메뉴 건너뛰기




Volumn 23, Issue 6, 2007, Pages 329-335

ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in α-synuclein transgenic C. elegans

Author keywords

synuclein; ATP; C. elegans; MPP+; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ADENOSINE TRIPHOSPHATE; ALPHA SYNUCLEIN;

EID: 38149111218     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-007-0049-3     Document Type: Article
Times cited : (38)

References (28)
  • 1
    • 11144243412 scopus 로고    scopus 로고
    • Modulation of neurodegeneration by molecular chaperones
    • Muchowski PJ, Wacker JL. Modulation of neurodegeneration by molecular chaperones. Nat Rev Neurosci 2005, 6: 11-22.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 11-22
    • Muchowski, P.J.1    Wacker, J.L.2
  • 2
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276: 2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3    Ide, S.E.4    Dehejia, A.5    Dutra, A.6
  • 4
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker WD Jr, Boyson SJ, Parks JK. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 1989, 26: 719-723.
    • (1989) Ann Neurol , vol.26 , pp. 719-723
    • Parker Jr, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 5
    • 0035214256 scopus 로고    scopus 로고
    • Neurochemical findings in the MPTP model of Parkinson's disease
    • Schmidt N, Ferger BJ. Neurochemical findings in the MPTP model of Parkinson's disease. J Neural Transm 2001, 108: 1263-1282.
    • (2001) J Neural Transm , vol.108 , pp. 1263-1282
    • Schmidt, N.1    Ferger, B.J.2
  • 6
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, et al. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 2002, 22: 7006-7015.
    • (2002) J Neurosci , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6
  • 7
    • 0018187738 scopus 로고
    • A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes
    • Ciehanover A, Hod Y, Hershko A. A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem Biophy Res Commun 1978, 81: 1100-1105.
    • (1978) Biochem Biophy Res Commun , vol.81 , pp. 1100-1105
    • Ciehanover, A.1    Hod, Y.2    Hershko, A.3
  • 8
    • 0035900793 scopus 로고    scopus 로고
    • CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubquitylation
    • Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Hohfeld J, et al. CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubquitylation. J Biol Chem 2001, 276: 42938-42944.
    • (2001) J Biol Chem , vol.276 , pp. 42938-42944
    • Jiang, J.1    Ballinger, C.A.2    Wu, Y.3    Dai, Q.4    Cyr, D.M.5    Hohfeld, J.6
  • 9
    • 0041430614 scopus 로고    scopus 로고
    • Dysfunction of mitochondrial complex I and the proteasome: Interactions between two biochemical deficits in a cellular model of Parkinson's disease
    • Hoglinger GU, Carrard G, Michel PP, Medja F, Hirsch EC. Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease. J Neurochem 2003, 86: 1297-1307.
    • (2003) J Neurochem , vol.86 , pp. 1297-1307
    • Hoglinger, G.U.1    Carrard, G.2    Michel, P.P.3    Medja, F.4    Hirsch, E.C.5
  • 10
    • 0032969563 scopus 로고    scopus 로고
    • +: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes
    • +: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res 1999, 9: 27-43.
    • (1999) Genome Res , vol.9 , pp. 27-43
    • Neuwald, A.F.1    Aravind, L.2    Spouge, J.L.3    Koonin, E.V.4
  • 11
    • 10944257609 scopus 로고    scopus 로고
    • Neurodegenerative conditions associated with ageing: A molecular interplay
    • Troulinaki K, Tavernarakis N. Neurodegenerative conditions associated with ageing: a molecular interplay. Mech Ageing Dev 2005, 126: 23-33.
    • (2005) Mech Ageing Dev , vol.126 , pp. 23-33
    • Troulinaki, K.1    Tavernarakis, N.2
  • 12
    • 0036846119 scopus 로고    scopus 로고
    • TorsinA and heat shock proteins act as molecular chaperones: Suppression of alpha-synuclein aggregation
    • Mclean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, et al. TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. J Neuronchem 2002, 83: 846-854.
    • (2002) J Neuronchem , vol.83 , pp. 846-854
    • Mclean, P.J.1    Kawamata, H.2    Shariff, S.3    Hewett, J.4    Sharma, N.5    Ueda, K.6
  • 13
    • 0037319121 scopus 로고    scopus 로고
    • Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins
    • Caldwell GA, Cao S, Sexton EG, Gelwix CC, Bevel JP, Caldwell KA. Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins. Hum Mol Genet 2003, 12: 307-319.
    • (2003) Hum Mol Genet , vol.12 , pp. 307-319
    • Caldwell, G.A.1    Cao, S.2    Sexton, E.G.3    Gelwix, C.C.4    Bevel, J.P.5    Caldwell, K.A.6
  • 14
    • 0028064964 scopus 로고
    • Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: Evidence for a primary involvement of energy depletion
    • Bates TE, Heales SJ, Davies SE, Boakye P, Clark JB. Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. J Neurochem 1994, 63: 640-648.
    • (1994) J Neurochem , vol.63 , pp. 640-648
    • Bates, T.E.1    Heales, S.J.2    Davies, S.E.3    Boakye, P.4    Clark, J.B.5
  • 15
    • 0037085288 scopus 로고    scopus 로고
    • Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • Lee HJ, Shin SY, Choi C, Lee YH, Lee SJ. Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem 2001, 277: 5411-5417.
    • (2001) J Biol Chem , vol.277 , pp. 5411-5417
    • Lee, H.J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.J.5
  • 16
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, Przedborski S. Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J Neurochem 2000, 74: 721-729.
    • (2000) J Neurochem , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 18
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
    • Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med 2002, 8: 600-606
    • (2002) Nat Med , vol.8 , pp. 600-606
    • Xu, J.1    Kao, S.Y.2    Lee, F.J.3    Song, W.4    Jin, L.W.5    Yankner, B.A.6
  • 21
    • 0037971209 scopus 로고    scopus 로고
    • Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein
    • Lakso M, Vartiainen S, Moilanen AM, Sirviö J, Thomas JH, Nass R, et al. Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. J Neurochem 2003, 86: 165-172.
    • (2003) J Neurochem , vol.86 , pp. 165-172
    • Lakso, M.1    Vartiainen, S.2    Moilanen, A.M.3    Sirviö, J.4    Thomas, J.H.5    Nass, R.6
  • 23
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77: 71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 24
    • 0037022668 scopus 로고    scopus 로고
    • Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
    • Nass R, Hall DH, Miller DM, Blakely RD. Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc Natl Acad Sci USA 2002, 99: 3264-3269.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3264-3269
    • Nass, R.1    Hall, D.H.2    Miller, D.M.3    Blakely, R.D.4
  • 25
    • 34347221219 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a model system for Parkinson's disease
    • Schmidt E, Seifert M, Baumeister R. Caenorhabditis elegans as a model system for Parkinson's disease. Neurodegener Dis 2007, 4: 199-217
    • (2007) Neurodegener Dis , vol.4 , pp. 199-217
    • Schmidt, E.1    Seifert, M.2    Baumeister, R.3
  • 26
    • 29344467120 scopus 로고    scopus 로고
    • A developmental timing microRNA and its Target regulate life span in C. elegans
    • Michelle Boehm, Frank Slack. A developmental timing microRNA and its Target regulate life span in C. elegans. Science 2005, 310: 1954-1957.
    • (2005) Science , vol.310 , pp. 1954-1957
    • Boehm, M.1    Slack, F.2
  • 27
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • Arrasate M, Mitra SM, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 2004, 431: 805-810.
    • (2004) Nature , vol.431 , pp. 805-810
    • Arrasate, M.1    Mitra, S.M.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 28
    • 17544369017 scopus 로고    scopus 로고
    • Parkinson's disease
    • Clarke C, Moore AP. Parkinson's disease. Clin Evid 2004, 11: 1736-1754.
    • (2004) Clin Evid , vol.11 , pp. 1736-1754
    • Clarke, C.1    Moore, A.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.