Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in caenorhabditis elegans

PLoS Genetics

Volumn 6, Issue 8, 2010, Pages

  Benedetto, Alexandre ^a,b   Au, Catherine ^a,c   Avila, Daiana Silva ^a   Milatovic, Dejan ^a,c   Aschner, Michael ^a,c  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; DOPAMINE TRANSPORTER; DOPAMINE TRANSPORTER 1; DOPAMINE TRANSPORTER 2; DUAL OXIDASE; MANGANESE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SKN 1; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CAENORHABDITIS ELEGANS; DOPAMINERGIC NERVE CELL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EXTRAPYRAMIDAL SYNDROME; GENE IDENTIFICATION; IN VIVO STUDY; INTOXICATION; LIFESPAN; NERVE CELL DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; RISK FACTOR;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; EXTRACELLULAR SPACE; FEMALE; HUMANS; LIFE EXPECTANCY; MALE; MANGANESE; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; OXIDOREDUCTASES; PARKINSON DISEASE; PROTEIN TRANSPORT;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 77957363643     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001084     Document Type: Article

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