Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

Journal of Biological Chemistry

Volumn 280, Issue 40, 2005, Pages 34025-34032

  Petit, Agnes ^a   Kawarai, Toshitaka ^a   Paitel, Erwan ^a   Sanjo, Nobuo ^a   Maj, Mary ^b   Scheid, Michael ^c   Chen, Fusheng ^a   Gu, Yongjun ^a   Hasegawa, Hiroshi ^a   Salehi Rad, Shabnam ^a   Wang, Linda ^a   Rogaeva, Ekaterina ^a   Fraser, Paul ^a   Robinson, Brian ^b   St George Hyslop, Peter ^a   Tandon, Anurag ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c YORK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; DISEASES; ENZYME KINETICS; MUTAGENESIS; REDUCTION;

AUTOSOMAL RECESSIVE SETS; CELL LINES; NEURONAL APOPTOSIS; NEURONAL CELLS;

NEUROLOGY;

CASPASE 3; CASPASE 7; CASPASE 9; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN PINK1; PTEN INDUCED KINASE 1; STAUROSPORINE; UNCLASSIFIED DRUG;

AGED; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CASE REPORT; CELL PROTECTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOPAMINERGIC NERVE CELL; GENE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALE; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; ONSET AGE; PARKINSON DISEASE; PHENOTYPE; PINK1 GENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PTEN GENE; WILD TYPE;

AGED; AMINO ACID SEQUENCE; APOPTOSIS; CASPASE 3; CASPASES; CELL CULTURE TECHNIQUES; CELL LINE; CYTOCHROMES C; DNA MUTATIONAL ANALYSIS; FIBROBLASTS; GENE EXPRESSION PROFILING; HUMANS; MALE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; NEURONS; PARKINSON DISEASE; PHENOTYPE; PROTEIN KINASES; RECEPTORS, DOPAMINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MURINAE;

EID: 26644440926     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M505143200     Document Type: Article

References (18)

1. Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., Albanese, A., Nussbaum, R., Gonzalez-Maldonado, R., Deller, T., Salvi, S., Cortelli, P., Gilks, W. P., Latchman, D. S., Harvey, R. J., Dallapiccola, B., Auburger, G., and Wood, N. W. (2004) Science 304, 1158-1160
2. Rogaeva, E., Johnson, J., Lang, A. E., Gulick, C., Gwinn-Hardy, K., Kawarai, T., Sato, C., Morgan, A., Werner, J., Nussbaum, R., Petit, A., Okun, M. S., McInerney, A., Mandel, R., Groen, J. L., Fernandez, H. H., Postuma, R., Foote, K. D., Salehi-Rad, S., Liang, Y., Reimsnider, S., Tandon, A., Hardy, J., St George-Hyslop, P., and Singleton, A. B. (2004) Arch. Neurol. 61, 1898-1904
3. Lang, A. E., and Lozano, A. M. (1998) N. Engl. J. Med. 339, 1130-1143
4. Lang, A. E., and Lozano, A. M. (1998) N. Engl. J. Med. 339, 1044-1053
5. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Outra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papepetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di lorio, G., and Nussbaum, R. L. (1997) Science 276, 2045-2047
6. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Nature 392, 605-608
7. Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibanez, P., Joosse, M., van Dongen, J. W., Vanacore, N., van Swieten, J. C., Brice, A., Meco, G., van Duijn, C. M., Oostra, B. A., and Heutink, P. (2003) Science 299, 256-259
8. Hague, S., Rogaeva, E., Hernandez, D., Gulick, C., Singleton, A., Hanson, M., Johnson, J., Weiser, R., Gallardo, M., Ravina, B., Gwinn-Hardy, K., Crawley, A., St George-Hyslop, P. H., Lang, A. E., Heutink, P., Bonifati, V., and Hardy, J. (2003) Ann. Neurol. 54, 271-274
9. Unoki, M., and Nakamura, Y. (2001) Oncogene 20, 4457-4465
10. Yang, D. S., Tandon, A., Chen, F., Yu, G., Yu, H., Arawaka, S., Hasegawa, H., Duthie, M., Schmidt, S. D., Ramabhadran, T. V., Nixon, R. A., Mathews, P. M., Gandy, S. E., Mount, H. T., St George-Hyslop, P., and Fraser, P. E. (2002) J. Biol. Chem. 277, 28135-28142
11. da Costa, C. A., Ancolio, K., and Checler, F. (2000) J. Biol. Chem. 275, 24065-24069
12. Paitel, E., Fahraeus, R., and Checler, F. (2003) J. Biol. Chem. 278, 10061-10066
13. Dawson, T. M., and Dawson, V. L. (2003) Science 302, 819-822
14. Lee, M., Hyun, D., Halliwell, B., and Jenner, P. (2001) J. Neurochem. 76, 998-1009
15. Sansal, I., and Sellers, W. R. (2004) J. Clin. Oncol. 22, 2954-2963
16. Parsons, R. (2004) Semin. Cell Dev. Biol. 15, 171-176
17. Gary, D. S., and Mattson, M. P. (2002) Neuromolecular Med. 2, 261-269
18. Kim, R. H., Peters, M., Jang, Y., Shi, W., Pintilie, M., Fletcher, G. C., DeLuca, C., Liepa, J., Zhou, L., Snow, B., Binari, R. C., Manoukian, A. S., Bray, M. R., Liu, F. F., Tsao, M. S., and Mak, T. W. (2005) Cancer Cell 7, 263-273