Elicitation of dopaminergic features of Parkinson's disease in C. elegans by monocrotophos, an organophosphorous insecticide

CNS and Neurological Disorders - Drug Targets

Volumn 11, Issue 8, 2012, Pages 993-1000

  Ali, Shaheen Jafri ^a   Rajini, Padmanabhan Sharda ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

Caenorhabditis elegans; Dopamine; Locomotory rate; Monocrotophos; Parkinson's disease; Transgenic strain

Indexed keywords

1, 2, 3, 6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACETYLCHOLINESTERASE; DOPAMINE; GREEN FLUORESCENT PROTEIN; MONOCROTOPHOS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIFESPAN; LOCOMOTION; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; SIGNAL TRANSDUCTION;

ANIMALS; CAENORHABDITIS ELEGANS; DOPAMINE; DOPAMINERGIC NEURONS; INSECTICIDES; MONOCROTOPHOS; MOTOR ACTIVITY; ORGANOPHOSPHORUS COMPOUNDS; PARKINSON DISEASE, SECONDARY;

EID: 84875035898     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527311211080008     Document Type: Article

References (45)

1. Olanow, C.W.; Tatton, W.G. Etiology and pathogenesis of Parkinson's disease. Ann. Rev. Neurosci., 1999, 22, 123-144.
2. Trancikova, A.; Ramonet, D.; Moore, D.J. Genetic mouse models of neurodegenerative diseases. Prog. Mol. Biol. Transl. Sci., 2011, 100, 419-482.
3. Bekris, L.M.; Mata, I.F.; Zabetian, C.P. The genetics of Parkinson disease, J. Geriatr. Psychiatry Neurol., 2010, 23, 228-242.
4. Gitler, A.D.; Chesi, A.; Geddie, M.L.; Strathearn, K.E.; Hamamichi, S.; Hill, K.J.; Caldwell, K.A.; Caldwell, G.A.; Cooper, A.A.; Rochet, J.C.; Lindquist, S. Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat. Genet., 2009, 41, 308-315.
5. Tanner, C.M.; Ottman, R.; Goldman, S.M.; Ellenberg, J.; Chan, P.; Mayeux, R.; Langston, J.W. Parkinson's disease in twins: an etiologic study. JAMA, 1999, 281, 341-346.
6. Le Couteur, D.G.; McLean, A.J.; Taylor, M.C.; Woodham, B.L.; Board, P.G. Pesticides and Parkinson's disease. Biomed. Pharmacother., 1999, 53, 122-130.
7. Priyadarshi, A.; Khuder, S.A.; Schaub, E.A.; Priyadarshi, S.S. Environmental risk factors and Parkinson's disease: a metaanalysis. Environ. Res., 2001, 86, 122-127.
8. Rajput, A.H.; Uitti, R.J.; Stern, W.; Laverty, W.; O'Donnell, K.; O'Donnell, D.; Yuen, W.K.; Dua, A. Geography, drinking water chemistry, pesticides and herbicides and the etiology of Parkinson's disease. Can. J. Neurol. Sci., 1987, 14, 414-418.
9. Semchuk, K.M.; Love, E.J.; Lee, R.G.; Parkinson's disease and exposure to rural environmental factors: a population based casecontrol study. Can. J. Neurol. Sci., 1991, 18, 279-286.
10. Stephenson, J. Exposure to home pesticides linked to Parkinson's disease. JAMA, 2000, 283, 3055-3056.
11. Choudhary, S.; Raheja G.; Gupta V.; Gill KD. Possible involvement of dopaminergic neurotransmitter systemin dichlorvos induced delayed neurotoxicity. J. Biochem. Mol. Biol. Biophys., 2002, 6, 29-36.
12. Karen, D.J.; Li, W.; Harp.P. R; Gillette.J. S; Bloomquist.J. R. Striatal dopaminergic pathways as a target for the insecticides permethrin and chlorpyrifos. Neurotoxicology, http://www.scienced irect.com/science/journal/0161813X/22/62001, 22, 811-817.
13. Nass, R.; Miller III D.M.; Blakely R.D. C. elegans: a novel pharmacogenetic model to study Parkinson's disease. Parkinsonism Relat. Disord., 2001, 7, 185-191.
14. Harrington, A.J.; Hamamichi, S.; Caldwell, G.A.; Caldwell, K.A. C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Develop. Dynam., 2010, 239, 1282-1295.
15. Schmidt, E.; Seifert, M.; Baumeister, R. Caenorhabditis elegans as a model system for Parkinson's disease. Neurodegener. Dis., 2007, 4, 199-217.
16. Nass R,; Blakely RD. The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration. Ann. Rev. Pharmacol. Toxicol., 2003, 43, 521-544.
17. Kuwahara, T.; Koyama, A.; Gengyo-Ando K.; Masuda, M.; Kowa, H.; Tsunoda, M.; Mitani, S.; Iwatsubo, T. Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. J. Biol. Chem., 2006, 281, 334-340.
18. Berkowitz, L.A.; Hamamichi, S.; Knight, A.L.; Harrington, A.J.; Caldwell, G.A.; Caldwell, K.A. Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson'sdisease genes. J. Vis. Exp., 2008, 17, 835.
19. Braungart, E.; Gerlach, M.; Riederer, P.; Baumeister, R.; Hoener, M.C.; Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings. Neurodegener. Dis., 2004, 1, 175-183.
20. Leung, M.C. K.; William, P. L; Benedetto, A; Au, C.; Kirsten J.; Helmcke, K. J; Aschner. M; Meyer, J.N. Caenorhabditis elegans: An emerging model in biomedical and environmental toxicology. Toxicol. Sci., 2008, 106(1), 5-28.
21. Peterson, R.T.; Nass, R.; Boyd, WA.; Freedman, J.H.; Dong, K.; Narahashi, T. Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology, 2008, 29, 546-55.
22. Williams, P.L.; Dusenbery, D.B. Using Caenorhabditis elegans to predict mammalian acute lethality to metallic salts. Toxicol. Ind. Health., 1988, 4, 469-478.
23. Brenner, S. The genetics of Caenorhbditis elegans. Genetics, 1974, 77, 1-94.
24. Fabian, T.E. Production of age-synchronous mass cultures of Caenorhabditis elegans. J. Gerontol. Biol. Sci., 1994, 49, B145-B156.
25. Galani, F.; Bocquene, G. Semi automated colorimetric and enzymatic assay for aquatic organisms using plate readers. Water Res., 1991, 25, 147-150.
26. Ellman, G.L.; Courtney, K.D.; Anders, V.; Featherstone, R.M. A new rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 1961, 7, 88-95.
27. Gruntenk, N.E.; Karpova, E.K.; Aleksee, v A.A.; Chentsova, N.A.; Saprykina, Z.V.; Bownes, M.; Rauschenbach, I.Y. Effects of dopamine on juvenile hormone metabolism and fitness in Drosophila virilis. J. Insect. Physiol., 2005, 51, 959-968.
28. Keaney, M.; Matthijssens, F.; Sharpe, M.; Vanfleteren, J.; Gems, D. Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans. Free Radic. Biol. Med., 2004, 37, 239-250.
29. Thiruchelvam, M.; Brockel, B.J.; Richfield, E.K.; Baggs, R.B.; Cory-Slechta, D.A. Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease?. Brain Res., 2000, 873, 225-234.
30. Thiruchelvam, M.; Richfield, E.K.; Baggs, R.B.; Tank, A.W.; Cory-Slechta, D.A. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J. Neurosci., 2000, 20, 9207-9214.
31. Schafer, W.R.; Kenyon, C.J. A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans. Nature, 1995, 375, 73-78.
32. Sawin, E.R.; Ranganathan, R.; Horvitz, H. R; C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron, 2000, 26, 619-631.
33. Hills, T.; Brockie, P.J.; Maricq, A.V. Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J. Neurosci., 2004, 24, 1217-1225.
34. Ruan, Q-L.; Ju, J-J.; Li, Y-H.; Liu, R.; Pu, Y-P.; Yin, L-H.; Wang, D-Y. Evaluation of pesticide toxicities with differing mechanisms using Caenorhabditis elegans. J. Toxicol. Environ. Health Part A, 2009, 72, 746-751.
35. Rand, J.B.; Nonet, M.L. Synaptic transmission. In C. elegans II (ed.D. L. Riddle, T. Blumenthal, B.J. Meyer, and J.R. Priess), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1997, pp. 611-644.
36. Rajini, P.S.; Melstrom, P.; William, P.W. A comparative study on the relationship between various toxicological endpoints in Caenorhabditis elegans exposed to organophosphorus insecticide. J. Toxicol. Environ. Health Part A, 2008, 71, 1043-1050.
37. Zang, L-Y.; Misra, H.P. Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride. Mol. Cell. Biochem., 2003, 254, 131-136.
38. Park, J.H.; Je Won Jung, J.W.; Ahn, Y-J.; Kwon, H.W. Neuroprotective properties of phytochemicals against paraquatinduced oxidative stress and neurotoxicity in Drosophila melanogaster. Pestic. Biochem. Physiol., 2012, http://dx. doi. org/10. 1016/j. pestbp. 2012. 07. 006.
39. Mandhane, S.N.; Chopde, C.T. Neurobehavioral effects of acute monocrotophos administration in rats and mice. Ind. J. Pharmacol., 1995, 27, 245-249.
40. Saha S.; Guillily M.D.; Ferree A.; Lanceta J.; Chan D.; Ghosh J.; Hsu C.H.; Segal L.; Raghavan K.; Matsumoto, K.; Hisamoto, N.; Kuwahara, T.; Iwatsubo, T,.; Moore, L.; Goldstein L.; Cookson M.; Wolozin, B. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J. Neurosci., 2009, 29, 9210-9218.
41. Marvanova, M.; Nichols, C.D. Identification of neuroprotective compounds of Caenorhabditis elegansdopaminergic neurons against 6-OHDA. J. Mol. Neurosci., 2007, 31, 127-137.
42. Ved, R.; Saha, S.; Westlund, B.; Perrier, C.; Burnam, L.; Sluder, A.; Hoene, r M.; Rodriguez, C.; Przedborski, S.; Alfonso, A.; Liu, L.; Wolozin, B. Similar patterns of mitochondrial vulnerability and rescueinduced by genetic modification of-synuclein, parkin and dj-1 in C. elegans. J. Biol. Chem., 2005, 280, 42655-4266.
43. Chaudhuri, A.; Bowling, K.; Funderburk, C.; Lawal, H.; Inamdar, A.; Wang, Z.; O'Donnell, J.M. Interaction of genetic and environmental factors in a Drosophila Parkinsonism model. J. Neurosci., 2007, 27, 2457-2467.
44. Kurauchi, M.; Morise, H.; Eki, T. Using the nematode Caenorhabditis elegans daf-16 mutant to assess the life span toxicity of prolonged exposure to ecotoxic agents. J. Health Sci., 2009, 55, 796-804.
45. Benedetto, A.; Au, C.; Avila, D.S.; Milatovic, D.; Aschner, M. Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans. PLoS Genet., 2010, 6(8), e1001084. doi:10. 1371/journal. pgen. 1001084.