The effect of different ubiquinones on lifespan in Caenorhabditis elegans

Mechanisms of Ageing and Development

Volumn 130, Issue 6, 2009, Pages 370-376

  Yang, Yu Ying ^a   Gangoiti, Jon A ^c   Sedensky, Margaret M ^a,b   Morgan, Phil G ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C. elegans; Genetics; Lifespan; Mitochondria; Reactive oxygen species; Respiration; Ubiquinone

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; HYDROGEN PEROXIDE; MITOCHONDRIAL PROTEIN; PROTEIN CLK 1; REACTIVE OXYGEN METABOLITE; UBIQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN FUNCTION; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; LIFESPAN; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL RESPIRATION; HYDROGEN PEROXIDE; LONGEVITY; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TIME FACTORS; UBIQUINONE;

ANIMALIA; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 67349139149     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2009.03.003     Document Type: Article

References (43)

1. Adam-Vizi V., and Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol. Sci. 27 (2006) 639-645
2. Arroyo A., Santos-Ocana C., Ruiz-Ferrer M., Padilla S., Gavilan A., Rodriguez-Aguilera J.C., and Navas P. Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans. FEBS Lett. 580 (2006) 1740-1746
3. Balaban R.S., Nemoto S., and Finkel T. Mitochondria, oxidants, and aging. Cell 120 (2005) 483-495
4. Battino M., Ferri E., Gorini A., Federico Villa R., Rodriguez Huertas J.F., Fiorella P., Genova M.L., Lenaz G., and Marchetti M. Natural distribution and occurrence of coenzyme Q homologues. Membr. Biochem. 9 (1990) 179-190
5. Bonawitz N.D., Chatenay-Lapointe M., Pan Y., and Shadel G.S. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab. 5 (2007) 265-277
6. Chen Q., Vazquez E.J., Moghaddas S., Hoppel C.L., and Lesnefsky E.J. Production of reactive oxygen species by mitochondria: central role of complex III. J. Biol. Chem. 278 (2003) 36027-36031
7. Esterbauer H., Schaur R.J., and Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11 (1991) 81-128
8. Francis G.R., and Waterston R.H. Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization. J. Cell Biol. 101 (1985) 1532-1549
9. Genova M.L., Pich M.M., Biondi A., Bernacchia A., Falasca A., Bovina C., Formiggini G., Parenti Castelli G., and Lenaz G. Mitochondrial production of oxygen radical species and the role of Coenzyme Q as an antioxidant. Exp. Biol. Med. (Maywood) 228 (2003) 506-513
10. Hihi A.K., Kebir H., and Hekimi S. Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes. J. Biol. Chem. 278 42 (2003) 41013-41018
11. Jiang N., Levavasseur F., McCright B., Shoubridge E.A., and Hekimi S. Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential. J. Biol. Chem. 276 (2001) 29218-29225
12. Jonassen T., Larsen P.L., and Clarke C.F. A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 421-426
13. Jonassen T., Marbois B.N., Faull K.F., Clarke C.F., and Larsen P.L. Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria. J. Biol. Chem. 277 (2002) 45020-45027
14. Jonassen T., Davis D.E., Larsen P.L., and Clarke C.F. Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length. J. Biol. Chem. 278 51 (2003) 51735-51742
15. Kagan V.E., Serbinova E.A., Koynova G.M., Kitanova S.A., Tyurin V.A., Stoytchev T.S., Quinn P.J., and Packer L. Antioxidant action of ubiquinol homologues with different isoprenoid chain length in biomembranes. Free Radic. Biol. Med. 9 (1990) 117-126
16. Kayser E.B., Morgan P.G., Hoppel C.L., and Sedensky M.M. Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans. J. Biol. Chem. 276 (2001) 20551-20558
17. Kayser E.B., Sedensky M.M., and Morgan P.G. The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans. Mech. Ageing Dev. 125 (2004) 455-464
18. Kayser E.B., Sedensky M.M., Morgan P.G., and Hoppel C.L. Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1. J. Biol. Chem. 279 (2004) 54479-54486
19. Lass A., Agarwal S., and Sohal R.S. Mitochondrial ubiquinone homologues, superoxide radical generation, and longevity in different mammalian species. J. Biol. Chem. 272 (1997) 19199-19204
20. Lee S.S., Lee R.Y., Fraser A.G., Kamath R.S., Ahringer J., and Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat. Genet. 33 (2003) 40-48
21. Lenaz G., Bovina C., D'Aurelio M., Fato R., Formiggini G., Genova M.L., Giuliano G., Merlo Pich M., Paolucci U., Parenti Castelli G., and Ventura B. Role of mitochondria in oxidative stress and aging. Ann. NY Acad. Sci. 959 (2002) 199-213
22. Levavasseur F., Miyadera H., Sirois J., Tremblay M.L., Kita K., Shoubridge E., and Hekimi S. Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration. J. Biol. Chem. 276 (2001) 46160-46164
23. Liu X., Jiang N., Hughes B., Bigras E., Shoubridge E., and Hekimi S. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev. 19 (2005) 2424-2434
24. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol. Chem. 193 (1951) 265-275
25. Marriage B.J., Clandinin M.T., Macdonald I.M., and Glerum D.M. Cofactor treatment improves ATP synthetic capacity in patients with oxidative phosphorylation disorders. Mol. Genet. Metab. 81 (2004) 263-272
26. Matthews R.T., Yang L., Browne S., Baik M., and Beal M.F. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 8892-8897
27. Miyadera H., Amino H., Hiraishi A., Taka H., Murayama K., Miyoshi H., Sakamoto K., Ishii N., Hekimi S., and Kita K. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. J. Biol. Chem. 276 (2001) 7713-7716
28. Miyadera H., Kano K., Miyoshi H., Ishii N., Hekimi S., and Kita K. Quinones in long-lived clk-1 mutants of Caenorhabditis elegans. FEBS Lett. 512 (2002) 33-37
29. Moon Y., Lee K.H., Park J.H., Geum D., and Kim K. Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10. J. Neurochem. 93 (2005) 1199-1208
30. Okada K., Minehira M., Zhu X., Suzuki K., Nakagawa T., Matsuda H., and Kawamukai M. The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli. J. Bacteriol. 179 (1997) 3058-3060
31. Olgun A., Akman S., Tezcan S., and Kutluay T. The effect of isoprenoid side chain length of ubiquinone on life span. Med. Hypotheses 60 (2003) 325-327
32. Padilla S., Jonassen T., Jimenez-Hidalgo M.A., Fernandez-Ayala D.J., Lopez-Lluch G., Marbois B., Navas P., Clarke C.F., and Santos-Ocana C. Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity. J. Biol. Chem. 279 (2004) 25995-26004
33. Rea S.L., Ventura N., and Johnson T.E. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol. 5 (2007) e259
34. Saiki R., Lunceford A.L., Bixler T., Dang P., Lee W., Furukawa S., Larsen P.L., and Clarke C.F. Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q. Aging Cell 7 (2008) 291-304
35. Stepanyan Z., Hughes B., Cliche D.O., Camp D., and Hekimi S. Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging. Exp. Gerontol. 41 (2006) 940-951
36. Suthammarak W., Yang Y.Y., Morgan P.G., and Sedensky M.M. Complex I function is defective in complex IV-deficient Caenorhabditis elegans. J. Biol. Chem. 284 10 (2009) 6425-6435
37. Tran U.C., and Clarke C.F. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion 7 Suppl. (2007) S62-S71
38. Tsai L., Szweda P.A., Vinogradova O., and Szweda L.I. Structural characterization and immuochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 7975-7980
39. Van Raamsdonk J.M., and Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 5 (2009) e1000361
40. Wong A., Boutis P., and Hekimi S. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139 (1995) 1247-1259
41. Wood W.B. The Nematode Caenorhabditis elegans (1988), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
42. Yang W., Li J., and Hekimi S. A measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. Genetics 177 (2007) 2063-2074
43. Yen D.H., Chan J.Y., Huang C.I., Lee C.H., Chan S.H., and Chang A.Y. Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat. Shock 23 (2005) 353-359