-
1
-
-
33644543761
-
Expanding insights of mitochondrial dysfunction in Parkinson's disease
-
DOI 10.1038/nrn1868, PII N1868
-
Abou-Sleiman PM, Muqit MM, and Wood NW. Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci 7: 207-219, 2006. (Pubitemid 43292466)
-
(2006)
Nature Reviews Neuroscience
, vol.7
, Issue.3
, pp. 207-219
-
-
Abou-Sleiman, P.M.1
Muqit, M.M.K.2
Wood, N.W.3
-
2
-
-
70349991886
-
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
-
Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, and Wade-Martins R. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 18: 4022-4034, 2009.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4022-4034
-
-
Alegre-Abarrategui, J.1
Christian, H.2
Lufino, M.M.3
Mutihac, R.4
Venda, L.L.5
Ansorge, O.6
Wade-Martins, R.7
-
3
-
-
73449124773
-
Parkinson disease LRRK2 and the endocytic-autophagic pathway
-
Alegre-Abarrategui J and Wade-Martins R. Parkinson disease, LRRK2 and the endocytic-autophagic pathway. Autophagy 5: 1208-1210, 2009.
-
(2009)
Autophagy
, vol.5
, pp. 1208-1210
-
-
Alegre-Abarrategui, J.1
Wade-Martins, R.2
-
4
-
-
79951560784
-
Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: Insights into memory loss in MCI
-
Aluise CD, Robinson RA, Cai J, Pierce WM, Markesbery WR, and Butterfield DA. Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: Insights into memory loss in MCI. J Alzheimers Dis 23: 257-269, 2011.
-
(2011)
J Alzheimers Dis
, vol.23
, pp. 257-269
-
-
Aluise, C.D.1
Robinson, R.A.2
Cai, J.3
Pierce, W.M.4
Markesbery, W.R.5
Butterfield, D.A.6
-
5
-
-
0031036896
-
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
-
Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J,Mouatt-Prigent A, RubergM,Hirsch EC, and Agid Y.Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 12: 25-31, 1997. (Pubitemid 27106916)
-
(1997)
Histology and Histopathology
, vol.12
, Issue.1
, pp. 25-31
-
-
Anglade, P.1
-
6
-
-
33745990556
-
Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Aβ(1-42): Implications for Alzheimer's disease
-
DOI 10.1016/j.neurobiolaging.2005.07.001, PII S0197458005001909
-
Boyd-Kimball D, Poon HF, Lynn BC, Cai J, Pierce WM, Jr., Klein JB, Ferguson J, Link CD, and Butterfield DA. Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): Implications for Alzheimer's disease. Neurobiol Aging 27: 1239-1249, 2006. (Pubitemid 44067304)
-
(2006)
Neurobiology of Aging
, vol.27
, Issue.9
, pp. 1239-1249
-
-
Boyd-Kimball, D.1
Poon, H.F.2
Lynn, B.C.3
Cai, J.4
Pierce Jr., W.M.5
Klein, J.B.6
Ferguson, J.7
Link, C.D.8
Butterfield, D.A.9
-
7
-
-
77953257870
-
Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease
-
Butterfield DA, Bader Lange ML, and Sultana R. Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease. Biochim Biophys Acta 1801: 924-929, 2010.
-
(1801)
Biochim Biophys Acta
, pp. 924-929
-
-
Butterfield, D.A.1
Bader Lange, M.L.2
Sultana, R.3
-
8
-
-
79955544006
-
Rac1 Protein rescues neurite retraction caused by G2019S leucinerich repeat kinase 2 (LRRK2)
-
Chan D, Citro A, Cordy JM, Shen GC, and Wolozin B. Rac1 Protein rescues neurite retraction caused by G2019S leucinerich repeat kinase 2 (LRRK2). J Biol Chem 286: 16140-16149, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 16140-16149
-
-
Chan, D.1
Citro, A.2
Cordy, J.M.3
Shen, G.C.4
Wolozin, B.5
-
9
-
-
1842581669
-
Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases
-
DOI 10.1074/jbc.M314124200
-
Choi J, Levey AI, Weintraub ST, Rees HD, Gearing M, Chin LS, and Li L. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J Biol Chem 279: 13256-13264, 2004. (Pubitemid 38445905)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.13
, pp. 13256-13264
-
-
Choi, J.1
Levey, A.I.2
Weintraub, S.T.3
Rees, H.D.4
Gearing, M.5
Chin, L.-S.6
Li, L.7
-
10
-
-
15744398884
-
Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with alzheimer and Parkinson diseases
-
DOI 10.1074/jbc.M414327200
-
Choi J, Rees HD, Weintraub ST, Levey AI, Chin LS, and Li L. Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J Biol Chem 280: 11648-11655, 2005. (Pubitemid 40418479)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.12
, pp. 11648-11655
-
-
Choi, J.1
Rees, H.D.2
Weintraub, S.T.3
Levey, A.I.4
Chin, L.-S.5
Li, L.6
-
11
-
-
77952122496
-
LRRK2 and Parkinson disease
-
Dachsel JC and Farrer MJ. LRRK2 and Parkinson disease. Arch Neurol 67: 542-547, 2010.
-
(2010)
Arch Neurol
, vol.67
, pp. 542-547
-
-
Dachsel, J.C.1
Farrer, M.J.2
-
12
-
-
24644514279
-
Evidence of oxidative stress in the neocortex in incidental Lewy body disease
-
Dalfo E, Portero-Otin M, Ayala V, Martinez A, Pamplona R, and Ferrer I. Evidence of oxidative stress in the neocortex in incidental Lewy body disease. J Neuropathol Exp Neurol 64: 816-830, 2005. (Pubitemid 41285815)
-
(2005)
Journal of Neuropathology and Experimental Neurology
, vol.64
, Issue.9
, pp. 816-830
-
-
Dalfo, E.1
Portero-Otin, M.2
Ayala, V.3
Martinez, A.4
Pamplona, R.5
Ferrer, I.6
-
14
-
-
55949098427
-
Emerging pathways in genetic Parkinson's disease: Tangles Lewy bodies and LRRK2
-
Devine MJ and Lewis PA. Emerging pathways in genetic Parkinson's disease: Tangles, Lewy bodies and LRRK2. FEBS J 275: 5748-5757, 2008.
-
(2008)
FEBS J
, vol.275
, pp. 5748-5757
-
-
Devine, M.J.1
Lewis, P.A.2
-
15
-
-
34248182509
-
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
-
DOI 10.1212/01.wnl.0000260963.08711.08, PII 0000611420070508000003
-
Di Fonzo A, Chien HF, Socal M, Giraudo S, Tassorelli C, Iliceto G, Fabbrini G, Marconi R, Fincati E, Abbruzzese G, Marini P, Squitieri F, Horstink MW, Montagna P, Libera AD, Stocchi F, Goldwurm S, Ferreira JJ, Meco G, Martignoni E, Lopiano L, Jardim LB, Oostra BA, Barbosa ER, Italian Parkinson Genetics N, and Bonifati V. ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology 68: 1557-1562, 2007. (Pubitemid 46717978)
-
(2007)
Neurology
, vol.68
, Issue.19
, pp. 1557-1562
-
-
Di Fonzo, A.1
Chien, H.F.2
Socal, M.3
Giraudo, S.4
Tassorelli, C.5
Iliceto, G.6
Fabbrini, G.7
Marconi, R.8
Fincati, E.9
Abbruzzese, G.10
Marini, P.11
Squitieri, F.12
Horstink, M.W.13
Montagna, P.14
Libera, A.D.15
Stocchi, F.16
Goldwurm, S.17
Ferreira, J.J.18
Meco, G.19
Martignoni, E.20
Lopiano, L.21
Jardim, L.B.22
Oostra, B.A.23
Barbosa, E.R.24
Bonifati, V.25
Bonifati, V.26
Vanacore, N.27
Meco, G.28
Fabbrini, G.29
Fabrizio, E.30
Locuratolo, N.31
Scoppetta, C.32
Manfredi, M.33
Berardelli, A.34
Lopiano, L.35
Giraudo, S.36
Bergamasco, B.37
Tassorelli, C.38
Pacchetti, C.39
Nappi, G.40
Goldwurm, S.41
Antonini, A.42
Pezzoli, G.43
Riboldazzi, G.44
Bono, G.45
Raudino, F.46
Manfredi, Mi.47
Fincati, E.48
Tinazzi, M.49
Bonizzato, A.50
Ferracci, C.51
Dalla Libera, A.52
Abbruzzese, G.53
Marchese, R.54
Montagna, P.55
Marini, P.56
Massaro, F.57
Marconi, R.58
Guidi, M.59
Minardi, C.60
Rasi, F.61
Onofrj, M.62
Thomas, A.63
Stocchi, F.64
Vacca, L.65
De Pandis, F.66
De Mari, M.67
Diroma, C.68
Iliceto, G.69
Lamberti, P.70
Toni, V.71
Trianni, G.72
Mauro, A.73
De Gaetano, A.74
Rizzo, M.75
Cossu, G.76
Rieder, C.R.M.77
Saraiva-Pereira, M.L.78
more..
-
16
-
-
33645116252
-
Genetics of Parkinson disease: Paradigm shifts and future prospects
-
Farrer MJ. Genetics of Parkinson disease: Paradigm shifts and future prospects. Nat Rev Genet 7: 306-318, 2006.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 306-318
-
-
Farrer, M.J.1
-
18
-
-
12244262766
-
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
-
Foroud T, Uniacke SK, Liu L, Pankratz N, Rudolph A, Halter C, Shults C, Marder K, Conneally PM, Nichols WC, and Parkinson Study G. Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease. Neurology 60: 796-801, 2003. (Pubitemid 36297363)
-
(2003)
Neurology
, vol.60
, Issue.5
, pp. 796-801
-
-
Foroud, T.1
Uniacke, S.K.2
Liu, L.3
Pankratz, N.4
Rudolph, A.5
Halter, C.6
Shults, C.7
Marder, K.8
Conneally, P.M.9
Nichols, W.C.10
Golbe, L.11
Koller, W.12
Lyons, K.13
Marshall, F.14
Oakes, D.15
Shinaman, A.16
Siemers, E.17
Wojcieszek, J.18
Belden, J.19
Carter, J.20
Camicioli, R.21
Andrews, P.22
Fernandez, M.23
Hubble, J.24
Reider, C.25
Rajput, A.26
Rajput, A.27
Shirley, T.28
Panisset, M.29
Hall, J.30
Mendis, T.31
Grimes, D.A.32
Gray, P.33
Serrano Ramos, C.34
Roque, S.35
Reich, S.36
Dunlop, B.37
Hauser, R.38
Sanchez-Ramos, J.39
Zesiewicz, T.40
Delgado, H.41
Friedman, J.42
Fernandez, H.43
Lannon, M.44
Seeberger, L.45
O'Brien, C.46
Judd, D.47
Elmer, L.48
Davis, K.49
Fontaine, D.50
Pfeiffer, R.51
Pfeiffer, B.52
Aminoff, M.53
DiMinno, M.54
Truong, D.55
Pathak, M.56
Tran, A.57
Rodnitzky, R.58
Dobson, J.59
Pahwa, R.60
Thomas, S.61
Jennings, D.62
Marek, K.63
Mendick, S.64
Harris, J.65
Weiner, W.66
Kurlan, R.67
Berry, D.68
Lewitt, P.69
DeAngelis, M.70
Tuite, P.71
Schacherer, R.72
Martin, W.73
Wieler, M.74
Manyam, B.75
Simpson, P.76
Bertoni, J.77
Peterson, C.78
Gordon, M.F.79
Hamann, J.80
Jankovic, J.81
Hunter, C.82
Factor, S.83
Evans, S.84
Nieves, A.85
So, J.86
Stacy, M.87
Williamson, K.88
Walker, F.89
Hunt, V.90
Kang, U.J.91
Uy, S.92
Bindauer, K.93
Petit, J.94
Simon, D.95
Scollins, L.96
Pullman, R.S.97
Boyer, K.98
Gordon, P.99
more..
-
19
-
-
33644824239
-
Interface between tauopathies and synucleinopathies: A tale of two proteins
-
DOI 10.1002/ana.20819
-
Galpern WR and Lang AE. Interface between tauopathies and synucleinopathies: A tale of two proteins. Ann Neurol 59: 449-458, 2006. (Pubitemid 43358065)
-
(2006)
Annals of Neurology
, vol.59
, Issue.3
, pp. 449-458
-
-
Galpern, W.R.1
Lang, A.E.2
-
20
-
-
65649142038
-
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro
-
Gloeckner CJ, Schumacher A, Boldt K, and Ueffing M. The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J Neurochem 109: 959-968, 2009.
-
(2009)
J Neurochem
, vol.109
, pp. 959-968
-
-
Gloeckner, C.J.1
Schumacher, A.2
Boldt, K.3
Ueffing, M.4
-
21
-
-
63849244747
-
Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases
-
Gomez A and Ferrer I. Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases. J Neurosci Res 87: 1002-1013, 2009.
-
(2009)
J Neurosci Res
, vol.87
, pp. 1002-1013
-
-
Gomez, A.1
Ferrer, I.2
-
22
-
-
77957276285
-
Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment
-
Gomez A and Ferrer I. Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment. Acta Neuropathol 120: 155-167, 2010.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 155-167
-
-
Gomez, A.1
Ferrer, I.2
-
23
-
-
65449156394
-
SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans
-
Guthrie CR, Schellenberg GD, and Kraemer BC. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. Hum Mol Genet 18: 1825-1838, 2009.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1825-1838
-
-
Guthrie, C.R.1
Schellenberg, G.D.2
Kraemer, B.C.3
-
24
-
-
34247098407
-
Leucine-rich repeat kinase 2 associates with lipid rafts
-
DOI 10.1093/hmg/ddm013
-
Hatano T, Kubo S, Imai S, Maeda M, Ishikawa K, Mizuno Y, and Hattori N. Leucine-rich repeat kinase 2 associates with lipid rafts. Hum Mol Genet 16: 678-690, 2007. (Pubitemid 46585667)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.6
, pp. 678-690
-
-
Hatano, T.1
Kubo, S.-I.2
Imai, S.3
Maeda, M.4
Ishikawa, K.5
Mizuno, Y.6
Hattori, N.7
-
25
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, and Lu B. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J 27: 2432-2443, 2008.
-
(2008)
EMBO J
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.Q.3
Takahashi, R.4
Hasegawa, K.5
Oota, E.6
Lu, B.7
-
26
-
-
33646133424
-
Molecular pathways that influence human tauinduced pathology in Caenorhabditis elegans
-
Kraemer BC, Burgess JK, Chen JH, Thomas JH, and Schellenberg GD. Molecular pathways that influence human tauinduced pathology in Caenorhabditis elegans. Hum Mol Genet 15: 1483-1496, 2006.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1483-1496
-
-
Kraemer, B.C.1
Burgess, J.K.2
Chen, J.H.3
Thomas, J.H.4
Schellenberg, G.D.5
-
27
-
-
0042889049
-
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
-
DOI 10.1073/pnas.1533448100
-
Kraemer BC, Zhang B, Leverenz JB, Thomas JH, Trojanowski JQ, and Schellenberg GD. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc Natl Acad Sci USA 100: 9980-9985, 2003. (Pubitemid 37087054)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.17
, pp. 9980-9985
-
-
Kraemer, B.C.1
Zhang, B.2
Leverenz, J.B.3
Thomas, J.H.4
Trojanowski, J.Q.5
Schellenberg, G.D.6
-
28
-
-
34247468302
-
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
-
DOI 10.1016/j.bbrc.2007.04.006, PII S0006291X07006894
-
Lewis PA, Greggio E, Beilina A, Jain S, Baker A, and Cookson MR. The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochem Biophys Res Commun 357: 668-671, 2007. (Pubitemid 46653831)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.357
, Issue.3
, pp. 668-671
-
-
Lewis, P.A.1
Greggio, E.2
Beilina, A.3
Jain, S.4
Baker, A.5
Cookson, M.R.6
-
29
-
-
34548621385
-
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
-
DOI 10.1111/j.1471-4159.2007.04743.x
-
Li X, Tan YC, Poulose S, Olanow CW, Huang XY, and Yue Z. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem 103: 238-247, 2007. (Pubitemid 47404210)
-
(2007)
Journal of Neurochemistry
, vol.103
, Issue.1
, pp. 238-247
-
-
Li, X.1
Tan, Y.-C.2
Poulose, S.3
Olanow, C.W.4
Huang, X.-Y.5
Yue, Z.6
-
30
-
-
71849112162
-
The R1441C mutation alters the folding properties of the ROC domain of LRRK2
-
Li Y, Dunn L, Greggio E, Krumm B, Jackson GS, Cookson MR, Lewis PA, and Deng J. The R1441C mutation alters the folding properties of the ROC domain of LRRK2. Biochim Biophys Acta 1792: 1194-1197, 2009.
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 1194-1197
-
-
Li, Y.1
Dunn, L.2
Greggio, E.3
Krumm, B.4
Jackson, G.S.5
Cookson, M.R.6
Lewis, P.A.7
Deng, J.8
-
31
-
-
77957377567
-
LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ss
-
Lin CH, Tsai PI, Wu RM, and Chien CT. LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ss. J Neurosci 30: 13138-13149, 2010.
-
(2010)
J Neurosci
, vol.30
, pp. 13138-13149
-
-
Lin, C.H.1
Tsai, P.I.2
Wu, R.M.3
Chien, C.T.4
-
32
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
DOI 10.1038/nature05292, PII NATURE05292
-
LinMT and BealMF.Mitochondrial dysfunction and oxidative stress in neurodegenerativediseases.Nature 443: 787-795, 2006. (Pubitemid 44622683)
-
(2006)
Nature
, vol.443
, Issue.7113
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
33
-
-
60049091402
-
Reisensburg Working Group for Tauopathies with P. Tauopathies with parkinsonism: Clinical spectrum, neuropathologic basis, biological markers, and treatment options
-
Ludolph AC, Kassubek J, Landwehrmeyer BG, Mandelkow E, Mandelkow EM, Burn DJ, Caparros-Lefebvre D, Frey KA, de Yebenes JG, Gasser T, Heutink P, Hoglinger G, Jamrozik Z, Jellinger KA, Kazantsev A, Kretzschmar H, Lang AE, Litvan I, Lucas JJ, McGeer PL, Melquist S, Oertel W, Otto M, Paviour D, Reum T, Saint-Raymond A, Steele JC, Tolnay M, Tumani H, van Swieten JC, Vanier MT, Vonsattel JP, Wagner S, and Wszolek ZK, Reisensburg Working Group for Tauopathies With P. Tauopathies with parkinsonism: Clinical spectrum, neuropathologic basis, biological markers, and treatment options. Eur J Neurol 16: 297-309, 2009.
-
(2009)
Eur J Neurol
, vol.16
, pp. 297-309
-
-
Ludolph, A.C.1
Kassubek, J.2
Landwehrmeyer, B.G.3
Mandelkow, E.4
Mandelkow, E.M.5
Burn, D.J.6
Caparros-Lefebvre, D.7
Frey, K.A.8
De Yebenes, J.G.9
Gasser, T.10
Heutink, P.11
Hoglinger, G.12
Jamrozik, Z.13
Jellinger, K.A.14
Kazantsev, A.15
Kretzschmar, H.16
Lang, A.E.17
Litvan, I.18
Lucas, J.J.19
McGeer, P.L.20
Melquist, S.21
Oertel, W.22
Otto, M.23
Paviour, D.24
Reum, T.25
Saint-Raymond, A.26
Steele, J.C.27
Tolnay, M.28
Tumani, H.29
Van Swieten, J.C.30
Vanier, M.T.31
Vonsattel, J.P.32
Wagner, S.33
Wszolek, Z.K.34
more..
-
34
-
-
33751256567
-
The Familial Parkinsonism Gene LRRK2 Regulates Neurite Process Morphology
-
DOI 10.1016/j.neuron.2006.10.008, PII S0896627306008075
-
MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, and Abeliovich A. The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52: 587-593, 2006. (Pubitemid 44781171)
-
(2006)
Neuron
, vol.52
, Issue.4
, pp. 587-593
-
-
MacLeod, D.1
Dowman, J.2
Hammond, R.3
Leete, T.4
Inoue, K.5
Abeliovich, A.6
-
35
-
-
12144289221
-
UCHL1 Is a Parkinson's Disease Susceptibility Gene
-
DOI 10.1002/ana.20017
-
Maraganore DM, Lesnick TG, Elbaz A, Chartier-Harlin MC, Gasser T, Kruger R, Hattori N, Mellick GD, Quattrone A, Satoh J, Toda T, Wang J, Ioannidis JP, de Andrade M, and Rocca WA, Consortium UGG. UCHL1 is a Parkinson's disease susceptibility gene. Ann Neurol 55: 512-521, 2004. (Pubitemid 38391968)
-
(2004)
Annals of Neurology
, vol.55
, Issue.4
, pp. 512-521
-
-
Maraganore, D.M.1
Lesnick, T.G.2
Elbaz, A.3
Chartier-Harlin, M.-C.4
Gasser, T.5
Kruger, R.6
Hattori, N.7
Mellick, G.D.8
Quattrone, A.9
Satoh, J.-I.10
Toda, T.11
Wang, J.12
Ioannidis, J.P.A.13
De Andrade, M.14
Rocca, W.A.15
-
36
-
-
33847652900
-
Autophagy and neurodegeneration: when the cleaning crew goes on strike
-
DOI 10.1016/S1474-4422(07)70076-5, PII S1474442207700765
-
Martinez-Vicente M and Cuervo AM. Autophagy and neurodegeneration: When the cleaning crew goes on strike. Lancet Neurol 6: 352-361, 2007. (Pubitemid 46367949)
-
(2007)
Lancet Neurology
, vol.6
, Issue.4
, pp. 352-361
-
-
Martinez-Vicente, M.1
Cuervo, A.M.2
-
37
-
-
33646151866
-
LRRK2 in Parkinson's disease: Protein domains and functional insights
-
Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, and Gallo KA. LRRK2 in Parkinson's disease: Protein domains and functional insights. Trends Neurosci 29: 286-293, 2006.
-
(2006)
Trends Neurosci
, vol.29
, pp. 286-293
-
-
Mata, I.F.1
Wedemeyer, W.J.2
Farrer, M.J.3
Taylor, J.P.4
Gallo, K.A.5
-
38
-
-
77957794336
-
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
-
Melrose HL, Dachsel JC, Behrouz B, Lincoln SJ, Yue M, Hinkle KM, Kent CB, Korvatska E, Taylor JP, Witten L, Liang YQ, Beevers JE, Boules M, Dugger BN, Serna VA, Gaukhman A, Yu X, Castanedes-Casey M, Braithwaite AT, Ogholikhan S, Yu N, Bass D, Tyndall G, Schellenberg GD, Dickson DW, Janus C, and Farrer MJ. Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice. Neurobiol Dis 40: 503-517, 2010.
-
(2010)
Neurobiol Dis
, vol.40
, pp. 503-517
-
-
Melrose, H.L.1
Dachsel, J.C.2
Behrouz, B.3
Lincoln, S.J.4
Yue, M.5
Hinkle, K.M.6
Kent, C.B.7
Korvatska, E.8
Taylor, J.P.9
Witten, L.10
Liang, Y.Q.11
Beevers, J.E.12
Boules, M.13
Dugger, B.N.14
Serna, V.A.15
Gaukhman, A.16
Yu, X.17
Castanedes-Casey, M.18
Braithwaite, A.T.19
Ogholikhan, S.20
Yu, N.21
Bass, D.22
Tyndall, G.23
Schellenberg, G.D.24
Dickson, D.W.25
Janus, C.26
Farrer, M.J.27
more..
-
39
-
-
0037159608
-
Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
-
DOI 10.1016/S0006-8993(02)03514-X, PII S000689930203514X
-
Meredith GE, Totterdell S, Petroske E, Santa Cruz K, Callison RC, Jr., and Lau YS. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res 956: 156-165, 2002. (Pubitemid 35335568)
-
(2002)
Brain Research
, vol.956
, Issue.1
, pp. 156-165
-
-
Meredith, G.E.1
Totterdell, S.2
Petroske, E.3
Santa Cruz, K.4
Callison Jr., R.C.5
Lau, Y.-S.6
-
40
-
-
41049086705
-
Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients
-
DOI 10.1038/sj.ejhg.5201986, PII 5201986
-
Nuytemans K, Rademakers R, Theuns J, Pals P, Engelborghs S, Pickut B, de Pooter T, Peeters K, Mattheijssens M, Van den Broeck M, Cras P, De Deyn PP, and van Broeckhoven C. Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients. Eur J Hum Genet 16: 471-479, 2008. (Pubitemid 351420380)
-
(2008)
European Journal of Human Genetics
, vol.16
, Issue.4
, pp. 471-479
-
-
Nuytemans, K.1
Rademakers, R.2
Theuns, J.3
Pals, P.4
Engelborghs, S.5
Pickut, B.6
De Pooter, T.7
Peeters, K.8
Mattheijssens, M.9
Van Den Broeck, M.10
Cras, P.11
De Deyn, P.P.12
Van Broeckhoven, C.13
-
41
-
-
41549114279
-
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
-
Pan T, Kondo S, Le W, and Jankovic J. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 131: 1969-1978, 2008.
-
(2008)
Brain
, vol.131
, pp. 1969-1978
-
-
Pan, T.1
Kondo Le S, W.2
Jankovic, J.3
-
42
-
-
39549117093
-
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
-
DOI 10.1111/j.1471-4159.2008.05217.x
-
Plowey ED, Cherra SJ, 3rd, Liu YJ, and Chu CT. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells.JNeurochem105: 1048-1056, 2008. (Pubitemid 351565713)
-
(2008)
Journal of Neurochemistry
, vol.105
, Issue.3
, pp. 1048-1056
-
-
Plowey, E.D.1
Cherra III, S.J.2
Liu, Y.-J.3
Chu, C.T.4
-
43
-
-
33750308194
-
Parkinsonism, Lrrk2 G2019S, and tau neuropathology
-
DOI 10.1212/01.wnl.0000240220.33950.0c, PII 0000611420061024000046
-
Rajput A, Dickson DW, Robinson CA, Ross OA, Dachsel JC, Lincoln SJ, Cobb SA, Rajput ML, and Farrer MJ. Parkinsonism, Lrrk2 G2019S, and tau neuropathology. Neurology 67: 1506-1508, 2006. (Pubitemid 44632090)
-
(2006)
Neurology
, vol.67
, Issue.8
, pp. 1506-1508
-
-
Rajput, A.1
Dickson, D.W.2
Robinson, C.A.3
Ross, O.A.4
Dachsel, J.C.5
Lincoln, S.J.6
Cobb, S.A.7
Rajput, M.L.8
Farrer, M.J.9
-
44
-
-
33749133430
-
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
-
DOI 10.1038/ng1884, PII NG1884
-
Ramirez A, Heimbach A, Grundemann J, Stiller B, Hampshire D, Cid LP, Goebel I, Mubaidin AF, Wriekat AL, Roeper J, Al-Din A, Hillmer AM, Karsak M, Liss B, Woods CG, Behrens MI, and Kubisch C. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet 38: 1184-1191, 2006. (Pubitemid 44470365)
-
(2006)
Nature Genetics
, vol.38
, Issue.10
, pp. 1184-1191
-
-
Ramirez, A.1
Heimbach, A.2
Grundemann, J.3
Stiller, B.4
Hampshire, D.5
Cid, L.P.6
Goebel, I.7
Mubaidin, A.F.8
Wriekat, A.-L.9
Roeper, J.10
Al-Din, A.11
Hillmer, A.M.12
Karsak, M.13
Liss, B.14
Woods, C.G.15
Behrens, M.I.16
Kubisch, C.17
-
45
-
-
79958698108
-
Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens
-
Rivera VM, Squillace RM, Miller D, Berk L, Wardwell SD, Ning Y, Pollock R, Narasimhan NI, Iuliucci JD, Wang F, and Clackson T. Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Mol Cancer Ther 10: 1059-1071, 2011.
-
Mol Cancer Ther
, vol.10
, pp. 1059-1071
-
-
Rivera, V.M.1
Squillace, R.M.2
Miller, D.3
Berk, L.4
Wardwell, S.D.5
Ning, Y.6
Pollock, R.7
Narasimhan, N.I.8
Iuliucci, J.D.9
Wang, F.10
Clackson, T.11
-
46
-
-
33750363298
-
The roles of intracellular protein-degradation pathways in neurodegeneration
-
DOI 10.1038/nature05291, PII NATURE05291
-
Rubinsztein DC. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443: 780-786, 2006. (Pubitemid 44622682)
-
(2006)
Nature
, vol.443
, Issue.7113
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
47
-
-
67651171368
-
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans
-
Saha S,GuillilyMD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, SegalL,RaghavanK,MatsumotoK,HisamotoN,Kuwahara T, Iwatsubo T, Moore L,Goldstein L, CooksonM, and Wolozin B. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci 29: 9210-9218, 2009.
-
(2009)
J Neurosci
, vol.29
, pp. 9210-9218
-
-
Saha, S.1
Guillily, M.D.2
Ferree, A.3
Lanceta, J.4
Chan, D.5
Ghosh, J.6
Hsu, C.H.7
Segal, L.8
Raghavan, K.9
Matsumoto, K.10
Hisamoto, N.11
Kuwahara, T.12
Iwatsubo, T.13
Moore, L.14
Goldstein, L.15
Cookson, M.16
Wolozin, B.17
-
48
-
-
61349137536
-
LRRK2 and neurodegeneration
-
Santpere G and Ferrer I. LRRK2 and neurodegeneration. Acta Neuropathol 117: 227-46, 2009.
-
(2009)
Acta Neuropathol
, vol.117
, pp. 227-246
-
-
Santpere, G.1
Ferrer, I.2
-
49
-
-
60549083568
-
Mitochondrial dysfunction in neurodegenerative diseases
-
Schapira AH. Mitochondrial dysfunction in neurodegenerative diseases. Neurochem Res 33: 2502-2509, 2008.
-
(2008)
Neurochem Res
, vol.33
, pp. 2502-2509
-
-
Schapira, A.H.1
-
50
-
-
46549089664
-
LRRK2 regulates synaptic vesicle endocytosis
-
Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, and Seol W. LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res 314: 2055-2065, 2008.
-
(2008)
Exp Cell Res
, vol.314
, pp. 2055-2065
-
-
Shin, N.1
Jeong, H.2
Kwon, J.3
Heo, H.Y.4
Kwon, J.J.5
Yun, H.J.6
Kim, C.H.7
Han, B.S.8
Tong, Y.9
Shen, J.10
Hatano, T.11
Hattori, N.12
Kim, K.S.13
Chang, S.14
Seol, W.15
-
51
-
-
33748993710
-
Kinase activity of mutant LRRK2 mediates neuronal toxicity
-
DOI 10.1038/nn1776, PII NN1776
-
Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, and Ross CA. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 9: 1231-1233, 2006. (Pubitemid 44454261)
-
(2006)
Nature Neuroscience
, vol.9
, Issue.10
, pp. 1231-1233
-
-
Smith, W.W.1
Pei, Z.2
Jiang, H.3
Dawson, V.L.4
Dawson, T.M.5
Ross, C.A.6
-
52
-
-
80053944575
-
Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models
-
Squillace RM, Miller D, Cookson M, Wardwell SD, Moran L, Clapham D, Wang F, Clackson T, and Rivera VM. Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models. Mol Cancer Ther 10: 1959-1968, 2011.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1959-1968
-
-
Squillace, R.M.1
Miller, D.2
Cookson, M.3
Wardwell, S.D.4
Moran, L.5
Clapham, D.6
Wang, F.7
Clackson, T.8
Rivera, V.M.9
-
53
-
-
79251617521
-
Identification of the oxidative stress proteome in the brain
-
Sultana R and Butterfield DA. Identification of the oxidative stress proteome in the brain. Free RadicBiolMed 50: 487-494, 2011.
-
Free RadicBiolMed
, vol.50
, pp. 487-494
-
-
Sultana, R.1
Butterfield, D.A.2
-
54
-
-
32044458576
-
LRRK2: A common pathway for parkinsonism, pathogenesis and prevention?
-
DOI 10.1016/j.molmed.2005.12.004, PII S1471491405002716
-
Taylor JP, Mata IF, and Farrer MJ. LRRK2: A common pathway for parkinsonism, pathogenesis and prevention? Trends Mol Med 12: 76-82, 2006. (Pubitemid 43202125)
-
(2006)
Trends in Molecular Medicine
, vol.12
, Issue.2
, pp. 76-82
-
-
Taylor, J.P.1
Mata, I.F.2
Farrer, M.J.3
-
55
-
-
77649105209
-
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau
-
Taymans JM and Cookson MR. Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau. Bioessays 32: 227-235, 2010.
-
(2010)
Bioessays
, vol.32
, pp. 227-235
-
-
Taymans, J.M.1
Cookson, M.R.2
-
56
-
-
30044434872
-
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
-
DOI 10.1074/jbc.M505910200
-
Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, and Wolozin B. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem 280: 42655-42668, 2005. (Pubitemid 43049224)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.52
, pp. 42655-42668
-
-
Ved, R.1
Saha, S.2
Westlund, B.3
Perier, C.4
Burnam, L.5
Sluder, A.6
Hoener, M.7
Rodrigues, C.M.P.8
Alfonso, A.9
Steer, C.10
Liu, L.11
Przedborski, S.12
Wolozin, B.13
-
57
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
DOI 10.1073/pnas.0507360102
-
West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, and Dawson TM. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci USA 102: 16842-16847, 2005. (Pubitemid 41688864)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.46
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
Bugayenko, A.4
Smith, W.W.5
Ross, C.A.6
Dawson, V.L.7
Dawson, T.M.8
-
58
-
-
33846562487
-
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
-
DOI 10.1093/hmg/ddl471
-
West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, and Dawson TM. Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum Mol Genet 16: 223-232, 2007. (Pubitemid 46179004)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.2
, pp. 223-232
-
-
West, A.B.1
Moore, D.J.2
Choi, C.3
Andrabi, S.A.4
Li, X.5
Dikeman, D.6
Biskup, S.7
Zhang, Z.8
Lim, K.-L.9
Dawson, V.L.10
Dawson, T.M.11
-
59
-
-
33847103297
-
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
-
Wszolek ZK, Tsuboi Y, Ghetti B, Pickering-Brown S, Baba Y, and Cheshire WP. Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Orphanet J Rare Dis 1: 30, 2006.
-
(2006)
Orphanet J Rare Dis
, vol.1
, pp. 30
-
-
Wszolek, Z.K.1
Tsuboi, Y.2
Ghetti, B.3
Pickering-Brown, S.4
Baba, Y.5
Cheshire, W.P.6
-
60
-
-
77956314467
-
Parkinson disease: A role for autophagy?
-
Yang Q and Mao Z. Parkinson disease: A role for autophagy? Neuroscientist 16: 335-341, 2010.
-
(2010)
Neuroscientist
, vol.16
, pp. 335-341
-
-
Yang, Q.1
Mao, Z.2
-
61
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
DOI 10.1016/j.neuron.2004.11.005, PII S0896627304007202
-
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Muller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, and Gasser T. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44: 601-607, 2004. (Pubitemid 39531225)
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
Stoessl, A.J.11
Pfeiffer, R.F.12
Patenge, N.13
Carbajal, I.C.14
Vieregge, P.15
Asmus, F.16
Muller-Myhsok, B.17
Dickson, D.W.18
Meitinger, T.19
Strom, T.M.20
Wszolek, Z.K.21
Gasser, T.22
more..
|