Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 5, 2008, Pages 1716-1721

  Haque, M Emdadul ^a   Thomas, Kelly J ^b   D'Souza, Cheryl ^d   Callaghan, Steve ^a   Kitada, Tohru ^c   Slack, Ruth S ^a   Fraser, Paul ^d   Cookson, Mark R ^b   Tandon, Anurag ^d   Park, David S ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Neurodegeneration; Neuroprotection; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; GENE PRODUCT; NEUROTOXIN; PTEN INDUCED PUTATIVE KINASE 1; UNCLASSIFIED DRUG; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE RECEPTOR STIMULATING AGENT; PROTEIN KINASE; PTEN INDUCED PUTATIVE KINASE; PTEN-INDUCED PUTATIVE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DOPAMINERGIC SYSTEM; GENE IDENTIFICATION; GENETIC ENGINEERING; MALE; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; WILD TYPE; ANIMAL; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MITOCHONDRION; MOUSE STRAIN; MUTATION; NERVE CELL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; CELL SURVIVAL; CYTOPLASM; DOPAMINE AGENTS; MICE; MICE, INBRED STRAINS; MITOCHONDRIA; MUTATION; NEURONS; NEUROTOXINS; PARKINSON DISEASE; PROTEIN KINASES; RNA INTERFERENCE;

EID: 39449098267     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0705363105     Document Type: Article

References (38)