Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, parkin, and DJ-1 in Caenorhabditis elegans

Journal of Biological Chemistry

Volumn 280, Issue 52, 2005, Pages 42655-42668

  Ved, Rina ^a   Saha, Shamol ^a   Westlund, Beth ^b   Perier, Celine ^d   Burnam, Lucinda ^b   Sluder, Anne ^b   Hoener, Marius ^c   Rodrigues, Cecilia M P ^e   Alfonso, Aixa ^f   Steer, Clifford ^g   Liu, Leo ^b   Przedborski, Serge ^d   Wolozin, Benjamin ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Cambria Pharmaceuticals Inc   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d NEUROLOGICAL INSTITUTE   (United States)

^e UNIVERSITY OF LISBON   (Portugal)

^f UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^g UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; DISEASES; SENSITIVITY ANALYSIS;

DIVALENT METAL IONS; PARKINSON DISEASE; SODIUM AZIDE;

GENETIC ENGINEERING;

3 HYDROXYBUTYRIC ACID; ALPHA SYNUCLEIN; BILE ACID; COPPER ION; DJ 1 PROTEIN; ENZYME INHIBITOR; ETOPOSIDE; FENPEROXIMATE; GENE PRODUCT; IRON; METAL ION; PARAQUAT; PARKIN; PROBUCOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SODIUM AZIDE; SUCCINATE DEHYDROGENASE (UBIQUINONE); TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DNA MODIFICATION; ENVIRONMENTAL FACTOR; ENZYME ACTIVATION; FAMILIAL DISEASE; GENE DELETION; HEREDITY; MITOCHONDRIAL MEMBRANE; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; TRANSGENIC ANIMAL;

3-HYDROXYBUTYRIC ACID; ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIOXIDANTS; APOPTOSIS; BENZOATES; BILE ACIDS AND SALTS; CAENORHABDITIS ELEGANS; CHOLAGOGUES AND CHOLERETICS; COPPER; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; GENE DELETION; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETIC TECHNIQUES; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IONS; IRON; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NEURONS; ONCOGENE PROTEINS; OXYGEN CONSUMPTION; PARAQUAT; PARKINSON DISEASE; POLYENES; PROBUCOL; PYRAZOLES; PYRIDAZINES; RNA, SMALL INTERFERING; ROTENONE; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM AZIDE; TAUROCHENODEOXYCHOLIC ACID; THIAZOLES; TIME FACTORS; TRANSGENES; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 30044434872     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M505910200     Document Type: Article

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