Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 46, 2005, Pages 16842-16847

  West, Andrew B ^a   Moore, Darren J ^a   Biskup, Saskia ^a   Bugayenko, Artem ^a   Smith, Wanli W ^a   Ross, Christopher A ^a   Dawson, Valina L ^a   Dawson, Ted M ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Broadway Research Building ^*  (United States)

Author keywords

Dardarin; PARK8; Parkinsonism

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; AUTOSOMAL DOMINANT INHERITANCE; BRAIN; CLINICAL FEATURE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE IDENTIFICATION; GENE MUTATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STEADY STATE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SUBCELLULAR FRACTIONS;

EID: 28044460070     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0507360102     Document Type: Article

References (20)

1. Funayama, M., Hasegawa, K., Kowa, H., Saito, M., Tsuji, S. & Obata, F. (2002) Ann. Neurol. 51, 296-301.
2. Zimprich, A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M., Lincoln, S., Kachergus, J., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) Neuron 44, 601-607.
3. Paisan-Ruiz, C., Jain, S., Evans, E. W., Gilks, W. P., Simon, J., van der Brug, M., Lopez de Munain, A., Aparicio, S., Gil, A. M., Khan, N., et al. (2004) Neuron 44, 595-600.
4. Nichols, W. C., Pankratz, N., Hernandez, D., Paisan-Ruiz, C., Jain, S., Halter, C. A., Michaels, V. E., Reed, T., Rudolph, A., Shults, C. W., et al. (2005) Lancet 365, 410-412.
5. Di Fonzo, A., Rohe, C. F., Ferreira, J., Chien, H. F., Vacca, L., Stocchi, F., Guedes, L., Fabrizio, E., Manfredi, M., Vanacore, N., et al. (2005) Lancet 365, 412-415.
6. Gilks, W. P., Abou-Sleiman, P. M., Gandhi, S., Jain, S., Singleton, A., Lees, A. J., Shaw, K., Bhatia, K. P., Bonifati, V., Quinn, N. P., et al. (2005) Lancet 365, 415-416.
7. Zabetian, C. P., Samii, A., Mosley, A. D., Roberts, J. W., Leis, B. C., Yearout, D., Raskind, W. H. & Griffith, A. (2005) Neurology 65, 741-744.
8. Farrer, M., Stone, J., Mata,I. F., Lincoln, S., Kachergus, J., Hulihan, M., Strain, K. J. & Maraganore, D. M. (2005) Neurology 65, 738-740.
9. Adams, J. R., van Netten, H., Schulzer, M., Mak, E., McKenzie, J., Strongosky, A., Sossi, V., Ruth, T. J., Lee, C. S., Farrer, et al. (August 4, 2005) Brain, 10.1093/brain/awh607.
10. Wszolek, Z. K., Pfeiffer, R. F., Tsuboi, Y., Uitti, R. J., McComb, R. D., Stoessl, A. J., Strongosky, A. J., Zimprich, A., Muller-Myhsok, B., Fairer, M. J., et al. (2004) Neurology 62, 1619-1622.
11. West, A. B., Lockhart, P. J., O'Farell, C. & Farrer, M. J. (2003) J. Mol. Biol. 326, 11-19.
12. Moore, D. J., Zhang, L., Dawson, T. M. & Dawson, V. L. (2003) J. Neurochem. 87, 1558-1567.
13. Moore, D. J., Zhang, L., Troncoso, J., Lee, M. K., Hattori, N., Mizuno, Y., Dawson, T. M. & Dawson, V. L. (2005) Hum. Mol. Genet. 14, 71-84.
14. Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S. W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M. & Dawson, V. L. (2005) Hum. Mol. Genet. 14, 2063-2073.
15. Moore, D. J., West, A. B., Dawson, V. L. & Dawson, T. M. (2004) Annu. Rev. Neurosci. 28, 57-87.
16. Kachergus, J., Mata, I. F., Hulihan, M., Taylor, J. P., Lincoln, S., Aasly, J., Gibson, J. M., Ross, O. A., Lynch, T., Wiley, J., et al. (2005) Am. J. Hum. Genet. 76, 672-680.
17. Dawson, T. M. & Dawson, V. L. (2003) Science 302, 819-822.
18. Darios, F., Corti, O., Lucking, C. B., Hampe, C., Muriel, M. P., Abbas, N., Gu, W. J., Hirsch, E. C., Rooney, T., Ruberg, M. & Brice, A. (2003) Hum. Mol. Genet. 12, 517-526.
19. Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) Science 304, 1158-1160.
20. Nolen, B., Taylor, S. & Ghosh, G. (2004) Mol. Cell 15, 661-675.