The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells

Mitochondrion

Volumn 11, Issue 5, 2011, Pages 707-715

  Shim, Jung Hee ^a   Yoon, Seung Hee ^a   Kim, Kyung Hee ^a   Han, Ji Young ^a   Ha, Ji Young ^a   Hyun, Dong Hoon ^a   Paek, Sun Ha ^b   Kang, Un Jung ^c   Zhuang, Xiaoxi ^c   Son, Jin H ^a  

^a Ewha Womans University   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Complex I; DJ 1; Dopaminergic neurons; HSP60; Oxidative stress; PINK1

Indexed keywords

BRAIN PROTEIN; CYTOCHROME C OXIDASE; DJ 1 PROTEIN; PROTEIN PINK1; REACTIVE OXYGEN METABOLITE; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DJ 1 GENE; DOPAMINERGIC NERVE CELL; DRUG INHIBITION; EMBRYO; ENZYME ACTIVITY; FAMILIAL DISEASE; GENE; GENE MUTATION; MOUSE; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PINK1 GENE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; TREATMENT OUTCOME;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CHAPERONIN 60; CHROMANS; CITRATE (SI)-SYNTHASE; CYTOCHROMES B5; DOPAMINERGIC NEURONS; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX IV; ENZYME ASSAYS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; ONCOGENE PROTEINS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PARKINSONIAN DISORDERS; PROTEIN KINASES;

EID: 79961207215     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2011.05.013     Document Type: Article

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