067
    • Paterna JC, Leng A, Weber E, Feldon J, Büeler H. DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice. Mol Ther. 2007;15:698-704. doi:10.1038/sj.mt.6300067.
    • (2007) Mol Ther , vol.15 , pp. 698-704
    • Paterna, J.C.1    Leng, A.2    Weber, E.3    Feldon, J.4    Büeler, H.5
  • 34
    • 77649266193 scopus 로고    scopus 로고
    • DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway
    • doi:10.1073/pnas.0914876107
    • Aleyasin H, Rousseaux MW, Marcogliese PC, et al. DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proc Natl Acad Sci USA. 2010;107:3186-3191. doi:10.1073/pnas.0914876107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3186-3191
    • Aleyasin, H.1    Rousseaux, M.W.2    Marcogliese, P.C.3
  • 35
    • 79960983489 scopus 로고    scopus 로고
    • Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases
    • doi:10.1172/JCI45803
    • Goldstein DS, Holmes C, Kopin IJ, Sharabi Y. Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases. J Clin Invest. 2011;121:3320-3330. doi:10.1172/JCI45803.
    • (2011) J Clin Invest , vol.121 , pp. 3320-3330
    • Goldstein, D.S.1    Holmes, C.2    Kopin, I.J.3    Sharabi, Y.4


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